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Volumn 86, Issue 8, 2008, Pages 700-708

Distinct functional capacities of mouse thymic and splenic dendritic cell populations (Immunology and Cell Biology (2007) 86, (700-708) DOI:10.1038/icb.2008.63);Distinct functional capacities of mouse thymic and splenic dendritic cell populations

Author keywords

Dendritic cells; Spleen; Thymus

Indexed keywords

ALPHA INTERFERON; CHEMOKINE; CHEMOKINE RECEPTOR; INTERLEUKIN 12P70; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; PROTEIN CCL22; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

EID: 56249122238     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2008.108     Document Type: Erratum
Times cited : (38)

References (64)
  • 1
    • 0025735629 scopus 로고
    • The dendritic cell system and its role in immunogenicity
    • Steinman RM. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991; 9: 271-296.
    • (1991) Annu Rev Immunol , vol.9 , pp. 271-296
    • Steinman, R.M.1
  • 2
    • 0036518287 scopus 로고    scopus 로고
    • Mouse and human dendritic cell subtypes
    • Shortman K, Liu YJ. Mouse and human dendritic cell subtypes. Nat Rev Immunol 2002; 2: 151-161.
    • (2002) Nat Rev Immunol , vol.2 , pp. 151-161
    • Shortman, K.1    Liu, Y.J.2
  • 4
    • 0034653434 scopus 로고    scopus 로고
    • CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen
    • Vremec D, Pooley J, Hochrein H, Wu L, Shortman K. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J Immunol 2000; 164: 2978-2986.
    • (2000) J Immunol , vol.164 , pp. 2978-2986
    • Vremec, D.1    Pooley, J.2    Hochrein, H.3    Wu, L.4    Shortman, K.5
  • 6
    • 0026691899 scopus 로고
    • The surface phenotype of dendritic cells purified from mouse thymus and spleen: Investigation of the CD8 expression by a subpopulation of dendritic cells
    • Vremec D, Zorbas M, Scollay R, Saunders DJ, Ardavin CF, Wu L et al. The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells. J Exp Med 1992; 176: 47-58.
    • (1992) J Exp Med , vol.176 , pp. 47-58
    • Vremec, D.1    Zorbas, M.2    Scollay, R.3    Saunders, D.J.4    Ardavin, C.F.5    Wu, L.6
  • 8
    • 0034684659 scopus 로고    scopus 로고
    • -) dendritic cells cross-prime cytotoxic T cells in vivo
    • -) dendritic cells cross-prime cytotoxic T cells in vivo. J Exp Med 2000; 192: 1685-1696.
    • (2000) J Exp Med , vol.192 , pp. 1685-1696
    • den Haan, J.M.1    Lehar, S.M.2    Bevan, M.J.3
  • 13
    • 0035339882 scopus 로고    scopus 로고
    • Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets
    • Hochrein H, Shortman K, Vremec D, Scott B, Hertzog P, O'Keeffe M. Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets. J Immunol 2001; 166: 5448-5455.
    • (2001) J Immunol , vol.166 , pp. 5448-5455
    • Hochrein, H.1    Shortman, K.2    Vremec, D.3    Scott, B.4    Hertzog, P.5    O'Keeffe, M.6
  • 14
    • 4544253774 scopus 로고    scopus 로고
    • Differential production of inflammatory chemokines by murine dendritic cell subsets
    • Proietto AI, O'Keeffe M, Gartlan K, Wright MD, Shortman K, Wu L et al. Differential production of inflammatory chemokines by murine dendritic cell subsets. Immunobiology 2004; 209: 163-172.
    • (2004) Immunobiology , vol.209 , pp. 163-172
    • Proietto, A.I.1    O'Keeffe, M.2    Gartlan, K.3    Wright, M.D.4    Shortman, K.5    Wu, L.6
  • 15
    • 0034278725 scopus 로고    scopus 로고
    • Dendritic cell regulation of TH1-TH2 development
    • Moser M, Murphy KM. Dendritic cell regulation of TH1-TH2 development. Nat Immunol 2000; 1: 199-205.
    • (2000) Nat Immunol , vol.1 , pp. 199-205
    • Moser, M.1    Murphy, K.M.2
  • 17
    • 0035887505 scopus 로고    scopus 로고
    • CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells
    • Nakano H, Yanagita M, Gunn MD. CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J Exp Med 2001; 194: 1171-1178.
    • (2001) J Exp Med , vol.194 , pp. 1171-1178
    • Nakano, H.1    Yanagita, M.2    Gunn, M.D.3
  • 18
    • 0035895048 scopus 로고    scopus 로고
    • Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice
    • Bjorck P. Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice. Blood 2001; 98: 3520-3526.
    • (2001) Blood , vol.98 , pp. 3520-3526
    • Bjorck, P.1
  • 19
    • 0037131976 scopus 로고    scopus 로고
    • Mouse plasmacytoid cells: Long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus
    • O'Keeffe M, Hochrein H, Vremec D, Caminschi I, Miller JL, Anders EM et al. Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus. J Exp Med 2002; 196: 1307-1319.
    • (2002) J Exp Med , vol.196 , pp. 1307-1319
    • O'Keeffe, M.1    Hochrein, H.2    Vremec, D.3    Caminschi, I.4    Miller, J.L.5    Anders, E.M.6
  • 20
    • 0031058466 scopus 로고    scopus 로고
    • Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo
    • Brocker T, Riedinger M, Karjalainen K. Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J Exp Med 1997; 185: 541-550.
    • (1997) J Exp Med , vol.185 , pp. 541-550
    • Brocker, T.1    Riedinger, M.2    Karjalainen, K.3
  • 22
    • 0025272416 scopus 로고
    • Strong T cell tolerance in parent - F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy
    • Gao EK, Lo D, Sprent J. Strong T cell tolerance in parent - F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy. J Exp Med 1990; 171: 1101-1121.
    • (1990) J Exp Med , vol.171 , pp. 1101-1121
    • Gao, E.K.1    Lo, D.2    Sprent, J.3
  • 23
    • 7244227645 scopus 로고    scopus 로고
    • Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
    • Gallegos AM, Bevan MJ. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J Exp Med 2004; 200: 1039-1049.
    • (2004) J Exp Med , vol.200 , pp. 1039-1049
    • Gallegos, A.M.1    Bevan, M.J.2
  • 24
    • 0028949219 scopus 로고
    • Mouse thymus dendritic cells: Kinetics of development and changes in surface markers during maturation
    • Wu L, Vremec D, Ardavin C, Winkel K, Süss G, Georgiou H et al. Mouse thymus dendritic cells: kinetics of development and changes in surface markers during maturation. Eur J Immunol 1995; 25: 418-425.
    • (1995) Eur J Immunol , vol.25 , pp. 418-425
    • Wu, L.1    Vremec, D.2    Ardavin, C.3    Winkel, K.4    Süss, G.5    Georgiou, H.6
  • 27
    • 0035761466 scopus 로고    scopus 로고
    • Development of thymic and splenic dendritic cell populations from different hemopoietic precursors
    • Wu L, D'Amico A, Hochrein H, O'Keeffe M, Shortman K, Lucas K. Development of thymic and splenic dendritic cell populations from different hemopoietic precursors. Blood 2001; 98: 3376-3382.
    • (2001) Blood , vol.98 , pp. 3376-3382
    • Wu, L.1    D'Amico, A.2    Hochrein, H.3    O'Keeffe, M.4    Shortman, K.5    Lucas, K.6
  • 28
    • 0035383775 scopus 로고    scopus 로고
    • Dendritic cell potentials of early lymphoid and myeloid progenitors
    • Manz MG, Traver D, Miyamoto T, Weissman IL, Akashi K. Dendritic cell potentials of early lymphoid and myeloid progenitors. Blood 2001; 97: 3333-3341.
    • (2001) Blood , vol.97 , pp. 3333-3341
    • Manz, M.G.1    Traver, D.2    Miyamoto, T.3    Weissman, I.L.4    Akashi, K.5
  • 29
    • 0035260758 scopus 로고    scopus 로고
    • Chemokines as regulators of T cell differentiation
    • Luther SA, Cyster JG. Chemokines as regulators of T cell differentiation. Nat Immunol 2001; 2: 102-107.
    • (2001) Nat Immunol , vol.2 , pp. 102-107
    • Luther, S.A.1    Cyster, J.G.2
  • 30
    • 12244297799 scopus 로고    scopus 로고
    • CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
    • Niess JH, Brand S, Gu X, Landsman L, Jung S, McCormick BA et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 2005; 307: 254-258.
    • (2005) Science , vol.307 , pp. 254-258
    • Niess, J.H.1    Brand, S.2    Gu, X.3    Landsman, L.4    Jung, S.5    McCormick, B.A.6
  • 32
    • 0036150006 scopus 로고    scopus 로고
    • Sequential involvement of CCR2 and CCR6 ligands for immature dendritic cell recruitment: Possible role at inflamed epithelial surfaces
    • Vanbervliet B, Homey B, Durand I, Massacrier C, Aït-Yahia S, de Bouteiller O et al. Sequential involvement of CCR2 and CCR6 ligands for immature dendritic cell recruitment: possible role at inflamed epithelial surfaces. Eur J Immunol 2002; 32: 231-242.
    • (2002) Eur J Immunol , vol.32 , pp. 231-242
    • Vanbervliet, B.1    Homey, B.2    Durand, I.3    Massacrier, C.4    Aït-Yahia, S.5    de Bouteiller, O.6
  • 33
    • 34548761490 scopus 로고    scopus 로고
    • The chemokine receptor CCR6 is an important component of the innate immune response
    • Wen H, Hogaboam CM, Lukacs NW, Cook DN, Lira SA, Kunkel SL. The chemokine receptor CCR6 is an important component of the innate immune response. Eur J Immunol 2007; 37: 2487-2498.
    • (2007) Eur J Immunol , vol.37 , pp. 2487-2498
    • Wen, H.1    Hogaboam, C.M.2    Lukacs, N.W.3    Cook, D.N.4    Lira, S.A.5    Kunkel, S.L.6
  • 35
    • 33750934617 scopus 로고    scopus 로고
    • Dendritic cells: Translating innate to adaptive immunity
    • Steinman RM, Hemmi H. Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol 2006; 311: 17-58.
    • (2006) Curr Top Microbiol Immunol , vol.311 , pp. 17-58
    • Steinman, R.M.1    Hemmi, H.2
  • 36
    • 2942541735 scopus 로고    scopus 로고
    • Crosspresentation, dendritic cell subsets, and the generation of immunity to cellular antigens
    • Heath WR, Belz GT, Behrens GM, Smith CM, Forehan SP, Parish IA et al. Crosspresentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunol Rev 2004; 199: 9-26.
    • (2004) Immunol Rev , vol.199 , pp. 9-26
    • Heath, W.R.1    Belz, G.T.2    Behrens, G.M.3    Smith, C.M.4    Forehan, S.P.5    Parish, I.A.6
  • 37
    • 0035854530 scopus 로고    scopus 로고
    • Sensing pathogens and tuning immune responses
    • Pulendran B, Palucka K, Banchereau J. Sensing pathogens and tuning immune responses. Science 2001; 293: 253-256.
    • (2001) Science , vol.293 , pp. 253-256
    • Pulendran, B.1    Palucka, K.2    Banchereau, J.3
  • 39
    • 22144441229 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells - virus experts of innate immunity
    • Barchet W, Cella M, Colonna M. Plasmacytoid dendritic cells - virus experts of innate immunity. Semin Immunol 2005; 17: 253-261.
    • (2005) Semin Immunol , vol.17 , pp. 253-261
    • Barchet, W.1    Cella, M.2    Colonna, M.3
  • 41
    • 0036889996 scopus 로고    scopus 로고
    • The two faces of IL-6 on Th1/Th2 differentiation
    • Diehl S, Rincon M. The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol 2002; 39: 531-536.
    • (2002) Mol Immunol , vol.39 , pp. 531-536
    • Diehl, S.1    Rincon, M.2
  • 42
    • 0142149043 scopus 로고    scopus 로고
    • Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus
    • Plotkin J, Prockop SE, Lepique A, Petrie HT. Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus. J Immunol 2003; 171: 4521-4527.
    • (2003) J Immunol , vol.171 , pp. 4521-4527
    • Plotkin, J.1    Prockop, S.E.2    Lepique, A.3    Petrie, H.T.4
  • 44
    • 2642511658 scopus 로고    scopus 로고
    • Molecular mechanisms governing thymocyte migration: Combined role of chemokines and extracellular matrix
    • Savino W, Mendes-Da-Cruz DA, Smaniotto S, Silva-Monteiro E, Villa-Verde DM. Molecular mechanisms governing thymocyte migration: combined role of chemokines and extracellular matrix. J Leukoc Biol 2004; 75: 951-961.
    • (2004) J Leukoc Biol , vol.75 , pp. 951-961
    • Savino, W.1    Mendes-Da-Cruz, D.A.2    Smaniotto, S.3    Silva-Monteiro, E.4    Villa-Verde, D.M.5
  • 45
    • 0033567963 scopus 로고    scopus 로고
    • Macrophage-derived chemokine is localized to thymic medullary epithelial cells and is a chemoattractant for CD3(+), CD4(+), CD8(low) thymocytes
    • Chantry D, Romagnani P, Raport CJ, Wood CL, Epp A, Romagnani S et al. Macrophage-derived chemokine is localized to thymic medullary epithelial cells and is a chemoattractant for CD3(+), CD4(+), CD8(low) thymocytes. Blood 1999; 94: 1890-1898.
    • (1999) Blood , vol.94 , pp. 1890-1898
    • Chantry, D.1    Romagnani, P.2    Raport, C.J.3    Wood, C.L.4    Epp, A.5    Romagnani, S.6
  • 46
    • 13444301304 scopus 로고    scopus 로고
    • Regulation of antigen presentation and cross-presentation in the dendritic cell network: Facts, hypothesis, and immunological implications
    • Wilson NS, Villadangos JA. Regulation of antigen presentation and cross-presentation in the dendritic cell network: facts, hypothesis, and immunological implications. Adv Immunol 2005; 86: 241-305.
    • (2005) Adv Immunol , vol.86 , pp. 241-305
    • Wilson, N.S.1    Villadangos, J.A.2
  • 47
    • 1642379407 scopus 로고    scopus 로고
    • Lymphoid organ dendritic cells: Beyond the Langerhans cells paradigm
    • Wilson NS, Villadangos JA. Lymphoid organ dendritic cells: beyond the Langerhans cells paradigm. Immunol Cell Biol 2004; 82: 91-98.
    • (2004) Immunol Cell Biol , vol.82 , pp. 91-98
    • Wilson, N.S.1    Villadangos, J.A.2
  • 48
    • 1542373657 scopus 로고    scopus 로고
    • Dendritic cells constitutively present self antigens in their immature state in vivo and regulate antigen presentation by controlling the rates of MHC class II synthesis and endocytosis
    • Wilson NS, El-Sukkari D, Villadangos JA. Dendritic cells constitutively present self antigens in their immature state in vivo and regulate antigen presentation by controlling the rates of MHC class II synthesis and endocytosis. Blood 2004; 103: 2187-2195.
    • (2004) Blood , vol.103 , pp. 2187-2195
    • Wilson, N.S.1    El-Sukkari, D.2    Villadangos, J.A.3
  • 49
    • 0030642188 scopus 로고    scopus 로고
    • Dendritic cells and T lymphocytes: Developmental and functional interactions
    • discussion 38-41
    • Shortman K, Wu L, Suss G, Kronin V, Winkel K, Saunders D et al. Dendritic cells and T lymphocytes: developmental and functional interactions. Ciba Found Symp 1997; 204: 130-138; discussion 38-41.
    • (1997) Ciba Found Symp , vol.204 , pp. 130-138
    • Shortman, K.1    Wu, L.2    Suss, G.3    Kronin, V.4    Winkel, K.5    Saunders, D.6
  • 51
    • 20144382346 scopus 로고    scopus 로고
    • Tumor antigen processing and presentation depend critically on dendritic cell type and the mode of antigen delivery
    • Schnurr M, Chen Q, Shin A, Chen W, Toy T, Jenderek C et al. Tumor antigen processing and presentation depend critically on dendritic cell type and the mode of antigen delivery. Blood 2005; 105: 2465-2472.
    • (2005) Blood , vol.105 , pp. 2465-2472
    • Schnurr, M.1    Chen, Q.2    Shin, A.3    Chen, W.4    Toy, T.5    Jenderek, C.6
  • 52
    • 0032903573 scopus 로고    scopus 로고
    • Distinct patterns and kinetics of chemokine production regulate dendritic cell function
    • Sallusto F, Palermo B, Lenig D, Miettinen M, Matikainen S, Julkunen I et al. Distinct patterns and kinetics of chemokine production regulate dendritic cell function. Eur J Immunol 1999; 29: 1617-1625.
    • (1999) Eur J Immunol , vol.29 , pp. 1617-1625
    • Sallusto, F.1    Palermo, B.2    Lenig, D.3    Miettinen, M.4    Matikainen, S.5    Julkunen, I.6
  • 55
    • 0036380917 scopus 로고    scopus 로고
    • The role of dendritic cell subsets in selection between tolerance and immunity
    • Belz GT, Heath WR, Carbone FR. The role of dendritic cell subsets in selection between tolerance and immunity. Immunol Cell Biol 2002; 80: 463-468.
    • (2002) Immunol Cell Biol , vol.80 , pp. 463-468
    • Belz, G.T.1    Heath, W.R.2    Carbone, F.R.3
  • 56
    • 0034678392 scopus 로고    scopus 로고
    • Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3alpha, MIP-3beta, and secondary lymphoid organ chemokine
    • Iwasaki A, Kelsall BL. Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3alpha, MIP-3beta, and secondary lymphoid organ chemokine. J Exp Med 2000; 191: 1381-1394.
    • (2000) J Exp Med , vol.191 , pp. 1381-1394
    • Iwasaki, A.1    Kelsall, B.L.2
  • 57
    • 0037378671 scopus 로고    scopus 로고
    • Two developmentally distinct populations of dendritic cells inhabit the adult mouse thymus: Demonstration by differential importation of hematogenous precursors under steady state conditions
    • Donskoy E, Goldschneider I. Two developmentally distinct populations of dendritic cells inhabit the adult mouse thymus: demonstration by differential importation of hematogenous precursors under steady state conditions. J Immunol 2003; 170: 3514.
    • (2003) J Immunol , vol.170 , pp. 3514
    • Donskoy, E.1    Goldschneider, I.2
  • 58
    • 0033490502 scopus 로고    scopus 로고
    • Interleukin-12: A cytokine at the interface of inflammation and immunity
    • Trinchieri G. Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv Immunol 1998; 70: 83-243.
    • (1998) Adv Immunol , vol.70 , pp. 83-243
    • Trinchieri, G.1
  • 59
    • 33644833492 scopus 로고    scopus 로고
    • Roles of chemokines in thymopoiesis: Redundancy and regulation
    • Fu W, Chen W. Roles of chemokines in thymopoiesis: redundancy and regulation. Cell Mol Immunol 2004; 1: 266-273.
    • (2004) Cell Mol Immunol , vol.1 , pp. 266-273
    • Fu, W.1    Chen, W.2
  • 60
    • 0025250455 scopus 로고
    • Tolerogenicity of thymic epithelium
    • Webb SR, Sprent J. Tolerogenicity of thymic epithelium. Eur J Immunol 1990; 20: 2525-2528.
    • (1990) Eur J Immunol , vol.20 , pp. 2525-2528
    • Webb, S.R.1    Sprent, J.2
  • 61
    • 0344850186 scopus 로고    scopus 로고
    • Cutting edge: Developmental switches in chemokine responses during T cell maturation
    • Campbell JJ, Pan J, Butcher EC. Cutting edge: developmental switches in chemokine responses during T cell maturation. J Immunol 1999; 163: 2353-2357.
    • (1999) J Immunol , vol.163 , pp. 2353-2357
    • Campbell, J.J.1    Pan, J.2    Butcher, E.C.3
  • 62
    • 1642289268 scopus 로고    scopus 로고
    • CCR7 directs the migration of thymocytes into the thymic medulla
    • Kwan J, Killeen N. CCR7 directs the migration of thymocytes into the thymic medulla. J Immunol 2004; 172: 3999-4007.
    • (2004) J Immunol , vol.172 , pp. 3999-4007
    • Kwan, J.1    Killeen, N.2
  • 63
    • 0031570952 scopus 로고    scopus 로고
    • Dendritic cell subtypes in mouse lymphoid organs: Cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes
    • Vremec D, Shortman K. Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes. J Immunol 1997; 159: 565-573.
    • (1997) J Immunol , vol.159 , pp. 565-573
    • Vremec, D.1    Shortman, K.2
  • 64
    • 0030816325 scopus 로고    scopus 로고
    • Macrophages sense pathogens via DNA motifs: Induction of tumor necrosis factor-alpha-mediated shock
    • Sparwasser T, Miethke T, Lipford G, Erdmann A, Häcker H, Heeg K et al. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock. Eur J Immunol 1997; 27: 1671-1679.
    • (1997) Eur J Immunol , vol.27 , pp. 1671-1679
    • Sparwasser, T.1    Miethke, T.2    Lipford, G.3    Erdmann, A.4    Häcker, H.5    Heeg, K.6


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