Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes

Osteoarthritis and Cartilage

Volumn 23, Issue 8, 2015, Pages 1412-1420

  Nagai, K ^a   Matsushita, T ^a   Matsuzaki, T ^a   Takayama, K ^a   Matsumoto, T ^a   Kuroda, R ^a   Kurosaka, M ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Chondrocyte; DNA damage; Senescence; SIRT6; Sirtuin; Telomere dysfunction

Indexed keywords

BETA GALACTOSIDASE; COLLAGENASE 3; CYCLINE; DNA; HISTONE H2AX; INTERSTITIAL COLLAGENASE; MESSENGER RNA; PROTEIN P16; PROTEIN P21; SIRTUIN 6; H2AFX PROTEIN, HUMAN; HISTONE; SIRT6 PROTEIN, HUMAN; SIRTUIN;

ARTICLE; CARTILAGE CELL; CELL AGING; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; KNEE OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN ISOLATION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA ISOLATION; TELOMERE; TELOMERE DYSFUNCTION; WESTERN BLOTTING; CELL CULTURE; DEFICIENCY; GENETICS; METABOLISM; PATHOLOGY; UPREGULATION;

BETA-GALACTOSIDASE; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; CHONDROCYTES; DNA DAMAGE; HISTONES; HUMANS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; OSTEOARTHRITIS, KNEE; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; SIRTUINS; TELOMERE; UP-REGULATION;

EID: 84938215105     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.03.024     Document Type: Article

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