Quantitative impact of thymic clonal deletion on the T cell repertoire

Journal of Experimental Medicine

Volumn 185, Issue 3, 1997, Pages 377-383

  Van Meerwijk, Joost P M ^a   Marguerat, Samuel ^a   Lees, Rosemary K ^a   Germain, Ronald N ^b   Fowlkes, B J ^c   MacDonald, H Robson ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; BONE MARROW; CELL DEATH; CELL MATURATION; CELL SELECTION; CONTROLLED STUDY; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION CHIMERA; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; THYMUS;

ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; CLONAL DELETION; HISTOCOMPATIBILITY ANTIGENS; MICE; MICE, INBRED C57BL; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0031048826     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.3.377     Document Type: Article

References (62)

1. Swain, S.L. 1983. T cell subsets and the recognition of MHC class. Immunol. Rev. 74:129-142.
2. Anderson, G., N.C. Moore, J.J.T. Owen, and E.J. Jenkinson. 1996. Cellular interactions in thymocyte development. Annu. Rev. Immunol. 14:73-99.
3. Jameson, S.C., K.A. Hogquist, and M.J. Bevan. 1995. Positive selection of thymocytes. Annu. Rev. Immunol. 13:93-126.
4. + thymocytes selected by MHC class I molecules. Science (Wash. DC). 263:1774-1778.
5. - thymocytes by class I molecules expressed by hematopoietic cells. J. Exp. Med. 178:901-908.
6. Bix, M., and D. Raulet. 1992. Inefficient positive selection of T cells directed by haematopoietic cells. Nature (Lond.). 359: 330-333.
7. + T lymphocytes in class II-deficient mice. Proc. Natl. Acad. Sci. USA. 90:2779-2783.
8. Nossal, G.J. 1994. Negative selection of lymphocytes. Cell. 76:229-239.
9. Schwartz, R.H. 1989. Acquisition of immunologic self-tolerance. Cell. 57:1073-1081.
10. Bonomo, A., and P. Matzinger. 1993. Thymus epithelium induces tissue-specific tolerance. J. Exp. Med. 177:1153-1164.
11. + T cells by transgenic I-E restricted to thymic medullary epithelium. J. Immunol. 151:3954-3960.
12. Carlow, D.A., S.J. Teh, and H.S. Teh. 1992. Altered thymocyte development resulting from expressing a deleting ligand on selecting thymic epithelium. J. Immunol. 148:2988-2995.
13. + thymocytes. J. Immunol. 152:3254-3263.
14. Gao, E.K., D. Lo, and J. Sprent. 1990. Strong T cell tolerance in parent→F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy. J. Exp. Med. 171:1101-1121.
15. + thymocytes in vitro does not require dedicated antigen-presenting cells. Eur. J. Immunol. 23:669-674.
16. Robey, E., and B.J. Fowlkes. 1994. Selective events in T cell development. Annu. Rev. Immunol. 12:675-705.
17. Speiser, D.E., H. Pircher, P.S. Ohashi, D. Kyburz, H. Hengartner, and R.M. Zinkernagel. 1992. Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny. J. Exp. Med. 175:1277-1283.
18. MacDonald, H.R., A.L. Glasebrook, R. Schneider, R.K. Lees, H. Pircher, T. Pedrazzini, O. Kanagawa, J.F. Nicolas, R.C. Howe, R.M. Zinkernagel, and H. Hengartner. 1989. T-cell reactivity and tolerance to Mls a-encoded antigens. Immunol. Rev. 107:89-108.
19. Simpson, E., P.J. Dyson, A.M. Knight, P.J. Robinson, J.I. Elliott, and D.M. Altmann. 1993. T-cell receptor repertoire selection by mouse mammary tumor viruses and MHC molecules. Immunol. Rev. 131:93-115.
20. von Boehmer, H. 1990. Developmental biology of T cells in T cell-receptor transgenic mice. Annu. Rev. Immunol. 8:531-556.
21. Fung-Leung, W.-P., C.D. Surh, M. Liljedahl, J. Pang, D. Leturcq, P.A. Peterson, S.R. Webb, and L. Karlsson. 1996. Antigen presentation and T cell development in H2-M-deficient mice. Science (Wash. DC). 271:1278-1281.
22. Ignatowicz, L., J. Kappler, and P. Marrack. 1996. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell. 84:521-529.
23. Martin, W.D., G.G. Hicks, S.K. Mendiratta, H.I. Leva, H.E. Ruley, and L. Van Kaer. 1996. H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell. 84:543-550.
24. Miyazaki, T., P. Wolf, S. Tourne, C. Waltzinger, A. Dierich, N. Barois, H. Ploegh, C. Benoist, and D. Mathis. 1996. Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell. 84:531-541.
25. Laufer, T.M., J. DeKoning, J.S. Markowitz, D. Lo, and L.H. Glimcher. 1996. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature (Lond.). 383:81-85.
26. + T cells. Science (Wash. DC). 248: 1227-1230.
27. + T cells in major histocompatibility complex class II-deficient mice. Science (Wash. DC). 253:1417-1420.
28. Koentgen, F., G. Suess, C. Stewart, M. Steinmetz, and H. Bluethmann. 1993. Targeted disruption of the MHC class II Aα gene in C57BL/6 mice. Int. Immunol. 5:957-964.
29. van Meerwijk, J.P.M., E.M. O'Connell, and R.N. Germain. 1995. Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes. J. Immunol. 154:6314-6324.
30. Bruce, J., F.W. Symington, T.J. McKearn, and J. Sprent. 1981. A monoclonal antibody discriminating between subsets of T and B cells. J. Immunol. 127:2496-2501.
31. Mark, C., F. Figueroa, Z.A. Nagy, and J. Klein. 1982. Cytotoxic monoclonal antibody specific for the Lyt-1.2 antigen. Immunogenetics. 16:95-97.
32. - variants of a cloned cytolytic T cell line lack an antigen receptor functional in cytolysis. J. Exp. Med. 153:595-604.
33. Lesley, J., and I.S. Trowbridge. 1982. Genetic characterization of a polymorphic murine cell-surface glycoprotein. Immunogenetics. 15:313-320.
34. Springer, T., G. Galfre, D.S. Secher, and C. Milstein. 1978. Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. Eur. J. Immunol. 8:539-551.
35. Yokoyama, W.M., F. Koning, P.J. Kehn, G.M. Pereira, G. Stingl, J.E. Coligan, and E.M. Shevach. 1988. Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation. J. Immunol. 141:369-376.
36. Dialynas, D.P., Z.S. Quan, K.A. Wall, A. Pierres, J. Quintans, M.R. Loken, M. Pierres, and F.W. Fitch. 1983. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J. Immunol. 131: 2445-2451.
37. Grusby, M.J., and L.H. Glimcher. 1995. Immune responses in MHC class II-deficient mice. Annu. Rev. Immunol. 13: 417-435.
38. Raulet, D.H. 1994. MHC class I-deficient mice. Adv. Immunol. 55:381-421.
39. Bendelac, A., P. Matzinger, R.A. Seder, W.E. Paul, and R.H. Schwartz. 1992. Activation events during thymic selection. J. Exp. Med. 175:731-742.
40. + thymocytes. Eur. J. Immunol. 23:739-746.
41. + thymocytes: selection rather than instruction? Science (Wash. DC). 261:911-915.
42. Nikolic-Zugic, J., and M.J. Bevan. 1990. Functional and phenotypic delineation of two subsets of CD4 single positive cells in the thymus. Int. Immunol. 2:135-141.
43. - thymocytes are functionally immature. J. Immunol. 147:1779-1785.
44. Agus, D.B., C.D. Surh, and J. Sprent. 1991. Re-entry of T cells to the adult thymus is restricted to activated T cells. J. Exp. Med. 173:1039-1046.
45. Fukushi, N., H. Arase, B. Wang, K. Ogasawara, T. Gotohda, R.A. Good, and K. Onoe. 1990. Thymus: a direct target tissue in graft-versus-host reaction after allogeneic bone marrow transplantation that results in abrogation of induction of self-tolerance. Proc. Natl. Acad. Sci. USA. 87:6301-6305.
46. Surh, C.D., J. Sprent, and S.R. Webb. 1993. Exclusion of circulating T cells from the thymus does not apply in the neonatal period. J. Exp. Med. 177:379-385.
47. Budd, R.C., J.C. Cerottini, C. Horvath, C. Bron, T. Pedrazzini, R.C. Howe, and H.R. MacDonald. 1987. Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation. J. Immunol. 138:3120-3129.
48. - intrathymic T cell precursors. Thymus. 15:65-78.
49. Huiskamp, R., and W. van Ewijk. 1985. Repopulation of the mouse thymus after sublethal fission neutron irradiation. I. Sequential appearance of thymocyte subpopulations. J. Immunol. 134:2161-2169.
50. Kadish, J.L., and R.S. Basch. 1975. Thymic regeneration after lethal irradiation: evidence for an intrathymic radioresistant T cell precursor. J. Immunol. 114:452-458.
51. Tomooka, S., G. Matsuzaki, K. Kishihara, K. Tanaka, Y. Yoshikai, K. Taniguchi, K. Himeno, and K. Nomoto. 1987. Sequential appearance of thymocyte subpopulations and T cell antigen receptor gene messages in the mouse thymus after sublethal irradiation. J. Immunol. 139:3986-3990.
52. Zúñiga-Pflücker, J.C., and A.M. Kruisbeek. 1990. Intrathymic radioresistant stem cells follow an IL-2/IL-2R pathway during thymic regeneration after sublethal irradiation. J. Immunol. 144:3736-3740.
53. Egerton, M., R. Scollay, and K. Shortman. 1990. Kinetics of mature T-cell development in the thymus. Proc. Natl. Acad. Sci. USA. 87:2579-2582.
54. Huesmann, M., B. Scott, P. Kisielow, and H. von Boehmer. 1991. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell. 66:533-540.
55. Surh, C.D., and J. Sprent. 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature (Lond.). 372:100-103.
56. Chan, S.H., D. Cosgrove, C. Waltzinger, C. Benoist, and D. Mathis. 1993. Another view of the selective model of thymocyte selection. Cell. 73:225-236.
57. Guidos, C.J., J.S. Danska, C.G. Fathman, and I.L. Weissman. 1990. T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages. J. Exp. Med. 172:835-845.
58. Kishimoto, H., Z. Cai, A. Brunmark, M.R. Jackson, P.A. Peterson, and J. Sprent. 1996. Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes. J. Exp. Med. 184:531-537.
59. + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J. Exp. Med. 179:709-713.
60. Marrack, P., L. Ignatowicz, J.W. Kappler, J. Boymel, and J.H. Freed. 1993. Comparison of peptides bound to spleen and thymus class II. J. Exp. Med. 178:2173-2183.
61. Ramsdell, F., and B.J. Fowlkes. 1990. Clonal deletion and clonal anergy: The role of the thymus in inducing self tolerance. Science (Wash. DC). 248:1342-1348.
62. Sprent, J., H. Kosaka, E.-K. Gao, C.D. Surh, and S.R. Webb. 1993. Intrathymic and extrathymic tolerance in bone marrow chimeras. Immunol. Rev. 133:151-176.