Autophagy in the thymic epithelium is dispensable for the development of self-tolerance in a novel mouse model

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Sukseree, Supawadee ^a,b   Mildner, Michael ^a   Rossiter, Heidemarie ^a   Pammer, Johannes ^c   Zhang, Cheng Feng ^a,d   Watanapokasin, Ramida ^b   Tschachler, Erwin ^a   Eckhart, Leopold ^a  

^a Universitatsklinik fur Dermatologie   (Austria)

^b SRINAKHARINWIROT UNIVERSITY   (Thailand)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; CELL PROTEIN; CRE RECOMBINASE; CYTOKERATIN 14; GREEN FLUORESCENT PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN LC3; PROTEIN LOXP; PROTEIN P62; PROTEIN SQSTM1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATG7 GENE; AUTOIMMUNITY; AUTOPHAGOSOME; AUTOPHAGY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SIZE; CELL STRUCTURE; CONTROLLED STUDY; EMBRYO; EPITHELIUM CELL; EXPERIMENTAL MODEL; FEMALE; FLUORESCENCE ANALYSIS; GENE; GENE DELETION; IMMUNOCOMPETENCE; IMMUNOLOGICAL TOLERANCE; INFLAMMATORY INFILTRATE; INTESTINE CELL; LIVER CELL; LUNG ALVEOLUS CELL; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; THYMUS; WESTERN BLOTTING;

ANIMALS; AUTOPHAGY; BLOTTING, WESTERN; FEMALE; GREEN FLUORESCENT PROTEINS; MICE; MODELS, ANIMAL; SELF TOLERANCE; THYMUS GLAND;

EID: 84862490479     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038933     Document Type: Article

References (24)

1. Mizushima N, (2007) Autophagy: process and function. Genes Dev 21: 2861-2873.
2. Mizushima N, Komatsu M, (2011) Autophagy: renovation of cells and tissues. Cell 147: 728-741.
3. Deretic V, (2011) Autophagy in immunity and cell-autonomous defense against intracellular microbes. Immunol Rev 240: 92-104.
4. Santambrogio L, Cuervo AM, (2011) Chasing the elusive mammalian microautophagy. Autophagy 7: 652-654.
5. Yang Z, Klionsky DJ, (2010) Eaten alive: a history of macroautophagy. Nat Cell Biol 12: 814-822.
6. Mizushima N, Levine B, (2010) Autophagy in mammalian development and differentiation. Nat Cell Biol 12: 823-830.
7. Mizushima N, Yoshimori T, Levine B, (2010) Methods in mammalian autophagy research. Cell 140: 313-326.
8. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y, (2004) In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 15: 1101-1111.
9. Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, et al. (2004) The role of autophagy during the early neonatal starvation period. Nature 432: 1032-1036.
10. Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, et al. (2005) Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169: 425-434.
11. Ichimura Y, Komatsu M, (2011) Pathophysiological role of autophagy: lesson from autophagy-deficient mouse models. Exp Anim 60: 329-345.
12. Nedjic J, Aichinger M, Emmerich J, Mizushima N, Klein L, (2008) Autophagy in thymic epithelium shapes the T cell repertoire and is essential for tolerance. Nature 455: 396-400.
13. Kasai M, Tanida I, Ueno T, Kominami E, Seki S, et al. (2009) Autophagic compartments gain access to the MHC class II compartments in thymic epithelium. J Immunol 183: 7278-7285.
14. Klein L, Hinterberger M, Wirnsberger G, Kyewski B, (2009) Antigen presentation in the thymus for positive selection and central tolerance induction. Nat Rev Immunol 9: 833-844.
15. Klein L, Hinterberger M, von Rohrscheidt J, Aichinger M, (2011) Autonomous versus dendritic cell-dependent contributions of medullary thymic epithelial cells to central tolerance. Trends Immunol 32: 188-193.
16. Bleul CC, Corbeaux T, Reuter A, Fisch P, Mönting JS, et al. (2006) Formation of a functional thymus initiated by a postnatal epithelial progenitor cell. Nature 441: 992-996.
17. Rossi SW, Jenkinson WE, Anderson G, Jenkinson EJ, (2006) Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium. Nature 441: 988-991.
18. Crotzer VL, Blum JS, (2010) Autophagy and adaptive immunity. Immunology 131: 9-17.
19. Nedjic J, Aichinger M, Mizushima N, Klein L, (2009) Macroautophagy, endogenous MHC II loading and T cell selection: the benefits of breaking the rules. Curr Opin Immunol 21: 92-97.
20. Nowell CS, Bredenkamp N, Tetélin S, Jin X, Tischner C, et al. (2011) Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet 7: e1002348.
21. Uddin MN, Nishio N, Ito S, Suzuki H, Isobe K, (2012) Autophagic activity in thymus and liver during aging. Age (Dordr) 34: 75-85.
22. Fischer H, Eckhart L, Mildner M, Jaeger K, Buchberger M, et al. (2007) DNase1L2 degrades nuclear DNA during corneocyte formation. J Invest Dermatol 127: 24-30.
23. Rendl M, Ban J, Mrass P, Mayer C, Lengauer B, et al. (2002) Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner. J Invest Dermatol 119: 1150-1155.
24. Maronpot R, (1999) Pathology of the mouse. 1st edition. Cache River Press, Vienna, IL.