메뉴 건너뛰기




Volumn 1865, Issue 2, 2016, Pages 155-167

Cellular senescence and tumor promotion: Is aging the key?

Author keywords

Aging; Cancer; Cellular senescence; Premalignant; Pseudo senescence; SASP

Indexed keywords

CHEMOKINE; CYTOKINE; DNA; GROWTH FACTOR; HISTONE DEACETYLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE; PROTEIN P16; PROTEIN P21; PROTEIN P53; PROTEINASE; TRANSCRIPTION FACTOR; CHROMATIN; TRANSCRIPTOME;

EID: 84960892584     PISSN: 0304419X     EISSN: 18792561     Source Type: Journal    
DOI: 10.1016/j.bbcan.2016.01.007     Document Type: Review
Times cited : (89)

References (135)
  • 2
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • Kirkwood T.B.L. Understanding the odd science of aging. Cell 2005, 120:437-447. 10.1016/j.cell.2005.01.027.
    • (2005) Cell , vol.120 , pp. 437-447
    • Kirkwood, T.B.L.1
  • 3
    • 84859929074 scopus 로고    scopus 로고
    • Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity
    • Montesanto A., Dato S., Bellizzi D., Rose G., Passarino G. Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity. Immun. Ageing A. 2012, 9:6. 10.1186/1742-4933-9-6.
    • (2012) Immun. Ageing A. , vol.9 , pp. 6
    • Montesanto, A.1    Dato, S.2    Bellizzi, D.3    Rose, G.4    Passarino, G.5
  • 4
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 1961, 25:585-621. 10.1016/0014-4827(61)90192-6.
    • (1961) Exp. Cell Res. , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 5
    • 0035500487 scopus 로고    scopus 로고
    • Cellular senescence as a tumor-suppressor mechanism
    • Campisi J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 2001, 11:S27-S31.
    • (2001) Trends Cell Biol. , vol.11 , pp. S27-S31
    • Campisi, J.1
  • 6
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
    • Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005, 120:513-522. 10.1016/j.cell.2005.02.003.
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 7
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M., Lin A.W., McCurrach M.E., Beach D., Lowe S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997, 88:593-602. 10.1016/S0092-8674(00)81902-9.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 9
    • 84874405465 scopus 로고    scopus 로고
    • Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling
    • Rajagopalan S., Long E.O. Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:20596-20601. 10.1073/pnas.1208248109.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 20596-20601
    • Rajagopalan, S.1    Long, E.O.2
  • 10
    • 84889565689 scopus 로고    scopus 로고
    • Senescence is a developmental mechanism that contributes to embryonic growth and patterning
    • Storer M., Mas A., Robert-Moreno A., Pecoraro M., Ortells M.C., Di Giacomo V., et al. Senescence is a developmental mechanism that contributes to embryonic growth and patterning. Cell 2013, 155:1119-1130. 10.1016/j.cell.2013.10.041.
    • (2013) Cell , vol.155 , pp. 1119-1130
    • Storer, M.1    Mas, A.2    Robert-Moreno, A.3    Pecoraro, M.4    Ortells, M.C.5    Di Giacomo, V.6
  • 11
    • 84919480323 scopus 로고    scopus 로고
    • An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA
    • Demaria M., Ohtani N., Youssef S.A., Rodier F., Toussaint W., Mitchell J.R., et al. An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev. Cell 2014, 31:722-733. 10.1016/j.devcel.2014.11.012.
    • (2014) Dev. Cell , vol.31 , pp. 722-733
    • Demaria, M.1    Ohtani, N.2    Youssef, S.A.3    Rodier, F.4    Toussaint, W.5    Mitchell, J.R.6
  • 12
    • 77954243065 scopus 로고    scopus 로고
    • The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
    • Jun J.-I., Lau L.F. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat. Cell Biol. 2010, 12:676-685. 10.1038/ncb2070.
    • (2010) Nat. Cell Biol. , vol.12 , pp. 676-685
    • Jun, J.-I.1    Lau, L.F.2
  • 13
    • 84901288438 scopus 로고    scopus 로고
    • The role of senescent cells in ageing
    • van Deursen J.M. The role of senescent cells in ageing. Nature 2014, 509:439-446. 10.1038/nature13193.
    • (2014) Nature , vol.509 , pp. 439-446
    • van Deursen, J.M.1
  • 14
    • 33846090789 scopus 로고    scopus 로고
    • Accumulation of senescent cells in mitotic tissue of aging primates
    • Jeyapalan J.C., Ferreira M., Sedivy J.M., Herbig U. Accumulation of senescent cells in mitotic tissue of aging primates. Mech. Ageing Dev. 2007, 128:36-44. 10.1016/j.mad.2006.11.008.
    • (2007) Mech. Ageing Dev. , vol.128 , pp. 36-44
    • Jeyapalan, J.C.1    Ferreira, M.2    Sedivy, J.M.3    Herbig, U.4
  • 15
    • 0034682721 scopus 로고    scopus 로고
    • Cellular senescence: minireview mitotic clock or culture shock?
    • Sherr C.J., DePinho R.A. Cellular senescence: minireview mitotic clock or culture shock?. Cell 2000, 102:407-410. 10.1016/S0092-8674(00)00046-5.
    • (2000) Cell , vol.102 , pp. 407-410
    • Sherr, C.J.1    DePinho, R.A.2
  • 16
    • 84933050555 scopus 로고    scopus 로고
    • Forging a signature of in vivo senescence
    • Sharpless N.E., Sherr C.J. Forging a signature of in vivo senescence. Nat. Rev. Cancer 2015, 15:397-408. 10.1038/nrc3960.
    • (2015) Nat. Rev. Cancer , vol.15 , pp. 397-408
    • Sharpless, N.E.1    Sherr, C.J.2
  • 17
    • 0142231578 scopus 로고    scopus 로고
    • Bcl-2 activates a programme of premature senescence in human carcinoma cells
    • Crescenzi E., Palumbo G., Brady H.J.M. Bcl-2 activates a programme of premature senescence in human carcinoma cells. Biochem. J. 2003, 375:263-274. 10.1042/BJ20030868.
    • (2003) Biochem. J. , vol.375 , pp. 263-274
    • Crescenzi, E.1    Palumbo, G.2    Brady, H.J.M.3
  • 18
    • 8344230643 scopus 로고    scopus 로고
    • Senescent fibroblasts resist apoptosis by downregulating caspase-3
    • Marcotte R., Lacelle C., Wang E. Senescent fibroblasts resist apoptosis by downregulating caspase-3. Mech. Ageing Dev. 2004, 125:777-783. 10.1016/j.mad.2004.07.007.
    • (2004) Mech. Ageing Dev. , vol.125 , pp. 777-783
    • Marcotte, R.1    Lacelle, C.2    Wang, E.3
  • 19
    • 84873638532 scopus 로고    scopus 로고
    • Aging, cellular senescence, and cancer
    • Campisi J. Aging, cellular senescence, and cancer. Annu. Rev. Physiol. 2013, 75:685-705. 10.1146/annurev-physiol-030212-183653.
    • (2013) Annu. Rev. Physiol. , vol.75 , pp. 685-705
    • Campisi, J.1
  • 20
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: when bad things happen to good cells
    • Campisi J., di Fagagna F.d'Adda Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 2007, 8:729-740. 10.1038/nrm2233.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 729-740
    • Campisi, J.1    di Fagagna, F.D.2
  • 21
    • 77949881221 scopus 로고    scopus 로고
    • The senescence-associated secretory phenotype: the dark side of tumor suppression
    • Coppé J.-P., Desprez P.-Y., Krtolica A., Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol. Mech. Dis. 2010, 5:99-118. 10.1146/annurev-pathol-121808-102144.
    • (2010) Annu. Rev. Pathol. Mech. Dis. , vol.5 , pp. 99-118
    • Coppé, J.-P.1    Desprez, P.-Y.2    Krtolica, A.3    Campisi, J.4
  • 22
    • 84926523961 scopus 로고    scopus 로고
    • Senescence-associated inflammatory responses: aging and cancer perspectives
    • Lasry A., Ben-Neriah Y. Senescence-associated inflammatory responses: aging and cancer perspectives. Trends Immunol. 2015, 36:217-228. 10.1016/j.it.2015.02.009.
    • (2015) Trends Immunol. , vol.36 , pp. 217-228
    • Lasry, A.1    Ben-Neriah, Y.2
  • 23
    • 23244461708 scopus 로고    scopus 로고
    • Oncogene-induced senescence as an initial barrier in lymphoma development
    • Braig M., Lee S., Loddenkemper C., Rudolph C., Peters A.H.F.M., Schlegelberger B., et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 2005, 436:660-665. 10.1038/nature03841.
    • (2005) Nature , vol.436 , pp. 660-665
    • Braig, M.1    Lee, S.2    Loddenkemper, C.3    Rudolph, C.4    Peters, A.H.F.M.5    Schlegelberger, B.6
  • 24
    • 23244460597 scopus 로고    scopus 로고
    • Crucial role of p53-dependent cellular senescence in suppression of PTEN-deficient tumorigenesis
    • Chen Z., Trotman L.C., Shaffer D., Lin H.-K., Dotan Z.A., Niki M., et al. Crucial role of p53-dependent cellular senescence in suppression of PTEN-deficient tumorigenesis. Nature 2005, 436:725-730. 10.1038/nature03918.
    • (2005) Nature , vol.436 , pp. 725-730
    • Chen, Z.1    Trotman, L.C.2    Shaffer, D.3    Lin, H.-K.4    Dotan, Z.A.5    Niki, M.6
  • 26
    • 24744454582 scopus 로고    scopus 로고
    • Senescence comes of age
    • Narita M., Lowe S.W. Senescence comes of age. Nat. Med. 2005, 11:920-922. 10.1038/nm0905-920.
    • (2005) Nat. Med. , vol.11 , pp. 920-922
    • Narita, M.1    Lowe, S.W.2
  • 27
    • 44649120132 scopus 로고    scopus 로고
    • Chemokine signaling via the CXCR2 receptor reinforces senescence
    • Acosta J.C., O'Loghlen A., Banito A., Guijarro M.V., Augert A., Raguz S., et al. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 2008, 133:1006-1018. 10.1016/j.cell.2008.03.038.
    • (2008) Cell , vol.133 , pp. 1006-1018
    • Acosta, J.C.1    O'Loghlen, A.2    Banito, A.3    Guijarro, M.V.4    Augert, A.5    Raguz, S.6
  • 28
    • 51649098243 scopus 로고    scopus 로고
    • A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion
    • Coppe J.-P., Boysen M., Sun C.H., Wong B.J.F., Kang M.K., Park N.-H., et al. A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion. Mol. Cancer Res. 2008, 6:1085-1098. 10.1158/1541-7786.MCR-08-0062.
    • (2008) Mol. Cancer Res. , vol.6 , pp. 1085-1098
    • Coppe, J.-P.1    Boysen, M.2    Sun, C.H.3    Wong, B.J.F.4    Kang, M.K.5    Park, N.-H.6
  • 29
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    • Coppé J.-P., Patil C.K., Rodier F., Sun Y., Muñoz D.P., Goldstein J., et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008, 6. 10.1371/journal.pbio.0060301.
    • (2008) PLoS Biol. , vol.6
    • Coppé, J.-P.1    Patil, C.K.2    Rodier, F.3    Sun, Y.4    Muñoz, D.P.5    Goldstein, J.6
  • 30
    • 0035834121 scopus 로고    scopus 로고
    • Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging
    • Krtolica A., Parrinello S., Lockett S., Desprez P.Y., Campisi J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:12072-12077. 10.1073/pnas.211053698.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 12072-12077
    • Krtolica, A.1    Parrinello, S.2    Lockett, S.3    Desprez, P.Y.4    Campisi, J.5
  • 31
    • 84874603171 scopus 로고    scopus 로고
    • Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
    • Tchkonia T., Zhu Y., van Deursen J., Campisi J., Kirkland J.L. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J. Clin. Invest. 2013, 123:966-972. 10.1172/JCI64098.
    • (2013) J. Clin. Invest. , vol.123 , pp. 966-972
    • Tchkonia, T.1    Zhu, Y.2    van Deursen, J.3    Campisi, J.4    Kirkland, J.L.5
  • 33
    • 80855138775 scopus 로고    scopus 로고
    • Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
    • Baker D.J., Wijshake T., Tchkonia T., LeBrasseur N.K., Childs B.G., van de Sluis B., et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 2011, 479:232-236. 10.1038/nature10600.
    • (2011) Nature , vol.479 , pp. 232-236
    • Baker, D.J.1    Wijshake, T.2    Tchkonia, T.3    LeBrasseur, N.K.4    Childs, B.G.5    van de Sluis, B.6
  • 34
    • 84943199949 scopus 로고    scopus 로고
    • Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy
    • Golomb L., Sagiv A., Pateras I.S., Maly A., Krizhanovsky V., Gorgoulis V.G., et al. Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy. Cell Death Differ. 2015, 22:1764-1774. 10.1038/cdd.2015.21.
    • (2015) Cell Death Differ. , vol.22 , pp. 1764-1774
    • Golomb, L.1    Sagiv, A.2    Pateras, I.S.3    Maly, A.4    Krizhanovsky, V.5    Gorgoulis, V.G.6
  • 36
    • 84881526073 scopus 로고    scopus 로고
    • A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism
    • Pribluda A., Elyada E., Wiener Z., Hamza H., Goldstein R.E., Biton M., et al. A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell 2013, 24:242-256. 10.1016/j.ccr.2013.06.005.
    • (2013) Cancer Cell , vol.24 , pp. 242-256
    • Pribluda, A.1    Elyada, E.2    Wiener, Z.3    Hamza, H.4    Goldstein, R.E.5    Biton, M.6
  • 37
    • 81855169964 scopus 로고    scopus 로고
    • Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
    • Kang T.-W., Yevsa T., Woller N., Hoenicke L., Wuestefeld T., Dauch D., et al. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 2011, 479:547-551. 10.1038/nature10599.
    • (2011) Nature , vol.479 , pp. 547-551
    • Kang, T.-W.1    Yevsa, T.2    Woller, N.3    Hoenicke, L.4    Wuestefeld, T.5    Dauch, D.6
  • 38
    • 19844382620 scopus 로고    scopus 로고
    • Senescence and immortalization: role of telomeres and telomerase
    • Shay J.W., Wright W.E. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis 2005, 26:867-874. 10.1093/carcin/bgh296.
    • (2005) Carcinogenesis , vol.26 , pp. 867-874
    • Shay, J.W.1    Wright, W.E.2
  • 39
    • 84859372986 scopus 로고    scopus 로고
    • Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
    • Fumagalli M., Rossiello F., Clerici M., Barozzi S., Cittaro D., Kaplunov J.M., et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat. Cell Biol. 2012, 14:355-365. 10.1038/ncb2466.
    • (2012) Nat. Cell Biol. , vol.14 , pp. 355-365
    • Fumagalli, M.1    Rossiello, F.2    Clerici, M.3    Barozzi, S.4    Cittaro, D.5    Kaplunov, J.M.6
  • 40
    • 2442511752 scopus 로고    scopus 로고
    • Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
    • Herbig U., Jobling W.A., Chen B.P.C., Chen D.J., Sedivy J.M. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 2004, 14:501-513.
    • (2004) Mol. Cell , vol.14 , pp. 501-513
    • Herbig, U.1    Jobling, W.A.2    Chen, B.P.C.3    Chen, D.J.4    Sedivy, J.M.5
  • 42
  • 43
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist C.J., Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003, 421:499-506. 10.1038/nature01368.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 44
    • 77950532788 scopus 로고    scopus 로고
    • Activation of ATM-dependent DNA damage signal pathway by a histone deacetylase inhibitor, trichostatin A
    • Lee J.-S. Activation of ATM-dependent DNA damage signal pathway by a histone deacetylase inhibitor, trichostatin A. Cancer Res. Treat. Off. J. Korean Cancer Assoc. 2007, 39:125-130. 10.4143/crt.2007.39.3.125.
    • (2007) Cancer Res. Treat. Off. J. Korean Cancer Assoc. , vol.39 , pp. 125-130
    • Lee, J.-S.1
  • 46
    • 21344440000 scopus 로고    scopus 로고
    • Reactive oxygen species as mediators of cellular senescence
    • Colavitti R., Finkel T. Reactive oxygen species as mediators of cellular senescence. IUBMB Life 2005, 57:277-281. 10.1080/15216540500091890.
    • (2005) IUBMB Life , vol.57 , pp. 277-281
    • Colavitti, R.1    Finkel, T.2
  • 47
    • 0030980641 scopus 로고    scopus 로고
    • Mitogenic signaling mediated by oxidants in ras-transformed fibroblasts
    • Irani K., Xia Y., Zweier J.L., Sollott S.J., Der C.J., Fearon E.R., et al. Mitogenic signaling mediated by oxidants in ras-transformed fibroblasts. Science 1997, 275:1649-1652.
    • (1997) Science , vol.275 , pp. 1649-1652
    • Irani, K.1    Xia, Y.2    Zweier, J.L.3    Sollott, S.J.4    Der, C.J.5    Fearon, E.R.6
  • 48
    • 0033583242 scopus 로고    scopus 로고
    • Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
    • Lee A.C., Fenster B.E., Ito H., Takeda K., Bae N.S., Hirai T., et al. Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J. Biol. Chem. 1999, 274:7936-7940.
    • (1999) J. Biol. Chem. , vol.274 , pp. 7936-7940
    • Lee, A.C.1    Fenster, B.E.2    Ito, H.3    Takeda, K.4    Bae, N.S.5    Hirai, T.6
  • 49
    • 84899929645 scopus 로고    scopus 로고
    • Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation
    • Ogrunc M., Di Micco R., Liontos M., Bombardelli L., Mione M., Fumagalli M., et al. Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation. Cell Death Differ. 2014, 21:998-1012. 10.1038/cdd.2014.16.
    • (2014) Cell Death Differ. , vol.21 , pp. 998-1012
    • Ogrunc, M.1    Di Micco, R.2    Liontos, M.3    Bombardelli, L.4    Mione, M.5    Fumagalli, M.6
  • 50
    • 33845235459 scopus 로고    scopus 로고
    • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    • Bartkova J., Rezaei N., Liontos M., Karakaidos P., Kletsas D., Issaeva N., et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006, 444:633-637. 10.1038/nature05268.
    • (2006) Nature , vol.444 , pp. 633-637
    • Bartkova, J.1    Rezaei, N.2    Liontos, M.3    Karakaidos, P.4    Kletsas, D.5    Issaeva, N.6
  • 51
    • 33845269825 scopus 로고    scopus 로고
    • Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
    • Di Micco R., Fumagalli M., Cicalese A., Piccinin S., Gasparini P., Luise C., et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 2006, 444:638-642. 10.1038/nature05327.
    • (2006) Nature , vol.444 , pp. 638-642
    • Di Micco, R.1    Fumagalli, M.2    Cicalese, A.3    Piccinin, S.4    Gasparini, P.5    Luise, C.6
  • 52
    • 42949129074 scopus 로고    scopus 로고
    • Many roads lead to oncogene-induced senescence
    • Courtois-Cox S., Jones S.L., Cichowski K. Many roads lead to oncogene-induced senescence. Oncogene 2008, 27:2801-2809. 10.1038/sj.onc.1210950.
    • (2008) Oncogene , vol.27 , pp. 2801-2809
    • Courtois-Cox, S.1    Jones, S.L.2    Cichowski, K.3
  • 53
    • 33745363911 scopus 로고    scopus 로고
    • DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation
    • Moiseeva O., Mallette F.A., Mukhopadhyay U.K., Moores A., Ferbeyre G. DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation. Mol. Biol. Cell 2006, 17:1583-1592. 10.1091/mbc.E05-09-0858.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 1583-1592
    • Moiseeva, O.1    Mallette, F.A.2    Mukhopadhyay, U.K.3    Moores, A.4    Ferbeyre, G.5
  • 54
    • 1842861744 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock
    • Munro J., Barr N.I., Ireland H., Morrison V., Parkinson E.K. Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock. Exp. Cell Res. 2004, 295:525-538. 10.1016/j.yexcr.2004.01.017.
    • (2004) Exp. Cell Res. , vol.295 , pp. 525-538
    • Munro, J.1    Barr, N.I.2    Ireland, H.3    Morrison, V.4    Parkinson, E.K.5
  • 55
    • 84860503063 scopus 로고    scopus 로고
    • Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression
    • Pazolli E., Alspach E., Milczarek A., Prior J., Piwnica-Worms D., Stewart S.A. Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression. Cancer Res. 2012, 72:2251-2261. 10.1158/0008-5472.CAN-11-3386.
    • (2012) Cancer Res. , vol.72 , pp. 2251-2261
    • Pazolli, E.1    Alspach, E.2    Milczarek, A.3    Prior, J.4    Piwnica-Worms, D.5    Stewart, S.A.6
  • 56
    • 0032190629 scopus 로고    scopus 로고
    • Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    • Lin A.W., Barradas M., Stone J.C., van Aelst L., Serrano M., Lowe S.W. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 1998, 12:3008-3019.
    • (1998) Genes Dev. , vol.12 , pp. 3008-3019
    • Lin, A.W.1    Barradas, M.2    Stone, J.C.3    van Aelst, L.4    Serrano, M.5    Lowe, S.W.6
  • 57
    • 0032192153 scopus 로고    scopus 로고
    • Senescence of human fibroblasts induced by oncogenic raf
    • Zhu J., Woods D., McMahon M., Bishop J.M. Senescence of human fibroblasts induced by oncogenic raf. Genes Dev. 1998, 12:2997-3007. 10.1101/gad.12.19.2997.
    • (1998) Genes Dev. , vol.12 , pp. 2997-3007
    • Zhu, J.1    Woods, D.2    McMahon, M.3    Bishop, J.M.4
  • 58
    • 78549268199 scopus 로고    scopus 로고
    • Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo
    • Takeuchi S., Takahashi A., Motoi N., Yoshimoto S., Tajima T., Yamakoshi K., et al. Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo. Cancer Res. 2010, 70:9381-9390. 10.1158/0008-5472.CAN-10-0801.
    • (2010) Cancer Res. , vol.70 , pp. 9381-9390
    • Takeuchi, S.1    Takahashi, A.2    Motoi, N.3    Yoshimoto, S.4    Tajima, T.5    Yamakoshi, K.6
  • 59
    • 79955017452 scopus 로고    scopus 로고
    • P38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
    • Freund A., Patil C.K., Campisi J. p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J. 2011, 30:1536-1548. 10.1038/emboj.2011.69.
    • (2011) EMBO J. , vol.30 , pp. 1536-1548
    • Freund, A.1    Patil, C.K.2    Campisi, J.3
  • 60
    • 77149164811 scopus 로고    scopus 로고
    • Feedback between p21 and reactive oxygen production is necessary for cell senescence
    • Passos J.F., Nelson G., Wang C., Richter T., Simillion C., Proctor C.J., et al. Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol. Syst. Biol. 2010, 6:347. 10.1038/msb.2010.5.
    • (2010) Mol. Syst. Biol. , vol.6 , pp. 347
    • Passos, J.F.1    Nelson, G.2    Wang, C.3    Richter, T.4    Simillion, C.5    Proctor, C.J.6
  • 61
    • 70349773104 scopus 로고    scopus 로고
    • Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence
    • Adams P.D. Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol. Cell 2009, 36:2-14. 10.1016/j.molcel.2009.09.021.
    • (2009) Mol. Cell , vol.36 , pp. 2-14
    • Adams, P.D.1
  • 62
    • 33947134834 scopus 로고    scopus 로고
    • The polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
    • Bracken A.P., Kleine-Kohlbrecher D., Dietrich N., Pasini D., Gargiulo G., Beekman C., et al. The polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev. 2007, 21:525-530. 10.1101/gad.415507.
    • (2007) Genes Dev. , vol.21 , pp. 525-530
    • Bracken, A.P.1    Kleine-Kohlbrecher, D.2    Dietrich, N.3    Pasini, D.4    Gargiulo, G.5    Beekman, C.6
  • 63
    • 1842483852 scopus 로고    scopus 로고
    • Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(arf) pathway
    • Bulavin D.V., Phillips C., Nannenga B., Timofeev O., Donehower L.A., Anderson C.W., et al. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(arf) pathway. Nat. Genet. 2004, 36:343-350. 10.1038/ng1317.
    • (2004) Nat. Genet. , vol.36 , pp. 343-350
    • Bulavin, D.V.1    Phillips, C.2    Nannenga, B.3    Timofeev, O.4    Donehower, L.A.5    Anderson, C.W.6
  • 64
    • 0346463059 scopus 로고    scopus 로고
    • High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts
    • Deng Q., Liao R., Wu B.-L., Sun P. High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts. J. Biol. Chem. 2004, 279:1050-1059. 10.1074/jbc.M308644200.
    • (2004) J. Biol. Chem. , vol.279 , pp. 1050-1059
    • Deng, Q.1    Liao, R.2    Wu, B.-L.3    Sun, P.4
  • 65
    • 33645730667 scopus 로고    scopus 로고
    • Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
    • Ito K., Hirao A., Arai F., Takubo K., Matsuoka S., Miyamoto K., et al. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat. Med. 2006, 12:446-451. 10.1038/nm1388.
    • (2006) Nat. Med. , vol.12 , pp. 446-451
    • Ito, K.1    Hirao, A.2    Arai, F.3    Takubo, K.4    Matsuoka, S.5    Miyamoto, K.6
  • 66
    • 0037068753 scopus 로고    scopus 로고
    • Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion
    • Olsen C.L., Gardie B., Yaswen P., Stampfer M.R. Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion. Oncogene 2002, 21:6328-6339. 10.1038/sj.onc.1205780.
    • (2002) Oncogene , vol.21 , pp. 6328-6339
    • Olsen, C.L.1    Gardie, B.2    Yaswen, P.3    Stampfer, M.R.4
  • 67
    • 33646946746 scopus 로고    scopus 로고
    • Senescence-associated beta-galactosidase is lysosomal beta-galactosidase
    • Lee B.Y., Han J.A., Im J.S., Morrone A., Johung K., Goodwin E.C., et al. Senescence-associated beta-galactosidase is lysosomal beta-galactosidase. Aging Cell 2006, 5:187-195. 10.1111/j.1474-9726.2006.00199.x.
    • (2006) Aging Cell , vol.5 , pp. 187-195
    • Lee, B.Y.1    Han, J.A.2    Im, J.S.3    Morrone, A.4    Johung, K.5    Goodwin, E.C.6
  • 68
    • 40749122641 scopus 로고    scopus 로고
    • Transcriptional repression mediated by repositioning of genes to the nuclear lamina
    • Reddy K.L., Zullo J.M., Bertolino E., Singh H. Transcriptional repression mediated by repositioning of genes to the nuclear lamina. Nature 2008, 452:243-247. 10.1038/nature06727.
    • (2008) Nature , vol.452 , pp. 243-247
    • Reddy, K.L.1    Zullo, J.M.2    Bertolino, E.3    Singh, H.4
  • 69
    • 84861673276 scopus 로고    scopus 로고
    • Lamin B1 loss is a senescence-associated biomarker
    • Freund A., Laberge R.-M., Demaria M., Campisi J. Lamin B1 loss is a senescence-associated biomarker. Mol. Biol. Cell 2012, 23:2066-2075. 10.1091/mbc.E11-10-0884.
    • (2012) Mol. Biol. Cell , vol.23 , pp. 2066-2075
    • Freund, A.1    Laberge, R.-M.2    Demaria, M.3    Campisi, J.4
  • 70
    • 34249725997 scopus 로고    scopus 로고
    • Alterations to nuclear architecture and genome behavior in senescent cells
    • Mehta I.S., Figgitt M., Clements C.S., Kill I.R., Bridger J.M. Alterations to nuclear architecture and genome behavior in senescent cells. Ann. N. Y. Acad. Sci. 2007, 1100:250-263. 10.1196/annals.1395.027.
    • (2007) Ann. N. Y. Acad. Sci. , vol.1100 , pp. 250-263
    • Mehta, I.S.1    Figgitt, M.2    Clements, C.S.3    Kill, I.R.4    Bridger, J.M.5
  • 71
    • 33947236204 scopus 로고    scopus 로고
    • Molecular dissection of formation of senescence-associated heterochromatin foci
    • Zhang R., Chen W., Adams P.D. Molecular dissection of formation of senescence-associated heterochromatin foci. Mol. Cell. Biol. 2007, 27:2343-2358. 10.1128/MCB.02019-06.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 2343-2358
    • Zhang, R.1    Chen, W.2    Adams, P.D.3
  • 72
    • 84878619211 scopus 로고    scopus 로고
    • P53-dependent release of alarmin HMGB1 is a central mediator of senescent phenotypes
    • Davalos A.R., Kawahara M., Malhotra G.K., Schaum N., Huang J., Ved U., et al. p53-dependent release of alarmin HMGB1 is a central mediator of senescent phenotypes. J. Cell Biol. 2013, 201:613-629. 10.1083/jcb.201206006.
    • (2013) J. Cell Biol. , vol.201 , pp. 613-629
    • Davalos, A.R.1    Kawahara, M.2    Malhotra, G.K.3    Schaum, N.4    Huang, J.5    Ved, U.6
  • 74
    • 0037667702 scopus 로고    scopus 로고
    • Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    • Narita M., Nuñez S., Heard E., Narita M., Lin A.W., Hearn S.A., et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 2003, 113:703-716. 10.1016/S0092-8674(03)00401-X.
    • (2003) Cell , vol.113 , pp. 703-716
    • Narita, M.1    Nuñez, S.2    Heard, E.3    Narita, M.4    Lin, A.W.5    Hearn, S.A.6
  • 75
    • 79851493300 scopus 로고    scopus 로고
    • Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a)
    • Kosar M., Bartkova J., Hubackova S., Hodny Z., Lukas J., Bartek J. Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). Cell Cycle Georget. Tex. 2011, 10:457-468.
    • (2011) Cell Cycle Georget. Tex. , vol.10 , pp. 457-468
    • Kosar, M.1    Bartkova, J.2    Hubackova, S.3    Hodny, Z.4    Lukas, J.5    Bartek, J.6
  • 76
    • 84882682843 scopus 로고    scopus 로고
    • Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
    • Shah P.P., Donahue G., Otte G.L., Capell B.C., Nelson D.M., Cao K., et al. Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape. Genes Dev. 2013, 27:1787-1799. 10.1101/gad.223834.113.
    • (2013) Genes Dev. , vol.27 , pp. 1787-1799
    • Shah, P.P.1    Donahue, G.2    Otte, G.L.3    Capell, B.C.4    Nelson, D.M.5    Cao, K.6
  • 77
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano M., Hannon G.J., Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993, 366:704-707. 10.1038/366704a0.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 78
    • 7044231343 scopus 로고    scopus 로고
    • The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression
    • Ohtani N., Yamakoshi K., Takahashi A., Hara E. The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression. J. Med. Investig. 2004, 51:146-153.
    • (2004) J. Med. Investig. , vol.51 , pp. 146-153
    • Ohtani, N.1    Yamakoshi, K.2    Takahashi, A.3    Hara, E.4
  • 79
    • 84931031396 scopus 로고    scopus 로고
    • Cell autonomous and non-autonomous effects of senescent cells in the skin
    • Demaria M., Desprez P.Y., Campisi J., Velarde M.C. Cell autonomous and non-autonomous effects of senescent cells in the skin. J. Invest. Dermatol. 2015, 135:1722-1726. 10.1038/jid.2015.108.
    • (2015) J. Invest. Dermatol. , vol.135 , pp. 1722-1726
    • Demaria, M.1    Desprez, P.Y.2    Campisi, J.3    Velarde, M.C.4
  • 80
    • 58849154235 scopus 로고    scopus 로고
    • Senescence-messaging secretome: SMS-ing cellular stress
    • Kuilman T., Peeper D.S. Senescence-messaging secretome: SMS-ing cellular stress. Nat. Rev. Cancer 2009, 9:81-94. 10.1038/nrc2560.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 81-94
    • Kuilman, T.1    Peeper, D.S.2
  • 81
    • 80054682555 scopus 로고    scopus 로고
    • Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype
    • Coppé J.-P., Rodier F., Patil C.K., Freund A., Desprez P.-Y., Campisi J. Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. J. Biol. Chem. 2011, 286:36396-36403. 10.1074/jbc.M111.257071.
    • (2011) J. Biol. Chem. , vol.286 , pp. 36396-36403
    • Coppé, J.-P.1    Rodier, F.2    Patil, C.K.3    Freund, A.4    Desprez, P.-Y.5    Campisi, J.6
  • 82
    • 77949458344 scopus 로고    scopus 로고
    • A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen
    • Coppé J.-P., Patil C.K., Rodier F., Krtolica A., Beauséjour C.M., Parrinello S., et al. A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS ONE 2010, 5. 10.1371/journal.pone.0009188.
    • (2010) PLoS ONE , vol.5
    • Coppé, J.-P.1    Patil, C.K.2    Rodier, F.3    Krtolica, A.4    Beauséjour, C.M.5    Parrinello, S.6
  • 83
    • 68249096784 scopus 로고    scopus 로고
    • Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
    • Rodier F., Coppé J.-P., Patil C.K., Hoeijmakers W.A.M., Muñoz D.P., Raza S.R., et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat. Cell Biol. 2009, 11:973-979. 10.1038/ncb1909.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 973-979
    • Rodier, F.1    Coppé, J.-P.2    Patil, C.K.3    Hoeijmakers, W.A.M.4    Muñoz, D.P.5    Raza, S.R.6
  • 84
    • 84942456107 scopus 로고    scopus 로고
    • The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
    • aaa5612
    • Kang C., Xu Q., Martin T.D., Li M.Z., Demaria M., Aron L., et al. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science 2015, 349:aaa5612. 10.1126/science.aaa5612.
    • (2015) Science , vol.349
    • Kang, C.1    Xu, Q.2    Martin, T.D.3    Li, M.Z.4    Demaria, M.5    Aron, L.6
  • 85
    • 44649101304 scopus 로고    scopus 로고
    • Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
    • Kuilman T., Michaloglou C., Vredeveld L.C.W., Douma S., van Doorn R., Desmet C.J., et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 2008, 133:1019-1031. 10.1016/j.cell.2008.03.039.
    • (2008) Cell , vol.133 , pp. 1019-1031
    • Kuilman, T.1    Michaloglou, C.2    Vredeveld, L.C.W.3    Douma, S.4    van Doorn, R.5    Desmet, C.J.6
  • 86
    • 38849168162 scopus 로고    scopus 로고
    • Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7
    • Wajapeyee N., Serra R.W., Zhu X., Mahalingam M., Green M.R. Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 2008, 132:363-374. 10.1016/j.cell.2007.12.032.
    • (2008) Cell , vol.132 , pp. 363-374
    • Wajapeyee, N.1    Serra, R.W.2    Zhu, X.3    Mahalingam, M.4    Green, M.R.5
  • 87
    • 33750798741 scopus 로고    scopus 로고
    • The chemokine growth-regulated oncogene 1 (gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis
    • Yang G., Rosen D.G., Zhang Z., Bast R.C., Mills G.B., Colacino J.A., et al. The chemokine growth-regulated oncogene 1 (gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:16472-16477. 10.1073/pnas.0605752103.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 16472-16477
    • Yang, G.1    Rosen, D.G.2    Zhang, Z.3    Bast, R.C.4    Mills, G.B.5    Colacino, J.A.6
  • 88
    • 73649118223 scopus 로고    scopus 로고
    • WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway
    • Binet R., Ythier D., Robles A.I., Collado M., Larrieu D., Fonti C., et al. WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway. Cancer Res. 2009, 69:9183-9191. 10.1158/0008-5472.CAN-09-1016.
    • (2009) Cancer Res. , vol.69 , pp. 9183-9191
    • Binet, R.1    Ythier, D.2    Robles, A.I.3    Collado, M.4    Larrieu, D.5    Fonti, C.6
  • 89
    • 84878357576 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells
    • Cahu J., Bustany S., Sola B. Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells. Cell Death Dis. 2012, 3. 10.1038/cddis.2012.183.
    • (2012) Cell Death Dis. , vol.3
    • Cahu, J.1    Bustany, S.2    Sola, B.3
  • 90
    • 84881399206 scopus 로고    scopus 로고
    • A complex secretory program orchestrated by the inflammasome controls paracrine senescence
    • Acosta J.C., Banito A., Wuestefeld T., Georgilis A., Janich P., Morton J.P., et al. A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat. Cell Biol. 2013, 15:978-990. 10.1038/ncb2784.
    • (2013) Nat. Cell Biol. , vol.15 , pp. 978-990
    • Acosta, J.C.1    Banito, A.2    Wuestefeld, T.3    Georgilis, A.4    Janich, P.5    Morton, J.P.6
  • 91
    • 64649084383 scopus 로고    scopus 로고
    • Radiation-induced bystander signalling in cancer therapy
    • Prise K.M., O'Sullivan J.M. Radiation-induced bystander signalling in cancer therapy. Nat. Rev. Cancer 2009, 9:351-360. 10.1038/nrc2603.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 351-360
    • Prise, K.M.1    O'Sullivan, J.M.2
  • 92
    • 84872569990 scopus 로고    scopus 로고
    • Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model
    • Burd C.E., Sorrentino J.A., Clark K.S., Darr D.B., Krishnamurthy J., Deal A.M., et al. Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model. Cell 2013, 152:340-351. 10.1016/j.cell.2012.12.010.
    • (2013) Cell , vol.152 , pp. 340-351
    • Burd, C.E.1    Sorrentino, J.A.2    Clark, K.S.3    Darr, D.B.4    Krishnamurthy, J.5    Deal, A.M.6
  • 93
    • 34447506658 scopus 로고    scopus 로고
    • Oncogenic ras-induced secretion of IL6 is required for tumorigenesis
    • Ancrile B., Lim K.-H., Counter C.M. Oncogenic ras-induced secretion of IL6 is required for tumorigenesis. Genes Dev. 2007, 21:1714-1719. 10.1101/gad.1549407.
    • (2007) Genes Dev. , vol.21 , pp. 1714-1719
    • Ancrile, B.1    Lim, K.-H.2    Counter, C.M.3
  • 94
    • 40649109728 scopus 로고    scopus 로고
    • The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer
    • Naugler W.E., Karin M. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol. Med. 2008, 14:109-119. 10.1016/j.molmed.2007.12.007.
    • (2008) Trends Mol. Med. , vol.14 , pp. 109-119
    • Naugler, W.E.1    Karin, M.2
  • 95
    • 7944223098 scopus 로고    scopus 로고
    • Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
    • Sparmann A., Bar-Sagi D. Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell 2004, 6:447-458. 10.1016/j.ccr.2004.09.028.
    • (2004) Cancer Cell , vol.6 , pp. 447-458
    • Sparmann, A.1    Bar-Sagi, D.2
  • 96
    • 33847401888 scopus 로고    scopus 로고
    • Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion
    • Blank C., Mackensen A. Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion. Cancer Immunol. Immunother. 2007, 56:739-745. 10.1007/s00262-006-0272-1.
    • (2007) Cancer Immunol. Immunother. , vol.56 , pp. 739-745
    • Blank, C.1    Mackensen, A.2
  • 97
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • Medzhitov R. Origin and physiological roles of inflammation. Nature 2008, 454:428-435. 10.1038/nature07201.
    • (2008) Nature , vol.454 , pp. 428-435
    • Medzhitov, R.1
  • 98
    • 77954563804 scopus 로고    scopus 로고
    • Senescent cells as a source of inflammatory factors for tumor progression
    • Davalos A.R., Coppe J.-P., Campisi J., Desprez P.-Y. Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev. 2010, 29:273-283. 10.1007/s10555-010-9220-9.
    • (2010) Cancer Metastasis Rev. , vol.29 , pp. 273-283
    • Davalos, A.R.1    Coppe, J.-P.2    Campisi, J.3    Desprez, P.-Y.4
  • 99
    • 84924908626 scopus 로고    scopus 로고
    • Melanoma expression of matrix metalloproteinase-23 is associated with blunted tumor immunity and poor responses to immunotherapy
    • Moogk D., da Silva I.P., Ma M.W., Friedman E.B., de Miera E.V.-S., Darvishian F., et al. Melanoma expression of matrix metalloproteinase-23 is associated with blunted tumor immunity and poor responses to immunotherapy. J. Transl. Med. 2014, 12. 10.1186/s12967-014-0342-7.
    • (2014) J. Transl. Med. , vol.12
    • Moogk, D.1    da Silva, I.P.2    Ma, M.W.3    Friedman, E.B.4    de Miera, E.V.-S.5    Darvishian, F.6
  • 101
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll D.M. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 2012, 12:252-264. 10.1038/nrc3239.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 102
    • 37249009271 scopus 로고    scopus 로고
    • Motif module map reveals enforcement of aging by continual NF-kappaB activity
    • Adler A.S., Sinha S., Kawahara T.L.A., Zhang J.Y., Segal E., Chang H.Y. Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev. 2007, 21:3244-3257. 10.1101/gad.1588507.
    • (2007) Genes Dev. , vol.21 , pp. 3244-3257
    • Adler, A.S.1    Sinha, S.2    Kawahara, T.L.A.3    Zhang, J.Y.4    Segal, E.5    Chang, H.Y.6
  • 103
    • 84856090875 scopus 로고    scopus 로고
    • Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock
    • Rando T.A., Chang H.Y. Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell 2012, 148:46-57. 10.1016/j.cell.2012.01.003.
    • (2012) Cell , vol.148 , pp. 46-57
    • Rando, T.A.1    Chang, H.Y.2
  • 105
    • 80054789761 scopus 로고    scopus 로고
    • Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity
    • Chien Y., Scuoppo C., Wang X., Fang X., Balgley B., Bolden J.E., et al. Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. Genes Dev. 2011, 25:2125-2136. 10.1101/gad.17276711.
    • (2011) Genes Dev. , vol.25 , pp. 2125-2136
    • Chien, Y.1    Scuoppo, C.2    Wang, X.3    Fang, X.4    Balgley, B.5    Bolden, J.E.6
  • 106
    • 84938751873 scopus 로고    scopus 로고
    • MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
    • Laberge R.-M., Sun Y., Orjalo A.V., Patil C.K., Freund A., Zhou L., et al. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat. Cell Biol. 2015, 17:1049-1061. 10.1038/ncb3195.
    • (2015) Nat. Cell Biol. , vol.17 , pp. 1049-1061
    • Laberge, R.-M.1    Sun, Y.2    Orjalo, A.V.3    Patil, C.K.4    Freund, A.5    Zhou, L.6
  • 107
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: from growth signal integration to cancer, diabetes and ageing
    • Zoncu R., Sabatini D.M., Efeyan A. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 2011, 12:21-35. 10.1038/nrm3025.
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 21-35
    • Zoncu, R.1    Sabatini, D.M.2    Efeyan, A.3
  • 108
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • Xue W., Zender L., Miething C., Dickins R.A., Hernando E., Krizhanovsky V., et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007, 445:656-660. 10.1038/nature05529.
    • (2007) Nature , vol.445 , pp. 656-660
    • Xue, W.1    Zender, L.2    Miething, C.3    Dickins, R.A.4    Hernando, E.5    Krizhanovsky, V.6
  • 109
    • 49749145668 scopus 로고    scopus 로고
    • Senescence of activated stellate cells limits liver fibrosis
    • Krizhanovsky V., Yon M., Dickins R.A., Hearn S., Simon J., Miething C., et al. Senescence of activated stellate cells limits liver fibrosis. Cell 2008, 134:657-667. 10.1016/j.cell.2008.06.049.
    • (2008) Cell , vol.134 , pp. 657-667
    • Krizhanovsky, V.1    Yon, M.2    Dickins, R.A.3    Hearn, S.4    Simon, J.5    Miething, C.6
  • 110
    • 84905741423 scopus 로고    scopus 로고
    • Stem cell aging: mechanisms, regulators and therapeutic opportunities
    • Oh J., Lee Y.D., Wagers A.J. Stem cell aging: mechanisms, regulators and therapeutic opportunities. Nat. Med. 2014, 20:870-880. 10.1038/nm.3651.
    • (2014) Nat. Med. , vol.20 , pp. 870-880
    • Oh, J.1    Lee, Y.D.2    Wagers, A.J.3
  • 111
    • 0022891340 scopus 로고
    • Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak H.F. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 1986, 315:1650-1659. 10.1056/NEJM198612253152606.
    • (1986) N. Engl. J. Med. , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 112
    • 33746907388 scopus 로고    scopus 로고
    • Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma
    • Riss J., Khanna C., Koo S., Chandramouli G.V.R., Yang H.H., Hu Y., et al. Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma. Cancer Res. 2006, 66:7216-7224. 10.1158/0008-5472.CAN-06-0040.
    • (2006) Cancer Res. , vol.66 , pp. 7216-7224
    • Riss, J.1    Khanna, C.2    Koo, S.3    Chandramouli, G.V.R.4    Yang, H.H.5    Hu, Y.6
  • 113
    • 84864306922 scopus 로고    scopus 로고
    • Immune surveillance of senescent cells-biological significance in cancer- and non-cancer pathologies
    • bgs124
    • Hoenicke L., Zender L. Immune surveillance of senescent cells-biological significance in cancer- and non-cancer pathologies. Carcinogenesis 2012, bgs124. 10.1093/carcin/bgs124.
    • (2012) Carcinogenesis
    • Hoenicke, L.1    Zender, L.2
  • 116
    • 84863974838 scopus 로고    scopus 로고
    • Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
    • Mao Z., Tian X., Van Meter M., Ke Z., Gorbunova V., Seluanov A. Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:11800-11805. 10.1073/pnas.1200583109.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 11800-11805
    • Mao, Z.1    Tian, X.2    Van Meter, M.3    Ke, Z.4    Gorbunova, V.5    Seluanov, A.6
  • 117
    • 84964063204 scopus 로고    scopus 로고
    • DNA double strand break repair via non-homologous end-joining
    • Davis A.J., Chen D.J. DNA double strand break repair via non-homologous end-joining. Transl. Cancer Res. 2013, 2:130-143. 10.3978/j.issn.2218-676X.2013.04.02.
    • (2013) Transl. Cancer Res. , vol.2 , pp. 130-143
    • Davis, A.J.1    Chen, D.J.2
  • 119
    • 0041966056 scopus 로고    scopus 로고
    • Reversal of human cellular senescence: roles of the p53 and p16 pathways
    • Beauséjour C.M., Krtolica A., Galimi F., Narita M., Lowe S.W., Yaswen P., et al. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J. 2003, 22:4212-4222. 10.1093/emboj/cdg417.
    • (2003) EMBO J. , vol.22 , pp. 4212-4222
    • Beauséjour, C.M.1    Krtolica, A.2    Galimi, F.3    Narita, M.4    Lowe, S.W.5    Yaswen, P.6
  • 120
    • 29244432159 scopus 로고    scopus 로고
    • Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice
    • Busuttil R.A., Rubio M., Dollé M.E.T., Campisi J., Vijg J. Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice. DNA Repair 2006, 5:52-60. 10.1016/j.dnarep.2005.07.006.
    • (2006) DNA Repair , vol.5 , pp. 52-60
    • Busuttil, R.A.1    Rubio, M.2    Dollé, M.E.T.3    Campisi, J.4    Vijg, J.5
  • 121
    • 2942570699 scopus 로고    scopus 로고
    • Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture
    • Busuttil R.A., Rubio M., Dollé M.E.T., Campisi J., Vijg J. Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell 2003, 2:287-294.
    • (2003) Aging Cell , vol.2 , pp. 287-294
    • Busuttil, R.A.1    Rubio, M.2    Dollé, M.E.T.3    Campisi, J.4    Vijg, J.5
  • 122
    • 84926665024 scopus 로고    scopus 로고
    • SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner
    • Xu Z., Zhang L., Zhang W., Meng D., Zhang H., Jiang Y., et al. SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. Cell Cycle Georget. Tex. 2015, 14:269-276. 10.4161/15384101.2014.980641.
    • (2015) Cell Cycle Georget. Tex. , vol.14 , pp. 269-276
    • Xu, Z.1    Zhang, L.2    Zhang, W.3    Meng, D.4    Zhang, H.5    Jiang, Y.6
  • 123
    • 84938215105 scopus 로고    scopus 로고
    • Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes
    • Nagai K., Matsushita T., Matsuzaki T., Takayama K., Matsumoto T., Kuroda R., et al. Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes. Osteoarthr. Cartil. 2015, 23:1412-1420. 10.1016/j.joca.2015.03.024.
    • (2015) Osteoarthr. Cartil. , vol.23 , pp. 1412-1420
    • Nagai, K.1    Matsushita, T.2    Matsuzaki, T.3    Takayama, K.4    Matsumoto, T.5    Kuroda, R.6
  • 124
    • 84949498541 scopus 로고    scopus 로고
    • Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development
    • Wu Y., Chen L., Wang Y., Li W., Lin Y., Yu D., et al. Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development. Sci. Rep. 2015, 5. 10.1038/srep17602.
    • (2015) Sci. Rep. , vol.5
    • Wu, Y.1    Chen, L.2    Wang, Y.3    Li, W.4    Lin, Y.5    Yu, D.6
  • 125
    • 81855212708 scopus 로고    scopus 로고
    • Cancer: final act of senescence
    • Serrano M. Cancer: final act of senescence. Nature 2011, 479:481-482. 10.1038/479481a.
    • (2011) Nature , vol.479 , pp. 481-482
    • Serrano, M.1
  • 126
    • 84947648638 scopus 로고    scopus 로고
    • MTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation
    • Damsky W., Micevic G., Meeth K., Muthusamy V., Curley D.P., Santhanakrishnan M., et al. mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation. Cancer Cell 2015, 27:41-56. 10.1016/j.ccell.2014.11.014.
    • (2015) Cancer Cell , vol.27 , pp. 41-56
    • Damsky, W.1    Micevic, G.2    Meeth, K.3    Muthusamy, V.4    Curley, D.P.5    Santhanakrishnan, M.6
  • 127
    • 84861163796 scopus 로고    scopus 로고
    • Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis
    • Vredeveld L.C.W., Possik P.A., Smit M.A., Meissl K., Michaloglou C., Horlings H.M., et al. Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis. Genes Dev. 2012, 26:1055-1069. 10.1101/gad.187252.112.
    • (2012) Genes Dev. , vol.26 , pp. 1055-1069
    • Vredeveld, L.C.W.1    Possik, P.A.2    Smit, M.A.3    Meissl, K.4    Michaloglou, C.5    Horlings, H.M.6
  • 128
    • 84964284192 scopus 로고    scopus 로고
    • MTOR signaling in melanoma: oncogene-induced pseudo-senescence?
    • Souroullas G.P., Sharpless N.E. mTOR signaling in melanoma: oncogene-induced pseudo-senescence?. Cancer Cell 2015, 27:3-5. 10.1016/j.ccell.2014.12.005.
    • (2015) Cancer Cell , vol.27 , pp. 3-5
    • Souroullas, G.P.1    Sharpless, N.E.2
  • 129
    • 84923093613 scopus 로고    scopus 로고
    • Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells
    • Webster M.R., Xu M., Kinzler K.A., Kaur A., Appleton J., O'Connell M.P., et al. Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells. Pigment Cell Melanoma Res. 2015, 28:184-195. 10.1111/pcmr.12330.
    • (2015) Pigment Cell Melanoma Res. , vol.28 , pp. 184-195
    • Webster, M.R.1    Xu, M.2    Kinzler, K.A.3    Kaur, A.4    Appleton, J.5    O'Connell, M.P.6
  • 130
    • 50549087736 scopus 로고    scopus 로고
    • Growth stimulation leads to cellular senescence when the cell cycle is blocked
    • Demidenko Z.N., Blagosklonny M.V. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle Georget. Tex. 2008, 7:3355-3361.
    • (2008) Cell Cycle Georget. Tex. , vol.7 , pp. 3355-3361
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 132
    • 84929287721 scopus 로고    scopus 로고
    • ATM couples replication stress and metabolic reprogramming during cellular senescence
    • Aird K.M., Worth A.J., Snyder N.W., Lee J.V., Sivanand S., Liu Q., et al. ATM couples replication stress and metabolic reprogramming during cellular senescence. Cell Rep. 2015, 11:893-901. 10.1016/j.celrep.2015.04.014.
    • (2015) Cell Rep. , vol.11 , pp. 893-901
    • Aird, K.M.1    Worth, A.J.2    Snyder, N.W.3    Lee, J.V.4    Sivanand, S.5    Liu, Q.6
  • 135
    • 84876535364 scopus 로고    scopus 로고
    • Understanding immunosenescence to improve responses to vaccines
    • Goronzy J.J., Weyand C.M. Understanding immunosenescence to improve responses to vaccines. Nat. Immunol. 2013, 14:428-436. 10.1038/ni.2588.
    • (2013) Nat. Immunol. , vol.14 , pp. 428-436
    • Goronzy, J.J.1    Weyand, C.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.