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Volumn 29, Issue 3, 2008, Pages 451-463

Autoantigen-Specific Interactions with CD4+ Thymocytes Control Mature Medullary Thymic Epithelial Cell Cellularity

Author keywords

CELLIMMUNO

Indexed keywords

AUTOANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

EID: 51349101423     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2008.08.007     Document Type: Article
Times cited : (214)

References (43)
  • 2
    • 51349111243 scopus 로고    scopus 로고
    • The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance
    • this issue
    • Akiyama T., Shimo Y., Yanai H., Qin J., Ohshima D., Maruyama Y., Asamui Y., Kitazawa J., Takayanagi H., Penninger J., et al. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity 29 (2008) 423-437 this issue
    • (2008) Immunity , vol.29 , pp. 423-437
    • Akiyama, T.1    Shimo, Y.2    Yanai, H.3    Qin, J.4    Ohshima, D.5    Maruyama, Y.6    Asamui, Y.7    Kitazawa, J.8    Takayanagi, H.9    Penninger, J.10
  • 6
    • 33845381897 scopus 로고    scopus 로고
    • Functional adaptive CD4 Foxp3 T cells develop in MHC class II-deficient mice
    • Bochtler P., Wahl C., Schirmbeck R., and Reimann J. Functional adaptive CD4 Foxp3 T cells develop in MHC class II-deficient mice. J. Immunol. 177 (2006) 8307-8314
    • (2006) J. Immunol. , vol.177 , pp. 8307-8314
    • Bochtler, P.1    Wahl, C.2    Schirmbeck, R.3    Reimann, J.4
  • 7
    • 0041884736 scopus 로고    scopus 로고
    • Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR
    • Boehm T., Scheu S., Pfeffer K., and Bleul C.C. Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR. J. Exp. Med. 198 (2003) 757-769
    • (2003) J. Exp. Med. , vol.198 , pp. 757-769
    • Boehm, T.1    Scheu, S.2    Pfeffer, K.3    Bleul, C.C.4
  • 9
    • 24744448656 scopus 로고    scopus 로고
    • Linking signalling pathways, thymic stroma integrity and autoimmunity
    • Derbinski J., and Kyewski B. Linking signalling pathways, thymic stroma integrity and autoimmunity. Trends Immunol. 26 (2005) 503-506
    • (2005) Trends Immunol. , vol.26 , pp. 503-506
    • Derbinski, J.1    Kyewski, B.2
  • 10
    • 0035171545 scopus 로고    scopus 로고
    • Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
    • Derbinski J., Schulte A., Kyewski B., and Klein L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2 (2001) 1032-1039
    • (2001) Nat. Immunol. , vol.2 , pp. 1032-1039
    • Derbinski, J.1    Schulte, A.2    Kyewski, B.3    Klein, L.4
  • 12
  • 13
    • 0036864744 scopus 로고    scopus 로고
    • Organization of thymic medullary epithelial heterogeneity: Implications for mechanisms of epithelial differentiation
    • Farr A.G., Dooley J.L., and Erickson M. Organization of thymic medullary epithelial heterogeneity: Implications for mechanisms of epithelial differentiation. Immunol. Rev. 189 (2002) 20-27
    • (2002) Immunol. Rev. , vol.189 , pp. 20-27
    • Farr, A.G.1    Dooley, J.L.2    Erickson, M.3
  • 14
    • 7244227645 scopus 로고    scopus 로고
    • Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
    • Gallegos A.M., and Bevan M.J. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J. Exp. Med. 200 (2004) 1039-1049
    • (2004) J. Exp. Med. , vol.200 , pp. 1039-1049
    • Gallegos, A.M.1    Bevan, M.J.2
  • 16
    • 33845239216 scopus 로고    scopus 로고
    • Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells
    • Gray D.H., Seach N., Ueno T., Milton M.K., Liston A., Lew A.M., Goodnow C.C., and Boyd R.L. Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood 108 (2006) 3777-3785
    • (2006) Blood , vol.108 , pp. 3777-3785
    • Gray, D.H.1    Seach, N.2    Ueno, T.3    Milton, M.K.4    Liston, A.5    Lew, A.M.6    Goodnow, C.C.7    Boyd, R.L.8
  • 17
    • 35748941369 scopus 로고    scopus 로고
    • Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
    • Gray D., Abramson J., Benoist C., and Mathis D. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J. Exp. Med. 204 (2007) 2521-2528
    • (2007) J. Exp. Med. , vol.204 , pp. 2521-2528
    • Gray, D.1    Abramson, J.2    Benoist, C.3    Mathis, D.4
  • 18
    • 51349092893 scopus 로고    scopus 로고
    • The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator
    • this issue
    • Hikosaka Y., Nitta T., Ohigashi I., Yano K., Ishimaru N., Hayashi Y., Matsumoto M., Matsuo K., Penninger J., Takayanagi H., et al. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity 29 (2008) 438-450 this issue
    • (2008) Immunity , vol.29 , pp. 438-450
    • Hikosaka, Y.1    Nitta, T.2    Ohigashi, I.3    Yano, K.4    Ishimaru, N.5    Hayashi, Y.6    Matsumoto, M.7    Matsuo, K.8    Penninger, J.9    Takayanagi, H.10
  • 22
    • 0029812040 scopus 로고    scopus 로고
    • Constitutive class I-restricted exogenous presentation of self antigens in vivo
    • Kurts C., Heath W.R., Carbone F.R., Allison J., Miller J.F., and Kosaka H. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J. Exp. Med. 184 (1996) 923-930
    • (1996) J. Exp. Med. , vol.184 , pp. 923-930
    • Kurts, C.1    Heath, W.R.2    Carbone, F.R.3    Allison, J.4    Miller, J.F.5    Kosaka, H.6
  • 23
    • 33646165128 scopus 로고    scopus 로고
    • A central role for central tolerance
    • Kyewski B., and Klein L. A central role for central tolerance. Annu. Rev. Immunol. 24 (2006) 571-606
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 571-606
    • Kyewski, B.1    Klein, L.2
  • 24
    • 0029835390 scopus 로고    scopus 로고
    • Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex
    • Laufer T.M., DeKoning J., Markowitz J.S., Lo D., and Glimcher L.H. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 383 (1996) 81-85
    • (1996) Nature , vol.383 , pp. 81-85
    • Laufer, T.M.1    DeKoning, J.2    Markowitz, J.S.3    Lo, D.4    Glimcher, L.H.5
  • 25
  • 26
    • 33746069706 scopus 로고    scopus 로고
    • Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival
    • Lesley R., Kelly L.M., Xu Y., and Cyster J.G. Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival. Proc. Natl. Acad. Sci. USA 103 (2006) 10717-10722
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 10717-10722
    • Lesley, R.1    Kelly, L.M.2    Xu, Y.3    Cyster, J.G.4
  • 27
    • 0030949011 scopus 로고    scopus 로고
    • Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA
    • Muhlethaler-Mottet A., Otten L.A., Steimle V., and Mach B. Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. EMBO J. 16 (1997) 2851-2860
    • (1997) EMBO J. , vol.16 , pp. 2851-2860
    • Muhlethaler-Mottet, A.1    Otten, L.A.2    Steimle, V.3    Mach, B.4
  • 28
    • 0141955147 scopus 로고    scopus 로고
    • In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medulla
    • Nasreen M., Ueno T., Saito F., and Takahama Y. In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medulla. J. Immunol. 171 (2003) 3394-3400
    • (2003) J. Immunol. , vol.171 , pp. 3394-3400
    • Nasreen, M.1    Ueno, T.2    Saito, F.3    Takahama, Y.4
  • 30
    • 0027758094 scopus 로고
    • Expression of the alpha beta T-cell receptor is necessary for the generation of the thymic medulla
    • Palmer D.B., Viney J.L., Ritter M.A., Hayday A.C., and Owen M.J. Expression of the alpha beta T-cell receptor is necessary for the generation of the thymic medulla. Dev. Immunol. 3 (1993) 175-179
    • (1993) Dev. Immunol. , vol.3 , pp. 175-179
    • Palmer, D.B.1    Viney, J.L.2    Ritter, M.A.3    Hayday, A.C.4    Owen, M.J.5
  • 31
    • 25844499012 scopus 로고    scopus 로고
    • Regulation of MHC class II gene expression by the class II transactivator
    • Reith W., LeibundGut-Landmann S., and Waldburger J.M. Regulation of MHC class II gene expression by the class II transactivator. Nat. Rev. Immunol. 5 (2005) 793-806
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 793-806
    • Reith, W.1    LeibundGut-Landmann, S.2    Waldburger, J.M.3
  • 32
    • 42649138855 scopus 로고    scopus 로고
    • Thymus organogenesis
    • Rodewald H.R. Thymus organogenesis. Annu. Rev. Immunol. 26 (2008) 355-388
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 355-388
    • Rodewald, H.R.1
  • 34
    • 0025885218 scopus 로고
    • Disorganization and restoration of thymic medullary epithelial cells in T cell receptor-negative scid mice: evidence that receptor-bearing lymphocytes influence maturation of the thymic microenvironment
    • Shores E.W., Van Ewijk W., and Singer A. Disorganization and restoration of thymic medullary epithelial cells in T cell receptor-negative scid mice: evidence that receptor-bearing lymphocytes influence maturation of the thymic microenvironment. Eur. J. Immunol. 21 (1991) 1657-1661
    • (1991) Eur. J. Immunol. , vol.21 , pp. 1657-1661
    • Shores, E.W.1    Van Ewijk, W.2    Singer, A.3
  • 35
    • 0026749048 scopus 로고
    • Growth of epithelial cells in the thymic medulla is under the control of mature T cells
    • Surh C.D., Ernst B., and Sprent J. Growth of epithelial cells in the thymic medulla is under the control of mature T cells. J. Exp. Med. 176 (1992) 611-616
    • (1992) J. Exp. Med. , vol.176 , pp. 611-616
    • Surh, C.D.1    Ernst, B.2    Sprent, J.3
  • 36
    • 33644845679 scopus 로고    scopus 로고
    • Journey through the thymus: stromal guides for T-cell development and selection
    • Takahama Y. Journey through the thymus: stromal guides for T-cell development and selection. Nat. Rev. Immunol. 6 (2006) 127-135
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 127-135
    • Takahama, Y.1
  • 38
    • 16644401049 scopus 로고    scopus 로고
    • Development of T-lymphocytes in mouse fetal thymus organ culture
    • Ueno T., Liu C., Nitta T., and Takahama Y. Development of T-lymphocytes in mouse fetal thymus organ culture. Methods Mol. Biol. 290 (2005) 117-133
    • (2005) Methods Mol. Biol. , vol.290 , pp. 117-133
    • Ueno, T.1    Liu, C.2    Nitta, T.3    Takahama, Y.4
  • 39
    • 0343183281 scopus 로고    scopus 로고
    • Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets
    • van Ewijk W., Hollander G., Terhorst C., and Wang B. Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets. Development 127 (2000) 1583-1591
    • (2000) Development , vol.127 , pp. 1583-1591
    • van Ewijk, W.1    Hollander, G.2    Terhorst, C.3    Wang, B.4
  • 40
    • 0025876488 scopus 로고
    • Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation
    • Vassar R., and Fuchs E. Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes Dev. 5 (1991) 714-727
    • (1991) Genes Dev. , vol.5 , pp. 714-727
    • Vassar, R.1    Fuchs, E.2
  • 41
    • 0035920552 scopus 로고    scopus 로고
    • Selective abrogation of major histocompatibility complex class II expression on extrahematopoietic cells in mice lacking promoter IV of the class II transactivator gene
    • Waldburger J.M., Suter T., Fontana A., Acha-Orbea H., and Reith W. Selective abrogation of major histocompatibility complex class II expression on extrahematopoietic cells in mice lacking promoter IV of the class II transactivator gene. J. Exp. Med. 194 (2001) 393-406
    • (2001) J. Exp. Med. , vol.194 , pp. 393-406
    • Waldburger, J.M.1    Suter, T.2    Fontana, A.3    Acha-Orbea, H.4    Reith, W.5
  • 42
    • 0037528761 scopus 로고    scopus 로고
    • Promoter IV of the class II transactivator gene is essential for positive selection of CD4+ T cells
    • Waldburger J.M., Rossi S., Hollander G.A., Rodewald H.R., Reith W., and Acha-Orbea H. Promoter IV of the class II transactivator gene is essential for positive selection of CD4+ T cells. Blood 101 (2003) 3550-3559
    • (2003) Blood , vol.101 , pp. 3550-3559
    • Waldburger, J.M.1    Rossi, S.2    Hollander, G.A.3    Rodewald, H.R.4    Reith, W.5    Acha-Orbea, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.