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Volumn 41, Issue 2, 2014, Pages 181-190

Revisiting thymic positive selection and the mature T cell repertoire for antigen

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE ANTIGEN;

EID: 84907308588     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2014.07.007     Document Type: Review
Times cited : (74)

References (111)
  • 1
    • 0019915995 scopus 로고
    • Tumor-specific antigen ofmurine T-lymphoma defined with monoclonal antibody
    • Allison J.P., McIntyre B.W., Bloch D. Tumor-specific antigen ofmurine T-lymphoma defined with monoclonal antibody. J.Immunol. 1982, 129:2293-2300.
    • (1982) J.Immunol. , vol.129 , pp. 2293-2300
    • Allison, J.P.1    McIntyre, B.W.2    Bloch, D.3
  • 2
    • 0032445491 scopus 로고    scopus 로고
    • CD5 expression is developmentally regulated by Tcell receptor (TCR) signals and TCR avidity
    • Azzam H.S., Grinberg A., Lui K., Shen H., Shores E.W., Love P.E. CD5 expression is developmentally regulated by Tcell receptor (TCR) signals and TCR avidity. J.Exp. Med. 1998, 188:2301-2311.
    • (1998) J.Exp. Med. , vol.188 , pp. 2301-2311
    • Azzam, H.S.1    Grinberg, A.2    Lui, K.3    Shen, H.4    Shores, E.W.5    Love, P.E.6
  • 3
    • 0021968677 scopus 로고
    • Binding of immunogenic peptides to Ia histocompatibility molecules
    • Babbitt B.P., Allen P.M., Matsueda G., Haber E., Unanue E.R. Binding of immunogenic peptides to Ia histocompatibility molecules. Nature 1985, 317:359-361.
    • (1985) Nature , vol.317 , pp. 359-361
    • Babbitt, B.P.1    Allen, P.M.2    Matsueda, G.3    Haber, E.4    Unanue, E.R.5
  • 4
    • 33748447541 scopus 로고    scopus 로고
    • Type I interferon in systemic lupus erythematosus and other autoimmune diseases
    • Banchereau J., Pascual V. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 2006, 25:383-392.
    • (2006) Immunity , vol.25 , pp. 383-392
    • Banchereau, J.1    Pascual, V.2
  • 5
    • 0032943540 scopus 로고    scopus 로고
    • Requirement for diverse, low-abundance peptides in positive selection of Tcells
    • Barton G.M., Rudensky A.Y. Requirement for diverse, low-abundance peptides in positive selection of Tcells. Science 1999, 283:67-70.
    • (1999) Science , vol.283 , pp. 67-70
    • Barton, G.M.1    Rudensky, A.Y.2
  • 6
    • 0017688347 scopus 로고
    • In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells
    • Bevan M.J. In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature 1977, 269:417-418.
    • (1977) Nature , vol.269 , pp. 417-418
    • Bevan, M.J.1
  • 9
    • 0031870528 scopus 로고    scopus 로고
    • Crossreactivity of the T-cell receptor
    • Borghans J.A., De Boer R.J. Crossreactivity of the T-cell receptor. Immunol. Today 1998, 19:428-429.
    • (1998) Immunol. Today , vol.19 , pp. 428-429
    • Borghans, J.A.1    De Boer, R.J.2
  • 10
    • 0036839081 scopus 로고    scopus 로고
    • Is selection for TCR affinity a factor in cytokine polarization?
    • Boyton R.J., Altmann D.M. Is selection for TCR affinity a factor in cytokine polarization?. Trends Immunol. 2002, 23:526-529.
    • (2002) Trends Immunol. , vol.23 , pp. 526-529
    • Boyton, R.J.1    Altmann, D.M.2
  • 11
    • 0036467432 scopus 로고    scopus 로고
    • CD4 Tcells selected by antigen under Th2 polarizing conditions favor an elongated TCR alpha chain complementarity-determining region 3
    • Boyton R.J., Zaccai N., Jones E.Y., Altmann D.M. CD4 Tcells selected by antigen under Th2 polarizing conditions favor an elongated TCR alpha chain complementarity-determining region 3. J.Immunol. 2002, 168:1018-1027.
    • (2002) J.Immunol. , vol.168 , pp. 1018-1027
    • Boyton, R.J.1    Zaccai, N.2    Jones, E.Y.3    Altmann, D.M.4
  • 13
    • 0033557173 scopus 로고    scopus 로고
    • T cell affinity maturation by selective expansion during infection
    • Busch D.H., Pamer E.G. T cell affinity maturation by selective expansion during infection. J.Exp. Med. 1999, 189:701-710.
    • (1999) J.Exp. Med. , vol.189 , pp. 701-710
    • Busch, D.H.1    Pamer, E.G.2
  • 14
    • 0035172347 scopus 로고    scopus 로고
    • Most alpha/beta Tcell receptor diversity is due to terminal deoxynucleotidyl transferase
    • Cabaniols J.P., Fazilleau N., Casrouge A., Kourilsky P., Kanellopoulos J.M. Most alpha/beta Tcell receptor diversity is due to terminal deoxynucleotidyl transferase. J.Exp. Med. 2001, 194:1385-1390.
    • (2001) J.Exp. Med. , vol.194 , pp. 1385-1390
    • Cabaniols, J.P.1    Fazilleau, N.2    Casrouge, A.3    Kourilsky, P.4    Kanellopoulos, J.M.5
  • 15
    • 84861173090 scopus 로고    scopus 로고
    • Degenerate T-cell recognition of peptides on MHC molecules creates large holes in the T-cell repertoire
    • Calis J.J., de Boer R.J., Keşmir C. Degenerate T-cell recognition of peptides on MHC molecules creates large holes in the T-cell repertoire. PLoS Comput. Biol. 2012, 8:e1002412.
    • (2012) PLoS Comput. Biol. , vol.8
    • Calis, J.J.1    de Boer, R.J.2    Keşmir, C.3
  • 16
    • 76949102246 scopus 로고    scopus 로고
    • T cell receptor-dependent regulation of lipid rafts controls naive CD8+ Tcell homeostasis
    • Cho J.H., Kim H.O., Surh C.D., Sprent J. T cell receptor-dependent regulation of lipid rafts controls naive CD8+ Tcell homeostasis. Immunity 2010, 32:214-226.
    • (2010) Immunity , vol.32 , pp. 214-226
    • Cho, J.H.1    Kim, H.O.2    Surh, C.D.3    Sprent, J.4
  • 17
    • 79955541353 scopus 로고    scopus 로고
    • Strength of TCR-peptide/MHC interactions and invivo Tcell responses
    • Corse E., Gottschalk R.A., Allison J.P. Strength of TCR-peptide/MHC interactions and invivo Tcell responses. J.Immunol. 2011, 186:5039-5045.
    • (2011) J.Immunol. , vol.186 , pp. 5039-5045
    • Corse, E.1    Gottschalk, R.A.2    Allison, J.P.3
  • 18
    • 84874562592 scopus 로고    scopus 로고
    • Helios marks strongly autoreactive CD4+ Tcells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB
    • Daley S.R., Hu D.Y., Goodnow C.C. Helios marks strongly autoreactive CD4+ Tcells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB. J.Exp. Med. 2013, 210:269-285.
    • (2013) J.Exp. Med. , vol.210 , pp. 269-285
    • Daley, S.R.1    Hu, D.Y.2    Goodnow, C.C.3
  • 19
    • 0023720148 scopus 로고
    • T-cell antigen receptor genes and T-cell recognition
    • Davis M.M., Bjorkman P.J. T-cell antigen receptor genes and T-cell recognition. Nature 1988, 334:395-402.
    • (1988) Nature , vol.334 , pp. 395-402
    • Davis, M.M.1    Bjorkman, P.J.2
  • 21
    • 0033981410 scopus 로고    scopus 로고
    • Deriving quantitative constraints on Tcell selection from data on the mature Tcell repertoire
    • Detours V., Mehr R., Perelson A.S. Deriving quantitative constraints on Tcell selection from data on the mature Tcell repertoire. J.Immunol. 2000, 164:121-128.
    • (2000) J.Immunol. , vol.164 , pp. 121-128
    • Detours, V.1    Mehr, R.2    Perelson, A.S.3
  • 22
    • 70350435670 scopus 로고    scopus 로고
    • An endogenous positively selecting peptide enhances mature Tcell responses and becomes an autoantigen in the absence of microRNA miR-181a
    • Ebert P.J., Jiang S., Xie J., Li Q.J., Davis M.M. An endogenous positively selecting peptide enhances mature Tcell responses and becomes an autoantigen in the absence of microRNA miR-181a. Nat. Immunol. 2009, 10:1162-1169.
    • (2009) Nat. Immunol. , vol.10 , pp. 1162-1169
    • Ebert, P.J.1    Jiang, S.2    Xie, J.3    Li, Q.J.4    Davis, M.M.5
  • 23
    • 84867413102 scopus 로고    scopus 로고
    • Insights into T cell recognition of antigen: significance of two-dimensional kinetic parameters
    • Edwards L.J., Zarnitzyna V.I., Hood J.D., Evavold B.D., Zhu C. Insights into T cell recognition of antigen: significance of two-dimensional kinetic parameters. Front. Immunol. 2012, 3:86.
    • (2012) Front. Immunol. , vol.3 , pp. 86
    • Edwards, L.J.1    Zarnitzyna, V.I.2    Hood, J.D.3    Evavold, B.D.4    Zhu, C.5
  • 24
    • 0028344533 scopus 로고
    • Structure of peptides associated with class I and class II MHC molecules
    • Engelhard V.H. Structure of peptides associated with class I and class II MHC molecules. Annu. Rev. Immunol. 1994, 12:181-207.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 181-207
    • Engelhard, V.H.1
  • 25
    • 62849126473 scopus 로고    scopus 로고
    • The function of follicular helper Tcells is regulated by the strength of Tcell antigen receptor binding
    • Fazilleau N., McHeyzer-Williams L.J., Rosen H., McHeyzer-Williams M.G. The function of follicular helper Tcells is regulated by the strength of Tcell antigen receptor binding. Nat. Immunol. 2009, 10:375-384.
    • (2009) Nat. Immunol. , vol.10 , pp. 375-384
    • Fazilleau, N.1    McHeyzer-Williams, L.J.2    Rosen, H.3    McHeyzer-Williams, M.G.4
  • 26
    • 36448937145 scopus 로고    scopus 로고
    • Specificity of T-cell alloreactivity
    • Felix N.J., Allen P.M. Specificity of T-cell alloreactivity. Nat. Rev. Immunol. 2007, 7:942-953.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 942-953
    • Felix, N.J.1    Allen, P.M.2
  • 27
    • 0016829314 scopus 로고
    • Further implications of a theory of immunity
    • Forsdyke D.R. Further implications of a theory of immunity. J.Theor. Biol. 1975, 52:187-198.
    • (1975) J.Theor. Biol. , vol.52 , pp. 187-198
    • Forsdyke, D.R.1
  • 28
    • 0029855347 scopus 로고    scopus 로고
    • Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
    • Garboczi D.N., Ghosh P., Utz U., Fan Q.R., Biddison W.E., Wiley D.C. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 1996, 384:134-141.
    • (1996) Nature , vol.384 , pp. 134-141
    • Garboczi, D.N.1    Ghosh, P.2    Utz, U.3    Fan, Q.R.4    Biddison, W.E.5    Wiley, D.C.6
  • 29
    • 84865281416 scopus 로고    scopus 로고
    • Reconciling views on Tcell receptor germline bias for MHC
    • Garcia K.C. Reconciling views on Tcell receptor germline bias for MHC. Trends Immunol. 2012, 33:429-436.
    • (2012) Trends Immunol. , vol.33 , pp. 429-436
    • Garcia, K.C.1
  • 30
    • 58649114309 scopus 로고    scopus 로고
    • The molecular basis of TCR germline bias for MHC is surprisingly simple
    • Garcia K.C., Adams J.J., Feng D., Ely L.K. The molecular basis of TCR germline bias for MHC is surprisingly simple. Nat. Immunol. 2009, 10:143-147.
    • (2009) Nat. Immunol. , vol.10 , pp. 143-147
    • Garcia, K.C.1    Adams, J.J.2    Feng, D.3    Ely, L.K.4
  • 31
    • 0027973205 scopus 로고
    • More efficient positive selection of thymocytes in mice lacking terminal deoxynucleotidyl transferase
    • Gilfillan S., Waltzinger C., Benoist C., Mathis D. More efficient positive selection of thymocytes in mice lacking terminal deoxynucleotidyl transferase. Int. Immunol. 1994, 6:1681-1686.
    • (1994) Int. Immunol. , vol.6 , pp. 1681-1686
    • Gilfillan, S.1    Waltzinger, C.2    Benoist, C.3    Mathis, D.4
  • 33
    • 0030848546 scopus 로고    scopus 로고
    • Deficient positive selection of CD4 Tcells in mice displaying altered repertoires of MHC class II-bound self-peptides
    • Grubin C.E., Kovats S., deRoos P., Rudensky A.Y. Deficient positive selection of CD4 Tcells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity 1997, 7:197-208.
    • (1997) Immunity , vol.7 , pp. 197-208
    • Grubin, C.E.1    Kovats, S.2    deRoos, P.3    Rudensky, A.Y.4
  • 34
    • 33645275372 scopus 로고    scopus 로고
    • Naive and memory CD4+ Tcell survival controlled by clonal abundance
    • Hataye J., Moon J.J., Khoruts A., Reilly C., Jenkins M.K. Naive and memory CD4+ Tcell survival controlled by clonal abundance. Science 2006, 312:114-116.
    • (2006) Science , vol.312 , pp. 114-116
    • Hataye, J.1    Moon, J.J.2    Khoruts, A.3    Reilly, C.4    Jenkins, M.K.5
  • 35
    • 0021215865 scopus 로고
    • Isolation of cDNA clones encoding Tcell-specific membrane-associated proteins
    • Hedrick S.M., Cohen D.I., Nielsen E.A., Davis M.M. Isolation of cDNA clones encoding Tcell-specific membrane-associated proteins. Nature 1984, 308:149-153.
    • (1984) Nature , vol.308 , pp. 149-153
    • Hedrick, S.M.1    Cohen, D.I.2    Nielsen, E.A.3    Davis, M.M.4
  • 36
    • 0031966527 scopus 로고    scopus 로고
    • Probing degeneracy in T-cell recognition using peptide combinatorial libraries
    • Hemmer B., Vergelli M., Pinilla C., Houghten R., Martin R. Probing degeneracy in T-cell recognition using peptide combinatorial libraries. Immunol. Today 1998, 19:163-168.
    • (1998) Immunol. Today , vol.19 , pp. 163-168
    • Hemmer, B.1    Vergelli, M.2    Pinilla, C.3    Houghten, R.4    Martin, R.5
  • 37
    • 0027478380 scopus 로고
    • Positive selection of CD8+ Tcells induced by major histocompatibility complex binding peptides in fetal thymic organ culture
    • Hogquist K.A., Gavin M.A., Bevan M.J. Positive selection of CD8+ Tcells induced by major histocompatibility complex binding peptides in fetal thymic organ culture. J.Exp. Med. 1993, 177:1469-1473.
    • (1993) J.Exp. Med. , vol.177 , pp. 1469-1473
    • Hogquist, K.A.1    Gavin, M.A.2    Bevan, M.J.3
  • 38
    • 0037234768 scopus 로고    scopus 로고
    • TCRs with high affinity for foreign pMHC show self-reactivity
    • Holler P.D., Chlewicki L.K., Kranz D.M. TCRs with high affinity for foreign pMHC show self-reactivity. Nat. Immunol. 2003, 4:55-62.
    • (2003) Nat. Immunol. , vol.4 , pp. 55-62
    • Holler, P.D.1    Chlewicki, L.K.2    Kranz, D.M.3
  • 40
    • 0030058657 scopus 로고    scopus 로고
    • The repertoire of Tcells shaped by a single MHC/peptide ligand
    • Ignatowicz L., Kappler J., Marrack P. The repertoire of Tcells shaped by a single MHC/peptide ligand. Cell 1996, 84:521-529.
    • (1996) Cell , vol.84 , pp. 521-529
    • Ignatowicz, L.1    Kappler, J.2    Marrack, P.3
  • 41
    • 84860346184 scopus 로고    scopus 로고
    • The role of naive Tcell precursor frequency and recruitment in dictating immune response magnitude
    • Jenkins M.K., Moon J.J. The role of naive Tcell precursor frequency and recruitment in dictating immune response magnitude. J.Immunol. 2012, 188:4135-4140.
    • (2012) J.Immunol. , vol.188 , pp. 4135-4140
    • Jenkins, M.K.1    Moon, J.J.2
  • 42
    • 0842303307 scopus 로고    scopus 로고
    • Unraveling V(D)J recombination; insights into gene regulation
    • Jung D., Alt F.W. Unraveling V(D)J recombination; insights into gene regulation. Cell 2004, 116:299-311.
    • (2004) Cell , vol.116 , pp. 299-311
    • Jung, D.1    Alt, F.W.2
  • 43
    • 0019458092 scopus 로고
    • Antigen-inducible, H-2-restricted, interleukin-2-producing Tcell hybridomas. Lack of independent antigen and H-2 recognition
    • Kappler J.W., Skidmore B., White J., Marrack P. Antigen-inducible, H-2-restricted, interleukin-2-producing Tcell hybridomas. Lack of independent antigen and H-2 recognition. J.Exp. Med. 1981, 153:1198-1214.
    • (1981) J.Exp. Med. , vol.153 , pp. 1198-1214
    • Kappler, J.W.1    Skidmore, B.2    White, J.3    Marrack, P.4
  • 44
    • 0021065056 scopus 로고
    • The major histocompatibility complex-restricted antigen receptor on Tcells in mouse and man: identification of constant and variable peptides
    • Kappler J., Kubo R., Haskins K., Hannum C., Marrack P., Pigeon M., McIntyre B., Allison J., Trowbridge I. The major histocompatibility complex-restricted antigen receptor on Tcells in mouse and man: identification of constant and variable peptides. Cell 1983, 35:295-302.
    • (1983) Cell , vol.35 , pp. 295-302
    • Kappler, J.1    Kubo, R.2    Haskins, K.3    Hannum, C.4    Marrack, P.5    Pigeon, M.6    McIntyre, B.7    Allison, J.8    Trowbridge, I.9
  • 46
    • 84881611232 scopus 로고    scopus 로고
    • Low-affinity Tcells are programmed to maintain normal primary responses but are impaired in their recall to low-affinity ligands
    • Knudson K.M., Goplen N.P., Cunningham C.A., Daniels M.A., Teixeiro E. Low-affinity Tcells are programmed to maintain normal primary responses but are impaired in their recall to low-affinity ligands. Cell Rep 2013, 4:554-565.
    • (2013) Cell Rep , vol.4 , pp. 554-565
    • Knudson, K.M.1    Goplen, N.P.2    Cunningham, C.A.3    Daniels, M.A.4    Teixeiro, E.5
  • 48
    • 0035865335 scopus 로고    scopus 로고
    • Alpha beta TCRs differ in the degree of their specificity for the positively selecting MHC/peptide ligand
    • Kraj P., Pacholczyk R., Ignatowicz L. Alpha beta TCRs differ in the degree of their specificity for the positively selecting MHC/peptide ligand. J.Immunol. 2001, 166:2251-2259.
    • (2001) J.Immunol. , vol.166 , pp. 2251-2259
    • Kraj, P.1    Pacholczyk, R.2    Ignatowicz, L.3
  • 49
    • 15044358353 scopus 로고    scopus 로고
    • Agonist/endogenous peptide-MHC heterodimers drive Tcell activation and sensitivity
    • Krogsgaard M., Li Q.J., Sumen C., Huppa J.B., Huse M., Davis M.M. Agonist/endogenous peptide-MHC heterodimers drive Tcell activation and sensitivity. Nature 2005, 434:238-243.
    • (2005) Nature , vol.434 , pp. 238-243
    • Krogsgaard, M.1    Li, Q.J.2    Sumen, C.3    Huppa, J.B.4    Huse, M.5    Davis, M.M.6
  • 50
    • 0023216961 scopus 로고
    • The E-T (elephant-tadpole) paradox necessitates the concept of a unit of B-cell function: the protection
    • Langman R.E., Cohn M. The E-T (elephant-tadpole) paradox necessitates the concept of a unit of B-cell function: the protection. Mol. Immunol. 1987, 24:675-697.
    • (1987) Mol. Immunol. , vol.24 , pp. 675-697
    • Langman, R.E.1    Cohn, M.2
  • 51
    • 0022597528 scopus 로고
    • Identity of cells that imprint H-2-restricted T-cell specificity in the thymus
    • Lo D., Sprent J. Identity of cells that imprint H-2-restricted T-cell specificity in the thymus. Nature 1986, 319:672-675.
    • (1986) Nature , vol.319 , pp. 672-675
    • Lo, D.1    Sprent, J.2
  • 52
    • 70350439671 scopus 로고    scopus 로고
    • An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ Tcells
    • Lo W.L., Felix N.J., Walters J.J., Rohrs H., Gross M.L., Allen P.M. An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ Tcells. Nat. Immunol. 2009, 10:1155-1161.
    • (2009) Nat. Immunol. , vol.10 , pp. 1155-1161
    • Lo, W.L.1    Felix, N.J.2    Walters, J.J.3    Rohrs, H.4    Gross, M.L.5    Allen, P.M.6
  • 53
    • 0030198513 scopus 로고    scopus 로고
    • T-cell repertoire: political correctness in the immune system
    • Lucas B., Germain R.N. T-cell repertoire: political correctness in the immune system. Curr. Biol. 1996, 6:783-787.
    • (1996) Curr. Biol. , vol.6 , pp. 783-787
    • Lucas, B.1    Germain, R.N.2
  • 54
    • 8444236620 scopus 로고    scopus 로고
    • Clonal selection of helper Tcells is determined by an affinity threshold with no further skewing of TCR binding properties
    • Malherbe L., Hausl C., Teyton L., McHeyzer-Williams M.G. Clonal selection of helper Tcells is determined by an affinity threshold with no further skewing of TCR binding properties. Immunity 2004, 21:669-679.
    • (2004) Immunity , vol.21 , pp. 669-679
    • Malherbe, L.1    Hausl, C.2    Teyton, L.3    McHeyzer-Williams, M.G.4
  • 56
    • 84874244135 scopus 로고    scopus 로고
    • T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens
    • Mandl J.N., Monteiro J.P., Vrisekoop N., Germain R.N. T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens. Immunity 2013, 38:263-274.
    • (2013) Immunity , vol.38 , pp. 263-274
    • Mandl, J.N.1    Monteiro, J.P.2    Vrisekoop, N.3    Germain, R.N.4
  • 59
    • 0032171644 scopus 로고    scopus 로고
    • A very high level of crossreactivity is an essential feature of the T-cell receptor
    • Mason D. A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol. Today 1998, 19:395-404.
    • (1998) Immunol. Today , vol.19 , pp. 395-404
    • Mason, D.1
  • 61
    • 2242419092 scopus 로고    scopus 로고
    • Direct link between mhc polymorphism, Tcell avidity, and diversity in immune defense
    • Messaoudi I., Guevara Patiño J.A., Dyall R., LeMaoult J., Nikolich-Zugich J. Direct link between mhc polymorphism, Tcell avidity, and diversity in immune defense. Science 2002, 298:1797-1800.
    • (2002) Science , vol.298 , pp. 1797-1800
    • Messaoudi, I.1    Guevara Patiño, J.A.2    Dyall, R.3    LeMaoult, J.4    Nikolich-Zugich, J.5
  • 63
    • 79952816254 scopus 로고    scopus 로고
    • Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination
    • Miles J.J., Douek D.C., Price D.A. Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination. Immunol. Cell Biol. 2011, 89:375-387.
    • (2011) Immunol. Cell Biol. , vol.89 , pp. 375-387
    • Miles, J.J.1    Douek, D.C.2    Price, D.A.3
  • 64
    • 77953639786 scopus 로고    scopus 로고
    • Cutting edge: lack of high affinity competition for peptide in polyclonal CD4+ responses unmasks IL-4 production
    • Milner J.D., Fazilleau N., McHeyzer-Williams M., Paul W. Cutting edge: lack of high affinity competition for peptide in polyclonal CD4+ responses unmasks IL-4 production. J.Immunol. 2010, 184:6569-6573.
    • (2010) J.Immunol. , vol.184 , pp. 6569-6573
    • Milner, J.D.1    Fazilleau, N.2    McHeyzer-Williams, M.3    Paul, W.4
  • 65
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • Moran A.E., Holzapfel K.L., Xing Y., Cunningham N.R., Maltzman J.S., Punt J., Hogquist K.A. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J.Exp. Med. 2011, 208:1279-1289.
    • (2011) J.Exp. Med. , vol.208 , pp. 1279-1289
    • Moran, A.E.1    Holzapfel, K.L.2    Xing, Y.3    Cunningham, N.R.4    Maltzman, J.S.5    Punt, J.6    Hogquist, K.A.7
  • 66
    • 84855957129 scopus 로고    scopus 로고
    • How the TCR balances sensitivity andspecificity for the recognition of self and pathogens
    • Morris G.P., Allen P.M. How the TCR balances sensitivity andspecificity for the recognition of self and pathogens. Nat. Immunol. 2012, 13:121-128.
    • (2012) Nat. Immunol. , vol.13 , pp. 121-128
    • Morris, G.P.1    Allen, P.M.2
  • 67
    • 84867095375 scopus 로고    scopus 로고
    • Statistical inference of the generation probability of T-cell receptors from sequence repertoires
    • Murugan A., Mora T., Walczak A.M., Callan C.G. Statistical inference of the generation probability of T-cell receptors from sequence repertoires. Proc. Natl. Acad. Sci. USA 2012, 109:16161-16166.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 16161-16166
    • Murugan, A.1    Mora, T.2    Walczak, A.M.3    Callan, C.G.4
  • 68
    • 70549093092 scopus 로고    scopus 로고
    • Non-genetic cell-to-cell variability and the consequences for pharmacology
    • Niepel M., Spencer S.L., Sorger P.K. Non-genetic cell-to-cell variability and the consequences for pharmacology. Curr. Opin. Chem. Biol. 2009, 13:556-561.
    • (2009) Curr. Opin. Chem. Biol. , vol.13 , pp. 556-561
    • Niepel, M.1    Spencer, S.L.2    Sorger, P.K.3
  • 70
    • 0038725685 scopus 로고    scopus 로고
    • Negative selection-clearing out the bad apples from the T-cell repertoire
    • Palmer E. Negative selection-clearing out the bad apples from the T-cell repertoire. Nat. Rev. Immunol. 2003, 3:383-391.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 383-391
    • Palmer, E.1
  • 72
    • 84894447120 scopus 로고    scopus 로고
    • Intrinsic CD4+ Tcell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC
    • Persaud S.P., Parker C.R., Lo W.L., Weber K.S., Allen P.M. Intrinsic CD4+ Tcell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC. Nat. Immunol. 2014, 15:266-274.
    • (2014) Nat. Immunol. , vol.15 , pp. 266-274
    • Persaud, S.P.1    Parker, C.R.2    Lo, W.L.3    Weber, K.S.4    Allen, P.M.5
  • 73
    • 84886724138 scopus 로고    scopus 로고
    • The basis for limited specificity and MHC restriction in a Tcell receptor interface
    • Piepenbrink K.H., Blevins S.J., Scott D.R., Baker B.M. The basis for limited specificity and MHC restriction in a Tcell receptor interface. Nat Commun 2013, 4:1948.
    • (2013) Nat Commun , vol.4 , pp. 1948
    • Piepenbrink, K.H.1    Blevins, S.J.2    Scott, D.R.3    Baker, B.M.4
  • 76
    • 0015898251 scopus 로고
    • Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes
    • Rosenthal A.S., Shevach E.M. Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes. J.Exp. Med. 1973, 138:1194-1212.
    • (1973) J.Exp. Med. , vol.138 , pp. 1194-1212
    • Rosenthal, A.S.1    Shevach, E.M.2
  • 78
    • 0033118739 scopus 로고    scopus 로고
    • A kinetic basis for Tcell receptor repertoire selection during an immune response
    • Savage P.A., Boniface J.J., Davis M.M. A kinetic basis for Tcell receptor repertoire selection during an immune response. Immunity 1999, 10:485-492.
    • (1999) Immunity , vol.10 , pp. 485-492
    • Savage, P.A.1    Boniface, J.J.2    Davis, M.M.3
  • 79
    • 0018833714 scopus 로고
    • Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice
    • Scollay R.G., Butcher E.C., Weissman I.L. Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice. Eur. J. Immunol. 1980, 10:210-218.
    • (1980) Eur. J. Immunol. , vol.10 , pp. 210-218
    • Scollay, R.G.1    Butcher, E.C.2    Weissman, I.L.3
  • 81
    • 0032102069 scopus 로고    scopus 로고
    • Preferential expression of TCR V alpha regions in CD4/CD8 subsets: class discrimination or co-receptor recognition?
    • Sim B.C., Lo D., Gascoigne N.R. Preferential expression of TCR V alpha regions in CD4/CD8 subsets: class discrimination or co-receptor recognition?. Immunol. Today 1998, 19:276-282.
    • (1998) Immunol. Today , vol.19 , pp. 276-282
    • Sim, B.C.1    Lo, D.2    Gascoigne, N.R.3
  • 82
    • 0141993921 scopus 로고    scopus 로고
    • The strength of persistent antigenic stimulation modulates adaptive tolerance in peripheral CD4+ Tcells
    • Singh N.J., Schwartz R.H. The strength of persistent antigenic stimulation modulates adaptive tolerance in peripheral CD4+ Tcells. J.Exp. Med. 2003, 198:1107-1117.
    • (2003) J.Exp. Med. , vol.198 , pp. 1107-1117
    • Singh, N.J.1    Schwartz, R.H.2
  • 83
    • 84867777146 scopus 로고    scopus 로고
    • Subsets of nonclonal neighboring CD4+ Tcells specifically regulate the frequency of individual antigen-reactive Tcells
    • Singh N.J., Bando J.K., Schwartz R.H. Subsets of nonclonal neighboring CD4+ Tcells specifically regulate the frequency of individual antigen-reactive Tcells. Immunity 2012, 37:735-746.
    • (2012) Immunity , vol.37 , pp. 735-746
    • Singh, N.J.1    Bando, J.K.2    Schwartz, R.H.3
  • 86
    • 0037191792 scopus 로고    scopus 로고
    • Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes
    • Stefanová I., Dorfman J.R., Germain R.N. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature 2002, 420:429-434.
    • (2002) Nature , vol.420 , pp. 429-434
    • Stefanová, I.1    Dorfman, J.R.2    Germain, R.N.3
  • 88
    • 84874253445 scopus 로고    scopus 로고
    • Virus-specific CD4(+) memory-phenotype Tcells are abundant in unexposed adults
    • Su L.F., Kidd B.A., Han A., Kotzin J.J., Davis M.M. Virus-specific CD4(+) memory-phenotype Tcells are abundant in unexposed adults. Immunity 2013, 38:373-383.
    • (2013) Immunity , vol.38 , pp. 373-383
    • Su, L.F.1    Kidd, B.A.2    Han, A.3    Kotzin, J.J.4    Davis, M.M.5
  • 89
    • 57449097558 scopus 로고    scopus 로고
    • Homeostasis of naive and memory Tcells
    • Surh C.D., Sprent J. Homeostasis of naive and memory Tcells. Immunity 2008, 29:848-862.
    • (2008) Immunity , vol.29 , pp. 848-862
    • Surh, C.D.1    Sprent, J.2
  • 90
    • 0030866855 scopus 로고    scopus 로고
    • Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ Tcells
    • Surh C.D., Lee D.S., Fung-Leung W.P., Karlsson L., Sprent J. Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ Tcells. Immunity 1997, 7:209-219.
    • (1997) Immunity , vol.7 , pp. 209-219
    • Surh, C.D.1    Lee, D.S.2    Fung-Leung, W.P.3    Karlsson, L.4    Sprent, J.5
  • 95
    • 84865282273 scopus 로고    scopus 로고
    • MHC restriction is imposed on a diverse Tcell receptor repertoire by CD4 and CD8 co-receptors during thymic selection
    • Van Laethem F., Tikhonova A.N., Singer A. MHC restriction is imposed on a diverse Tcell receptor repertoire by CD4 and CD8 co-receptors during thymic selection. Trends Immunol. 2012, 33:437-441.
    • (2012) Trends Immunol. , vol.33 , pp. 437-441
    • Van Laethem, F.1    Tikhonova, A.N.2    Singer, A.3
  • 97
    • 84904443484 scopus 로고    scopus 로고
    • T-cell-receptor-dependent signal intensity dominantly controls CD4+ Tcell polarization invivo
    • van Panhuys N., Klauschen F., Germain R.N. T-cell-receptor-dependent signal intensity dominantly controls CD4+ Tcell polarization invivo. Immunity 2014, 41:63-74.
    • (2014) Immunity , vol.41 , pp. 63-74
    • van Panhuys, N.1    Klauschen, F.2    Germain, R.N.3
  • 99
    • 78651480854 scopus 로고    scopus 로고
    • Thymus-specific serine protease contributes to the diversification of the functional endogenous CD4 Tcell receptor repertoire
    • Viret C., Lamare C., Guiraud M., Fazilleau N., Bour A., Malissen B., Carrier A., Guerder S. Thymus-specific serine protease contributes to the diversification of the functional endogenous CD4 Tcell receptor repertoire. J.Exp. Med. 2011, 208:3-11.
    • (2011) J.Exp. Med. , vol.208 , pp. 3-11
    • Viret, C.1    Lamare, C.2    Guiraud, M.3    Fazilleau, N.4    Bour, A.5    Malissen, B.6    Carrier, A.7    Guerder, S.8
  • 100
    • 0242551584 scopus 로고    scopus 로고
    • Homing and cellular traffic in lymph nodes
    • von Andrian U.H., Mempel T.R. Homing and cellular traffic in lymph nodes. Nat. Rev. Immunol. 2003, 3:867-878.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 867-878
    • von Andrian, U.H.1    Mempel, T.R.2
  • 101
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry E.J. T cell exhaustion. Nat. Immunol. 2011, 12:492-499.
    • (2011) Nat. Immunol. , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 102
    • 2342559084 scopus 로고    scopus 로고
    • Some scaling principles for the immune system
    • Wiegel F.W., Perelson A.S. Some scaling principles for the immune system. Immunol. Cell Biol. 2004, 82:127-131.
    • (2004) Immunol. Cell Biol. , vol.82 , pp. 127-131
    • Wiegel, F.W.1    Perelson, A.S.2
  • 104
    • 84876829466 scopus 로고    scopus 로고
    • Thymoproteasome subunit-β5T generates peptide-MHC complexes specialized for positive selection
    • Xing Y., Jameson S.C., Hogquist K.A. Thymoproteasome subunit-β5T generates peptide-MHC complexes specialized for positive selection. Proc. Natl. Acad. Sci. USA 2013, 110:6979-6984.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 6979-6984
    • Xing, Y.1    Jameson, S.C.2    Hogquist, K.A.3
  • 105
    • 0034292358 scopus 로고    scopus 로고
    • Thymocyte maturation: selection for in-frame TCR alpha-chain rearrangement is followed by selection for shorter TCR beta-chain complementarity-determining region 3
    • Yassai M., Gorski J. Thymocyte maturation: selection for in-frame TCR alpha-chain rearrangement is followed by selection for shorter TCR beta-chain complementarity-determining region 3. J.Immunol. 2000, 165:3706-3712.
    • (2000) J.Immunol. , vol.165 , pp. 3706-3712
    • Yassai, M.1    Gorski, J.2
  • 106
    • 0037090140 scopus 로고    scopus 로고
    • A molecular marker for thymocyte-positive selection: selection of CD4 single-positive thymocytes with shorter TCRB CDR3 during Tcell development
    • Yassai M., Ammon K., Goverman J., Marrack P., Naumov Y., Gorski J. A molecular marker for thymocyte-positive selection: selection of CD4 single-positive thymocytes with shorter TCRB CDR3 during Tcell development. J.Immunol. 2002, 168:3801-3807.
    • (2002) J.Immunol. , vol.168 , pp. 3801-3807
    • Yassai, M.1    Ammon, K.2    Goverman, J.3    Marrack, P.4    Naumov, Y.5    Gorski, J.6
  • 109
    • 0016318314 scopus 로고
    • Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis
    • Zinkernagel R.M., Doherty P.C. Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis. Nature 1974, 251:547-548.
    • (1974) Nature , vol.251 , pp. 547-548
    • Zinkernagel, R.M.1    Doherty, P.C.2
  • 110
    • 0016345568 scopus 로고
    • Restriction of invitro Tcell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system
    • Zinkernagel R.M., Doherty P.C. Restriction of invitro Tcell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 1974, 248:701-702.
    • (1974) Nature , vol.248 , pp. 701-702
    • Zinkernagel, R.M.1    Doherty, P.C.2
  • 111
    • 0018170714 scopus 로고
    • Cytotoxic Tcells learn specificity for self H-2 during differentiation in the thymus
    • Zinkernagel R.M., Callahan G.N., Klein J., Dennert G. Cytotoxic Tcells learn specificity for self H-2 during differentiation in the thymus. Nature 1978, 271:251-253.
    • (1978) Nature , vol.271 , pp. 251-253
    • Zinkernagel, R.M.1    Callahan, G.N.2    Klein, J.3    Dennert, G.4


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