Erratum: The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing (Nature Cell Biology (2010) 12 DOI: 10.1038/ncb2070);The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

Nature Cell Biology

Volumn 12, Issue 7, 2010, Pages 676-685

  Jun, Joon Il ^a   Lau, Lester F ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYSTEINE RICH PROTEIN 61; MUTANT PROTEIN; PROTEIN P53; PROTEOHEPARAN SULFATE; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; RETINOBLASTOMA PROTEIN; VERY LATE ACTIVATION ANTIGEN 6;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL AGING; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; FIBROBLAST; GENE EXPRESSION; GRANULATION TISSUE; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; SKIN BIOPSY; SKIN FIBROSIS; WILD TYPE; WOUND HEALING;

MUS;

EID: 77954243065     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1210-1249     Document Type: Erratum

References (69)

1. Hayflick, L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37, 614-636 (1965).
2. Campisi, J. & d'Adda di Fagagna, F. Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 8, 729-740 (2007).
3. Collado, M., Blasco, M. A. & Serrano, M. Cellular senescence in cancer and aging. Cell 130, 223-233 (2007).
4. Braig, M. et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436, 660-665 (2005).
5. Chen, Z. et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436, 725-730 (2005).
6. Michaloglou, C. et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436, 720-724 (2005).
7. Kuilman, T. & Peeper, D. S. Senescence-messaging secretome: SMS-ing cellular stress. Nat. Rev. Cancer 9, 81-94 (2009).
8. Young, A. R. & Narita, M. SASP reflects senescence. EMBO Rep. 10, 228-230 (2009).
9. Kortlever, R. M., Higgins, P. J. & Bernards, R. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat. Cell Biol. 8, 877-884 (2006).
10. Kuilman, T. et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 133, 1019-1031 (2008).
11. Acosta, J. C. et al. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 133, 1006-1018 (2008).
12. Wajapeyee, N., Serra, R. W., Zhu, X., Mahalingam, M. & Green, M. R. Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132, 363-374 (2008).
13. Augert, A. et al. The M-type receptor PLA2R regulates senescence through the p53 pathway. EMBO Rep. 10, 271-277 (2009).
14. Coppe, J. P. et al. Senescence-associated secretory phenotypes reveal cell-nonau-tonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS. Biol. 6, 2853-2868 (2008).
15. Krizhanovsky, V. et al. Senescence of activated stellate cells limits liver fibrosis. Cell 134, 657-667 (2008).
16. Adams, P. D. Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol. Cell 36, 2-14 (2009).
17. Evan, G. I. & d'Adda di Fagagna, F. Cellular senescence: hot or what? Curr. Opin. Genet. Dev. 19, 25-31 (2009).
18. Chen, C.-C. & Lau, L. F. Functions and mechanisms of action of CCN matricellular proteins. Int. J. Biochem. Cell Biol. 41, 771-783 (2009).
19. Babic, A. M., Kireeva, M. L., Kolesnikova, T. V. & Lau, L. F. CYR61, product of a growth factor-inducible immediate-early gene, promotes angiogenesis and tumor growth. Proc. Natl Acad. Sci. USA. 95, 6355-6360 (1998).
20. Mo, F. E. et al. CYR61 (CCN1) is essential for placental development and vascular integrity. Mol. Cell Biol. 22, 8709-8720 (2002).
21. Mo, F.-E. & Lau, L. F. The matricellular protein CCN1 is essential for cardiac development. Circ. Res. 99, 961-969 (2006).
22. Chen, C.-C., Mo, F.-E. & Lau, L. F. The angiogenic inducer Cyr61 induces a genetic program for wound healing in human skin fibroblasts. J. Biol. Chem. 276, 47329-47337 (2001).
23. Stramer, B. M., Mori, R. & Martin, P. The inflammation-fibrosis link? A Jekyll and Hyde role for blood cells during wound repair. J. Invest. Dermatol. 127, 1009-1017 (2007).
24. Gurtner, G. C., Werner, S., Barrandon, Y. & Longaker, M. T. Wound repair and regeneration. Nature 453, 314-321 (2008).
25. 1 and cell surface heparan sulphate proteoglycans. J. Biol. Chem. 275, 24953-24961 (2000).
26. Leu, S.-J. et al. Targeted mutagenesis of the matricellular protein CCN1 (CYR61): selective inactivation of integrin aheparan sulphate proteoglycan coreceptor-mediated cellular activities. J. Biol. Chem. 279, 44177-44187 (2004).
27. Todorovic, V., Chen, C.-C, Hay, N. & Lau, L. F. The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. J. Cell Biol. 171, 559-568 (2005).
28. Chen, C.-C. et al. Cytotoxicity of TNFa is regulated by integrin-mediated matrix signaling. EMBO J. 26, 1257-1267 (2007).
29. Juric, V., Chen, C. C. & Lau, L. F. Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo. Mol. Cell Biol. 29, 3266-3279 (2009).
30. 3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells. J. Biol. Chem. 279, 44166-44176 (2004).
31. Mendez, M. V. et al. Fibroblasts cultured from venous ulcers display cellular characteristics of senescence. J. Vasc. Surg. 28, 876-883 (1998).
32. Stanley, A. & Osler, T. Senescence and the healing rates of venous ulcers. J. Vasc. Surg. 33, 1206-1211 (2001).
33. 1 binding site in the angiogenic Inducer CCN1 (CYR61). J. Biol. Chem. 278, 33801-33808 (2003).
34. Caspari, T. How to activate p53. Curr. Biol. 10, R315-R317 (2000).
35. Herbig, U., Jobling, W. A., Chen, B. P., Chen, D. J. & Sedivy, J. M. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14, 501-513 (2004).
36. Catalano, A., Rodilossi, S., Caprari, P., Coppola, V. & Procopio, A. 5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation. EMBO J. 24, 170-179 (2005).
37. Jacobs, J. J., Kieboom, K., Marino, S., DePinho, R. A. & van, L. M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397, 164-168 (1999).
38. Lu, T. & Finkel, T. Free radicals and senescence. Exp. Cell Res. 314, 1918-1922 (2008).
39. Chiarugi, P. Reactive oxygen species as mediators of cell adhesion. Ital. J. Biochem. 52, 28-32 (2003).
40. Lambeth, J. D., Kawahara, T. & Diebold, B. Regulation of Nox and Duox enzymatic activity and expression. Free Radic. Biol. Med. 43, 319-331 (2007).
41. Chen, C.-C, Chen, N. & Lau, L. F. The angiogenic factors Cyr61 and CTGF induce adhesive signaling in primary human skin fibroblasts. J. Biol. Chem. 276, 10443-10452 (2001).
42. Iwasa, H., Han, J. & Ishikawa, F. Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 8, 131-144 (2003). (Pubitemid 36511698)
43. Wen-Sheng, W. ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a. Oncogene 22, 955-963 (2003).
44. Tobiume, K. et al. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep. 2, 222-228 (2001).
45. Traore, K. et al. Redox-regulation of Erk1/2-directed phosphatase by reactive oxygen species: role in signaling TPA-induced growth arrest in ML-1 cells. J. Cell. Physiol. 216, 276-285 (2008).
46. Wynn, T. A. Cellular and molecular mechanisms of fibrosis. J. Pathol. 214, 199-210 (2008).
47. O'Brien, T. P., Yang, G. P., Sanders, L. & Lau, L. F. Expression of cyr61, a growth factor-inducible immediate-early gene. Mol. Cell Biol. 10, 3569-3577 (1990).
48. Iyer, V. R. et al. The transcriptional program in the response of human fibroblasts to serum. Science 283, 83-87 (1999).
49. Hanna, M. et al. Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyl-transferase. J. Biol. Chem. 284, 23125-23136 (2009).
50. Sisco, M. et al. Antisense inhibition of connective tissue growth factor (CTGF/CCN2) mRNA limits hypertrophic scarring without affecting wound healing in vivo. Wound Repair Regen. 16, 661-673 (2008).
51. Shi-wen, X., Leask, A. & Abraham, D. Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev. 19, 133-144 (2008).
52. Ushio-Fukai, M. Compartmentalization of redox signaling through NADPH oxidase-derived ROS. Antioxid. Redox. Signal. 11, 1289-1299 (2009).
53. Castro, P., Giri, D., Lamb, D. & Ittmann, M. Cellular senescence in the pathogenesis of benign prostatic hyperplasia. Prostate 55, 30-38 (2003).
54. Sakamoto, S. et al. Increased expression of CYR61, an extracellular matrix signaling protein, in human benign prostatic hyperplasia and its regulation by lysophosphatidic acid. Endocrinology 145, 2929-2940 (2004).
55. Quan, T. et al. Elevated cysteine-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skin. Am. J. Pathol. 169, 482-490 (2006).
56. Littlewood, T. D. & Bennett, M. R. Foxing smooth muscle cells: FOXO3a-CYR61 connection. Circ. Res. 100, 302-304 (2007).
57. Franzen, C. A. et al. The Matrix Protein CCN1 is Critical for Prostate Carcinoma Cell Proliferation and TRAIL-Induced Apoptosis. Mol. Cancer Res. 7, 1045-1055 (2009).
58. Chien, W. et al. Cyr61 suppresses growth of human endometrial cancer cells. J. Biol. Chem. 279, 53087-53096 (2004).
59. Wang, B., Ren, J., Ooi, L. L., Chong, S. S. & Lee, C. G. Dinucleotide repeats negatively modulate the promoter activity of Cyr61 and is unstable in hepatocellular carcinoma patients. Oncogene 24, 3999-4008 (2005).
60. Mori, A. et al. CYR61: a new measure of lung cancer outcome. Cancer Invest. 25, 738-741 (2007).
61. Dobroff, A. S. et al. Silencing cAMP-response element binding protein (CREB) identifies cysteine-rich protein 61 (CYR61) as a tumor suppressor gene in melanoma. J. Biol. Chem. 284, 26194-26206 (2009).
62. Debacq-Chainiaux, F., Erusalimsky, J. D., Campisi, J. & Toussaint, O. Protocols to detect senescence-associated beta-galactosidase (SA-β-gal) activity, a biomarker of senescent cells in culture and in vivo. Nat. Protoc. 4, 1798-1806 (2009).
63. Brummelkamp, T. R., Bernards, R. & Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550-553 (2002).
64. Schomber, T., Kalberer, C. P., Wodnar-Filipowicz, A. & Skoda, R. C. Gene silencing by lentivirus-mediated delivery of siRNA in human CD34+ cells. Blood 103, 4511-4513 (2004).
65. Sablina, A. A. et al. The antioxidant function of the p53 tumor suppressor. Nat. Med. 11, 1306-1313 (2005).
66. Narita, M. et al. A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 126, 503-514 (2006).
67. Luo, J. D., Wang, Y. Y., Fu, W. L., Wu, J. & Chen, A. F. Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice. Circulation 110, 2484-2493 (2004).
68. Wilson, L., Fathke, C. & Isik, F. Tissue dispersion and flow cytometry for the cellular analysis of wound healing. Biotechniques 32, 548-551 (2002).
69. Edwards, C. A. & O'Brien, J. Modified assay for determination of hydroxyproline in tissue hydrolyzate. Clinica Chimica Acta 104, 161-167 (1980).