메뉴 건너뛰기




Volumn 206, Issue 7, 2009, Pages 1505-1513

The thymic medulla: A unique microenvironment for intercellular self-antigen transfer

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CELL ANTIGEN; HLA ANTIGEN CLASS 2; OVALBUMIN; P1A ANTIGEN; PROTEOLIPID PROTEIN; UNCLASSIFIED DRUG;

EID: 67650507153     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20082449     Document Type: Article
Times cited : (201)

References (36)
  • 1
    • 3543053363 scopus 로고    scopus 로고
    • Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
    • Albert, M.L., S.F. Pearce, L.M. Francisco, B. Sauter, P. Roy, R.L. Silverstein, and N. Bhardwaj. 1998. Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J. Exp. Med. 188:1359-1368.
    • (1998) J. Exp. Med , vol.188 , pp. 1359-1368
    • Albert, M.L.1    Pearce, S.F.2    Francisco, L.M.3    Sauter, B.4    Roy, P.5    Silverstein, R.L.6    Bhardwaj, N.7
  • 2
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou, I., A. Sarukhan, L. Klein, and H. von Boehmer. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3:756-763.
    • (2002) Nat. Immunol , vol.3 , pp. 756-763
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    von Boehmer, H.4
  • 3
    • 34248598295 scopus 로고    scopus 로고
    • Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
    • Aschenbrenner, K., L.M. D'Cruz, E.H. Vollmann, M. Hinterberger, J. Emmerich, L.K. Swee, A. Rolink, and L. Klein. 2007. Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat. Immunol. 8:351-358.
    • (2007) Nat. Immunol , vol.8 , pp. 351-358
    • Aschenbrenner, K.1    D'Cruz, L.M.2    Vollmann, E.H.3    Hinterberger, M.4    Emmerich, J.5    Swee, L.K.6    Rolink, A.7    Klein, L.8
  • 5
    • 0030048075 scopus 로고    scopus 로고
    • Expression of gp40, the murine homologue of human epithelial cell adhesion molecule (Ep-CAM), by murine dendritic cells
    • Borkowski, T.A., A.J. Nelson, A.G. Farr, and M.C. Udey. 1996. Expression of gp40, the murine homologue of human epithelial cell adhesion molecule (Ep-CAM), by murine dendritic cells. Eur. J. Immunol. 26:110-114.
    • (1996) Eur. J. Immunol , vol.26 , pp. 110-114
    • Borkowski, T.A.1    Nelson, A.J.2    Farr, A.G.3    Udey, M.C.4
  • 8
    • 0035171545 scopus 로고    scopus 로고
    • Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
    • Derbinski, J., A. Schulte, B. Kyewski, and L. Klein. 2001. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2:1032-1039.
    • (2001) Nat. Immunol , vol.2 , pp. 1032-1039
    • Derbinski, J.1    Schulte, A.2    Kyewski, B.3    Klein, L.4
  • 9
    • 7244227645 scopus 로고    scopus 로고
    • Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
    • Gallegos, A.M., and M.J. Bevan. 2004. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J. Exp. Med. 200:1039-1049.
    • (2004) J. Exp. Med , vol.200 , pp. 1039-1049
    • Gallegos, A.M.1    Bevan, M.J.2
  • 10
    • 0035869278 scopus 로고    scopus 로고
    • Dendritic cells acquire antigens from live cells for cross-presentation to CTL
    • Harshyne, L.A., S.C. Watkins, A. Gambotto, and S.M. Barratt-Boyes. 2001. Dendritic cells acquire antigens from live cells for cross-presentation to CTL. J. Immunol. 166:3717-3723.
    • (2001) J. Immunol , vol.166 , pp. 3717-3723
    • Harshyne, L.A.1    Watkins, S.C.2    Gambotto, A.3    Barratt-Boyes, S.M.4
  • 11
    • 0028590184 scopus 로고
    • Presentation and intercellular transfer of self antigen within the thymic microenvironment: Expression of the E alpha peptide-I-Ab complex by isolated thymic stromal cells
    • Humblet, C., A. Rudensky, and B. Kyewski. 1994. Presentation and intercellular transfer of self antigen within the thymic microenvironment: expression of the E alpha peptide-I-Ab complex by isolated thymic stromal cells. Int. Immunol. 6:1949-1958.
    • (1994) Int. Immunol , vol.6 , pp. 1949-1958
    • Humblet, C.1    Rudensky, A.2    Kyewski, B.3
  • 14
    • 0036467523 scopus 로고    scopus 로고
    • Peripheral tolerance to a nuclear autoantigen: Dendritic cells expressing a nuclear autoantigen lead to persistent anergic state of CD4+ autoreactive T cells after proliferation
    • Kawahata, K., Y. Misaki, M. Yamauchi, S. Tsunekawa, K. Setoguchi, J. Miyazaki, and K. Yamamoto. 2002. Peripheral tolerance to a nuclear autoantigen: dendritic cells expressing a nuclear autoantigen lead to persistent anergic state of CD4+ autoreactive T cells after proliferation. J. Immunol. 168:1103-1112.
    • (2002) J. Immunol , vol.168 , pp. 1103-1112
    • Kawahata, K.1    Misaki, Y.2    Yamauchi, M.3    Tsunekawa, S.4    Setoguchi, K.5    Miyazaki, J.6    Yamamoto, K.7
  • 15
    • 0034055693 scopus 로고    scopus 로고
    • Self-antigen presentation by thymic stromal cells: A subtle division of labor
    • Klein, L., and B. Kyewski. 2000. Self-antigen presentation by thymic stromal cells: a subtle division of labor. Curr. Opin. Immunol. 12:179-186.
    • (2000) Curr. Opin. Immunol , vol.12 , pp. 179-186
    • Klein, L.1    Kyewski, B.2
  • 16
    • 0032490563 scopus 로고    scopus 로고
    • CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium
    • Klein, L., T. Klein, U. Ruther, and B. Kyewski. 1998. CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium. J. Exp. Med. 188:5-16.
    • (1998) J. Exp. Med , vol.188 , pp. 5-16
    • Klein, L.1    Klein, T.2    Ruther, U.3    Kyewski, B.4
  • 17
    • 0033984067 scopus 로고    scopus 로고
    • Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells
    • Klein, L., M. Klugmann, K.A. Nave, V.K. Tuohy, and B. Kyewski. 2000. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat. Med. 6:56-61.
    • (2000) Nat. Med , vol.6 , pp. 56-61
    • Klein, L.1    Klugmann, M.2    Nave, K.A.3    Tuohy, V.K.4    Kyewski, B.5
  • 18
    • 0034857910 scopus 로고    scopus 로고
    • Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance
    • Klein, L., B. Roettinger, and B. Kyewski. 2001. Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance. Eur. J. Immunol. 31:2476-2486.
    • (2001) Eur. J. Immunol , vol.31 , pp. 2476-2486
    • Klein, L.1    Roettinger, B.2    Kyewski, B.3
  • 19
    • 63449133991 scopus 로고    scopus 로고
    • Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus
    • Li, J., J. Park, D. Foss, and I. Goldschneider. 2009. Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus. J. Exp. Med. 206:607-622.
    • (2009) J. Exp. Med , vol.206 , pp. 607-622
    • Li, J.1    Park, J.2    Foss, D.3    Goldschneider, I.4
  • 20
    • 58149154739 scopus 로고    scopus 로고
    • Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
    • McCaughtry, T.M., T.A. Baldwin, M.S. Wilken, and K.A. Hogquist. 2008. Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla. J. Exp. Med. 205:2575-2584.
    • (2008) J. Exp. Med , vol.205 , pp. 2575-2584
    • McCaughtry, T.M.1    Baldwin, T.A.2    Wilken, M.S.3    Hogquist, K.A.4
  • 21
    • 47049085776 scopus 로고    scopus 로고
    • Intercellular MHC transfer between thymic epithelial and dendritic cells
    • Millet, V., P. Naquet, and R.R. Guinamard. 2008. Intercellular MHC transfer between thymic epithelial and dendritic cells. Eur. J. Immunol. 38:1257-1263.
    • (2008) Eur. J. Immunol , vol.38 , pp. 1257-1263
    • Millet, V.1    Naquet, P.2    Guinamard, R.R.3
  • 22
    • 0025697469 scopus 로고
    • Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo
    • Murphy, K.M., A.B. Heimberger, and D.Y. Loh. 1990. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science. 250:1720-1723.
    • (1990) Science , vol.250 , pp. 1720-1723
    • Murphy, K.M.1    Heimberger, A.B.2    Loh, D.Y.3
  • 23
    • 52149099867 scopus 로고    scopus 로고
    • Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
    • Nedjic, J., M. Aichinger, J. Emmerich, N. Mizushima, and L. Klein. 2008. Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature. 455:396-400.
    • (2008) Nature , vol.455 , pp. 396-400
    • Nedjic, J.1    Aichinger, M.2    Emmerich, J.3    Mizushima, N.4    Klein, L.5
  • 24
  • 27
    • 51149098813 scopus 로고    scopus 로고
    • Endogenous presentation of a nuclear antigen on MHC class II by autophagy in the absence of CRM1-mediated nuclear export
    • Riedel, A., F. Nimmerjahn, S. Burdach, U. Behrends, G.W. Bornkamm, and J. Mautner. 2008. Endogenous presentation of a nuclear antigen on MHC class II by autophagy in the absence of CRM1-mediated nuclear export. Eur. J. Immunol. 38:2090-2095.
    • (2008) Eur. J. Immunol , vol.38 , pp. 2090-2095
    • Riedel, A.1    Nimmerjahn, F.2    Burdach, S.3    Behrends, U.4    Bornkamm, G.W.5    Mautner, J.6
  • 28
    • 1842423787 scopus 로고    scopus 로고
    • Thymocyte-intrinsic genetic factors influence CD8 T cell lineage commitment and affect selection of a tumor-reactive TCR
    • Shanker, A., N. Auphan-Anezin, P. Chomez, L. Giraudo, B. Van den Eynde, and A.M. Schmitt-Verhulst. 2004. Thymocyte-intrinsic genetic factors influence CD8 T cell lineage commitment and affect selection of a tumor-reactive TCR. J. Immunol. 172:5069-5077.
    • (2004) J. Immunol , vol.172 , pp. 5069-5077
    • Shanker, A.1    Auphan-Anezin, N.2    Chomez, P.3    Giraudo, L.4    Van den Eynde, B.5    Schmitt-Verhulst, A.M.6
  • 29
    • 38949101205 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells promiscuously accept thymic signals critical for their development
    • Spence, P.J., and E.A. Green. 2008. Foxp3+ regulatory T cells promiscuously accept thymic signals critical for their development. Proc. Natl. Acad. Sci. USA. 105:973-978.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 973-978
    • Spence, P.J.1    Green, E.A.2
  • 31
    • 0036906477 scopus 로고    scopus 로고
    • Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes
    • Thery, C., L. Duban, E. Segura, P. Veron, O. Lantz, and S. Amigorena. 2002. Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes. Nat. Immunol. 3:1156-1162.
    • (2002) Nat. Immunol , vol.3 , pp. 1156-1162
    • Thery, C.1    Duban, L.2    Segura, E.3    Veron, P.4    Lantz, O.5    Amigorena, S.6
  • 32
    • 0026691899 scopus 로고
    • The surface phenotype of dendritic cells purified from mouse thymus and spleen: Investigation of the CD8 expression by a subpopulation of dendritic cells
    • Vremec, D., M. Zorbas, R. Scollay, D.J. Saunders, C.F. Ardavin, L. Wu, and K. Shortman. 1992. The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells. J. Exp. Med. 176:47-58.
    • (1992) J. Exp. Med , vol.176 , pp. 47-58
    • Vremec, D.1    Zorbas, M.2    Scollay, R.3    Saunders, D.J.4    Ardavin, C.F.5    Wu, L.6    Shortman, K.7
  • 33
    • 24144480562 scopus 로고    scopus 로고
    • Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus
    • Watanabe, N., Y.H. Wang, H.K. Lee, T. Ito, Y.H. Wang, W. Cao, and Y.J. Liu. 2005. Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature. 436:1181-1185.
    • (2005) Nature , vol.436 , pp. 1181-1185
    • Watanabe, N.1    Wang, Y.H.2    Lee, H.K.3    Ito, T.4    Wang, Y.H.5    Cao, W.6    Liu, Y.J.7
  • 34
    • 67649844269 scopus 로고    scopus 로고
    • Regulatory T cell differentiation of thymocytes does not require a dedicated antigen resenting cell but is under T cell intrinsic developmental control
    • In press
    • Wirnsberger, G., F. Mair, and L. Klein. 2009. Regulatory T cell differentiation of thymocytes does not require a dedicated antigen resenting cell but is under T cell intrinsic developmental control. Proc. Natl. Acad. Sci. USA. In press.
    • (2009) Proc. Natl. Acad. Sci. USA
    • Wirnsberger, G.1    Mair, F.2    Klein, L.3
  • 35
    • 33747092627 scopus 로고    scopus 로고
    • T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity
    • Zehn, D., and M.J. Bevan. 2006. T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity. 25:261-270.
    • (2006) Immunity , vol.25 , pp. 261-270
    • Zehn, D.1    Bevan, M.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.