-
1
-
-
84872180216
-
Epigenetics and aging
-
D'Aquila P., Rose G., Bellizzi D., Passarino G. Epigenetics and aging. Maturitas 2013, 74:130-136. 10.1016/j.maturitas.2012.11.005.
-
(2013)
Maturitas
, vol.74
, pp. 130-136
-
-
D'Aquila, P.1
Rose, G.2
Bellizzi, D.3
Passarino, G.4
-
2
-
-
13944262937
-
Understanding the odd science of aging
-
Kirkwood T.B.L. Understanding the odd science of aging. Cell 2005, 120:437-447. 10.1016/j.cell.2005.01.027.
-
(2005)
Cell
, vol.120
, pp. 437-447
-
-
Kirkwood, T.B.L.1
-
3
-
-
84859929074
-
Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity
-
Montesanto A., Dato S., Bellizzi D., Rose G., Passarino G. Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity. Immun. Ageing A. 2012, 9:6. 10.1186/1742-4933-9-6.
-
(2012)
Immun. Ageing A.
, vol.9
, pp. 6
-
-
Montesanto, A.1
Dato, S.2
Bellizzi, D.3
Rose, G.4
Passarino, G.5
-
4
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 1961, 25:585-621. 10.1016/0014-4827(61)90192-6.
-
(1961)
Exp. Cell Res.
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
5
-
-
0035500487
-
Cellular senescence as a tumor-suppressor mechanism
-
Campisi J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 2001, 11:S27-S31.
-
(2001)
Trends Cell Biol.
, vol.11
, pp. S27-S31
-
-
Campisi, J.1
-
6
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
-
Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005, 120:513-522. 10.1016/j.cell.2005.02.003.
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
7
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M., Lin A.W., McCurrach M.E., Beach D., Lowe S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997, 88:593-602. 10.1016/S0092-8674(00)81902-9.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
8
-
-
84889600900
-
Programmed cell senescence during mammalian embryonic development
-
Muñoz-Espín D., Cañamero M., Maraver A., Gómez-López G., Contreras J., Murillo-Cuesta S., et al. Programmed cell senescence during mammalian embryonic development. Cell 2013, 155:1104-1118. 10.1016/j.cell.2013.10.019.
-
(2013)
Cell
, vol.155
, pp. 1104-1118
-
-
Muñoz-Espín, D.1
Cañamero, M.2
Maraver, A.3
Gómez-López, G.4
Contreras, J.5
Murillo-Cuesta, S.6
-
9
-
-
84874405465
-
Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling
-
Rajagopalan S., Long E.O. Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:20596-20601. 10.1073/pnas.1208248109.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 20596-20601
-
-
Rajagopalan, S.1
Long, E.O.2
-
10
-
-
84889565689
-
Senescence is a developmental mechanism that contributes to embryonic growth and patterning
-
Storer M., Mas A., Robert-Moreno A., Pecoraro M., Ortells M.C., Di Giacomo V., et al. Senescence is a developmental mechanism that contributes to embryonic growth and patterning. Cell 2013, 155:1119-1130. 10.1016/j.cell.2013.10.041.
-
(2013)
Cell
, vol.155
, pp. 1119-1130
-
-
Storer, M.1
Mas, A.2
Robert-Moreno, A.3
Pecoraro, M.4
Ortells, M.C.5
Di Giacomo, V.6
-
11
-
-
84919480323
-
An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA
-
Demaria M., Ohtani N., Youssef S.A., Rodier F., Toussaint W., Mitchell J.R., et al. An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev. Cell 2014, 31:722-733. 10.1016/j.devcel.2014.11.012.
-
(2014)
Dev. Cell
, vol.31
, pp. 722-733
-
-
Demaria, M.1
Ohtani, N.2
Youssef, S.A.3
Rodier, F.4
Toussaint, W.5
Mitchell, J.R.6
-
12
-
-
77954243065
-
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
-
Jun J.-I., Lau L.F. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat. Cell Biol. 2010, 12:676-685. 10.1038/ncb2070.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 676-685
-
-
Jun, J.-I.1
Lau, L.F.2
-
13
-
-
84901288438
-
The role of senescent cells in ageing
-
van Deursen J.M. The role of senescent cells in ageing. Nature 2014, 509:439-446. 10.1038/nature13193.
-
(2014)
Nature
, vol.509
, pp. 439-446
-
-
van Deursen, J.M.1
-
14
-
-
33846090789
-
Accumulation of senescent cells in mitotic tissue of aging primates
-
Jeyapalan J.C., Ferreira M., Sedivy J.M., Herbig U. Accumulation of senescent cells in mitotic tissue of aging primates. Mech. Ageing Dev. 2007, 128:36-44. 10.1016/j.mad.2006.11.008.
-
(2007)
Mech. Ageing Dev.
, vol.128
, pp. 36-44
-
-
Jeyapalan, J.C.1
Ferreira, M.2
Sedivy, J.M.3
Herbig, U.4
-
15
-
-
0034682721
-
Cellular senescence: minireview mitotic clock or culture shock?
-
Sherr C.J., DePinho R.A. Cellular senescence: minireview mitotic clock or culture shock?. Cell 2000, 102:407-410. 10.1016/S0092-8674(00)00046-5.
-
(2000)
Cell
, vol.102
, pp. 407-410
-
-
Sherr, C.J.1
DePinho, R.A.2
-
16
-
-
84933050555
-
Forging a signature of in vivo senescence
-
Sharpless N.E., Sherr C.J. Forging a signature of in vivo senescence. Nat. Rev. Cancer 2015, 15:397-408. 10.1038/nrc3960.
-
(2015)
Nat. Rev. Cancer
, vol.15
, pp. 397-408
-
-
Sharpless, N.E.1
Sherr, C.J.2
-
17
-
-
0142231578
-
Bcl-2 activates a programme of premature senescence in human carcinoma cells
-
Crescenzi E., Palumbo G., Brady H.J.M. Bcl-2 activates a programme of premature senescence in human carcinoma cells. Biochem. J. 2003, 375:263-274. 10.1042/BJ20030868.
-
(2003)
Biochem. J.
, vol.375
, pp. 263-274
-
-
Crescenzi, E.1
Palumbo, G.2
Brady, H.J.M.3
-
18
-
-
8344230643
-
Senescent fibroblasts resist apoptosis by downregulating caspase-3
-
Marcotte R., Lacelle C., Wang E. Senescent fibroblasts resist apoptosis by downregulating caspase-3. Mech. Ageing Dev. 2004, 125:777-783. 10.1016/j.mad.2004.07.007.
-
(2004)
Mech. Ageing Dev.
, vol.125
, pp. 777-783
-
-
Marcotte, R.1
Lacelle, C.2
Wang, E.3
-
19
-
-
84873638532
-
Aging, cellular senescence, and cancer
-
Campisi J. Aging, cellular senescence, and cancer. Annu. Rev. Physiol. 2013, 75:685-705. 10.1146/annurev-physiol-030212-183653.
-
(2013)
Annu. Rev. Physiol.
, vol.75
, pp. 685-705
-
-
Campisi, J.1
-
20
-
-
34548186667
-
Cellular senescence: when bad things happen to good cells
-
Campisi J., di Fagagna F.d'Adda Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 2007, 8:729-740. 10.1038/nrm2233.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 729-740
-
-
Campisi, J.1
di Fagagna, F.D.2
-
21
-
-
77949881221
-
The senescence-associated secretory phenotype: the dark side of tumor suppression
-
Coppé J.-P., Desprez P.-Y., Krtolica A., Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol. Mech. Dis. 2010, 5:99-118. 10.1146/annurev-pathol-121808-102144.
-
(2010)
Annu. Rev. Pathol. Mech. Dis.
, vol.5
, pp. 99-118
-
-
Coppé, J.-P.1
Desprez, P.-Y.2
Krtolica, A.3
Campisi, J.4
-
22
-
-
84926523961
-
Senescence-associated inflammatory responses: aging and cancer perspectives
-
Lasry A., Ben-Neriah Y. Senescence-associated inflammatory responses: aging and cancer perspectives. Trends Immunol. 2015, 36:217-228. 10.1016/j.it.2015.02.009.
-
(2015)
Trends Immunol.
, vol.36
, pp. 217-228
-
-
Lasry, A.1
Ben-Neriah, Y.2
-
23
-
-
23244461708
-
Oncogene-induced senescence as an initial barrier in lymphoma development
-
Braig M., Lee S., Loddenkemper C., Rudolph C., Peters A.H.F.M., Schlegelberger B., et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 2005, 436:660-665. 10.1038/nature03841.
-
(2005)
Nature
, vol.436
, pp. 660-665
-
-
Braig, M.1
Lee, S.2
Loddenkemper, C.3
Rudolph, C.4
Peters, A.H.F.M.5
Schlegelberger, B.6
-
24
-
-
23244460597
-
Crucial role of p53-dependent cellular senescence in suppression of PTEN-deficient tumorigenesis
-
Chen Z., Trotman L.C., Shaffer D., Lin H.-K., Dotan Z.A., Niki M., et al. Crucial role of p53-dependent cellular senescence in suppression of PTEN-deficient tumorigenesis. Nature 2005, 436:725-730. 10.1038/nature03918.
-
(2005)
Nature
, vol.436
, pp. 725-730
-
-
Chen, Z.1
Trotman, L.C.2
Shaffer, D.3
Lin, H.-K.4
Dotan, Z.A.5
Niki, M.6
-
25
-
-
23244447037
-
BRAFE600-associated senescence-like cell cycle arrest of human naevi
-
Michaloglou C., Vredeveld L.C.W., Soengas M.S., Denoyelle C., Kuilman T., van der Horst C.M.A.M., et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 2005, 436:720-724. 10.1038/nature03890.
-
(2005)
Nature
, vol.436
, pp. 720-724
-
-
Michaloglou, C.1
Vredeveld, L.C.W.2
Soengas, M.S.3
Denoyelle, C.4
Kuilman, T.5
van der Horst, C.M.A.M.6
-
26
-
-
24744454582
-
Senescence comes of age
-
Narita M., Lowe S.W. Senescence comes of age. Nat. Med. 2005, 11:920-922. 10.1038/nm0905-920.
-
(2005)
Nat. Med.
, vol.11
, pp. 920-922
-
-
Narita, M.1
Lowe, S.W.2
-
27
-
-
44649120132
-
Chemokine signaling via the CXCR2 receptor reinforces senescence
-
Acosta J.C., O'Loghlen A., Banito A., Guijarro M.V., Augert A., Raguz S., et al. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 2008, 133:1006-1018. 10.1016/j.cell.2008.03.038.
-
(2008)
Cell
, vol.133
, pp. 1006-1018
-
-
Acosta, J.C.1
O'Loghlen, A.2
Banito, A.3
Guijarro, M.V.4
Augert, A.5
Raguz, S.6
-
28
-
-
51649098243
-
A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion
-
Coppe J.-P., Boysen M., Sun C.H., Wong B.J.F., Kang M.K., Park N.-H., et al. A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion. Mol. Cancer Res. 2008, 6:1085-1098. 10.1158/1541-7786.MCR-08-0062.
-
(2008)
Mol. Cancer Res.
, vol.6
, pp. 1085-1098
-
-
Coppe, J.-P.1
Boysen, M.2
Sun, C.H.3
Wong, B.J.F.4
Kang, M.K.5
Park, N.-H.6
-
29
-
-
84891713034
-
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
-
Coppé J.-P., Patil C.K., Rodier F., Sun Y., Muñoz D.P., Goldstein J., et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008, 6. 10.1371/journal.pbio.0060301.
-
(2008)
PLoS Biol.
, vol.6
-
-
Coppé, J.-P.1
Patil, C.K.2
Rodier, F.3
Sun, Y.4
Muñoz, D.P.5
Goldstein, J.6
-
30
-
-
0035834121
-
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging
-
Krtolica A., Parrinello S., Lockett S., Desprez P.Y., Campisi J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:12072-12077. 10.1073/pnas.211053698.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 12072-12077
-
-
Krtolica, A.1
Parrinello, S.2
Lockett, S.3
Desprez, P.Y.4
Campisi, J.5
-
31
-
-
84874603171
-
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
-
Tchkonia T., Zhu Y., van Deursen J., Campisi J., Kirkland J.L. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J. Clin. Invest. 2013, 123:966-972. 10.1172/JCI64098.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 966-972
-
-
Tchkonia, T.1
Zhu, Y.2
van Deursen, J.3
Campisi, J.4
Kirkland, J.L.5
-
32
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U. S. A. 1995, 92:9363-9367.
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
-
33
-
-
80855138775
-
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
-
Baker D.J., Wijshake T., Tchkonia T., LeBrasseur N.K., Childs B.G., van de Sluis B., et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 2011, 479:232-236. 10.1038/nature10600.
-
(2011)
Nature
, vol.479
, pp. 232-236
-
-
Baker, D.J.1
Wijshake, T.2
Tchkonia, T.3
LeBrasseur, N.K.4
Childs, B.G.5
van de Sluis, B.6
-
34
-
-
84943199949
-
Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy
-
Golomb L., Sagiv A., Pateras I.S., Maly A., Krizhanovsky V., Gorgoulis V.G., et al. Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy. Cell Death Differ. 2015, 22:1764-1774. 10.1038/cdd.2015.21.
-
(2015)
Cell Death Differ.
, vol.22
, pp. 1764-1774
-
-
Golomb, L.1
Sagiv, A.2
Pateras, I.S.3
Maly, A.4
Krizhanovsky, V.5
Gorgoulis, V.G.6
-
35
-
-
84878864199
-
The hallmarks of aging
-
López-Otín C., Blasco M.A., Partridge L., Serrano M., Kroemer G. The hallmarks of aging. Cell 2013, 153:1194-1217. 10.1016/j.cell.2013.05.039.
-
(2013)
Cell
, vol.153
, pp. 1194-1217
-
-
López-Otín, C.1
Blasco, M.A.2
Partridge, L.3
Serrano, M.4
Kroemer, G.5
-
36
-
-
84881526073
-
A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism
-
Pribluda A., Elyada E., Wiener Z., Hamza H., Goldstein R.E., Biton M., et al. A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell 2013, 24:242-256. 10.1016/j.ccr.2013.06.005.
-
(2013)
Cancer Cell
, vol.24
, pp. 242-256
-
-
Pribluda, A.1
Elyada, E.2
Wiener, Z.3
Hamza, H.4
Goldstein, R.E.5
Biton, M.6
-
37
-
-
81855169964
-
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
-
Kang T.-W., Yevsa T., Woller N., Hoenicke L., Wuestefeld T., Dauch D., et al. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 2011, 479:547-551. 10.1038/nature10599.
-
(2011)
Nature
, vol.479
, pp. 547-551
-
-
Kang, T.-W.1
Yevsa, T.2
Woller, N.3
Hoenicke, L.4
Wuestefeld, T.5
Dauch, D.6
-
38
-
-
19844382620
-
Senescence and immortalization: role of telomeres and telomerase
-
Shay J.W., Wright W.E. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis 2005, 26:867-874. 10.1093/carcin/bgh296.
-
(2005)
Carcinogenesis
, vol.26
, pp. 867-874
-
-
Shay, J.W.1
Wright, W.E.2
-
39
-
-
84859372986
-
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
-
Fumagalli M., Rossiello F., Clerici M., Barozzi S., Cittaro D., Kaplunov J.M., et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat. Cell Biol. 2012, 14:355-365. 10.1038/ncb2466.
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 355-365
-
-
Fumagalli, M.1
Rossiello, F.2
Clerici, M.3
Barozzi, S.4
Cittaro, D.5
Kaplunov, J.M.6
-
40
-
-
2442511752
-
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
-
Herbig U., Jobling W.A., Chen B.P.C., Chen D.J., Sedivy J.M. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 2004, 14:501-513.
-
(2004)
Mol. Cell
, vol.14
, pp. 501-513
-
-
Herbig, U.1
Jobling, W.A.2
Chen, B.P.C.3
Chen, D.J.4
Sedivy, J.M.5
-
42
-
-
1642602686
-
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks
-
Sedelnikova O.A., Horikawa I., Zimonjic D.B., Popescu N.C., Bonner W.M., Barrett J.C. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat. Cell Biol. 2004, 6:168-170. 10.1038/ncb1095.
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 168-170
-
-
Sedelnikova, O.A.1
Horikawa, I.2
Zimonjic, D.B.3
Popescu, N.C.4
Bonner, W.M.5
Barrett, J.C.6
-
43
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist C.J., Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003, 421:499-506. 10.1038/nature01368.
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
44
-
-
77950532788
-
Activation of ATM-dependent DNA damage signal pathway by a histone deacetylase inhibitor, trichostatin A
-
Lee J.-S. Activation of ATM-dependent DNA damage signal pathway by a histone deacetylase inhibitor, trichostatin A. Cancer Res. Treat. Off. J. Korean Cancer Assoc. 2007, 39:125-130. 10.4143/crt.2007.39.3.125.
-
(2007)
Cancer Res. Treat. Off. J. Korean Cancer Assoc.
, vol.39
, pp. 125-130
-
-
Lee, J.-S.1
-
45
-
-
38949124412
-
ATR signaling can drive cells into senescence in the absence of DNA breaks
-
Toledo L.I., Murga M., Gutierrez-Martinez P., Soria R., Fernandez-Capetillo O. ATR signaling can drive cells into senescence in the absence of DNA breaks. Genes Dev. 2008, 22:297-302. 10.1101/gad.452308.
-
(2008)
Genes Dev.
, vol.22
, pp. 297-302
-
-
Toledo, L.I.1
Murga, M.2
Gutierrez-Martinez, P.3
Soria, R.4
Fernandez-Capetillo, O.5
-
46
-
-
21344440000
-
Reactive oxygen species as mediators of cellular senescence
-
Colavitti R., Finkel T. Reactive oxygen species as mediators of cellular senescence. IUBMB Life 2005, 57:277-281. 10.1080/15216540500091890.
-
(2005)
IUBMB Life
, vol.57
, pp. 277-281
-
-
Colavitti, R.1
Finkel, T.2
-
47
-
-
0030980641
-
Mitogenic signaling mediated by oxidants in ras-transformed fibroblasts
-
Irani K., Xia Y., Zweier J.L., Sollott S.J., Der C.J., Fearon E.R., et al. Mitogenic signaling mediated by oxidants in ras-transformed fibroblasts. Science 1997, 275:1649-1652.
-
(1997)
Science
, vol.275
, pp. 1649-1652
-
-
Irani, K.1
Xia, Y.2
Zweier, J.L.3
Sollott, S.J.4
Der, C.J.5
Fearon, E.R.6
-
48
-
-
0033583242
-
Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
-
Lee A.C., Fenster B.E., Ito H., Takeda K., Bae N.S., Hirai T., et al. Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J. Biol. Chem. 1999, 274:7936-7940.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 7936-7940
-
-
Lee, A.C.1
Fenster, B.E.2
Ito, H.3
Takeda, K.4
Bae, N.S.5
Hirai, T.6
-
49
-
-
84899929645
-
Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation
-
Ogrunc M., Di Micco R., Liontos M., Bombardelli L., Mione M., Fumagalli M., et al. Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation. Cell Death Differ. 2014, 21:998-1012. 10.1038/cdd.2014.16.
-
(2014)
Cell Death Differ.
, vol.21
, pp. 998-1012
-
-
Ogrunc, M.1
Di Micco, R.2
Liontos, M.3
Bombardelli, L.4
Mione, M.5
Fumagalli, M.6
-
50
-
-
33845235459
-
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
-
Bartkova J., Rezaei N., Liontos M., Karakaidos P., Kletsas D., Issaeva N., et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006, 444:633-637. 10.1038/nature05268.
-
(2006)
Nature
, vol.444
, pp. 633-637
-
-
Bartkova, J.1
Rezaei, N.2
Liontos, M.3
Karakaidos, P.4
Kletsas, D.5
Issaeva, N.6
-
51
-
-
33845269825
-
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
-
Di Micco R., Fumagalli M., Cicalese A., Piccinin S., Gasparini P., Luise C., et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 2006, 444:638-642. 10.1038/nature05327.
-
(2006)
Nature
, vol.444
, pp. 638-642
-
-
Di Micco, R.1
Fumagalli, M.2
Cicalese, A.3
Piccinin, S.4
Gasparini, P.5
Luise, C.6
-
52
-
-
42949129074
-
Many roads lead to oncogene-induced senescence
-
Courtois-Cox S., Jones S.L., Cichowski K. Many roads lead to oncogene-induced senescence. Oncogene 2008, 27:2801-2809. 10.1038/sj.onc.1210950.
-
(2008)
Oncogene
, vol.27
, pp. 2801-2809
-
-
Courtois-Cox, S.1
Jones, S.L.2
Cichowski, K.3
-
53
-
-
33745363911
-
DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation
-
Moiseeva O., Mallette F.A., Mukhopadhyay U.K., Moores A., Ferbeyre G. DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation. Mol. Biol. Cell 2006, 17:1583-1592. 10.1091/mbc.E05-09-0858.
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 1583-1592
-
-
Moiseeva, O.1
Mallette, F.A.2
Mukhopadhyay, U.K.3
Moores, A.4
Ferbeyre, G.5
-
54
-
-
1842861744
-
Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock
-
Munro J., Barr N.I., Ireland H., Morrison V., Parkinson E.K. Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock. Exp. Cell Res. 2004, 295:525-538. 10.1016/j.yexcr.2004.01.017.
-
(2004)
Exp. Cell Res.
, vol.295
, pp. 525-538
-
-
Munro, J.1
Barr, N.I.2
Ireland, H.3
Morrison, V.4
Parkinson, E.K.5
-
55
-
-
84860503063
-
Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression
-
Pazolli E., Alspach E., Milczarek A., Prior J., Piwnica-Worms D., Stewart S.A. Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression. Cancer Res. 2012, 72:2251-2261. 10.1158/0008-5472.CAN-11-3386.
-
(2012)
Cancer Res.
, vol.72
, pp. 2251-2261
-
-
Pazolli, E.1
Alspach, E.2
Milczarek, A.3
Prior, J.4
Piwnica-Worms, D.5
Stewart, S.A.6
-
56
-
-
0032190629
-
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
-
Lin A.W., Barradas M., Stone J.C., van Aelst L., Serrano M., Lowe S.W. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 1998, 12:3008-3019.
-
(1998)
Genes Dev.
, vol.12
, pp. 3008-3019
-
-
Lin, A.W.1
Barradas, M.2
Stone, J.C.3
van Aelst, L.4
Serrano, M.5
Lowe, S.W.6
-
57
-
-
0032192153
-
Senescence of human fibroblasts induced by oncogenic raf
-
Zhu J., Woods D., McMahon M., Bishop J.M. Senescence of human fibroblasts induced by oncogenic raf. Genes Dev. 1998, 12:2997-3007. 10.1101/gad.12.19.2997.
-
(1998)
Genes Dev.
, vol.12
, pp. 2997-3007
-
-
Zhu, J.1
Woods, D.2
McMahon, M.3
Bishop, J.M.4
-
58
-
-
78549268199
-
Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo
-
Takeuchi S., Takahashi A., Motoi N., Yoshimoto S., Tajima T., Yamakoshi K., et al. Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo. Cancer Res. 2010, 70:9381-9390. 10.1158/0008-5472.CAN-10-0801.
-
(2010)
Cancer Res.
, vol.70
, pp. 9381-9390
-
-
Takeuchi, S.1
Takahashi, A.2
Motoi, N.3
Yoshimoto, S.4
Tajima, T.5
Yamakoshi, K.6
-
59
-
-
79955017452
-
P38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
-
Freund A., Patil C.K., Campisi J. p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J. 2011, 30:1536-1548. 10.1038/emboj.2011.69.
-
(2011)
EMBO J.
, vol.30
, pp. 1536-1548
-
-
Freund, A.1
Patil, C.K.2
Campisi, J.3
-
60
-
-
77149164811
-
Feedback between p21 and reactive oxygen production is necessary for cell senescence
-
Passos J.F., Nelson G., Wang C., Richter T., Simillion C., Proctor C.J., et al. Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol. Syst. Biol. 2010, 6:347. 10.1038/msb.2010.5.
-
(2010)
Mol. Syst. Biol.
, vol.6
, pp. 347
-
-
Passos, J.F.1
Nelson, G.2
Wang, C.3
Richter, T.4
Simillion, C.5
Proctor, C.J.6
-
61
-
-
70349773104
-
Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence
-
Adams P.D. Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol. Cell 2009, 36:2-14. 10.1016/j.molcel.2009.09.021.
-
(2009)
Mol. Cell
, vol.36
, pp. 2-14
-
-
Adams, P.D.1
-
62
-
-
33947134834
-
The polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
-
Bracken A.P., Kleine-Kohlbrecher D., Dietrich N., Pasini D., Gargiulo G., Beekman C., et al. The polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev. 2007, 21:525-530. 10.1101/gad.415507.
-
(2007)
Genes Dev.
, vol.21
, pp. 525-530
-
-
Bracken, A.P.1
Kleine-Kohlbrecher, D.2
Dietrich, N.3
Pasini, D.4
Gargiulo, G.5
Beekman, C.6
-
63
-
-
1842483852
-
Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(arf) pathway
-
Bulavin D.V., Phillips C., Nannenga B., Timofeev O., Donehower L.A., Anderson C.W., et al. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(arf) pathway. Nat. Genet. 2004, 36:343-350. 10.1038/ng1317.
-
(2004)
Nat. Genet.
, vol.36
, pp. 343-350
-
-
Bulavin, D.V.1
Phillips, C.2
Nannenga, B.3
Timofeev, O.4
Donehower, L.A.5
Anderson, C.W.6
-
64
-
-
0346463059
-
High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts
-
Deng Q., Liao R., Wu B.-L., Sun P. High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts. J. Biol. Chem. 2004, 279:1050-1059. 10.1074/jbc.M308644200.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 1050-1059
-
-
Deng, Q.1
Liao, R.2
Wu, B.-L.3
Sun, P.4
-
65
-
-
33645730667
-
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
-
Ito K., Hirao A., Arai F., Takubo K., Matsuoka S., Miyamoto K., et al. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat. Med. 2006, 12:446-451. 10.1038/nm1388.
-
(2006)
Nat. Med.
, vol.12
, pp. 446-451
-
-
Ito, K.1
Hirao, A.2
Arai, F.3
Takubo, K.4
Matsuoka, S.5
Miyamoto, K.6
-
66
-
-
0037068753
-
Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion
-
Olsen C.L., Gardie B., Yaswen P., Stampfer M.R. Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion. Oncogene 2002, 21:6328-6339. 10.1038/sj.onc.1205780.
-
(2002)
Oncogene
, vol.21
, pp. 6328-6339
-
-
Olsen, C.L.1
Gardie, B.2
Yaswen, P.3
Stampfer, M.R.4
-
67
-
-
33646946746
-
Senescence-associated beta-galactosidase is lysosomal beta-galactosidase
-
Lee B.Y., Han J.A., Im J.S., Morrone A., Johung K., Goodwin E.C., et al. Senescence-associated beta-galactosidase is lysosomal beta-galactosidase. Aging Cell 2006, 5:187-195. 10.1111/j.1474-9726.2006.00199.x.
-
(2006)
Aging Cell
, vol.5
, pp. 187-195
-
-
Lee, B.Y.1
Han, J.A.2
Im, J.S.3
Morrone, A.4
Johung, K.5
Goodwin, E.C.6
-
68
-
-
40749122641
-
Transcriptional repression mediated by repositioning of genes to the nuclear lamina
-
Reddy K.L., Zullo J.M., Bertolino E., Singh H. Transcriptional repression mediated by repositioning of genes to the nuclear lamina. Nature 2008, 452:243-247. 10.1038/nature06727.
-
(2008)
Nature
, vol.452
, pp. 243-247
-
-
Reddy, K.L.1
Zullo, J.M.2
Bertolino, E.3
Singh, H.4
-
69
-
-
84861673276
-
Lamin B1 loss is a senescence-associated biomarker
-
Freund A., Laberge R.-M., Demaria M., Campisi J. Lamin B1 loss is a senescence-associated biomarker. Mol. Biol. Cell 2012, 23:2066-2075. 10.1091/mbc.E11-10-0884.
-
(2012)
Mol. Biol. Cell
, vol.23
, pp. 2066-2075
-
-
Freund, A.1
Laberge, R.-M.2
Demaria, M.3
Campisi, J.4
-
70
-
-
34249725997
-
Alterations to nuclear architecture and genome behavior in senescent cells
-
Mehta I.S., Figgitt M., Clements C.S., Kill I.R., Bridger J.M. Alterations to nuclear architecture and genome behavior in senescent cells. Ann. N. Y. Acad. Sci. 2007, 1100:250-263. 10.1196/annals.1395.027.
-
(2007)
Ann. N. Y. Acad. Sci.
, vol.1100
, pp. 250-263
-
-
Mehta, I.S.1
Figgitt, M.2
Clements, C.S.3
Kill, I.R.4
Bridger, J.M.5
-
71
-
-
33947236204
-
Molecular dissection of formation of senescence-associated heterochromatin foci
-
Zhang R., Chen W., Adams P.D. Molecular dissection of formation of senescence-associated heterochromatin foci. Mol. Cell. Biol. 2007, 27:2343-2358. 10.1128/MCB.02019-06.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 2343-2358
-
-
Zhang, R.1
Chen, W.2
Adams, P.D.3
-
72
-
-
84878619211
-
P53-dependent release of alarmin HMGB1 is a central mediator of senescent phenotypes
-
Davalos A.R., Kawahara M., Malhotra G.K., Schaum N., Huang J., Ved U., et al. p53-dependent release of alarmin HMGB1 is a central mediator of senescent phenotypes. J. Cell Biol. 2013, 201:613-629. 10.1083/jcb.201206006.
-
(2013)
J. Cell Biol.
, vol.201
, pp. 613-629
-
-
Davalos, A.R.1
Kawahara, M.2
Malhotra, G.K.3
Schaum, N.4
Huang, J.5
Ved, U.6
-
73
-
-
69949125332
-
Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence
-
Nakamura A.J., Chiang Y.J., Hathcock K.S., Horikawa I., Sedelnikova O.A., Hodes R.J., et al. Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence. Epigenetics Chromatin 2008, 1:6. 10.1186/1756-8935-1-6.
-
(2008)
Epigenetics Chromatin
, vol.1
, pp. 6
-
-
Nakamura, A.J.1
Chiang, Y.J.2
Hathcock, K.S.3
Horikawa, I.4
Sedelnikova, O.A.5
Hodes, R.J.6
-
74
-
-
0037667702
-
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
-
Narita M., Nuñez S., Heard E., Narita M., Lin A.W., Hearn S.A., et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 2003, 113:703-716. 10.1016/S0092-8674(03)00401-X.
-
(2003)
Cell
, vol.113
, pp. 703-716
-
-
Narita, M.1
Nuñez, S.2
Heard, E.3
Narita, M.4
Lin, A.W.5
Hearn, S.A.6
-
75
-
-
79851493300
-
Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a)
-
Kosar M., Bartkova J., Hubackova S., Hodny Z., Lukas J., Bartek J. Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). Cell Cycle Georget. Tex. 2011, 10:457-468.
-
(2011)
Cell Cycle Georget. Tex.
, vol.10
, pp. 457-468
-
-
Kosar, M.1
Bartkova, J.2
Hubackova, S.3
Hodny, Z.4
Lukas, J.5
Bartek, J.6
-
76
-
-
84882682843
-
Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
-
Shah P.P., Donahue G., Otte G.L., Capell B.C., Nelson D.M., Cao K., et al. Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape. Genes Dev. 2013, 27:1787-1799. 10.1101/gad.223834.113.
-
(2013)
Genes Dev.
, vol.27
, pp. 1787-1799
-
-
Shah, P.P.1
Donahue, G.2
Otte, G.L.3
Capell, B.C.4
Nelson, D.M.5
Cao, K.6
-
77
-
-
0027769876
-
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
-
Serrano M., Hannon G.J., Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993, 366:704-707. 10.1038/366704a0.
-
(1993)
Nature
, vol.366
, pp. 704-707
-
-
Serrano, M.1
Hannon, G.J.2
Beach, D.3
-
78
-
-
7044231343
-
The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression
-
Ohtani N., Yamakoshi K., Takahashi A., Hara E. The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression. J. Med. Investig. 2004, 51:146-153.
-
(2004)
J. Med. Investig.
, vol.51
, pp. 146-153
-
-
Ohtani, N.1
Yamakoshi, K.2
Takahashi, A.3
Hara, E.4
-
79
-
-
84931031396
-
Cell autonomous and non-autonomous effects of senescent cells in the skin
-
Demaria M., Desprez P.Y., Campisi J., Velarde M.C. Cell autonomous and non-autonomous effects of senescent cells in the skin. J. Invest. Dermatol. 2015, 135:1722-1726. 10.1038/jid.2015.108.
-
(2015)
J. Invest. Dermatol.
, vol.135
, pp. 1722-1726
-
-
Demaria, M.1
Desprez, P.Y.2
Campisi, J.3
Velarde, M.C.4
-
80
-
-
58849154235
-
Senescence-messaging secretome: SMS-ing cellular stress
-
Kuilman T., Peeper D.S. Senescence-messaging secretome: SMS-ing cellular stress. Nat. Rev. Cancer 2009, 9:81-94. 10.1038/nrc2560.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 81-94
-
-
Kuilman, T.1
Peeper, D.S.2
-
81
-
-
80054682555
-
Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype
-
Coppé J.-P., Rodier F., Patil C.K., Freund A., Desprez P.-Y., Campisi J. Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. J. Biol. Chem. 2011, 286:36396-36403. 10.1074/jbc.M111.257071.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 36396-36403
-
-
Coppé, J.-P.1
Rodier, F.2
Patil, C.K.3
Freund, A.4
Desprez, P.-Y.5
Campisi, J.6
-
82
-
-
77949458344
-
A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen
-
Coppé J.-P., Patil C.K., Rodier F., Krtolica A., Beauséjour C.M., Parrinello S., et al. A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS ONE 2010, 5. 10.1371/journal.pone.0009188.
-
(2010)
PLoS ONE
, vol.5
-
-
Coppé, J.-P.1
Patil, C.K.2
Rodier, F.3
Krtolica, A.4
Beauséjour, C.M.5
Parrinello, S.6
-
83
-
-
68249096784
-
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
-
Rodier F., Coppé J.-P., Patil C.K., Hoeijmakers W.A.M., Muñoz D.P., Raza S.R., et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat. Cell Biol. 2009, 11:973-979. 10.1038/ncb1909.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 973-979
-
-
Rodier, F.1
Coppé, J.-P.2
Patil, C.K.3
Hoeijmakers, W.A.M.4
Muñoz, D.P.5
Raza, S.R.6
-
84
-
-
84942456107
-
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
-
aaa5612
-
Kang C., Xu Q., Martin T.D., Li M.Z., Demaria M., Aron L., et al. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science 2015, 349:aaa5612. 10.1126/science.aaa5612.
-
(2015)
Science
, vol.349
-
-
Kang, C.1
Xu, Q.2
Martin, T.D.3
Li, M.Z.4
Demaria, M.5
Aron, L.6
-
85
-
-
44649101304
-
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
-
Kuilman T., Michaloglou C., Vredeveld L.C.W., Douma S., van Doorn R., Desmet C.J., et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 2008, 133:1019-1031. 10.1016/j.cell.2008.03.039.
-
(2008)
Cell
, vol.133
, pp. 1019-1031
-
-
Kuilman, T.1
Michaloglou, C.2
Vredeveld, L.C.W.3
Douma, S.4
van Doorn, R.5
Desmet, C.J.6
-
86
-
-
38849168162
-
Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7
-
Wajapeyee N., Serra R.W., Zhu X., Mahalingam M., Green M.R. Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 2008, 132:363-374. 10.1016/j.cell.2007.12.032.
-
(2008)
Cell
, vol.132
, pp. 363-374
-
-
Wajapeyee, N.1
Serra, R.W.2
Zhu, X.3
Mahalingam, M.4
Green, M.R.5
-
87
-
-
33750798741
-
The chemokine growth-regulated oncogene 1 (gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis
-
Yang G., Rosen D.G., Zhang Z., Bast R.C., Mills G.B., Colacino J.A., et al. The chemokine growth-regulated oncogene 1 (gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:16472-16477. 10.1073/pnas.0605752103.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 16472-16477
-
-
Yang, G.1
Rosen, D.G.2
Zhang, Z.3
Bast, R.C.4
Mills, G.B.5
Colacino, J.A.6
-
88
-
-
73649118223
-
WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway
-
Binet R., Ythier D., Robles A.I., Collado M., Larrieu D., Fonti C., et al. WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway. Cancer Res. 2009, 69:9183-9191. 10.1158/0008-5472.CAN-09-1016.
-
(2009)
Cancer Res.
, vol.69
, pp. 9183-9191
-
-
Binet, R.1
Ythier, D.2
Robles, A.I.3
Collado, M.4
Larrieu, D.5
Fonti, C.6
-
89
-
-
84878357576
-
Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells
-
Cahu J., Bustany S., Sola B. Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells. Cell Death Dis. 2012, 3. 10.1038/cddis.2012.183.
-
(2012)
Cell Death Dis.
, vol.3
-
-
Cahu, J.1
Bustany, S.2
Sola, B.3
-
90
-
-
84881399206
-
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
-
Acosta J.C., Banito A., Wuestefeld T., Georgilis A., Janich P., Morton J.P., et al. A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat. Cell Biol. 2013, 15:978-990. 10.1038/ncb2784.
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 978-990
-
-
Acosta, J.C.1
Banito, A.2
Wuestefeld, T.3
Georgilis, A.4
Janich, P.5
Morton, J.P.6
-
91
-
-
64649084383
-
Radiation-induced bystander signalling in cancer therapy
-
Prise K.M., O'Sullivan J.M. Radiation-induced bystander signalling in cancer therapy. Nat. Rev. Cancer 2009, 9:351-360. 10.1038/nrc2603.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 351-360
-
-
Prise, K.M.1
O'Sullivan, J.M.2
-
92
-
-
84872569990
-
Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model
-
Burd C.E., Sorrentino J.A., Clark K.S., Darr D.B., Krishnamurthy J., Deal A.M., et al. Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model. Cell 2013, 152:340-351. 10.1016/j.cell.2012.12.010.
-
(2013)
Cell
, vol.152
, pp. 340-351
-
-
Burd, C.E.1
Sorrentino, J.A.2
Clark, K.S.3
Darr, D.B.4
Krishnamurthy, J.5
Deal, A.M.6
-
93
-
-
34447506658
-
Oncogenic ras-induced secretion of IL6 is required for tumorigenesis
-
Ancrile B., Lim K.-H., Counter C.M. Oncogenic ras-induced secretion of IL6 is required for tumorigenesis. Genes Dev. 2007, 21:1714-1719. 10.1101/gad.1549407.
-
(2007)
Genes Dev.
, vol.21
, pp. 1714-1719
-
-
Ancrile, B.1
Lim, K.-H.2
Counter, C.M.3
-
94
-
-
40649109728
-
The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer
-
Naugler W.E., Karin M. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol. Med. 2008, 14:109-119. 10.1016/j.molmed.2007.12.007.
-
(2008)
Trends Mol. Med.
, vol.14
, pp. 109-119
-
-
Naugler, W.E.1
Karin, M.2
-
95
-
-
7944223098
-
Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
-
Sparmann A., Bar-Sagi D. Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell 2004, 6:447-458. 10.1016/j.ccr.2004.09.028.
-
(2004)
Cancer Cell
, vol.6
, pp. 447-458
-
-
Sparmann, A.1
Bar-Sagi, D.2
-
96
-
-
33847401888
-
Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion
-
Blank C., Mackensen A. Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion. Cancer Immunol. Immunother. 2007, 56:739-745. 10.1007/s00262-006-0272-1.
-
(2007)
Cancer Immunol. Immunother.
, vol.56
, pp. 739-745
-
-
Blank, C.1
Mackensen, A.2
-
97
-
-
47949099098
-
Origin and physiological roles of inflammation
-
Medzhitov R. Origin and physiological roles of inflammation. Nature 2008, 454:428-435. 10.1038/nature07201.
-
(2008)
Nature
, vol.454
, pp. 428-435
-
-
Medzhitov, R.1
-
98
-
-
77954563804
-
Senescent cells as a source of inflammatory factors for tumor progression
-
Davalos A.R., Coppe J.-P., Campisi J., Desprez P.-Y. Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev. 2010, 29:273-283. 10.1007/s10555-010-9220-9.
-
(2010)
Cancer Metastasis Rev.
, vol.29
, pp. 273-283
-
-
Davalos, A.R.1
Coppe, J.-P.2
Campisi, J.3
Desprez, P.-Y.4
-
99
-
-
84924908626
-
Melanoma expression of matrix metalloproteinase-23 is associated with blunted tumor immunity and poor responses to immunotherapy
-
Moogk D., da Silva I.P., Ma M.W., Friedman E.B., de Miera E.V.-S., Darvishian F., et al. Melanoma expression of matrix metalloproteinase-23 is associated with blunted tumor immunity and poor responses to immunotherapy. J. Transl. Med. 2014, 12. 10.1186/s12967-014-0342-7.
-
(2014)
J. Transl. Med.
, vol.12
-
-
Moogk, D.1
da Silva, I.P.2
Ma, M.W.3
Friedman, E.B.4
de Miera, E.V.-S.5
Darvishian, F.6
-
100
-
-
84871709325
-
Aging is associated with increased activities of matrix metalloproteinase-2 and -9 in tenocytes
-
Yu T.-Y., Pang J.-H.S., Wu K.P.-H., Chen M.J.-L., Chen C.-H., Tsai W.-C. Aging is associated with increased activities of matrix metalloproteinase-2 and -9 in tenocytes. BMC Musculoskelet. Disord. 2013, 14:2. 10.1186/1471-2474-14-2.
-
(2013)
BMC Musculoskelet. Disord.
, vol.14
, pp. 2
-
-
Yu, T.-Y.1
Pang, J.-H.S.2
Wu, K.P.-H.3
Chen, M.J.-L.4
Chen, C.-H.5
Tsai, W.-C.6
-
101
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
Pardoll D.M. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 2012, 12:252-264. 10.1038/nrc3239.
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 252-264
-
-
Pardoll, D.M.1
-
102
-
-
37249009271
-
Motif module map reveals enforcement of aging by continual NF-kappaB activity
-
Adler A.S., Sinha S., Kawahara T.L.A., Zhang J.Y., Segal E., Chang H.Y. Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev. 2007, 21:3244-3257. 10.1101/gad.1588507.
-
(2007)
Genes Dev.
, vol.21
, pp. 3244-3257
-
-
Adler, A.S.1
Sinha, S.2
Kawahara, T.L.A.3
Zhang, J.Y.4
Segal, E.5
Chang, H.Y.6
-
103
-
-
84856090875
-
Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock
-
Rando T.A., Chang H.Y. Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell 2012, 148:46-57. 10.1016/j.cell.2012.01.003.
-
(2012)
Cell
, vol.148
, pp. 46-57
-
-
Rando, T.A.1
Chang, H.Y.2
-
104
-
-
84863550186
-
NF-κB inhibition delays DNA damage-induced senescence and aging in mice
-
Tilstra J.S., Robinson A.R., Wang J., Gregg S.Q., Clauson C.L., Reay D.P., et al. NF-κB inhibition delays DNA damage-induced senescence and aging in mice. J. Clin. Invest. 2012, 122:2601-2612. 10.1172/JCI45785.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 2601-2612
-
-
Tilstra, J.S.1
Robinson, A.R.2
Wang, J.3
Gregg, S.Q.4
Clauson, C.L.5
Reay, D.P.6
-
105
-
-
80054789761
-
Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity
-
Chien Y., Scuoppo C., Wang X., Fang X., Balgley B., Bolden J.E., et al. Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. Genes Dev. 2011, 25:2125-2136. 10.1101/gad.17276711.
-
(2011)
Genes Dev.
, vol.25
, pp. 2125-2136
-
-
Chien, Y.1
Scuoppo, C.2
Wang, X.3
Fang, X.4
Balgley, B.5
Bolden, J.E.6
-
106
-
-
84938751873
-
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
-
Laberge R.-M., Sun Y., Orjalo A.V., Patil C.K., Freund A., Zhou L., et al. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat. Cell Biol. 2015, 17:1049-1061. 10.1038/ncb3195.
-
(2015)
Nat. Cell Biol.
, vol.17
, pp. 1049-1061
-
-
Laberge, R.-M.1
Sun, Y.2
Orjalo, A.V.3
Patil, C.K.4
Freund, A.5
Zhou, L.6
-
107
-
-
78650510609
-
MTOR: from growth signal integration to cancer, diabetes and ageing
-
Zoncu R., Sabatini D.M., Efeyan A. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 2011, 12:21-35. 10.1038/nrm3025.
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Sabatini, D.M.2
Efeyan, A.3
-
108
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
Xue W., Zender L., Miething C., Dickins R.A., Hernando E., Krizhanovsky V., et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007, 445:656-660. 10.1038/nature05529.
-
(2007)
Nature
, vol.445
, pp. 656-660
-
-
Xue, W.1
Zender, L.2
Miething, C.3
Dickins, R.A.4
Hernando, E.5
Krizhanovsky, V.6
-
109
-
-
49749145668
-
Senescence of activated stellate cells limits liver fibrosis
-
Krizhanovsky V., Yon M., Dickins R.A., Hearn S., Simon J., Miething C., et al. Senescence of activated stellate cells limits liver fibrosis. Cell 2008, 134:657-667. 10.1016/j.cell.2008.06.049.
-
(2008)
Cell
, vol.134
, pp. 657-667
-
-
Krizhanovsky, V.1
Yon, M.2
Dickins, R.A.3
Hearn, S.4
Simon, J.5
Miething, C.6
-
110
-
-
84905741423
-
Stem cell aging: mechanisms, regulators and therapeutic opportunities
-
Oh J., Lee Y.D., Wagers A.J. Stem cell aging: mechanisms, regulators and therapeutic opportunities. Nat. Med. 2014, 20:870-880. 10.1038/nm.3651.
-
(2014)
Nat. Med.
, vol.20
, pp. 870-880
-
-
Oh, J.1
Lee, Y.D.2
Wagers, A.J.3
-
111
-
-
0022891340
-
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing
-
Dvorak H.F. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 1986, 315:1650-1659. 10.1056/NEJM198612253152606.
-
(1986)
N. Engl. J. Med.
, vol.315
, pp. 1650-1659
-
-
Dvorak, H.F.1
-
112
-
-
33746907388
-
Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma
-
Riss J., Khanna C., Koo S., Chandramouli G.V.R., Yang H.H., Hu Y., et al. Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma. Cancer Res. 2006, 66:7216-7224. 10.1158/0008-5472.CAN-06-0040.
-
(2006)
Cancer Res.
, vol.66
, pp. 7216-7224
-
-
Riss, J.1
Khanna, C.2
Koo, S.3
Chandramouli, G.V.R.4
Yang, H.H.5
Hu, Y.6
-
113
-
-
84864306922
-
Immune surveillance of senescent cells-biological significance in cancer- and non-cancer pathologies
-
bgs124
-
Hoenicke L., Zender L. Immune surveillance of senescent cells-biological significance in cancer- and non-cancer pathologies. Carcinogenesis 2012, bgs124. 10.1093/carcin/bgs124.
-
(2012)
Carcinogenesis
-
-
Hoenicke, L.1
Zender, L.2
-
114
-
-
38049023620
-
Changes in DNA repair during aging
-
Gorbunova V., Seluanov A., Mao Z., Hine C. Changes in DNA repair during aging. Nucleic Acids Res. 2007, 35:7466-7474. 10.1093/nar/gkm756.
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 7466-7474
-
-
Gorbunova, V.1
Seluanov, A.2
Mao, Z.3
Hine, C.4
-
116
-
-
84863974838
-
Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
-
Mao Z., Tian X., Van Meter M., Ke Z., Gorbunova V., Seluanov A. Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:11800-11805. 10.1073/pnas.1200583109.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 11800-11805
-
-
Mao, Z.1
Tian, X.2
Van Meter, M.3
Ke, Z.4
Gorbunova, V.5
Seluanov, A.6
-
117
-
-
84964063204
-
DNA double strand break repair via non-homologous end-joining
-
Davis A.J., Chen D.J. DNA double strand break repair via non-homologous end-joining. Transl. Cancer Res. 2013, 2:130-143. 10.3978/j.issn.2218-676X.2013.04.02.
-
(2013)
Transl. Cancer Res.
, vol.2
, pp. 130-143
-
-
Davis, A.J.1
Chen, D.J.2
-
118
-
-
2442704201
-
DNA end joining becomes less efficient and more error-prone during cellular senescence
-
Seluanov A., Mittelman D., Pereira-Smith O.M., Wilson J.H., Gorbunova V. DNA end joining becomes less efficient and more error-prone during cellular senescence. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:7624-7629. 10.1073/pnas.0400726101.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 7624-7629
-
-
Seluanov, A.1
Mittelman, D.2
Pereira-Smith, O.M.3
Wilson, J.H.4
Gorbunova, V.5
-
119
-
-
0041966056
-
Reversal of human cellular senescence: roles of the p53 and p16 pathways
-
Beauséjour C.M., Krtolica A., Galimi F., Narita M., Lowe S.W., Yaswen P., et al. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J. 2003, 22:4212-4222. 10.1093/emboj/cdg417.
-
(2003)
EMBO J.
, vol.22
, pp. 4212-4222
-
-
Beauséjour, C.M.1
Krtolica, A.2
Galimi, F.3
Narita, M.4
Lowe, S.W.5
Yaswen, P.6
-
120
-
-
29244432159
-
Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice
-
Busuttil R.A., Rubio M., Dollé M.E.T., Campisi J., Vijg J. Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice. DNA Repair 2006, 5:52-60. 10.1016/j.dnarep.2005.07.006.
-
(2006)
DNA Repair
, vol.5
, pp. 52-60
-
-
Busuttil, R.A.1
Rubio, M.2
Dollé, M.E.T.3
Campisi, J.4
Vijg, J.5
-
121
-
-
2942570699
-
Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture
-
Busuttil R.A., Rubio M., Dollé M.E.T., Campisi J., Vijg J. Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell 2003, 2:287-294.
-
(2003)
Aging Cell
, vol.2
, pp. 287-294
-
-
Busuttil, R.A.1
Rubio, M.2
Dollé, M.E.T.3
Campisi, J.4
Vijg, J.5
-
122
-
-
84926665024
-
SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner
-
Xu Z., Zhang L., Zhang W., Meng D., Zhang H., Jiang Y., et al. SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. Cell Cycle Georget. Tex. 2015, 14:269-276. 10.4161/15384101.2014.980641.
-
(2015)
Cell Cycle Georget. Tex.
, vol.14
, pp. 269-276
-
-
Xu, Z.1
Zhang, L.2
Zhang, W.3
Meng, D.4
Zhang, H.5
Jiang, Y.6
-
123
-
-
84938215105
-
Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes
-
Nagai K., Matsushita T., Matsuzaki T., Takayama K., Matsumoto T., Kuroda R., et al. Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes. Osteoarthr. Cartil. 2015, 23:1412-1420. 10.1016/j.joca.2015.03.024.
-
(2015)
Osteoarthr. Cartil.
, vol.23
, pp. 1412-1420
-
-
Nagai, K.1
Matsushita, T.2
Matsuzaki, T.3
Takayama, K.4
Matsumoto, T.5
Kuroda, R.6
-
124
-
-
84949498541
-
Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development
-
Wu Y., Chen L., Wang Y., Li W., Lin Y., Yu D., et al. Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development. Sci. Rep. 2015, 5. 10.1038/srep17602.
-
(2015)
Sci. Rep.
, vol.5
-
-
Wu, Y.1
Chen, L.2
Wang, Y.3
Li, W.4
Lin, Y.5
Yu, D.6
-
125
-
-
81855212708
-
Cancer: final act of senescence
-
Serrano M. Cancer: final act of senescence. Nature 2011, 479:481-482. 10.1038/479481a.
-
(2011)
Nature
, vol.479
, pp. 481-482
-
-
Serrano, M.1
-
126
-
-
84947648638
-
MTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation
-
Damsky W., Micevic G., Meeth K., Muthusamy V., Curley D.P., Santhanakrishnan M., et al. mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation. Cancer Cell 2015, 27:41-56. 10.1016/j.ccell.2014.11.014.
-
(2015)
Cancer Cell
, vol.27
, pp. 41-56
-
-
Damsky, W.1
Micevic, G.2
Meeth, K.3
Muthusamy, V.4
Curley, D.P.5
Santhanakrishnan, M.6
-
127
-
-
84861163796
-
Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis
-
Vredeveld L.C.W., Possik P.A., Smit M.A., Meissl K., Michaloglou C., Horlings H.M., et al. Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis. Genes Dev. 2012, 26:1055-1069. 10.1101/gad.187252.112.
-
(2012)
Genes Dev.
, vol.26
, pp. 1055-1069
-
-
Vredeveld, L.C.W.1
Possik, P.A.2
Smit, M.A.3
Meissl, K.4
Michaloglou, C.5
Horlings, H.M.6
-
128
-
-
84964284192
-
MTOR signaling in melanoma: oncogene-induced pseudo-senescence?
-
Souroullas G.P., Sharpless N.E. mTOR signaling in melanoma: oncogene-induced pseudo-senescence?. Cancer Cell 2015, 27:3-5. 10.1016/j.ccell.2014.12.005.
-
(2015)
Cancer Cell
, vol.27
, pp. 3-5
-
-
Souroullas, G.P.1
Sharpless, N.E.2
-
129
-
-
84923093613
-
Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells
-
Webster M.R., Xu M., Kinzler K.A., Kaur A., Appleton J., O'Connell M.P., et al. Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells. Pigment Cell Melanoma Res. 2015, 28:184-195. 10.1111/pcmr.12330.
-
(2015)
Pigment Cell Melanoma Res.
, vol.28
, pp. 184-195
-
-
Webster, M.R.1
Xu, M.2
Kinzler, K.A.3
Kaur, A.4
Appleton, J.5
O'Connell, M.P.6
-
130
-
-
50549087736
-
Growth stimulation leads to cellular senescence when the cell cycle is blocked
-
Demidenko Z.N., Blagosklonny M.V. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle Georget. Tex. 2008, 7:3355-3361.
-
(2008)
Cell Cycle Georget. Tex.
, vol.7
, pp. 3355-3361
-
-
Demidenko, Z.N.1
Blagosklonny, M.V.2
-
131
-
-
84865173843
-
Hypoxia suppresses conversion from proliferative arrest to cellular senescence
-
Leontieva O.V., Natarajan V., Demidenko Z.N., Burdelya L.G., Gudkov A.V., Blagosklonny M.V. Hypoxia suppresses conversion from proliferative arrest to cellular senescence. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:13314-13318. 10.1073/pnas.1205690109.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 13314-13318
-
-
Leontieva, O.V.1
Natarajan, V.2
Demidenko, Z.N.3
Burdelya, L.G.4
Gudkov, A.V.5
Blagosklonny, M.V.6
-
132
-
-
84929287721
-
ATM couples replication stress and metabolic reprogramming during cellular senescence
-
Aird K.M., Worth A.J., Snyder N.W., Lee J.V., Sivanand S., Liu Q., et al. ATM couples replication stress and metabolic reprogramming during cellular senescence. Cell Rep. 2015, 11:893-901. 10.1016/j.celrep.2015.04.014.
-
(2015)
Cell Rep.
, vol.11
, pp. 893-901
-
-
Aird, K.M.1
Worth, A.J.2
Snyder, N.W.3
Lee, J.V.4
Sivanand, S.5
Liu, Q.6
-
133
-
-
23244447893
-
Tumour biology: senescence in premalignant tumours
-
Collado M., Gil J., Efeyan A., Guerra C., Schuhmacher A.J., Barradas M., et al. Tumour biology: senescence in premalignant tumours. Nature 2005, 436:642. 10.1038/436642a.
-
(2005)
Nature
, vol.436
, pp. 642
-
-
Collado, M.1
Gil, J.2
Efeyan, A.3
Guerra, C.4
Schuhmacher, A.J.5
Barradas, M.6
-
134
-
-
84893397675
-
Senescent cells harbour features of the cancer epigenome
-
Cruickshanks H.A., McBryan T., Nelson D.M., VanderKraats N.D., Shah P.P., van Tuyn J., et al. Senescent cells harbour features of the cancer epigenome. Nat. Cell Biol. 2013, 15:1495-1506. 10.1038/ncb2879.
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 1495-1506
-
-
Cruickshanks, H.A.1
McBryan, T.2
Nelson, D.M.3
VanderKraats, N.D.4
Shah, P.P.5
van Tuyn, J.6
-
135
-
-
84876535364
-
Understanding immunosenescence to improve responses to vaccines
-
Goronzy J.J., Weyand C.M. Understanding immunosenescence to improve responses to vaccines. Nat. Immunol. 2013, 14:428-436. 10.1038/ni.2588.
-
(2013)
Nat. Immunol.
, vol.14
, pp. 428-436
-
-
Goronzy, J.J.1
Weyand, C.M.2
|