Diversity of TCRs on natural Foxp3+ T cells in mice lacking Aire expression

Journal of Immunology

Volumn 184, Issue 12, 2010, Pages 6865-6873

  Daniely, Danielle ^a   Kern, Joanna ^a   Cebula, Anna ^a   Ignatowicz, Leszek ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; ANTIGEN; AUTOIMMUNE REGULATOR PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; EPITHELIUM CELL; HYBRIDOMA; MOUSE; NONHUMAN; PHENOTYPE; PRECURSOR; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; THYMOCYTE; ANIMAL; CELL SEPARATION; FLOW CYTOMETRY; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS; CELL SEPARATION; FLOW CYTOMETRY; IMMUNE TOLERANCE; MICE; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TRANSCRIPTION FACTORS;

EID: 77953645370     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0903609     Document Type: Article

References (34)

1. Shevach, E. M., R. A. DiPaolo, J. Andersson, D. M. Zhao, G. L. Stephens, and A. M. Thornton. 2006. The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells. Immunol. Rev. 212: 60-73.
2. Sakaguchi, S., T. Yamaguchi, T. Nomura, and M. Ono. 2008. Regulatory T cells and immune tolerance. Cell 133: 775-787.
3. Bensinger, S. J., A. Bandeira, M. S. Jordan, A. J. Caton, and T. M. Laufer. 2001. Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells. J. Exp. Med. 194: 427-438.
4. Jordan, M. S., A. Boesteanu, A. J. Reed, A. L. Petrone, A. E. Holenbeck, M. A. Lerman, A. Naji, and A. J. Caton. 2001. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2: 301-306.
5. Fujishima, M., M. Hirokawa, N. Fujishima, and K. i. Sawada. 2005. TCRalphabeta repertoire diversity of human naturally occurring CD4+CD25+ regulatory T cells. Immunol. Lett. 99: 193-197.
6. Fontenot, J. D., J. L. Dooley, A. G. Farr, and A. Y. Rudensky. 2005. Developmental regulation of Foxp3 expression during ontogeny. J. Exp. Med. 202: 901-906.
7. Lee, H. M., and C. S. Hsieh. 2009. Rare development of Foxp3+ thymocytes in the CD4+CD8+ subset. J. Immunol. 183: 2261-2266.
8. Liu, Y. J. 2006. A unified theory of central tolerance in the thymus. Trends Immunol. 27: 215-221.
9. Aschenbrenner, K., L. M. D'Cruz, E. H. Vollmann, M. Hinterberger, J. Emmerich, L. K. Swee, A. Rolink, and L. Klein. 2007. Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat. Immunol. 8: 351-358.
10. Li, J., J. Park, D. Foss, and I. Goldschneider. 2009. Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus. J. Exp. Med. 206: 607-622.
11. Hansenne, I., C. Louis, H. Martens, G. Dorban, C. Charlet-Renard, P. Peterson, and V. Geenen. 2009. Aire and Foxp3 expression in a particular microenvironment for T cell differentiation. Neuroimmunomodulation 16: 35-44.
12. Kekäläinen, E., H. Tuovinen, J. Joensuu, M. Gylling, R. Franssila, N. Pöntynen, K. Talvensaari, J. Perheentupa, A. Miettinen, and T. P. Arstila. 2007. A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J. Immunol. 178: 1208-1215.
13. Bettini, M. L., and D. A. Vignali. 2010. Development of thymically derived natural regulatory T cells. Ann. N. Y. Acad. Sci. 1183: 1-12.
14. Guerau-de-Arellano, M., M. Martinic, C. Benoist, and D. Mathis. 2009. Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity. J. Exp. Med. 206: 1245-1252.
15. Samy, E. T., K. M. Wheeler, R. J. Roper, C. Teuscher, and K. S. Tung. 2008. Cutting edge: Autoimmune disease in day 3 thymectomized mice is actively controlled by endogenous disease-specific regulatory T cells. J. Immunol. 180: 4366-4370.
16. Cabaniols, J. P., N. Fazilleau, A. Casrouge, P. Kourilsky, and J. M. Kanellopoulos. 2001. Most alpha/beta T cell receptor diversity is due to terminal deoxynucleotidyl transferase. J. Exp. Med. 194: 1385-1390.
17. Pacholczyk, R., H. Ignatowicz, P. Kraj, and L. Ignatowicz. 2006. Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells. Immunity 25: 249-259.
18. Wang, C., C. M. Sanders, Q. Yang, H. W. Schroeder, Jr., E. Wang, F. Babrzadeh, B. Gharizadeh, R. M. Myers, J. R. Hudson, Jr., R. W. Davis, and J. Han. 2010. High throughput sequencing reveals a complex pattern of dynamic inter-relationships among human T cell subsets. Proc. Natl. Acad. Sci. USA 107: 1518-1523.
19. Anderson, M. S., E. S. Venanzi, Z. Chen, S. P. Berzins, C. Benoist, and D. Mathis. 2005. The cellular mechanism of Aire control of T cell tolerance. Immunity 23: 227-239.
20. Ribot, J., P. Romagnoli, and J. P. vanMeerwijk. 2006. Agonist ligands expressed by thymic epithelium enhance positive selection of regulatory T lymphocytes from precursors with a normally diverse TCR repertoire. J. Immunol. 177: 1101-1107.
21. Pacholczyk, R., J. Kern, N. Singh, M. Iwashima, P. Kraj, and L. Ignatowicz. 2007. Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Immunity 27: 493-504. (Pubitemid 47418672)
22. Wong, J., R. Obst, M. Correia-Neves, G. Losyev, D. Mathis, and C. Benoist. 2007. Adaptation of TCR repertoires to self-peptides in regulatory and non-regulatory CD4+ T cells. J. Immunol. 178: 7032-7041. (Pubitemid 46847429)
23. Ramsey, C., O. Winqvist, L. Puhakka, M. Halonen, A. Moro, O. Kämpe, P. Eskelin, M. Pelto-Huikko, and L. Peltonen. 2002. Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum. Mol. Genet. 11: 397-409.
24. Kuczma, M., R. Podolsky, N. Garge, D. Daniely, R. Pacholczyk, L. Ignatowicz, and P. Kraj. 2009. Foxp3-deficient regulatory T cells do not revert into conventional effectorCD4+ T cells but constitute a unique cell subset. J. Immunol. 183: 3731-3741.
25. Ueno, T., C. Liu, T. Nitta, and Y. Takahama. 2005. Development of T-lymphocytes in mouse fetal thymus organ culture. Methods Mol. Biol. 290: 117-133.
26. Hsieh, C. S., Y. Liang, A. J. Tyznik, S. G. Self, D. Liggitt, and A. Y. Rudensky. 2004. Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity 21: 267-277.
27. Anderson, M. S., E. S. Venanzi, L. Klein, Z. Chen, S. P. Berzins, S. J. Turley, H. von Boehmer, R. Bronson, A. Dierich, C. Benoist, and D. Mathis. 2002. Projection of an immunological self shadow within the thymus by the aire protein. Science 298: 1395-1401.
28. Grakoui, A., D. L. Donermeyer, O. Kanagawa, K. M. Murphy, and P. M. Allen. 1999. TCR-independent pathways mediate the effects of antigen dose and altered peptide ligands on Th cell polarization. J. Immunol. 162: 1923-1930.
29. Felix, N. J., D. L. Donermeyer, S. Horvath, J. J. Walters, M. L. Gross, A. Suri, and P. M. Allen. 2007. Alloreactive T cells respond specifically to multiple distinct peptide-MHC complexes. Nat. Immunol. 8: 388-397.
30. Ignatowicz, L., J. Kappler, and P. Marrack. 1996. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84: 521-529. (Pubitemid 26071733)
31. Lio, C. W., and C. S. Hsieh. 2008. A two-step process for thymic regulatory T cell development. Immunity 28: 100-111.
32. Seddon, B., and D. Mason. 2000. The third function of the thymus. Immunol. Today 21: 95-99.
33. Kretschmer, K., I. Apostolou, E. Jaeckel, K. Khazaie, and H. von Boehmer. 2006. Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancer. Immunol. Rev. 212: 163-169.
34. O'Connor, R. A., and S. M. Anderton. 2008. Multi-faceted control of autoaggression: Foxp3+ regulatory T cells in murine models of organ-specific autoimmune disease. Cell. Immunol. 251: 8-18.