Feedback between p21 and reactive oxygen production is necessary for cell senescence

Molecular Systems Biology

Volumn 6, Issue , 2010, Pages

  Passos, João F ^a   Nelson, Glyn ^a   Wang, Chunfang ^a   Richter, Torsten ^a   Simillion, Cedric ^a   Proctor, Carole J ^a   Miwa, Satomi ^a   Olijslagers, Sharon ^a   Hallinan, Jennifer ^a   Wipat, Anil ^a   Saretzki, Gabriele ^a   Rudolph, Karl Lenhard ^b   Kirkwood, Tom B L ^a   Von Zglinicki, Thomas ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

Aging; Cell senescence; DNA damage foci; Mitochondria; Reactive oxygen

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A; DNA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; CDKN1A PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL CYCLE ARREST; CELL GRANULE; COMPUTER MODEL; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; FEEDBACK SYSTEM; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MICROSCOPY; MITOCHONDRION; MOUSE; NONHUMAN; PHENOTYPE; POSITIVE FEEDBACK; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STOCHASTIC MODEL; TELOMERE; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL CYCLE; COMPUTER SIMULATION; CYTOCHEMISTRY; GENETICS; METABOLISM; METHODOLOGY; PHYSIOLOGY; STATISTICS; SYSTEMS BIOLOGY;

MAMMALIA;

CELL AGING; CELL CYCLE; COMPUTER SIMULATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; FEEDBACK, PHYSIOLOGICAL; HISTOCYTOCHEMISTRY; HUMANS; MITOCHONDRIA; MODELS, BIOLOGICAL; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STOCHASTIC PROCESSES; SYSTEMS BIOLOGY;

EID: 77149164811     PISSN: 17444292     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb.2010.5     Document Type: Article

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