Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation

Cell Death and Differentiation

Volumn 21, Issue 6, 2014, Pages 998-1012

  Ogrunc, M ^a   Di Micco, R ^a,e   Liontos, M ^b   Bombardelli, L ^a,f   Mione, M ^a,g   Fumagalli, M ^a,h   Gorgoulis, V G ^b,c   D'Adda Di Fagagna, F ^a,d  

^a FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^b UNIVERSITY OF ATHENS   (Greece)

^c BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^d CNR   (Italy)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f NETHERLANDS CANCER INSTITUTE   (Netherlands)

^g KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^h TTFactor Srl   (Italy)

Author keywords

DNA damage response (DDR); oncogene induced cellular senescence; pancreatic cancer; reactive oxygen species (ROS); zebrafish

Indexed keywords

RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; NOX4 PROTEIN, HUMAN; RAC1 PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER MODEL; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; MITOGENESIS; MOUSE; NONHUMAN; ONCOGENE; PANCREAS CANCER; PRIORITY JOURNAL; SENESCENCE; SIGNAL TRANSDUCTION; TRANSGENIC ZEBRAFISH; ANIMAL; DRUG EFFECTS; DRUG SCREENING; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PANCREAS TUMOR; PATHOLOGY; TOXICITY; TUMOR CELL LINE;

ANIMALIA; DANIO RERIO;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA DAMAGE; HUMANS; MICE; NADPH OXIDASE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PANCREATIC NEOPLASMS; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84899929645     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2014.16     Document Type: Article

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