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Volumn 42, Issue 6, 2015, Pages 1048-1061

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; TRANSCRIPTOME; ANTIGENS, CD40; ANTIGENS, CD80; APECED PROTEIN; AUTOANTIGENS; HISTOCOMPATIBILITY ANTIGENS CLASS II; TRANSCRIPTION FACTORS;

EID: 84937631527     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2015.05.013     Document Type: Article
Times cited : (192)

References (55)
  • 1
    • 73149115486 scopus 로고    scopus 로고
    • Aire's partners in the molecular control of immunological tolerance
    • Abramson J., Giraud M., Benoist C., Mathis D. Aire's partners in the molecular control of immunological tolerance. Cell 2010, 140:123-135.
    • (2010) Cell , vol.140 , pp. 123-135
    • Abramson, J.1    Giraud, M.2    Benoist, C.3    Mathis, D.4
  • 3
    • 51349111243 scopus 로고    scopus 로고
    • The tumor necrosis factor family receptors RANK and CD40 cooperatively establish thethymic medullary microenvironment and self-tolerance
    • Akiyama T., Shimo Y., Yanai H., Qin J., Ohshima D., Maruyama Y., Asaumi Y., Kitazawa J., Takayanagi H., Penninger J.M., et al. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish thethymic medullary microenvironment and self-tolerance. Immunity 2008, 29:423-437.
    • (2008) Immunity , vol.29 , pp. 423-437
    • Akiyama, T.1    Shimo, Y.2    Yanai, H.3    Qin, J.4    Ohshima, D.5    Maruyama, Y.6    Asaumi, Y.7    Kitazawa, J.8    Takayanagi, H.9    Penninger, J.M.10
  • 6
  • 7
    • 76249088374 scopus 로고    scopus 로고
    • Thymus-blood protein interactions are highly effective in negative selection and regulatory Tcell induction
    • Atibalentja D.F., Byersdorfer C.A., Unanue E.R. Thymus-blood protein interactions are highly effective in negative selection and regulatory Tcell induction. J.Immunol. 2009, 183:7909-7918.
    • (2009) J.Immunol. , vol.183 , pp. 7909-7918
    • Atibalentja, D.F.1    Byersdorfer, C.A.2    Unanue, E.R.3
  • 12
    • 0035171545 scopus 로고    scopus 로고
    • Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
    • Derbinski J., Schulte A., Kyewski B., Klein L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2001, 2:1032-1039.
    • (2001) Nat. Immunol. , vol.2 , pp. 1032-1039
    • Derbinski, J.1    Schulte, A.2    Kyewski, B.3    Klein, L.4
  • 14
    • 78149462017 scopus 로고    scopus 로고
    • B cells participate in thymic negative selection of murine auto-reactive CD4+ Tcells
    • Frommer F., Waisman A. B cells participate in thymic negative selection of murine auto-reactive CD4+ Tcells. PLoS ONE 2010, 5:e15372.
    • (2010) PLoS ONE , vol.5 , pp. e15372
    • Frommer, F.1    Waisman, A.2
  • 15
    • 84912573148 scopus 로고    scopus 로고
    • T cell-B cell thymic cross-talk: maintenance and function of thymic B cells requires cognate CD40-CD40 ligand interaction
    • Fujihara C., Williams J.A., Watanabe M., Jeon H., Sharrow S.O., Hodes R.J. T cell-B cell thymic cross-talk: maintenance and function of thymic B cells requires cognate CD40-CD40 ligand interaction. J.Immunol. 2014, 193:5534-5544.
    • (2014) J.Immunol. , vol.193 , pp. 5534-5544
    • Fujihara, C.1    Williams, J.A.2    Watanabe, M.3    Jeon, H.4    Sharrow, S.O.5    Hodes, R.J.6
  • 20
    • 35748941369 scopus 로고    scopus 로고
    • Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
    • Gray D., Abramson J., Benoist C., Mathis D. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J.Exp. Med. 2007, 204:2521-2528.
    • (2007) J.Exp. Med. , vol.204 , pp. 2521-2528
    • Gray, D.1    Abramson, J.2    Benoist, C.3    Mathis, D.4
  • 21
    • 84857059706 scopus 로고    scopus 로고
    • Differential processing of self-antigens by subsets of thymic stromal cells
    • Guerder S., Viret C., Luche H., Ardouin L., Malissen B. Differential processing of self-antigens by subsets of thymic stromal cells. Curr. Opin. Immunol. 2012, 24:99-104.
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 99-104
    • Guerder, S.1    Viret, C.2    Luche, H.3    Ardouin, L.4    Malissen, B.5
  • 27
    • 84901487911 scopus 로고    scopus 로고
    • Positive and negative selection of the Tcell repertoire: what thymocytes see (and don't see)
    • Klein L., Kyewski B., Allen P.M., Hogquist K.A. Positive and negative selection of the Tcell repertoire: what thymocytes see (and don't see). Nat. Rev. Immunol. 2014, 14:377-391.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 377-391
    • Klein, L.1    Kyewski, B.2    Allen, P.M.3    Hogquist, K.A.4
  • 28
    • 0034655648 scopus 로고    scopus 로고
    • Functional comparison of thymic B cells and dendritic cells invivo
    • Kleindienst P., Chretien I., Winkler T., Brocker T. Functional comparison of thymic B cells and dendritic cells invivo. Blood 2000, 95:2610-2616.
    • (2000) Blood , vol.95 , pp. 2610-2616
    • Kleindienst, P.1    Chretien, I.2    Winkler, T.3    Brocker, T.4
  • 29
    • 67650507153 scopus 로고    scopus 로고
    • The thymic medulla: a unique microenvironment for intercellular self-antigen transfer
    • Koble C., Kyewski B. The thymic medulla: a unique microenvironment for intercellular self-antigen transfer. J.Exp. Med. 2009, 206:1505-1513.
    • (2009) J.Exp. Med. , vol.206 , pp. 1505-1513
    • Koble, C.1    Kyewski, B.2
  • 30
    • 76249101988 scopus 로고    scopus 로고
    • Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes
    • Laan M., Kisand K., Kont V., Möll K., Tserel L., Scott H.S., Peterson P. Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes. J.Immunol. 2009, 183:7682-7691.
    • (2009) J.Immunol. , vol.183 , pp. 7682-7691
    • Laan, M.1    Kisand, K.2    Kont, V.3    Möll, K.4    Tserel, L.5    Scott, H.S.6    Peterson, P.7
  • 31
    • 0021956416 scopus 로고
    • Antigen-specific interaction between T and B cells
    • Lanzavecchia A. Antigen-specific interaction between T and B cells. Nature 1985, 314:537-539.
    • (1985) Nature , vol.314 , pp. 537-539
    • Lanzavecchia, A.1
  • 32
  • 34
    • 77952302980 scopus 로고    scopus 로고
    • Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation
    • Nishikawa Y., Hirota F., Yano M., Kitajima H., Miyazaki J., Kawamoto H., Mouri Y., Matsumoto M. Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation. J.Exp. Med. 2010, 207:963-971.
    • (2010) J.Exp. Med. , vol.207 , pp. 963-971
    • Nishikawa, Y.1    Hirota, F.2    Yano, M.3    Kitajima, H.4    Miyazaki, J.5    Kawamoto, H.6    Mouri, Y.7    Matsumoto, M.8
  • 35
    • 0033533891 scopus 로고    scopus 로고
    • Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
    • Nutt S.L., Heavey B., Rolink A.G., Busslinger M. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 1999, 401:556-562.
    • (1999) Nature , vol.401 , pp. 556-562
    • Nutt, S.L.1    Heavey, B.2    Rolink, A.G.3    Busslinger, M.4
  • 36
    • 63449108301 scopus 로고    scopus 로고
    • Constitutive ablation of dendritic cells breaks self-tolerance of CD4 Tcells and results in spontaneous fatal autoimmunity
    • Ohnmacht C., Pullner A., King S.B., Drexler I., Meier S., Brocker T., Voehringer D. Constitutive ablation of dendritic cells breaks self-tolerance of CD4 Tcells and results in spontaneous fatal autoimmunity. J.Exp. Med. 2009, 206:549-559.
    • (2009) J.Exp. Med. , vol.206 , pp. 549-559
    • Ohnmacht, C.1    Pullner, A.2    King, S.B.3    Drexler, I.4    Meier, S.5    Brocker, T.6    Voehringer, D.7
  • 37
    • 84885801968 scopus 로고    scopus 로고
    • Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for Tcell negative selection
    • Perera J., Meng L., Meng F., Huang H. Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for Tcell negative selection. Proc. Natl. Acad. Sci. USA 2013, 110:17011-17016.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 17011-17016
    • Perera, J.1    Meng, L.2    Meng, F.3    Huang, H.4
  • 38
    • 84907982768 scopus 로고    scopus 로고
    • Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus
    • Perry J.S., Lio C.W., Kau A.L., Nutsch K., Yang Z., Gordon J.I., Murphy K.M., Hsieh C.S. Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus. Immunity 2014, 41:414-426.
    • (2014) Immunity , vol.41 , pp. 414-426
    • Perry, J.S.1    Lio, C.W.2    Kau, A.L.3    Nutsch, K.4    Yang, Z.5    Gordon, J.I.6    Murphy, K.M.7    Hsieh, C.S.8
  • 39
    • 56749161528 scopus 로고    scopus 로고
    • Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
    • Peterson P., Org T., Rebane A. Transcriptional regulation by AIRE: molecular mechanisms of central tolerance. Nat. Rev. Immunol. 2008, 8:948-957.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 948-957
    • Peterson, P.1    Org, T.2    Rebane, A.3
  • 40
    • 0037390660 scopus 로고    scopus 로고
    • B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells
    • Phan T.G., Amesbury M., Gardam S., Crosbie J., Hasbold J., Hodgkin P.D., Basten A., Brink R. B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells. J.Exp. Med. 2003, 197:845-860.
    • (2003) J.Exp. Med. , vol.197 , pp. 845-860
    • Phan, T.G.1    Amesbury, M.2    Gardam, S.3    Crosbie, J.4    Hasbold, J.5    Hodgkin, P.D.6    Basten, A.7    Brink, R.8
  • 43
    • 84913594338 scopus 로고    scopus 로고
    • Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia
    • Sansom S.N., Shikama-Dorn N., Zhanybekova S., Nusspaumer G., Macaulay I.C., Deadman M.E., Heger A., Ponting C.P., Holländer G.A. Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia. Genome Res. 2014, 24:1918-1931.
    • (2014) Genome Res. , vol.24 , pp. 1918-1931
    • Sansom, S.N.1    Shikama-Dorn, N.2    Zhanybekova, S.3    Nusspaumer, G.4    Macaulay, I.C.5    Deadman, M.E.6    Heger, A.7    Ponting, C.P.8    Holländer, G.A.9
  • 45
    • 84862777339 scopus 로고    scopus 로고
    • β5t-containing thymoproteasome: specific expression in thymic cortical epithelial cells and role in positive selection of CD8+ Tcells
    • Takahama Y., Takada K., Murata S., Tanaka K. β5t-containing thymoproteasome: specific expression in thymic cortical epithelial cells and role in positive selection of CD8+ Tcells. Curr. Opin. Immunol. 2012, 24:92-98.
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 92-98
    • Takahama, Y.1    Takada, K.2    Murata, S.3    Tanaka, K.4
  • 48
    • 0031568068 scopus 로고    scopus 로고
    • Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted Tcells recognizing a circulating self antigen
    • Volkmann A., Zal T., Stockinger B. Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted Tcells recognizing a circulating self antigen. J.Immunol. 1997, 158:693-706.
    • (1997) J.Immunol. , vol.158 , pp. 693-706
    • Volkmann, A.1    Zal, T.2    Stockinger, B.3
  • 49
    • 84903625200 scopus 로고    scopus 로고
    • A role for intrathymic B cells in the generation of natural regulatory Tcells
    • Walters S.N., Webster K.E., Daley S., Grey S.T. A role for intrathymic B cells in the generation of natural regulatory Tcells. J.Immunol. 2014, 193:170-176.
    • (2014) J.Immunol. , vol.193 , pp. 170-176
    • Walters, S.N.1    Webster, K.E.2    Daley, S.3    Grey, S.T.4
  • 53
    • 22144444873 scopus 로고    scopus 로고
    • Heterogeneity of thymic dendritic cells
    • Wu L., Shortman K. Heterogeneity of thymic dendritic cells. Semin. Immunol. 2005, 17:304-312.
    • (2005) Semin. Immunol. , vol.17 , pp. 304-312
    • Wu, L.1    Shortman, K.2
  • 55
    • 84879647283 scopus 로고    scopus 로고
    • How B cells capture, process and present antigens: a crucial role for cell polarity
    • Yuseff M.I., Pierobon P., Reversat A., Lennon-Duménil A.M. How B cells capture, process and present antigens: a crucial role for cell polarity. Nat. Rev. Immunol. 2013, 13:475-486.
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 475-486
    • Yuseff, M.I.1    Pierobon, P.2    Reversat, A.3    Lennon-Duménil, A.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.