메뉴 건너뛰기




Volumn 23, Issue 11, 2012, Pages 2066-2075

Lamin B1 loss is a senescence-associated biomarker

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CASPASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LAMIN B; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN LAMIN B1; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

EID: 84861673276     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E11-10-0884     Document Type: Article
Times cited : (700)

References (76)
  • 1
    • 84857995837 scopus 로고    scopus 로고
    • Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation
    • Barascu A, Le Chalony C, Pennarun G, Genet D, Imam N, Lopez B, Bertrand P (2012). Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation. EMBO J 31, 1080-1094.
    • (2012) EMBO J , vol.31 , pp. 1080-1094
    • Barascu, A.1    Le Chalony, C.2    Pennarun, G.3    Genet, D.4    Imam, N.5    Lopez, B.6    Bertrand, P.7
  • 2
    • 0036145018 scopus 로고    scopus 로고
    • Multiple roles of the tumor suppressor p53
    • DOI 10.1097/00001622-200201000-00015
    • Bargonetti J, Manfredi JJ (2002). Multiple roles of the tumor suppressor p53. Curr Opin Oncol 14, 86-91. (Pubitemid 34072969)
    • (2002) Current Opinion in Oncology , vol.14 , Issue.1 , pp. 86-91
    • Bargonetti, J.1    Manfredi, J.J.2
  • 4
    • 77955385716 scopus 로고    scopus 로고
    • Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence
    • Benson EK, Lee SW, Aaronson SA (2010). Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence. J Cell Sci 123, 2605-2612.
    • (2010) J Cell Sci , vol.123 , pp. 2605-2612
    • Benson, E.K.1    Lee, S.W.2    Aaronson, S.A.3
  • 5
    • 33847342966 scopus 로고    scopus 로고
    • The nuclear lamina: Both a structural framework and a platform for genome organization
    • DOI 10.1111/j.1742-4658.2007.05694.x
    • Bridger JM, Foeger N, Kill IR, Herrmann H (2007). The nuclear lamina. Both a structural framework and a platform for genome organization. FEBS J 274, 1354-1361. (Pubitemid 46333745)
    • (2007) FEBS Journal , vol.274 , Issue.6 , pp. 1354-1361
    • Bridger, J.M.1    Foeger, N.2    Kill, I.R.3    Herrmann, H.4
  • 8
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: When bad things happen to good cells
    • DOI 10.1038/nrm2233, PII NRM2233
    • Campisi J, d'Adda di Fagagna F (2007). Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8, 729-740. (Pubitemid 47312822)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.9 , pp. 729-740
    • Campisi, J.1    D'Adda, D.F.F.2
  • 9
    • 72949096792 scopus 로고    scopus 로고
    • Senescence in tumours: Evidence from mice and humans
    • Collado M, Serrano M (2010). Senescence in tumours: evidence from mice and humans. Nat Rev Cancer 10, 51-57.
    • (2010) Nat Rev Cancer , vol.10 , pp. 51-57
    • Collado, M.1    Serrano, M.2
  • 10
    • 33749549246 scopus 로고    scopus 로고
    • Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence
    • DOI 10.1074/jbc.M603307200
    • Coppe JP, Kauser K, Campisi J, Beausejour CM (2006). Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem 281, 29568-29574. (Pubitemid 44536964)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.40 , pp. 29568-29574
    • Coppe, J.-P.1    Kauser, K.2    Campisi, J.3    Beausejour, C.M.4
  • 12
  • 13
    • 0028988138 scopus 로고
    • SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
    • Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF, Young PR, Lee JC (1995). SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364, 229-233.
    • (1995) FEBS Lett , vol.364 , pp. 229-233
    • Cuenda, A.1    Rouse, J.2    Doza, Y.N.3    Meier, R.4    Cohen, P.5    Gallagher, T.F.6    Young, P.R.7    Lee, J.C.8
  • 15
    • 41649097238 scopus 로고    scopus 로고
    • Nuclear lamins: Major factors in the structural organization and function of the nucleus and chromatin
    • DOI 10.1101/gad.1652708
    • Dechat T, Pfleghaar K, Sengupta K, Shimi T, Shumaker DK, Solimando L, Goldman RD (2008). Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin. Genes Dev 22, 832-853. (Pubitemid 351482836)
    • (2008) Genes and Development , vol.22 , Issue.7 , pp. 832-853
    • Dechat, T.1    Pfleghaar, K.2    Sengupta, K.3    Shimi, T.4    Shumaker, D.K.5    Solimando, L.6    Goldman, R.D.7
  • 16
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri GP et al. (1995). A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92, 9363-9367.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9363-9367
    • Dimri, G.P.1
  • 17
    • 34547625742 scopus 로고    scopus 로고
    • Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin
    • DOI 10.1158/0008-5472.CAN-07-0200
    • Efeyan A, Ortega-Molina A, Velasco-Miguel S, Herranz D, Vassilev LT, Serrano M (2007). Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin. Cancer Res 67, 7350-7357. (Pubitemid 47206565)
    • (2007) Cancer Research , vol.67 , Issue.15 , pp. 7350-7357
    • Efeyan, A.1    Ortega-Molina, A.2    Velasco-Miguel, S.3    Herranz, D.4    Vassilev, L.T.5    Serrano, M.6
  • 20
    • 77952105389 scopus 로고    scopus 로고
    • Inflammatory networks during cellular senescence: Causes and consequences
    • Freund A, Orjalo A, Desprez PY, Campisi J (2010). Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med 16, 238-248.
    • (2010) Trends Mol Med , vol.16 , pp. 238-248
    • Freund, A.1    Orjalo, A.2    Desprez, P.Y.3    Campisi, J.4
  • 21
    • 79955017452 scopus 로고    scopus 로고
    • p38 MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
    • Freund A, Patil CK, Campisi J (2011). p38 MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J 30, 1536-1548.
    • (2011) EMBO J , vol.30 , pp. 1536-1548
    • Freund, A.1    Patil, C.K.2    Campisi, J.3
  • 23
    • 0018840796 scopus 로고
    • The nuclear envelope lamina is reversibly depolymerized during mitosis
    • Gerace L, Blobel G (1980). The nuclear envelope lamina is reversibly depolymerized during mitosis. Cell 19, 277-287. (Pubitemid 10154232)
    • (1980) Cell , vol.19 , Issue.1 , pp. 277-287
    • Gerace, L.1    Blobel, G.2
  • 25
    • 0035694237 scopus 로고    scopus 로고
    • Identification of essential genes in cultured mammalian cells using small interfering RNAs
    • Harborth J, Elbashir SM, Bechert K, Tuschl T, Weber K (2001). Identification of essential genes in cultured mammalian cells using small interfering RNAs. J Cell Sci 114, 4557-4565. (Pubitemid 34086890)
    • (2001) Journal of Cell Science , vol.114 , Issue.24 , pp. 4557-4565
    • Harborth, J.1    Elbashir, S.M.2    Bechert, K.3    Tuschl, T.4    Weber, K.5
  • 26
    • 0345099455 scopus 로고    scopus 로고
    • Cellular senescence, an unpopular yet trustworthy tumor suppressor mechanism
    • Ishikawa F (2003). Cellular senescence, an unpopular yet trustworthy tumor suppressor mechanism. Cancer Sci 94, 944-947.
    • (2003) Cancer Sci , vol.94 , pp. 944-947
    • Ishikawa, F.1
  • 27
    • 0345932931 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway
    • DOI 10.1046/j.1365-2443.2003.00620.x
    • Iwasa H, Han J, Ishikawa F (2003). Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 8, 131-144. (Pubitemid 36511698)
    • (2003) Genes to Cells , vol.8 , Issue.2 , pp. 131-144
    • Iwasa, H.1    Han, J.2    Ishikawa, F.3
  • 28
    • 33846090789 scopus 로고    scopus 로고
    • Accumulation of senescent cells in mitotic tissue of aging primates
    • DOI 10.1016/j.mad.2006.11.008, PII S0047637406002417, Functional Genomics of Aging III
    • Jeyapalan JC, Ferreira M, Sedivy JM, Herbig U (2007). Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev 128, 36-44. (Pubitemid 46073058)
    • (2007) Mechanisms of Ageing and Development , vol.128 , Issue.1 , pp. 36-44
    • Jeyapalan, J.C.1    Ferreira, M.2    Sedivy, J.M.3    Herbig, U.4
  • 29
    • 45449084795 scopus 로고    scopus 로고
    • Cellular senescence and organismal aging
    • Jeyapalan JC, Sedivy JM (2008). Cellular senescence and organismal aging. Mech Ageing Dev 129, 467-474.
    • (2008) Mech Ageing Dev , vol.129 , pp. 467-474
    • Jeyapalan, J.C.1    Sedivy, J.M.2
  • 30
    • 77954243065 scopus 로고    scopus 로고
    • The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
    • Jun JI, Lau LF (2010). The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol 12, 676-685.
    • (2010) Nat Cell Biol , vol.12 , pp. 676-685
    • Jun, J.I.1    Lau, L.F.2
  • 32
    • 27344454003 scopus 로고    scopus 로고
    • Caspase-3 is required in the apoptotic disintegration of the nuclear matrix
    • DOI 10.1016/j.yexcr.2005.08.006, PII S0014482705003836
    • Kivinen K, Kallajoki M, Taimen P (2005). Caspase-3 is required in the apoptotic disintegration of the nuclear matrix. Exp Cell Res 311, 62-73. (Pubitemid 41527175)
    • (2005) Experimental Cell Research , vol.311 , Issue.1 , pp. 62-73
    • Kivinen, K.1    Kallajoki, M.2    Taimen, P.3
  • 34
    • 49749145668 scopus 로고    scopus 로고
    • Senescence of activated stellate cells limits liver fibrosis. Cell 134, 657-667.Krohne G, Benavente R (1986). The nuclear lamins. A multigene family of proteins in evolution and differentiation
    • Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, Yee H, Zender L, Lowe SW (2008). Senescence of activated stellate cells limits liver fibrosis. Cell 134, 657-667.Krohne G, Benavente R (1986). The nuclear lamins. A multigene family of proteins in evolution and differentiation. Exp Cell Res 162, 1-10.
    • (2008) Exp Cell Res , vol.162 , pp. 1-10
    • Krizhanovsky, V.1    Yon, M.2    Dickins, R.A.3    Hearn, S.4    Simon, J.5    Miething, C.6    Yee, H.7    Zender, L.8    Lowe, S.W.9
  • 38
    • 66449084405 scopus 로고    scopus 로고
    • p38alpha and p38gamma mediate oncogenic Ras-induced senescence through differential mechanisms
    • Kwong J, Hong L, Liao R, Deng Q, Han J, Sun P (2009). p38alpha and p38gamma mediate oncogenic Ras-induced senescence through differential mechanisms. J Biol Chem 284, 11237-11246.
    • (2009) J Biol Chem , vol.284 , pp. 11237-11246
    • Kwong, J.1    Hong, L.2    Liao, R.3    Deng, Q.4    Han, J.5    Sun, P.6
  • 39
    • 79952691843 scopus 로고    scopus 로고
    • The p53 inducing drug dosage may determine quiescence or senescence
    • Albany NY
    • Lane DP, Verma C, Fang CC (2010). The p53 inducing drug dosage may determine quiescence or senescence. Aging (Albany NY) 2, 748.
    • (2010) Aging , vol.2 , pp. 748
    • Lane, D.P.1    Verma, C.2    Fang, C.C.3
  • 42
    • 79952622680 scopus 로고    scopus 로고
    • PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation
    • Lee JJ, Kim BC, Park MJ, Lee YS, Kim YN, Lee BL, Lee JS (2010). PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation. Cell Death Differ 18, 666-677.
    • (2010) Cell Death Differ , vol.18 , pp. 666-677
    • Lee, J.J.1    Kim, B.C.2    Park, M.J.3    Lee, Y.S.4    Kim, Y.N.5    Lee, B.L.6    Lee, J.S.7
  • 43
    • 0027257461 scopus 로고
    • Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C
    • Lin F, Worman HJ (1993). Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C. J Biol Chem 268, 16321-16326. (Pubitemid 23229934)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.22 , pp. 16321-16326
    • Lin, F.1    Worman, H.J.2
  • 44
    • 43049163718 scopus 로고    scopus 로고
    • Free radicals and senescence
    • Lu T, Finkel T (2008). Free radicals and senescence. Exp Cell Res 314, 1918-1922.
    • (2008) Exp Cell Res , vol.314 , pp. 1918-1922
    • Lu, T.1    Finkel, T.2
  • 45
    • 33846128155 scopus 로고    scopus 로고
    • The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
    • DOI 10.1101/gad.1487307
    • Mallette FA, Gaumont-Leclerc M-F, Ferbeyre G (2007). The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence. Genes Dev 21, 43-48. (Pubitemid 46089705)
    • (2007) Genes and Development , vol.21 , Issue.1 , pp. 43-48
    • Mallette, F.A.1    Gaumont-Leclerc, M.-F.2    Ferbeyre, G.3
  • 48
    • 0037667702 scopus 로고    scopus 로고
    • Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    • DOI 10.1016/S0092-8674(03)00401-X
    • Narita M, Nunez S, Heard E, Narita M, Lin AW, Hearn SA, Spector DL, Hannon GJ, Lowe SW (2003). Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113, 703-716. (Pubitemid 36724935)
    • (2003) Cell , vol.113 , Issue.6 , pp. 703-716
    • Narita, M.1    Nunez, S.2    Heard, E.3    Narita, M.4    Lin, A.W.5    Hearn, S.A.6    Spector, D.L.7    Hannon, G.J.8    Lowe, S.W.9
  • 49
    • 14844356354 scopus 로고
    • Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei
    • Neamati N, Fernandez A, Wright S, Kiefer J, McConkey DJ (1995). Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei. J Immunol 154, 3788-3795.
    • (1995) J Immunol , vol.154 , pp. 3788-3795
    • Neamati, N.1    Fernandez, A.2    Wright, S.3    Kiefer, J.4    McConkey, D.J.5
  • 50
    • 7044231343 scopus 로고    scopus 로고
    • INK4a-RB pathway: Molecular link between cellular senescence and tumor suppression
    • DOI 10.2152/jmi.51.146
    • Ohtani N, Yamakoshi K, Takahashi A, Hara E (2004). The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression. J Med Invest 51, 146-153. (Pubitemid 39610908)
    • (2004) Journal of Medical Investigation , vol.51 , Issue.3-4 , pp. 146-153
    • Ohtani, N.1    Yamakoshi, K.2    Takahashi, A.3    Hara, E.4
  • 51
    • 76749101144 scopus 로고    scopus 로고
    • Real-time in vivo imaging of p16 gene expression: A new approach to study senescence stress signaling in living animals
    • Ohtani N, Yamakoshi K, Takahashi A, Hara E (2010). Real-time in vivo imaging of p16 gene expression: a new approach to study senescence stress signaling in living animals. Cell Div 5, 1.
    • (2010) Cell Div , vol.5 , pp. 1
    • Ohtani, N.1    Yamakoshi, K.2    Takahashi, A.3    Hara, E.4
  • 52
    • 0037068753 scopus 로고    scopus 로고
    • Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion
    • Olsen CL, Gardie B, Yaswen P, Stampfer MR (2002). Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion. Oncogene 21, 6328-6339.
    • (2002) Oncogene , vol.21 , pp. 6328-6339
    • Olsen, C.L.1    Gardie, B.2    Yaswen, P.3    Stampfer, M.R.4
  • 53
    • 0035079864 scopus 로고    scopus 로고
    • Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas
    • DOI 10.1053/hupa.2001.22747
    • Paradis V, Youssef N, Dargere D, Ba N, Bonvoust F, Bedossa P (2001). Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas. Hum Pathol 32, 327-332. (Pubitemid 32246808)
    • (2001) Human Pathology , vol.32 , Issue.3 , pp. 327-332
    • Paradis, V.1    Youssef, N.2    Dargere, D.3    Ba, N.4    Bonvoust, F.5    Deschatrette, J.6    Bedossa, P.7
  • 54
    • 13944260728 scopus 로고    scopus 로고
    • Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation
    • DOI 10.1242/jcs.01635
    • Parrinello S, Coppe J-P, Krtolica A, Campisi J (2005). Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci 118, 485-496. (Pubitemid 40310116)
    • (2005) Journal of Cell Science , vol.118 , Issue.3 , pp. 485-496
    • Parrinello, S.1    Coppe, J.-P.2    Krtolica, A.3    Campisi, J.4
  • 55
    • 0042195820 scopus 로고    scopus 로고
    • Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
    • DOI 10.1038/ncb1024
    • Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J (2003). Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol 5, 741-747. (Pubitemid 36986782)
    • (2003) Nature Cell Biology , vol.5 , Issue.8 , pp. 741-747
    • Parrinello, S.1    Samper, E.2    Krtolica, A.3    Goldstein, J.4    Melov, S.5    Campisi, J.6
  • 56
    • 77149164811 scopus 로고    scopus 로고
    • Feedback between p21 and reactive oxygen production is necessary for cell senescence
    • Passos JF et al. (2010). Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol Syst Biol 6, 347.
    • (2010) Mol Syst Biol , vol.6 , pp. 347
    • Passos, J.F.1
  • 57
    • 79953033356 scopus 로고    scopus 로고
    • Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence
    • Rai P, Young JJ, Burton DG, Giribaldi MG, Onder TT, Weinberg RA (2011). Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence. Oncogene 30, 1489-1496.
    • (2011) Oncogene , vol.30 , pp. 1489-1496
    • Rai, P.1    Young, J.J.2    Burton, D.G.3    Giribaldi, M.G.4    Onder, T.T.5    Weinberg, R.A.6
  • 58
    • 0030051528 scopus 로고    scopus 로고
    • MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
    • Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ (1996). MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol Cell Biol 16, 1247-1255.
    • (1996) Mol Cell Biol , vol.16 , pp. 1247-1255
    • Raingeaud, J.1    Whitmarsh, A.J.2    Barrett, T.3    Derijard, B.4    Davis, R.J.5
  • 59
    • 0030465544 scopus 로고    scopus 로고
    • Lamin proteolysis facilitates nuclear events during apoptosis
    • Rao L, Perez D, White E (1996). Lamin proteolysis facilitates nuclear events during apoptosis. J Cell Biol 135, 1441-1455.
    • (1996) J Cell Biol , vol.135 , pp. 1441-1455
    • Rao, L.1    Perez, D.2    White, E.3
  • 60
    • 40749122641 scopus 로고    scopus 로고
    • Transcriptional repression mediated by repositioning of genes to the nuclear lamina
    • DOI 10.1038/nature06727, PII NATURE06727
    • Reddy KL, Zullo JM, Bertolino E, Singh H (2008). Transcriptional repression mediated by repositioning of genes to the nuclear lamina. Nature 452, 243-247. (Pubitemid 351380248)
    • (2008) Nature , vol.452 , Issue.7184 , pp. 243-247
    • Reddy, K.L.1    Zullo, J.M.2    Bertolino, E.3    Singh, H.4
  • 61
    • 79951912532 scopus 로고    scopus 로고
    • Four faces of cellular senescence
    • Rodier F, Campisi J (2011). Four faces of cellular senescence. J Cell Biol 192, 547-556.
    • (2011) J Cell Biol , vol.192 , pp. 547-556
    • Rodier, F.1    Campisi, J.2
  • 63
    • 33646745137 scopus 로고    scopus 로고
    • Lamin A-dependent nuclear defects in human aging
    • Scaffidi P, Misteli T (2006). Lamin A-dependent nuclear defects in human aging. Science 312, 1059-1063.
    • (2006) Science , vol.312 , pp. 1059-1063
    • Scaffidi, P.1    Misteli, T.2
  • 64
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16(INK4a)
    • DOI 10.1016/S0092-8674(00)81902-9
    • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997). Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602. (Pubitemid 27152402)
    • (1997) Cell , vol.88 , Issue.5 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 65
    • 58049195492 scopus 로고    scopus 로고
    • The A- and B-type nuclear lamin networks: Microdomains involved in chromatin organization and transcription
    • Shimi T et al. (2008). The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription. Genes Dev 22, 3409-3421.
    • (2008) Genes Dev , vol.22 , pp. 3409-3421
    • Shimi, T.1
  • 68
    • 10944257464 scopus 로고    scopus 로고
    • Human cell senescence as a DNA damage response
    • von Zglinicki TV (2005). Human cell senescence as a DNA damage response. Mech Ageing Dev 126, 111-117.
    • (2005) Mech Ageing Dev , vol.126 , pp. 111-117
    • Von Zglinicki, T.V.1
  • 70
    • 0036242247 scopus 로고    scopus 로고
    • Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence
    • DOI 10.1128/MCB.22.10.3389-3403.2002
    • Wang W, Chen JX, Liao R, Deng Q, Zhou JJ, Huang S, Sun P (2002). Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol Cell Biol 22, 3389-3403. (Pubitemid 34453979)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.10 , pp. 3389-3403
    • Wang, W.1    Chen, J.X.2    Liao, R.3    Deng, Q.4    Zhou, J.J.5    Huang, S.6    Sun, P.7
  • 73
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • DOI 10.1038/nature05529, PII NATURE05529
    • Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V, Cordon-Cardo C, Lowe SW (2007). Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445, 656-660. (Pubitemid 46232886)
    • (2007) Nature , vol.445 , Issue.7128 , pp. 656-660
    • Xue, W.1    Zender, L.2    Miething, C.3    Dickins, R.A.4    Hernando, E.5    Krizhanovsky, V.6    Cordon-Cardo, C.7    Lowe, S.W.8
  • 75
    • 33947236204 scopus 로고    scopus 로고
    • Molecular dissection of formation of senescence-associated heterochromatin foci
    • Zhang R, Chen W, Adams PD (2007). Molecular dissection of formation of senescence-associated heterochromatin foci. Mol Cell Biol 27, 2343-2358.
    • (2007) Mol Cell Biol , vol.27 , pp. 2343-2358
    • Zhang, R.1    Chen, W.2    Adams, P.D.3
  • 76
    • 0030612349 scopus 로고    scopus 로고
    • Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging
    • Zindy F, Quelle DE, Roussel MF, Sherr CJ (1997). Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 15, 203-211.
    • (1997) Oncogene , vol.15 , pp. 203-211
    • Zindy, F.1    Quelle, D.E.2    Roussel, M.F.3    Sherr, C.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.