-
1
-
-
0036345337
-
Origin of regulatory T cells with known specificity for antigen
-
Apostolou I., Sarukhan A., Klein L., von Boehmer H. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 2002, 3:756-763.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 756-763
-
-
Apostolou, I.1
Sarukhan, A.2
Klein, L.3
von Boehmer, H.4
-
2
-
-
76249088374
-
Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction
-
Atibalentja D.F., Byersdorfer C.A., Unanue E.R. Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction. J. Immunol. 2009, 183:7909-7918.
-
(2009)
J. Immunol.
, vol.183
, pp. 7909-7918
-
-
Atibalentja, D.F.1
Byersdorfer, C.A.2
Unanue, E.R.3
-
3
-
-
65749120321
-
Intraclonal competition limits the fate determination of regulatory T cells in the thymus
-
Bautista J.L., Lio C.W., Lathrop S.K., Forbush K., Liang Y., Luo J., Rudensky A.Y., Hsieh C.S. Intraclonal competition limits the fate determination of regulatory T cells in the thymus. Nat. Immunol. 2009, 10:610-617.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 610-617
-
-
Bautista, J.L.1
Lio, C.W.2
Lathrop, S.K.3
Forbush, K.4
Liang, Y.5
Luo, J.6
Rudensky, A.Y.7
Hsieh, C.S.8
-
4
-
-
0034507693
-
Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion
-
Bouneaud C., Kourilsky P., Bousso P. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity 2000, 13:829-840.
-
(2000)
Immunity
, vol.13
, pp. 829-840
-
-
Bouneaud, C.1
Kourilsky, P.2
Bousso, P.3
-
5
-
-
57649114834
-
DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes
-
Bredemeyer A.L., Helmink B.A., Innes C.L., Calderon B., McGinnis L.M., Mahowald G.K., Gapud E.J., Walker L.M., Collins J.B., Weaver B.K., et al. DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature 2008, 456:819-823.
-
(2008)
Nature
, vol.456
, pp. 819-823
-
-
Bredemeyer, A.L.1
Helmink, B.A.2
Innes, C.L.3
Calderon, B.4
McGinnis, L.M.5
Mahowald, G.K.6
Gapud, E.J.7
Walker, L.M.8
Collins, J.B.9
Weaver, B.K.10
-
6
-
-
80052572177
-
+ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion
-
+ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion. Proc. Natl. Acad. Sci. USA 2011, 108:14890-14895.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 14890-14895
-
-
Cozzo Picca, C.1
Simons, D.M.2
Oh, S.3
Aitken, M.4
Perng, O.A.5
Mergenthaler, C.6
Kropf, E.7
Erikson, J.8
Caton, A.J.9
-
7
-
-
0032101405
-
Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes
-
Crawford F., Kozono H., White J., Marrack P., Kappler J. Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes. Immunity 1998, 8:675-682.
-
(1998)
Immunity
, vol.8
, pp. 675-682
-
-
Crawford, F.1
Kozono, H.2
White, J.3
Marrack, P.4
Kappler, J.5
-
8
-
-
33845607123
-
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
-
Daniels M.A., Teixeiro E., Gill J., Hausmann B., Roubaty D., Holmberg K., Werlen G., Holländer G.A., Gascoigne N.R., Palmer E. Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature 2006, 444:724-729.
-
(2006)
Nature
, vol.444
, pp. 724-729
-
-
Daniels, M.A.1
Teixeiro, E.2
Gill, J.3
Hausmann, B.4
Roubaty, D.5
Holmberg, K.6
Werlen, G.7
Holländer, G.A.8
Gascoigne, N.R.9
Palmer, E.10
-
9
-
-
38649131259
-
Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism
-
Derbinski J., Pinto S., Rösch S., Hexel K., Kyewski B. Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism. Proc. Natl. Acad. Sci. USA 2008, 105:657-662.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 657-662
-
-
Derbinski, J.1
Pinto, S.2
Rösch, S.3
Hexel, K.4
Kyewski, B.5
-
10
-
-
0028175804
-
V beta 5+ T cell receptors skew toward OVA+H-2Kb recognition
-
Dillon S.R., Jameson S.C., Fink P.J. V beta 5+ T cell receptors skew toward OVA+H-2Kb recognition. J. Immunol. 1994, 152:1790-1801.
-
(1994)
J. Immunol.
, vol.152
, pp. 1790-1801
-
-
Dillon, S.R.1
Jameson, S.C.2
Fink, P.J.3
-
11
-
-
36749031198
-
Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes
-
Feuerer M., Jiang W., Holler P.D., Satpathy A., Campbell C., Bogue M., Mathis D., Benoist C. Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc. Natl. Acad. Sci. USA 2007, 104:18181-18186.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 18181-18186
-
-
Feuerer, M.1
Jiang, W.2
Holler, P.D.3
Satpathy, A.4
Campbell, C.5
Bogue, M.6
Mathis, D.7
Benoist, C.8
-
12
-
-
15244354286
-
Regulatory T cell lineage specification by the forkhead transcription factor foxp3
-
Fontenot J.D., Rasmussen J.P., Williams L.M., Dooley J.L., Farr A.G., Rudensky A.Y. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005, 22:329-341.
-
(2005)
Immunity
, vol.22
, pp. 329-341
-
-
Fontenot, J.D.1
Rasmussen, J.P.2
Williams, L.M.3
Dooley, J.L.4
Farr, A.G.5
Rudensky, A.Y.6
-
13
-
-
77955391804
-
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
-
Gottschalk R.A., Corse E., Allison J.P. TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo. J. Exp. Med. 2010, 207:1701-1711.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 1701-1711
-
-
Gottschalk, R.A.1
Corse, E.2
Allison, J.P.3
-
14
-
-
41149113441
-
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
-
Haxhinasto S., Mathis D., Benoist C. The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J. Exp. Med. 2008, 205:565-574.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 565-574
-
-
Haxhinasto, S.1
Mathis, D.2
Benoist, C.3
-
15
-
-
77952568022
-
Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance
-
Hinterberger M., Aichinger M., Prazeres da Costa O., Voehringer D., Hoffmann R., Klein L. Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance. Nat. Immunol. 2010, 11:512-519.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 512-519
-
-
Hinterberger, M.1
Aichinger, M.2
Prazeres da Costa, O.3
Voehringer, D.4
Hoffmann, R.5
Klein, L.6
-
16
-
-
4143066714
-
Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors
-
Hsieh C.-S., Liang Y., Tyznik A.J., Self S.G., Liggitt D., Rudensky A.Y. Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity 2004, 21:267-277.
-
(2004)
Immunity
, vol.21
, pp. 267-277
-
-
Hsieh, C.-S.1
Liang, Y.2
Tyznik, A.J.3
Self, S.G.4
Liggitt, D.5
Rudensky, A.Y.6
-
17
-
-
33645102841
-
An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
-
Hsieh C.S., Zheng Y., Liang Y., Fontenot J.D., Rudensky A.Y. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat. Immunol. 2006, 7:401-410.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 401-410
-
-
Hsieh, C.S.1
Zheng, Y.2
Liang, Y.3
Fontenot, J.D.4
Rudensky, A.Y.5
-
18
-
-
0025933951
-
Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice
-
Huesmann M., Scott B., Kisielow P., von Boehmer H. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell 1991, 66:533-540.
-
(1991)
Cell
, vol.66
, pp. 533-540
-
-
Huesmann, M.1
Scott, B.2
Kisielow, P.3
von Boehmer, H.4
-
19
-
-
33750113432
-
Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide
-
Huseby E.S., Crawford F., White J., Marrack P., Kappler J.W. Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide. Nat. Immunol. 2006, 7:1191-1199.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 1191-1199
-
-
Huseby, E.S.1
Crawford, F.2
White, J.3
Marrack, P.4
Kappler, J.W.5
-
20
-
-
75649095238
-
CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms
-
Ise W., Kohyama M., Nutsch K.M., Lee H.M., Suri A., Unanue E.R., Murphy T.L., Murphy K.M. CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms. Nat. Immunol. 2010, 11:129-135.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 129-135
-
-
Ise, W.1
Kohyama, M.2
Nutsch, K.M.3
Lee, H.M.4
Suri, A.5
Unanue, E.R.6
Murphy, T.L.7
Murphy, K.M.8
-
21
-
-
0033136302
-
Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
-
Itoh M., Takahashi T., Sakaguchi N., Kuniyasu Y., Shimizu J., Otsuka F., Sakaguchi S. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 1999, 162:5317-5326.
-
(1999)
J. Immunol.
, vol.162
, pp. 5317-5326
-
-
Itoh, M.1
Takahashi, T.2
Sakaguchi, N.3
Kuniyasu, Y.4
Shimizu, J.5
Otsuka, F.6
Sakaguchi, S.7
-
22
-
-
0035320679
-
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
-
Jordan M.S., Boesteanu A., Reed A.J., Petrone A.L., Holenbeck A.E., Lerman M.A., Naji A., Caton A.J. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2001, 2:301-306.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 301-306
-
-
Jordan, M.S.1
Boesteanu, A.2
Reed, A.J.3
Petrone, A.L.4
Holenbeck, A.E.5
Lerman, M.A.6
Naji, A.7
Caton, A.J.8
-
23
-
-
0029812040
-
Constitutive class I-restricted exogenous presentation of self antigens in vivo
-
Kurts C., Heath W.R., Carbone F.R., Allison J., Miller J.F., Kosaka H. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J. Exp. Med. 1996, 184:923-930.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 923-930
-
-
Kurts, C.1
Heath, W.R.2
Carbone, F.R.3
Allison, J.4
Miller, J.F.5
Kosaka, H.6
-
24
-
-
80054020840
-
Peripheral education of the immune system by colonic commensal microbiota
-
Lathrop S.K., Bloom S.M., Rao S.M., Nutsch K., Lio C.W., Santacruz N., Peterson D.A., Stappenbeck T.S., Hsieh C.S. Peripheral education of the immune system by colonic commensal microbiota. Nature 2011, 478:250-254.
-
(2011)
Nature
, vol.478
, pp. 250-254
-
-
Lathrop, S.K.1
Bloom, S.M.2
Rao, S.M.3
Nutsch, K.4
Lio, C.W.5
Santacruz, N.6
Peterson, D.A.7
Stappenbeck, T.S.8
Hsieh, C.S.9
-
25
-
-
70350440009
-
TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes
-
Leung M.W., Shen S., Lafaille J.J. TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes. J. Exp. Med. 2009, 206:2121-2130.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 2121-2130
-
-
Leung, M.W.1
Shen, S.2
Lafaille, J.J.3
-
26
-
-
37849009964
-
A two-step process for thymic regulatory T cell development
-
Lio C.W., Hsieh C.S. A two-step process for thymic regulatory T cell development. Immunity 2008, 28:100-111.
-
(2008)
Immunity
, vol.28
, pp. 100-111
-
-
Lio, C.W.1
Hsieh, C.S.2
-
27
-
-
57249095650
-
Central tolerance: what have we learned from mice?
-
McCaughtry T.M., Hogquist K.A. Central tolerance: what have we learned from mice?. Semin. Immunopathol. 2008, 30:399-409.
-
(2008)
Semin. Immunopathol.
, vol.30
, pp. 399-409
-
-
McCaughtry, T.M.1
Hogquist, K.A.2
-
28
-
-
80052294339
-
Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells
-
Moon J.J., Dash P., Oguin T.H., McClaren J.L., Chu H.H., Thomas P.G., Jenkins M.K. Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells. Proc. Natl. Acad. Sci. USA 2011, 108:14602-14607.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 14602-14607
-
-
Moon, J.J.1
Dash, P.2
Oguin, T.H.3
McClaren, J.L.4
Chu, H.H.5
Thomas, P.G.6
Jenkins, M.K.7
-
29
-
-
79958251745
-
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
-
Moran A.E., Holzapfel K.L., Xing Y., Cunningham N.R., Maltzman J.S., Punt J., Hogquist K.A. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med. 2011, 208:1279-1289.
-
(2011)
J. Exp. Med.
, vol.208
, pp. 1279-1289
-
-
Moran, A.E.1
Holzapfel, K.L.2
Xing, Y.3
Cunningham, N.R.4
Maltzman, J.S.5
Punt, J.6
Hogquist, K.A.7
-
30
-
-
34548680545
-
Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells
-
Pacholczyk R., Kern J., Singh N., Iwashima M., Kraj P., Ignatowicz L. Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Immunity 2007, 27:493-504.
-
(2007)
Immunity
, vol.27
, pp. 493-504
-
-
Pacholczyk, R.1
Kern, J.2
Singh, N.3
Iwashima, M.4
Kraj, P.5
Ignatowicz, L.6
-
31
-
-
61349149901
-
Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper
-
Palmer E., Naeher D. Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper. Nat. Rev. Immunol. 2009, 9:207-213.
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 207-213
-
-
Palmer, E.1
Naeher, D.2
-
32
-
-
0033118739
-
A kinetic basis for T cell receptor repertoire selection during an immune response
-
Savage P.A., Boniface J.J., Davis M.M. A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity 1999, 10:485-492.
-
(1999)
Immunity
, vol.10
, pp. 485-492
-
-
Savage, P.A.1
Boniface, J.J.2
Davis, M.M.3
-
33
-
-
77953308663
-
Identification of an immediate Foxp3(-) precursor to Foxp3(+) regulatory T cells in peripheral lymphoid organs of nonmanipulated mice
-
Schallenberg S., Tsai P.Y., Riewaldt J., Kretschmer K. Identification of an immediate Foxp3(-) precursor to Foxp3(+) regulatory T cells in peripheral lymphoid organs of nonmanipulated mice. J. Exp. Med. 2010, 207:1393-1407.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 1393-1407
-
-
Schallenberg, S.1
Tsai, P.Y.2
Riewaldt, J.3
Kretschmer, K.4
-
34
-
-
67349280397
-
Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection
-
Scott-Browne J.P., White J., Kappler J.W., Gapin L., Marrack P. Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection. Nature 2009, 458:1043-1046.
-
(2009)
Nature
, vol.458
, pp. 1043-1046
-
-
Scott-Browne, J.P.1
White, J.2
Kappler, J.W.3
Gapin, L.4
Marrack, P.5
-
35
-
-
80755190003
-
Evolutionarily conserved features contribute to αβ T cell receptor specificity
-
Scott-Browne J.P., Crawford F., Young M.H., Kappler J.W., Marrack P., Gapin L. Evolutionarily conserved features contribute to αβ T cell receptor specificity. Immunity 2011, 35:526-535.
-
(2011)
Immunity
, vol.35
, pp. 526-535
-
-
Scott-Browne, J.P.1
Crawford, F.2
Young, M.H.3
Kappler, J.W.4
Marrack, P.5
Gapin, L.6
-
36
-
-
9244244736
-
Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells
-
van Santen H.-M., Benoist C., Mathis D. Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J. Exp. Med. 2004, 200:1221-1230.
-
(2004)
J. Exp. Med.
, vol.200
, pp. 1221-1230
-
-
van Santen, H.-M.1
Benoist, C.2
Mathis, D.3
-
37
-
-
0043244867
-
Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo
-
Walker L.S., Chodos A., Eggena M., Dooms H., Abbas A.K. Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo. J. Exp. Med. 2003, 198:249-258.
-
(2003)
J. Exp. Med.
, vol.198
, pp. 249-258
-
-
Walker, L.S.1
Chodos, A.2
Eggena, M.3
Dooms, H.4
Abbas, A.K.5
-
38
-
-
67649844269
-
Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control
-
Wirnsberger G., Mair F., Klein L. Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control. Proc. Natl. Acad. Sci. USA 2009, 106:10278-10283.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 10278-10283
-
-
Wirnsberger, G.1
Mair, F.2
Klein, L.3
-
39
-
-
33747092627
-
T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity
-
Zehn D., Bevan M.J. T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity 2006, 25:261-270.
-
(2006)
Immunity
, vol.25
, pp. 261-270
-
-
Zehn, D.1
Bevan, M.J.2
|