-
1
-
-
36248952699
-
Seeing is believing: A focus on the contribution of microscopic imaging to our understanding of immune system function
-
Bajénoff, M. & Germain, R. Seeing is believing: a focus on the contribution of microscopic imaging to our understanding of immune system function. Eur. J. Immunol. 37, S18-S33 (2007).
-
(2007)
Eur. J. Immunol
, vol.37
-
-
Bajénoff, M.1
Germain, R.2
-
2
-
-
28444434798
-
In vivo imaging of lymphocyte trafficking
-
Halin, C., Rodrigo Mora, J., Sumen, C. & von Andrian, U. In vivo imaging of lymphocyte trafficking. Annu. Rev. Cell Dev. Biol. 21, 581-603 (2005).
-
(2005)
Annu. Rev. Cell Dev. Biol
, vol.21
, pp. 581-603
-
-
Halin, C.1
Rodrigo Mora, J.2
Sumen, C.3
von Andrian, U.4
-
3
-
-
0242551584
-
-
von Andrian, U. & Mempel, T. Homing and cellular traffic in lymph nodes. Nature Rev. Immunol. 3, 867-878 (2003). References 1-3 are three excellent reviews detailing key historical insights into the function of the immune system and have served as the foundation for subsequent high-resolution imaging investigations.
-
von Andrian, U. & Mempel, T. Homing and cellular traffic in lymph nodes. Nature Rev. Immunol. 3, 867-878 (2003). References 1-3 are three excellent reviews detailing key historical insights into the function of the immune system and have served as the foundation for subsequent high-resolution imaging investigations.
-
-
-
-
4
-
-
4444329364
-
Visualizing the first 50 hr of the primary immune response to a soluble antigen
-
Catron, D., Itano, A., Pape, K., Mueller, D. & Jenkins, M. Visualizing the first 50 hr of the primary immune response to a soluble antigen. Immunity 21, 341-347 (2004).
-
(2004)
Immunity
, vol.21
, pp. 341-347
-
-
Catron, D.1
Itano, A.2
Pape, K.3
Mueller, D.4
Jenkins, M.5
-
5
-
-
33745582806
-
Dynamic imaging of the immune system: Progress, pitfalls and promise
-
Germain, R., Miller, M., Dustin, M. & Nussenzweig, M. Dynamic imaging of the immune system: progress, pitfalls and promise. Nature Rev. Immunol. 6, 497-507 (2006).
-
(2006)
Nature Rev. Immunol
, vol.6
, pp. 497-507
-
-
Germain, R.1
Miller, M.2
Dustin, M.3
Nussenzweig, M.4
-
6
-
-
3042734521
-
In vivo imaging of leukocyte trafficking in blood vessels and tissues
-
Mempel, T., Scimone, M., Mora, J. & von Andrian, U. In vivo imaging of leukocyte trafficking in blood vessels and tissues. Curr. Opin. Immunol. 16, 406-417 (2004).
-
(2004)
Curr. Opin. Immunol
, vol.16
, pp. 406-417
-
-
Mempel, T.1
Scimone, M.2
Mora, J.3
von Andrian, U.4
-
7
-
-
33745405518
-
Imaging the choreography of lymphocyte trafficking and the immune response
-
Cahalan, M. & Parker, I. Imaging the choreography of lymphocyte trafficking and the immune response. Curr. Opin. Immunol. 18, 476-482 (2006).
-
(2006)
Curr. Opin. Immunol
, vol.18
, pp. 476-482
-
-
Cahalan, M.1
Parker, I.2
-
8
-
-
4344629204
-
Dynamic behavior of T cells and thymocytes in lymphoid organs as revealed by two-photon microscopy
-
Bousso, P. & Robey, E. Dynamic behavior of T cells and thymocytes in lymphoid organs as revealed by two-photon microscopy. Immunity 21, 349-355 (2004).
-
(2004)
Immunity
, vol.21
, pp. 349-355
-
-
Bousso, P.1
Robey, E.2
-
9
-
-
0033538574
-
The immunological synapse: A molecular machine controlling T cell activation
-
Grakoui, A. et al. The immunological synapse: a molecular machine controlling T cell activation. Science 285, 221-227 (1999).
-
(1999)
Science
, vol.285
, pp. 221-227
-
-
Grakoui, A.1
-
10
-
-
0034714184
-
Differential clustering of CD4 and CD3ζ during T cell recognition
-
Krummel, M., Sjaastad, M., Wülfing, C. & Davis, M. Differential clustering of CD4 and CD3ζ during T cell recognition. Science 289, 1349-1352 (2000).
-
(2000)
Science
, vol.289
, pp. 1349-1352
-
-
Krummel, M.1
Sjaastad, M.2
Wülfing, C.3
Davis, M.4
-
11
-
-
0032480279
-
Three-dimensional segregation of supramolecular activation clusters in T cells
-
Monks, C., Freiberg, B., Kupfer, H., Sciaky, N. & Kupfer, A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395, 82-86 (1998).
-
(1998)
Nature
, vol.395
, pp. 82-86
-
-
Monks, C.1
Freiberg, B.2
Kupfer, H.3
Sciaky, N.4
Kupfer, A.5
-
12
-
-
0035942781
-
B cells acquire antigen from target cells after synapse formation
-
This paper describes the formation of the immunological synapse in response to membrane-bound antigen and the necessity of internalization of antigen through the central supramolecular activation cluster for maximal B-cell activation
-
Batista, F., Iber, D. & Neuberger, M. B cells acquire antigen from target cells after synapse formation. Nature 411, 489-494 (2001). This paper describes the formation of the immunological synapse in response to membrane-bound antigen and the necessity of internalization of antigen through the central supramolecular activation cluster for maximal B-cell activation.
-
(2001)
Nature
, vol.411
, pp. 489-494
-
-
Batista, F.1
Iber, D.2
Neuberger, M.3
-
13
-
-
33746545207
-
B cell recognition of membrane-bound antigen: An exquisite way of sensing ligands
-
Carrasco, Y. R. & Batista, F. D. B cell recognition of membrane-bound antigen: an exquisite way of sensing ligands. Curr. Opin. Immunol. 18, 286-291 (2006).
-
(2006)
Curr. Opin. Immunol
, vol.18
, pp. 286-291
-
-
Carrasco, Y.R.1
Batista, F.D.2
-
14
-
-
37349077033
-
-
Depoil, D. et al. CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand. Nature Immunol. 9, 63-72 (2008). This paper visualizes the formation of antigen-BCR microclusters and, by identifying an essential role for CD19 in B-cell activation by membrane-bound antigen, it indicates the importance of the recognition of this type of antigen in vivo during the development of immune responses.
-
Depoil, D. et al. CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand. Nature Immunol. 9, 63-72 (2008). This paper visualizes the formation of antigen-BCR microclusters and, by identifying an essential role for CD19 in B-cell activation by membrane-bound antigen, it indicates the importance of the recognition of this type of antigen in vivo during the development of immune responses.
-
-
-
-
15
-
-
0021956416
-
Antigen-specific interaction between T and B cells
-
Lanzavecchia, A. Antigen-specific interaction between T and B cells. Nature 314, 537-539 (1985).
-
(1985)
Nature
, vol.314
, pp. 537-539
-
-
Lanzavecchia, A.1
-
16
-
-
0021209335
-
Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors
-
Rock, K., Benacerraf, B. & Abbas, A. Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. J. Exp. Med. 160, 1102-1113 (1984).
-
(1984)
J. Exp. Med
, vol.160
, pp. 1102-1113
-
-
Rock, K.1
Benacerraf, B.2
Abbas, A.3
-
17
-
-
0028324816
-
Germinal centers
-
MacLennan, I. Germinal centers. Annu. Rev. Immunol. 12, 117-139 (1994).
-
(1994)
Annu. Rev. Immunol
, vol.12
, pp. 117-139
-
-
MacLennan, I.1
-
18
-
-
0030006070
-
Clonal selection and learning in the antibody system
-
Rajewsky, K. Clonal selection and learning in the antibody system. Nature 381, 751-758 (1996).
-
(1996)
Nature
, vol.381
, pp. 751-758
-
-
Rajewsky, K.1
-
19
-
-
42649101626
-
Choreography of Cell. Motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs
-
Cahalan, M. & Parker, I. Choreography of Cell. Motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs. Annu. Rev. Immunol. 26, 585-626 (2008).
-
(2008)
Annu. Rev. Immunol
, vol.26
, pp. 585-626
-
-
Cahalan, M.1
Parker, I.2
-
20
-
-
38949191290
-
Decoding the dynamics of T cell-dendritic cell interactions in vivo
-
Celli, S., Garcia, Z., Beuneu, H. & Bousso, P. Decoding the dynamics of T cell-dendritic cell interactions in vivo. Immunol. Rev. 221, 182-187 (2008).
-
(2008)
Immunol. Rev
, vol.221
, pp. 182-187
-
-
Celli, S.1
Garcia, Z.2
Beuneu, H.3
Bousso, P.4
-
21
-
-
38949137056
-
Making friends in out-of-the-way places: How cells of the immune system get together and how they conduct their business as revealed by intravital imaging
-
Germain, R. et al. Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging. Immunol. Rev. 221, 163-181 (2008).
-
(2008)
Immunol. Rev
, vol.221
, pp. 163-181
-
-
Germain, R.1
-
22
-
-
52949090785
-
Form follows function: Lymphoid tissue microarchitecture in antimicrobial immune defence
-
Junt, T., Scandella, E. & Ludewig, B. Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defence. Nature Rev. Immunol. 8, 764-775 (2008).
-
(2008)
Nature Rev. Immunol
, vol.8
, pp. 764-775
-
-
Junt, T.1
Scandella, E.2
Ludewig, B.3
-
23
-
-
0030906253
-
-/-) mutant mice
-
-/-) mutant mice. J. Exp. Med. 185, 2157-2170 (1997).
-
(1997)
J. Exp. Med
, vol.185
, pp. 2157-2170
-
-
Karrer, U.1
-
24
-
-
17644365138
-
Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs
-
Cyster, J. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol. 23, 127-159 (2005).
-
(2005)
Annu. Rev. Immunol
, vol.23
, pp. 127-159
-
-
Cyster, J.1
-
25
-
-
0019231842
-
The follicular dendritic cell: Its role in antigen presentation in the generation of immunological memory
-
Klaus, G., Humphrey, J., Kunkl, A. & Dongworth, D. The follicular dendritic cell: its role in antigen presentation in the generation of immunological memory. Immunol. Rev. 53, 3-28 (1980).
-
(1980)
Immunol. Rev
, vol.53
, pp. 3-28
-
-
Klaus, G.1
Humphrey, J.2
Kunkl, A.3
Dongworth, D.4
-
26
-
-
0019231835
-
-
Mandel, T., Phipps, R., Abbot, A. & Tew, J. The follicular dendritic cell: long term antigen retention during immunity. Immunol. Rev. 53, 29-59 (1980). References 25 and 26 are two excellent reviews that summarize much of the early work that characterized the role of FDCs in the presentation and retention of antigen and described how FDCs influence immune responses.
-
Mandel, T., Phipps, R., Abbot, A. & Tew, J. The follicular dendritic cell: long term antigen retention during immunity. Immunol. Rev. 53, 29-59 (1980). References 25 and 26 are two excellent reviews that summarize much of the early work that characterized the role of FDCs in the presentation and retention of antigen and described how FDCs influence immune responses.
-
-
-
-
27
-
-
0031921084
-
The role of complement and complement receptors in induction and regulation of immunity
-
Carroll, M. The role of complement and complement receptors in induction and regulation of immunity. Annu. Rev. Immunol. 16, 545-568 (1998).
-
(1998)
Annu. Rev. Immunol
, vol.16
, pp. 545-568
-
-
Carroll, M.1
-
28
-
-
0034659826
-
Fcγ receptor IIB on follicular dendritic cells regulates the B cell recall response
-
Qin, D. et al. Fcγ receptor IIB on follicular dendritic cells regulates the B cell recall response. J. Immunol. 164, 6268-6275 (2000).
-
(2000)
J. Immunol
, vol.164
, pp. 6268-6275
-
-
Qin, D.1
-
29
-
-
0033821807
-
Follicular stromal cells and lymphocyte homing to follicles
-
Cyster, J. et al. Follicular stromal cells and lymphocyte homing to follicles. Immunol. Rev. 176, 181-193 (2000).
-
(2000)
Immunol. Rev
, vol.176
, pp. 181-193
-
-
Cyster, J.1
-
30
-
-
0033006011
-
Development and maturation of secondary lymphoid tissues
-
Fu, Y. & Chaplin, D. Development and maturation of secondary lymphoid tissues. Annu. Rev. Immunol. 17, 399-433 (1999).
-
(1999)
Annu. Rev. Immunol
, vol.17
, pp. 399-433
-
-
Fu, Y.1
Chaplin, D.2
-
31
-
-
0030944142
-
Cords, channels, corridors and conduits: Critical architectural elements facilitating cell interactions in the lymph node cortex
-
Gretz, J., Anderson, A. & Shaw, S. Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex. Immunol. Rev. 156, 11-24 (1997).
-
(1997)
Immunol. Rev
, vol.156
, pp. 11-24
-
-
Gretz, J.1
Anderson, A.2
Shaw, S.3
-
32
-
-
0034693949
-
-
Gretz, J., Norbury, C., Anderson, A., Proudfoot, A. & Shaw, S. Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex. J. Exp. Med. 192, 1425-1440 (2000). This paper examines the distribution of various fluorescently labelled soluble antigens in the draining lymph node following subcutaneous administration, showing that low-molecular-mass molecules, but not larger antigens, can gain access to the interior of the lymph node by direct diffusion from the conduit network.
-
Gretz, J., Norbury, C., Anderson, A., Proudfoot, A. & Shaw, S. Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex. J. Exp. Med. 192, 1425-1440 (2000). This paper examines the distribution of various fluorescently labelled soluble antigens in the draining lymph node following subcutaneous administration, showing that low-molecular-mass molecules, but not larger antigens, can gain access to the interior of the lymph node by direct diffusion from the conduit network.
-
-
-
-
33
-
-
12444297666
-
The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node
-
Sixt, M. et al. The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node. Immunity 22, 19-29 (2005).
-
(2005)
Immunity
, vol.22
, pp. 19-29
-
-
Sixt, M.1
-
34
-
-
0007997964
-
Antigens in immunity. VI. The phagocytic reticulum of lymph node of follicles
-
Miller, J. & Nossal, G. Antigens in immunity. VI. The phagocytic reticulum of lymph node of follicles. J. Exp. Med. 120, 1075-1086 (1964).
-
(1964)
J. Exp. Med
, vol.120
, pp. 1075-1086
-
-
Miller, J.1
Nossal, G.2
-
35
-
-
0002618425
-
The effect of the continuous re-infusion of lymph and lymphocytes on the output of lymphocytes from the thoracic duct of unanaesthetized rats
-
Gowans, J. The effect of the continuous re-infusion of lymph and lymphocytes on the output of lymphocytes from the thoracic duct of unanaesthetized rats. Brit J. Exp. Pathol. 38, 67-78 (1957).
-
(1957)
Brit J. Exp. Pathol
, vol.38
, pp. 67-78
-
-
Gowans, J.1
-
36
-
-
0042624814
-
A conduit system distributes chemokines and small blood-borne molecules through the splenic white pulp
-
Nolte, M. et al. A conduit system distributes chemokines and small blood-borne molecules through the splenic white pulp. J. Exp. Med. 198, 505-512 (2003).
-
(2003)
J. Exp. Med
, vol.198
, pp. 505-512
-
-
Nolte, M.1
-
37
-
-
33750442190
-
Normal structure, function, and histology of the spleen
-
Cesta, M. Normal structure, function, and histology of the spleen. Toxicol. Path. 34, 455-465 (2006).
-
(2006)
Toxicol. Path
, vol.34
, pp. 455-465
-
-
Cesta, M.1
-
38
-
-
0023923197
-
Reticular meshwork of the spleen in rats studied by electron microscopy
-
Saito, H. et al. Reticular meshwork of the spleen in rats studied by electron microscopy. Am. J. Anat. 181, 235-252 (1988).
-
(1988)
Am. J. Anat
, vol.181
, pp. 235-252
-
-
Saito, H.1
-
39
-
-
0026578234
-
Cells in the marginal zone of the spleen
-
Kraal, G. Cells in the marginal zone of the spleen. Int. Rev. Cytol. 132, 31-74 (1992).
-
(1992)
Int. Rev. Cytol
, vol.132
, pp. 31-74
-
-
Kraal, G.1
-
40
-
-
0027605979
-
Comparative aspects of splenic microcirculatory pathways in mammals: The region bordering the white pulp
-
Schmidt, E., MacDonald, I. & Groom, A. Comparative aspects of splenic microcirculatory pathways in mammals: the region bordering the white pulp. Scanning Microsc. 7, 613-628 (1993).
-
(1993)
Scanning Microsc
, vol.7
, pp. 613-628
-
-
Schmidt, E.1
MacDonald, I.2
Groom, A.3
-
41
-
-
0019865787
-
Marginal zones: The major B cell compartment of rat spleens
-
Kumararatne, D., Bazin, H. & MacLennan, I. Marginal zones: the major B cell compartment of rat spleens. Eur. J. Immunol. 11, 858-864 (1981).
-
(1981)
Eur. J. Immunol
, vol.11
, pp. 858-864
-
-
Kumararatne, D.1
Bazin, H.2
MacLennan, I.3
-
43
-
-
0022567432
-
The role of the spleen in resistance to infection
-
Bohnsack, J. & Brown, E. The role of the spleen in resistance to infection. Annu. Rev. Med. 37, 49-59 (1986).
-
(1986)
Annu. Rev. Med
, vol.37
, pp. 49-59
-
-
Bohnsack, J.1
Brown, E.2
-
44
-
-
0037036140
-
Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy
-
Bousso, P., Bhakta, N., Lewis, R. & Robey, E. Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy. Science 296, 1876-1880 (2002).
-
(2002)
Science
, vol.296
, pp. 1876-1880
-
-
Bousso, P.1
Bhakta, N.2
Lewis, R.3
Robey, E.4
-
45
-
-
0037036142
-
Two-photon imaging of lymphocyte motility and antigen response in intact lymph node
-
Miller, M., Wei, S., Parker, I. & Cahalan, M. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296, 1869-1873 (2002).
-
(2002)
Science
, vol.296
, pp. 1869-1873
-
-
Miller, M.1
Wei, S.2
Parker, I.3
Cahalan, M.4
-
46
-
-
0037036114
-
-
Stoll, S., Delon, J., Brotz, T. & Germain, R. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 296, 1873-1876 (2002). References 44-46 are three key papers published back-to-back that describe the first use of two-photon microscopy for the investigation of lymphocyte behaviour, visualizing the unexpected and rapid migration of lymphocytes in the absence of antigen.
-
Stoll, S., Delon, J., Brotz, T. & Germain, R. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 296, 1873-1876 (2002). References 44-46 are three key papers published back-to-back that describe the first use of two-photon microscopy for the investigation of lymphocyte behaviour, visualizing the unexpected and rapid migration of lymphocytes in the absence of antigen.
-
-
-
-
47
-
-
0037501371
-
+ T cell priming by dendritic cells in intact lymph nodes
-
+ T cell priming by dendritic cells in intact lymph nodes. Nature Immunol. 4, 579-585 (2003).
-
(2003)
Nature Immunol
, vol.4
, pp. 579-585
-
-
Bousso, P.1
Robey, E.2
-
48
-
-
21844450539
-
Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells
-
This paper uses multiphoton microscopy to observe the dynamics of B cells and their interaction with antigen-specific T cells within the lymph node following antigen exposure
-
Okada, T. et al. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol. 3, e150 (2005). This paper uses multiphoton microscopy to observe the dynamics of B cells and their interaction with antigen-specific T cells within the lymph node following antigen exposure.
-
(2005)
PLoS Biol
, vol.3
-
-
Okada, T.1
-
49
-
-
33845455093
-
-
Bajénoff, M. et al. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25, 989-1001 (2006). In this paper, the authors develop an elegant chimeric system to visualize the highly organized migration of B and T cells within lymph nodes across networks of FDCs and FRCs, respectively.
-
Bajénoff, M. et al. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25, 989-1001 (2006). In this paper, the authors develop an elegant chimeric system to visualize the highly organized migration of B and T cells within lymph nodes across networks of FDCs and FRCs, respectively.
-
-
-
-
50
-
-
16544371809
-
Visualizing dendritic cell networks in vivo
-
Lindquist, R. et al. Visualizing dendritic cell networks in vivo. Nature Immunol. 5, 1243-1250 (2004).
-
(2004)
Nature Immunol
, vol.5
, pp. 1243-1250
-
-
Lindquist, R.1
-
51
-
-
0014247921
-
Antigens in immunity. XV. Ultrastructural features of antigen capture in primary and secondary lymphoid follicles
-
Nossal, G., Abbot, A., Mitchell, J. & Lummus, Z. Antigens in immunity. XV. Ultrastructural features of antigen capture in primary and secondary lymphoid follicles. J. Exp. Med. 127, 277-290 (1968).
-
(1968)
J. Exp. Med
, vol.127
, pp. 277-290
-
-
Nossal, G.1
Abbot, A.2
Mitchell, J.3
Lummus, Z.4
-
52
-
-
0001107681
-
The reticulum of lymph nodes in mice studied with the electron microscope
-
Clark, S. The reticulum of lymph nodes in mice studied with the electron microscope. Am. J. Anat. 110, 217-257 (1962).
-
(1962)
Am. J. Anat
, vol.110
, pp. 217-257
-
-
Clark, S.1
-
53
-
-
0018836978
-
The structure of the sinus wall of the lymph node relative to its endocytic properties and transmural cell passage
-
Farr, A., Cho, Y. & De Bruyn, P. The structure of the sinus wall of the lymph node relative to its endocytic properties and transmural cell passage. Am. J. Anat. 157, 265-284 (1980).
-
(1980)
Am. J. Anat
, vol.157
, pp. 265-284
-
-
Farr, A.1
Cho, Y.2
De Bruyn, P.3
-
54
-
-
0024235240
-
Lymphoid microenvironments in the thymus and lymph node
-
van Ewijk, W., Brekelmans, P., Jacobs, R. & Wisse, E. Lymphoid microenvironments in the thymus and lymph node. Scanning Microsc. 2, 2129-2140 (1988).
-
(1988)
Scanning Microsc
, vol.2
, pp. 2129-2140
-
-
van Ewijk, W.1
Brekelmans, P.2
Jacobs, R.3
Wisse, E.4
-
55
-
-
34247149876
-
The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles
-
This study tracks the diffusion of a low-molecular-mass fluorescent antigen from the subcapsular sinus and shows the rapid acquisition of this antigen by follicular B cells within minutes of administration
-
Pape, K., Catron, D., Itano, A. & Jenkins, M. The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles. Immunity 26, 491-502 (2007). This study tracks the diffusion of a low-molecular-mass fluorescent antigen from the subcapsular sinus and shows the rapid acquisition of this antigen by follicular B cells within minutes of administration.
-
(2007)
Immunity
, vol.26
, pp. 491-502
-
-
Pape, K.1
Catron, D.2
Itano, A.3
Jenkins, M.4
-
56
-
-
0020592178
-
Transport of immune complexes from the subcapsular sinus to lymph node follicles on the surface of nonphagocytic cells, including cells with dendritic morphology
-
Szakal, A., Holmes, K. & Tew, J. Transport of immune complexes from the subcapsular sinus to lymph node follicles on the surface of nonphagocytic cells, including cells with dendritic morphology. J. Immunol. 131, 1714-1727 (1983).
-
(1983)
J. Immunol
, vol.131
, pp. 1714-1727
-
-
Szakal, A.1
Holmes, K.2
Tew, J.3
-
57
-
-
0024390162
-
Microanatomy of lymphoid tissue during humoral immune responses: Structure function relationships
-
Szakal, A., Kosco, M. & Tew, J. Microanatomy of lymphoid tissue during humoral immune responses: structure function relationships. Annu. Rev. Immunol. 7, 91-109 (1989).
-
(1989)
Annu. Rev. Immunol
, vol.7
, pp. 91-109
-
-
Szakal, A.1
Kosco, M.2
Tew, J.3
-
58
-
-
0018975112
-
The architecture of rat lymph nodes. IV. Distribution of ferritin and colloidal carbon in the draining lymph nodes after foot-pad injection
-
Fossum, S. The architecture of rat lymph nodes. IV. Distribution of ferritin and colloidal carbon in the draining lymph nodes after foot-pad injection. Scand. J. Immunol. 12, 433-441 (1980).
-
(1980)
Scand. J. Immunol
, vol.12
, pp. 433-441
-
-
Fossum, S.1
-
59
-
-
0021240781
-
Relation of intra-splenic migration of marginal zone B cells to antigen localization on follicular dendritic cells
-
Gray, D., Kumararatne, D., Lortan, J., Khan, M. & MacLennan, I. Relation of intra-splenic migration of marginal zone B cells to antigen localization on follicular dendritic cells. Immunology 52, 659-669 (1984).
-
(1984)
Immunology
, vol.52
, pp. 659-669
-
-
Gray, D.1
Kumararatne, D.2
Lortan, J.3
Khan, M.4
MacLennan, I.5
-
60
-
-
0019523819
-
Different macrophage populations distinguished by means of fluorescent polysaccharides. Recognition and properties of marginal-zone macrophages
-
Humphrey, J. & Grennan, D. Different macrophage populations distinguished by means of fluorescent polysaccharides. Recognition and properties of marginal-zone macrophages. Eur. J. Immunol. 11, 221-228 (1981).
-
(1981)
Eur. J. Immunol
, vol.11
, pp. 221-228
-
-
Humphrey, J.1
Grennan, D.2
-
61
-
-
0029829528
-
Fc chimeric protein containing the cysteine-rich domain of the murine mannose receptor binds to macrophages from splenic marginal zone and lymph node subcapsular sinus and to germinal centers
-
Martínez-Pomares, L. et al. Fc chimeric protein containing the cysteine-rich domain of the murine mannose receptor binds to macrophages from splenic marginal zone and lymph node subcapsular sinus and to germinal centers. J. Exp. Med. 184, 1927-1937 (1996).
-
(1996)
J. Exp. Med
, vol.184
, pp. 1927-1937
-
-
Martínez-Pomares, L.1
-
62
-
-
0014686719
-
Persistence of antigen on the surface of macrophages
-
Unanue, E., Cerottini, J. & Bedford, M. Persistence of antigen on the surface of macrophages. Nature 222, 1193-1195 (1969).
-
(1969)
Nature
, vol.222
, pp. 1193-1195
-
-
Unanue, E.1
Cerottini, J.2
Bedford, M.3
-
63
-
-
11844254888
-
Macrophage receptors and immune recognition
-
Taylor, P. et al. Macrophage receptors and immune recognition. Annu. Rev. Immunol. 23, 901-944 (2005).
-
(2005)
Annu. Rev. Immunol
, vol.23
, pp. 901-944
-
-
Taylor, P.1
-
64
-
-
34548044827
-
Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells
-
Phan, T., Grigorova, I., Okada, T. & Cyster, J. Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells. Nature Immunol. 8, 992-1000 (2007).
-
(2007)
Nature Immunol
, vol.8
, pp. 992-1000
-
-
Phan, T.1
Grigorova, I.2
Okada, T.3
Cyster, J.4
-
65
-
-
27744576801
-
Cell surface recycling of internalized antigen permits dendritic cell priming of B cells
-
Bergtold, A., Desai, D. D., Gavhane, A. & Clynes, R. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 23, 503-514 (2005).
-
(2005)
Immunity
, vol.23
, pp. 503-514
-
-
Bergtold, A.1
Desai, D.D.2
Gavhane, A.3
Clynes, R.4
-
66
-
-
27644532332
-
Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection
-
Koppel, E. et al. Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection. Eur. J. Immunol. 35, 2962-2969 (2005).
-
(2005)
Eur. J. Immunol
, vol.35
, pp. 2962-2969
-
-
Koppel, E.1
-
67
-
-
34447623566
-
B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node
-
Carrasco, Y. & Batista, F. B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node. Immunity 27, 160-171 (2007).
-
(2007)
Immunity
, vol.27
, pp. 160-171
-
-
Carrasco, Y.1
Batista, F.2
-
68
-
-
35948935059
-
-
Junt, T. et al. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature 450, 110-114 (2007). References 64, 67 and 68 reveal a role for macrophages within the subcapsular sinus in the presentation of larger antigens, such as particulates, immune complexes and viruses, to follicular B cells, using multiphoton microscopy to visualize the distribution of B cells in vivo over time following antigen administration.
-
Junt, T. et al. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature 450, 110-114 (2007). References 64, 67 and 68 reveal a role for macrophages within the subcapsular sinus in the presentation of larger antigens, such as particulates, immune complexes and viruses, to follicular B cells, using multiphoton microscopy to visualize the distribution of B cells in vivo over time following antigen administration.
-
-
-
-
69
-
-
2442467885
-
LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation
-
Carrasco, Y., Fleire, S., Cameron, T., Dustin, M. & Batista, F. LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation. Immunity 20, 589-599 (2004).
-
(2004)
Immunity
, vol.20
, pp. 589-599
-
-
Carrasco, Y.1
Fleire, S.2
Cameron, T.3
Dustin, M.4
Batista, F.5
-
70
-
-
0032479526
-
Visualization of specific B and T lymphocyte interactions in the lymph node
-
Garside, P. et al. Visualization of specific B and T lymphocyte interactions in the lymph node. Science 281, 96-99 (1998).
-
(1998)
Science
, vol.281
, pp. 96-99
-
-
Garside, P.1
-
71
-
-
44649180474
-
+ T cell help for antibody responses to a large viral pathogen: Deterministic linkage of specificities
-
+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities. Immunity 28, 847-858 (2008).
-
(2008)
Immunity
, vol.28
, pp. 847-858
-
-
Sette, A.1
-
72
-
-
14844340568
-
Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate
-
Delamarre, L., Pack, M., Chang, H., Mellman, I. & Trombetta, E. Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science 307, 1630-1634 (2005).
-
(2005)
Science
, vol.307
, pp. 1630-1634
-
-
Delamarre, L.1
Pack, M.2
Chang, H.3
Mellman, I.4
Trombetta, E.5
-
73
-
-
0037769037
-
Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity
-
Itano, A. et al. Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity 19, 47-57 (2003).
-
(2003)
Immunity
, vol.19
, pp. 47-57
-
-
Itano, A.1
-
74
-
-
33846636409
-
Differential antigen processing by dendritic cell subsets in vivo
-
Dudziak, D. et al. Differential antigen processing by dendritic cell subsets in vivo. Science 315, 107-111 (2007).
-
(2007)
Science
, vol.315
, pp. 107-111
-
-
Dudziak, D.1
-
75
-
-
28244492832
-
B cells productively engage soluble antigen-pulsed dendritic cells: Visualization of live-cell dynamics of B cell-dendritic cell interactions
-
Huang, N., Han, S., Hwang, I. & Kehrl, J. B cells productively engage soluble antigen-pulsed dendritic cells: visualization of live-cell dynamics of B cell-dendritic cell interactions. J. Immunol. 175, 7125-7134 (2005).
-
(2005)
J. Immunol
, vol.175
, pp. 7125-7134
-
-
Huang, N.1
Han, S.2
Hwang, I.3
Kehrl, J.4
-
76
-
-
0036172314
-
DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection
-
Kwon, D., Gregorio, G., Bitton, N., Hendrickson, W. & Littman, D. DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity 16, 135-144 (2002).
-
(2002)
Immunity
, vol.16
, pp. 135-144
-
-
Kwon, D.1
Gregorio, G.2
Bitton, N.3
Hendrickson, W.4
Littman, D.5
-
77
-
-
0032145432
-
Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response
-
Wykes, M., Pombo, A., Jenkins, C. & MacPherson, G. Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response. J. Immunol. 161, 1313-1319 (1998).
-
(1998)
J. Immunol
, vol.161
, pp. 1313-1319
-
-
Wykes, M.1
Pombo, A.2
Jenkins, C.3
MacPherson, G.4
-
78
-
-
0037033281
-
Dendritic cells pulsed with intact Streptococcus pneumoniae elicit both protein- and polysaccharide- specific immunoglobulin isotype responses in vivo through distinct mechanisms
-
Colino, J., Shen, Y. & Snapper, C. Dendritic cells pulsed with intact Streptococcus pneumoniae elicit both protein- and polysaccharide- specific immunoglobulin isotype responses in vivo through distinct mechanisms. J. Exp. Med. 195, 1-13 (2002).
-
(2002)
J. Exp. Med
, vol.195
, pp. 1-13
-
-
Colino, J.1
Shen, Y.2
Snapper, C.3
-
79
-
-
33745133006
-
-
Qi, H., Egen, J. G., Huang, A. Y. & Germain, R. N. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 312, 1672-1676 (2006). This paper uses two-photon microscopy to visualize the presentation of intact antigen by DCs to B cells as they enter the lymph node.
-
Qi, H., Egen, J. G., Huang, A. Y. & Germain, R. N. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 312, 1672-1676 (2006). This paper uses two-photon microscopy to visualize the presentation of intact antigen by DCs to B cells as they enter the lymph node.
-
-
-
-
80
-
-
0033588950
-
A member of the dendritic cell family that enters B cell follicles and stimulates primary antibody responses identified by a mannose receptor fusion protein
-
Berney, C. et al. A member of the dendritic cell family that enters B cell follicles and stimulates primary antibody responses identified by a mannose receptor fusion protein. J. Exp. Med. 190, 851-860 (1999).
-
(1999)
J. Exp. Med
, vol.190
, pp. 851-860
-
-
Berney, C.1
-
81
-
-
18844398045
-
Marginal zone B cells in lymphocyte activation and regulation
-
Lopes-Carvalho, T., Foote, J. & Kearney, J. Marginal zone B cells in lymphocyte activation and regulation. Curr. Opin. Immunol. 17, 244-250 (2005).
-
(2005)
Curr. Opin. Immunol
, vol.17
, pp. 244-250
-
-
Lopes-Carvalho, T.1
Foote, J.2
Kearney, J.3
-
82
-
-
0036754302
-
Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses
-
Balázs, M., Martin, F., Zhou, T. & Kearney, J. Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses. Immunity 17, 341-352 (2002).
-
(2002)
Immunity
, vol.17
, pp. 341-352
-
-
Balázs, M.1
Martin, F.2
Zhou, T.3
Kearney, J.4
-
83
-
-
0019052682
-
Immunohistologic analysis of the organization of normal lymphoid tissue and non-Hodgkin's lymphomas
-
Stein, H. et al. Immunohistologic analysis of the organization of normal lymphoid tissue and non-Hodgkin's lymphomas. J. Histochem. Cytochem. 28, 746-760 (1980).
-
(1980)
J. Histochem. Cytochem
, vol.28
, pp. 746-760
-
-
Stein, H.1
-
84
-
-
0013856326
-
Ultrastructure of the antigen-retaining reticulum of lymph node follicles as shown by high-resolution autoradiography
-
Mitchell, J. & Abbot, A. Ultrastructure of the antigen-retaining reticulum of lymph node follicles as shown by high-resolution autoradiography. Nature 208, 500-502 (1965).
-
(1965)
Nature
, vol.208
, pp. 500-502
-
-
Mitchell, J.1
Abbot, A.2
-
85
-
-
0018135592
-
Distribution of horseradish peroxidase (HRP)-anti-HRP immune complexes in mouse spleen with special reference to follicular dendritic cells
-
Chen, L., Frank, A., Adams, J. & Steinman, R. Distribution of horseradish peroxidase (HRP)-anti-HRP immune complexes in mouse spleen with special reference to follicular dendritic cells. J. Cell Biol. 79, 184-199 (1978).
-
(1978)
J. Cell Biol
, vol.79
, pp. 184-199
-
-
Chen, L.1
Frank, A.2
Adams, J.3
Steinman, R.4
-
86
-
-
0019231837
-
The maintenance and regulation of the humoral immune response: Persisting antigen and the role of follicular antigen-binding dendritic cells as accessory cells
-
Tew, J., Phipps, R. & Mandel, T. The maintenance and regulation of the humoral immune response: persisting antigen and the role of follicular antigen-binding dendritic cells as accessory cells. Immunol. Rev. 53, 175-201 (1980).
-
(1980)
Immunol. Rev
, vol.53
, pp. 175-201
-
-
Tew, J.1
Phipps, R.2
Mandel, T.3
-
87
-
-
0034919420
-
Follicular dendritic cells: Beyond the necessity of T-cell help
-
Tew, J., Wu, J., Fakher, M., Szakal, A. & Qin, D. Follicular dendritic cells: beyond the necessity of T-cell help. Trends Immunol. 22, 361-367 (2001).
-
(2001)
Trends Immunol
, vol.22
, pp. 361-367
-
-
Tew, J.1
Wu, J.2
Fakher, M.3
Szakal, A.4
Qin, D.5
-
88
-
-
0017683634
-
The generation of memory cells. I. The role of C3 in the generation of B memory cells
-
Klaus, G. & Humphrey, J. The generation of memory cells. I. The role of C3 in the generation of B memory cells. Immunology 33, 31-40 (1977).
-
(1977)
Immunology
, vol.33
, pp. 31-40
-
-
Klaus, G.1
Humphrey, J.2
-
89
-
-
0016767823
-
Complement dependence of localisation of aggregated IgG in germinal centres
-
Papamichail, M. et al. Complement dependence of localisation of aggregated IgG in germinal centres. Scand. J. Immunol. 4, 343-347 (1975).
-
(1975)
Scand. J. Immunol
, vol.4
, pp. 343-347
-
-
Papamichail, M.1
-
90
-
-
0032104018
-
Expression of complement receptors 1 and 2 on follicular dendritic cells is necessary for the generation of a strong antigen-specific IgG response
-
Fang, Y., Xu, C., Fu, Y., Holers, V. & Molina, H. Expression of complement receptors 1 and 2 on follicular dendritic cells is necessary for the generation of a strong antigen-specific IgG response. J. Immunol. 160, 5273-5279 (1998).
-
(1998)
J. Immunol
, vol.160
, pp. 5273-5279
-
-
Fang, Y.1
Xu, C.2
Fu, Y.3
Holers, V.4
Molina, H.5
-
91
-
-
0037020850
-
B lymphocyte memory: Role of stromal cell complement and FcγRIIB receptors
-
Barrington, R., Pozdnyakova, O., Zafari, M., Benjamin, C. & Carroll, M. B lymphocyte memory: role of stromal cell complement and FcγRIIB receptors. J. Exp. Med. 196, 1189-1199 (2002).
-
(2002)
J. Exp. Med
, vol.196
, pp. 1189-1199
-
-
Barrington, R.1
Pozdnyakova, O.2
Zafari, M.3
Benjamin, C.4
Carroll, M.5
-
92
-
-
0032211091
-
Evidence for an important interaction between a complement-derived CD21 ligand on follicular dendritic cells and CD21 on B cells in the initiation of IgG responses
-
Qin, D. et al. Evidence for an important interaction between a complement-derived CD21 ligand on follicular dendritic cells and CD21 on B cells in the initiation of IgG responses. J. Immunol. 161, 4549-4554 (1998).
-
(1998)
J. Immunol
, vol.161
, pp. 4549-4554
-
-
Qin, D.1
-
93
-
-
0027420543
-
Two functionally different follicular dendritic cells in secondary lymphoid follicles of mouse spleen, as revealed by CR1/2 and FcRγII-mediated immune-complex trapping
-
Yoshida, K., van den Berg, T. & Dijkstra, C. Two functionally different follicular dendritic cells in secondary lymphoid follicles of mouse spleen, as revealed by CR1/2 and FcRγII-mediated immune-complex trapping. Immunology 80, 34-39 (1993).
-
(1993)
Immunology
, vol.80
, pp. 34-39
-
-
Yoshida, K.1
van den Berg, T.2
Dijkstra, C.3
-
94
-
-
0013809528
-
Antigens in immunity. 8. Localization of 125-I-labelled antigens in the secondary response
-
Nossal, G., Ada, G., Austin, C. & Pye, J. Antigens in immunity. 8. Localization of 125-I-labelled antigens in the secondary response. Immunology 9, 349-357 (1965).
-
(1965)
Immunology
, vol.9
, pp. 349-357
-
-
Nossal, G.1
Ada, G.2
Austin, C.3
Pye, J.4
-
95
-
-
0030593030
-
-
Dempsey, P., Allison, M., Akkaraju, S., Goodnow, C. & Fearon, D. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 271, 348-350 (1996).
-
Dempsey, P., Allison, M., Akkaraju, S., Goodnow, C. & Fearon, D. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 271, 348-350 (1996).
-
-
-
-
96
-
-
0034046181
-
Regulation of antibody responses via antibodies, complement, and Fc receptors
-
Heyman, B. Regulation of antibody responses via antibodies, complement, and Fc receptors. Annu. Rev. Immunol. 18, 709-737 (2000).
-
(2000)
Annu. Rev. Immunol
, vol.18
, pp. 709-737
-
-
Heyman, B.1
-
97
-
-
0022931325
-
The Ly-1 B cell lineage
-
Herzenberg, L. et al. The Ly-1 B cell lineage. Immunol. Rev. 93, 81-102 (1986).
-
(1986)
Immunol. Rev
, vol.93
, pp. 81-102
-
-
Herzenberg, L.1
-
98
-
-
0032445137
-
A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection
-
Boes, M., Prodeus, A., Schmidt, T., Carroll, M. & Chen, J. A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection. J. Exp. Med. 188, 2381-2386 (1998).
-
(1998)
J. Exp. Med
, vol.188
, pp. 2381-2386
-
-
Boes, M.1
Prodeus, A.2
Schmidt, T.3
Carroll, M.4
Chen, J.5
-
99
-
-
0032544110
-
Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response
-
Ehrenstein, M., O'Keefe, T., Davies, S. & Neuberger, M. Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response. Proc. Natl Acad. Sci. USA 95, 10089-10093 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 10089-10093
-
-
Ehrenstein, M.1
O'Keefe, T.2
Davies, S.3
Neuberger, M.4
-
100
-
-
34548118681
-
Holding antigen where B cells can find it
-
MacLennan, I. Holding antigen where B cells can find it. Nature Immunol. 8, 909-910 (2007).
-
(2007)
Nature Immunol
, vol.8
, pp. 909-910
-
-
MacLennan, I.1
-
101
-
-
0141465063
-
Are follicular dendritic cells really good for nothing?
-
Kosco-Vilbois, M. Are follicular dendritic cells really good for nothing? Nature Rev. Immunol. 3, 764-769 (2003).
-
(2003)
Nature Rev. Immunol
, vol.3
, pp. 764-769
-
-
Kosco-Vilbois, M.1
-
102
-
-
33846635838
-
Imaging of germinal center selection events during affinity maturation
-
Allen, C., Okada, T., Tang, H. & Cyster, J. Imaging of germinal center selection events during affinity maturation. Science 315, 528-531 (2007).
-
(2007)
Science
, vol.315
, pp. 528-531
-
-
Allen, C.1
Okada, T.2
Tang, H.3
Cyster, J.4
-
103
-
-
34248585765
-
Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns
-
Hauser, A. et al. Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity 26, 655-667 (2007).
-
(2007)
Immunity
, vol.26
, pp. 655-667
-
-
Hauser, A.1
-
104
-
-
33847206141
-
-
Schwickert, T. et al. In vivo imaging of germinal centres reveals a dynamic open structure. Nature 446, 83-87 (2007). Studies 102-104, published concurrently, provide a description of the cellular events in the germinal centre, calling into question the classic light-zone and dark-zone model of germinal-centre function.
-
Schwickert, T. et al. In vivo imaging of germinal centres reveals a dynamic open structure. Nature 446, 83-87 (2007). Studies 102-104, published concurrently, provide a description of the cellular events in the germinal centre, calling into question the classic light-zone and dark-zone model of germinal-centre function.
-
-
-
-
105
-
-
0032100706
-
Affinity dependence of the B cell response to antigen: A threshold, a ceiling, and the importance of off-rate
-
Batista, F. & Neuberger, M. Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate. Immunity 8, 751-759 (1998).
-
(1998)
Immunity
, vol.8
, pp. 751-759
-
-
Batista, F.1
Neuberger, M.2
-
106
-
-
39649094515
-
Follicular dendritic cell networks of primary follicles and germinal centers: Phenotype and function
-
Allen, C. & Cyster, J. Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function. Semin. Immunol. 20, 14-25 (2008).
-
(2008)
Semin. Immunol
, vol.20
, pp. 14-25
-
-
Allen, C.1
Cyster, J.2
-
107
-
-
33645795240
-
Memory B cell survival and function in the absence of secreted antibody and immune complexes on follicular dendritic cells
-
Anderson, S., Hannum, L. & Shlomchik, M. Memory B cell survival and function in the absence of secreted antibody and immune complexes on follicular dendritic cells. J. Immunol. 176, 4515-4519 (2006).
-
(2006)
J. Immunol
, vol.176
, pp. 4515-4519
-
-
Anderson, S.1
Hannum, L.2
Shlomchik, M.3
-
108
-
-
0034596892
-
Germinal center initiation, variable gene region hypermutation, and mutant B cell selection without detectable immune complexes on follicular dendritic cells
-
Hannum, L., Haberman, A., Anderson, S. & Shlomchik, M. Germinal center initiation, variable gene region hypermutation, and mutant B cell selection without detectable immune complexes on follicular dendritic cells. J. Exp. Med. 192, 931-942 (2000).
-
(2000)
J. Exp. Med
, vol.192
, pp. 931-942
-
-
Hannum, L.1
Haberman, A.2
Anderson, S.3
Shlomchik, M.4
-
109
-
-
0141576692
-
Reassessing the function of immune-complex retention by follicular dendritic cells
-
Haberman, A. & Shlomchik, M. Reassessing the function of immune-complex retention by follicular dendritic cells. Nature Rev. Immunol. 3, 757-764 (2003).
-
(2003)
Nature Rev. Immunol
, vol.3
, pp. 757-764
-
-
Haberman, A.1
Shlomchik, M.2
-
110
-
-
0014960964
-
Lymphocyte-mediated transport of aggregated human γ-globulin into germinal centre areas of normal mouse spleen
-
Brown, J., De Jesus, D., Holborow, E. & Harris, G. Lymphocyte-mediated transport of aggregated human γ-globulin into germinal centre areas of normal mouse spleen. Nature 228, 367-369 (1970).
-
(1970)
Nature
, vol.228
, pp. 367-369
-
-
Brown, J.1
De Jesus, D.2
Holborow, E.3
Harris, G.4
-
111
-
-
0022375222
-
In vivo effects of LPS on B lymphocyte subpopulations. Migration of marginal zone-lymphocytes and IgD-blast formation in the mouse spleen
-
Groeneveld, P., Erich, T. & Kraal, G. In vivo effects of LPS on B lymphocyte subpopulations. Migration of marginal zone-lymphocytes and IgD-blast formation in the mouse spleen. Immunobiology 170, 402-411 (1985).
-
(1985)
Immunobiology
, vol.170
, pp. 402-411
-
-
Groeneveld, P.1
Erich, T.2
Kraal, G.3
-
112
-
-
0022574401
-
The differential effects of bacterial lipopolysaccharide (LPS) on splenic non-lymphoid cells demonstrated by monoclonal antibodies
-
Groeneveld, P., Erich, T. & Kraal, G. The differential effects of bacterial lipopolysaccharide (LPS) on splenic non-lymphoid cells demonstrated by monoclonal antibodies. Immunology 58, 285-290 (1986).
-
(1986)
Immunology
, vol.58
, pp. 285-290
-
-
Groeneveld, P.1
Erich, T.2
Kraal, G.3
-
113
-
-
5044252309
-
Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells
-
Ferguson, A., Youd, M. & Corley, R. Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells. Int. Immunol. 16, 1411-1422 (2004).
-
(2004)
Int. Immunol
, vol.16
, pp. 1411-1422
-
-
Ferguson, A.1
Youd, M.2
Corley, R.3
-
114
-
-
0026517074
-
Selective inhibition of immune complex trapping by follicular dendritic cells with monoclonal antibodies against rat C3
-
Van den Berg, T., Döpp, E., Daha, M., Kraal, G. & Dijkstra, C. Selective inhibition of immune complex trapping by follicular dendritic cells with monoclonal antibodies against rat C3. Eur. J. Immunol. 22, 957-962 (1992).
-
(1992)
Eur. J. Immunol
, vol.22
, pp. 957-962
-
-
Van den Berg, T.1
Döpp, E.2
Daha, M.3
Kraal, G.4
Dijkstra, C.5
-
115
-
-
0036686286
-
Synergistic roles of IgM and complement in antigen trapping and follicular localization
-
Youd, M., Ferguson, A. & Corley, R. Synergistic roles of IgM and complement in antigen trapping and follicular localization. Eur. J. Immunol. 32, 2328-2337 (2002).
-
(2002)
Eur. J. Immunol
, vol.32
, pp. 2328-2337
-
-
Youd, M.1
Ferguson, A.2
Corley, R.3
-
116
-
-
37349013401
-
-
Cinamon, G., Zachariah, M., Lam, O., Foss, F. & Cyster, J. Follicular shuttling of marginal zone B cells facilitates antigen transport. Nature Immunol. 9, 54-62 (2007). In this paper, the authors demonstrate the continual shuttling of splenic marginal-zone B cells into the follicle and suggest that this is a mechanism for the capture and delivery of antigen to follicular B cells.
-
Cinamon, G., Zachariah, M., Lam, O., Foss, F. & Cyster, J. Follicular shuttling of marginal zone B cells facilitates antigen transport. Nature Immunol. 9, 54-62 (2007). In this paper, the authors demonstrate the continual shuttling of splenic marginal-zone B cells into the follicle and suggest that this is a mechanism for the capture and delivery of antigen to follicular B cells.
-
-
-
-
117
-
-
4043065702
-
Analyses of the in vivo trafficking of stoichiometric doses of an anti-complement receptor 1/2 monoclonal antibody infused intravenously in mice
-
Whipple, E., Shanahan, R., Ditto, A., Taylor, R. & Lindorfer, M. Analyses of the in vivo trafficking of stoichiometric doses of an anti-complement receptor 1/2 monoclonal antibody infused intravenously in mice. J. Immunol. 173, 2297-2306 (2004).
-
(2004)
J. Immunol
, vol.173
, pp. 2297-2306
-
-
Whipple, E.1
Shanahan, R.2
Ditto, A.3
Taylor, R.4
Lindorfer, M.5
-
118
-
-
0022619921
-
Transfer of immune complexes from lymphocytes to follicular dendritic cells
-
Heinen, E. et al. Transfer of immune complexes from lymphocytes to follicular dendritic cells. Eur. J. Immunol. 16, 167-172 (1986).
-
(1986)
Eur. J. Immunol
, vol.16
, pp. 167-172
-
-
Heinen, E.1
-
119
-
-
45549096691
-
A novel B cell-mediated transport of IgE-immune complexes to the follicle of the spleen
-
Hjelm, F., Karlsson, M. & Heyman, B. A novel B cell-mediated transport of IgE-immune complexes to the follicle of the spleen. J. Immunol. 180, 6604-6610 (2008).
-
(2008)
J. Immunol
, vol.180
, pp. 6604-6610
-
-
Hjelm, F.1
Karlsson, M.2
Heyman, B.3
-
120
-
-
33646454106
-
B cell ligand discrimination through a spreading and contraction response
-
Fleire, S. et al. B cell ligand discrimination through a spreading and contraction response. Science 312, 738-741 (2006).
-
(2006)
Science
, vol.312
, pp. 738-741
-
-
Fleire, S.1
-
121
-
-
0037144842
-
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies
-
Bunnell, S. et al. T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J. Cell Biol. 158, 1263-1275 (2002).
-
(2002)
J. Cell Biol
, vol.158
, pp. 1263-1275
-
-
Bunnell, S.1
-
122
-
-
27544441784
-
Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling
-
Campi, G., Varma, R. & Dustin, M. Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J. Exp. Med. 202, 1031-1036 (2005).
-
(2005)
J. Exp. Med
, vol.202
, pp. 1031-1036
-
-
Campi, G.1
Varma, R.2
Dustin, M.3
-
123
-
-
30044441433
-
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76
-
Yokosuka, T. et al. Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nature Immunol. 6, 1253-1262 (2005).
-
(2005)
Nature Immunol
, vol.6
, pp. 1253-1262
-
-
Yokosuka, T.1
-
124
-
-
42249090333
-
Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen
-
Weber, M. et al. Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen. J. Exp. Med. 205, 853-868 (2008).
-
(2008)
J. Exp. Med
, vol.205
, pp. 853-868
-
-
Weber, M.1
-
125
-
-
48249124978
-
Membrane heterogeneities in the formation of B cell receptor-Lyn kinase microclusters and the immune synapse
-
Sohn, H. W., Tolar, P. & Pierce, S. K. Membrane heterogeneities in the formation of B cell receptor-Lyn kinase microclusters and the immune synapse. J. Cell Biol. 182, 367-379 (2008).
-
(2008)
J. Cell Biol
, vol.182
, pp. 367-379
-
-
Sohn, H.W.1
Tolar, P.2
Pierce, S.K.3
-
126
-
-
0028289244
-
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α
-
Sallusto, F. & Lanzavecchia, A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 179, 1109-1118 (1994).
-
(1994)
J. Exp. Med
, vol.179
, pp. 1109-1118
-
-
Sallusto, F.1
Lanzavecchia, A.2
-
127
-
-
33644848385
-
Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells
-
Crawford, A., Macleod, M., Schumacher, T., Corlett, L. & Gray, D. Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells. J. Immunol. 176, 3498-3506 (2006).
-
(2006)
J. Immunol
, vol.176
, pp. 3498-3506
-
-
Crawford, A.1
Macleod, M.2
Schumacher, T.3
Corlett, L.4
Gray, D.5
-
128
-
-
53649107278
-
SAP-controlled T-B cell interactions underlie germinal centre formation
-
Qi, H., Cannons, J. L., Klauschen, F., Schwartzberg, P. L. & Germain, R. N. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature 455, 764-769 (2008).
-
(2008)
Nature
, vol.455
, pp. 764-769
-
-
Qi, H.1
Cannons, J.L.2
Klauschen, F.3
Schwartzberg, P.L.4
Germain, R.N.5
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