An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

Nature Immunology

Volumn 7, Issue 4, 2006, Pages 401-410

  Hsieh, Chyi Song ^a,b   Zheng, Ye ^a   Liang, Yuqiong ^a   Fontenot, Jason D ^a   Rudensky, Alexander Y ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CELL ISOLATION; CONTROLLED STUDY; FLOW CYTOMETRY; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN INTERACTION; THYMUS; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; AUTOIMMUNITY; FORKHEAD TRANSCRIPTION FACTORS; GENE LIBRARY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL; SEQUENCE ANALYSIS, DNA; SPECIFIC PATHOGEN-FREE ORGANISMS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY; THYMUS GLAND;

EID: 33645102841     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1318     Document Type: Article

References (38)

1. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). J. Immunol. 155, 1151-1164 (1995).
2. +T cells induce or protect from chronic intestinal inflammation. Int. Immunol. 5, 1461-1471 (1993).
3. 1 regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22, 531-562 (2004).
4. Maloy, K.J. & Powrie, F. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2, 816-822 (2001).
5. + suppressor T cells: More questions than answers. Nat. Rev. Immunol. 2, 389-4OO (2002).
6. Taguchi, O. et al. Tissue-specific suppressor T cells involved in self-tolerance are activated extrathymically by self-antigens. Immunology 82, 365-369 (1994).
7. Seddon, B. & Mason, D. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity. J. Exp. Med. 189, 877-882 (1999).
8. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2, 301-306 (2001).
9. + T cell receptors. Immunity 21, 267-277 (2004).
10. + regulatory T cells in vivo. J. Exp. Med. 198, 249-258 (2003).
11. Van Santen, H.-M., Benoist, C. & Mathis, D. Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J. Exp. Med. 200, 1221-1230 (2004).
12. + T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J. Exp. Med. 188, 1883-1894 (1998).
13. Fontenot, J.D. & Rudensky, A.Y. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol. 6, 331-337 (2005).
14. Sakaguchi, S. & Sakaguchi, N. Thymus and autoimmunity: Capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for their induction of autoimmune disease. J. Exp. Med. 172, 537-545 (1990).
15. Fontenot, J.D., Dooley, J.L., Farr, A.G. & Rudensky, A.Y. Developmental regulation of Foxp3 expression during ontogeny. J. Exp. Med. 202, 901-906 (2005).
16. Apostolou, I. & von Boehmer, H. In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med. 199, 1401-1408 (2004).
17. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886 (2003).
18. - T cells. J. Clin. Invest. 112, 1437-1443 (2003).
19. + regulatory T cells control Leishmania major persistence and immunity. Nature 420, 502-507 (2002).
20. Yu, W. et al. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature 400, 682-687 (1999).
21. Fontenot, J.D. et al. Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 22, 329-341 (2005).
22. Correia-Neves, M., Waltzinger, C., Mathis, D. & Benoist, C. The shaping of the T cell repertoire. Immunity 14, 21-32 (2001).
23. Klein, L., Khazaie, K. & von Boehmer, H. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc. Natl. Acad. Sci. USA 100, 8886-8891 (2003).
24. + suppressor T cells in vivo. Nat. Immunol. 3, 33-41 (2002).
25. Chen, Z., Benoist, C. & Mathis, D. How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc. Natl. Acad. Sci. USA 102, 14735-14740 (2005).
26. + regulatory T cells. Nat. Immunol. 4, 330-336 (2003).
27. Hori,S., Nomura, T. & Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057-1061 (2003).
28. + T regulatory cells. Nat. Immunol. 4, 337-342 (2003).
29. Bennett, C.L. et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 27, 20-21 (2001).
30. Apostolou, I., Sarukhan, A., Klein, L. & von Boehmer, H. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3, 756-763 (2002).
31. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162, 5317-5326 (1999).
32. + regulatory T cells in the steady state. J. Exp. Med. 198, 737-746 (2003).
33. + T cells: Evidence from a lymphopenic T cell model. Immunity 17, 425-436 (2002).
34. + T cell development. J. Immunol. 164, 6252-6259 (2000).
35. Mach, N. et al. Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand. Cancer Res. 60, 3239-3246 (2000).
36. Magurran, A.E. Ecological diversity and its Measurement 95 (Princeton University Press, Princeton, New Jersey, 1988).
37. Colwell, R.K. EstimateS: Statistical estimation of species richness and shared species from samples. Version 6. User's Guide and application (http://viceroy.eeb,uconn.edu/estimates; 1997).
38. Casrouge, A. et al. Size estimate of the αβ TCR repertoire of naive mouse splenocytes. J. Immunol. 164, 5782-5787 (2000).