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Volumn 148, Issue 1-2, 2012, Pages 46-57

Aging, rejuvenation, and epigenetic reprogramming: Resetting the aging clock

Author keywords

[No Author keywords available]

Indexed keywords

AGING; CELL DIFFERENTIATION; EMBRYONIC STEM CELL; ENVIRONMENTAL FACTOR; EPIGENETICS; HEREDITY; MOLECULAR CLOCK; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REJUVENATION; REVIEW; SENESCENCE; TISSUE REGENERATION;

EID: 84856090875     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2012.01.003     Document Type: Review
Times cited : (419)

References (113)
  • 1
    • 37249009271 scopus 로고    scopus 로고
    • Motif module map reveals enforcement of aging by continual NF-κB activity
    • DOI 10.1101/gad.1588507
    • A.S. Adler, S. Sinha, T.L. Kawahara, J.Y. Zhang, E. Segal, and H.Y. Chang Motif module map reveals enforcement of aging by continual NF-kappaB activity Genes Dev. 21 2007 3244 3257 (Pubitemid 350277752)
    • (2007) Genes and Development , vol.21 , Issue.24 , pp. 3244-3257
    • Adler, A.S.1    Sinha, S.2    Kawahara, T.L.A.3    Zhang, J.Y.4    Segal, E.5    Chang, H.Y.6
  • 3
    • 66149138053 scopus 로고    scopus 로고
    • The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence
    • K. Agger, P.A. Cloos, L. Rudkjaer, K. Williams, G. Andersen, J. Christensen, and K. Helin The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence Genes Dev. 23 2009 1171 1176
    • (2009) Genes Dev. , vol.23 , pp. 1171-1176
    • Agger, K.1    Cloos, P.A.2    Rudkjaer, L.3    Williams, K.4    Andersen, G.5    Christensen, J.6    Helin, K.7
  • 4
    • 10644282295 scopus 로고    scopus 로고
    • The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
    • DOI 10.1101/gad.1255404
    • J. Apfeld, G. O'Connor, T. McDonagh, P.S. DiStefano, and R. Curtis The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans Genes Dev. 18 2004 3004 3009 (Pubitemid 39658169)
    • (2004) Genes and Development , vol.18 , Issue.24 , pp. 3004-3009
    • Apfeld, J.1    O'Connor, G.2    McDonagh, T.3    DiStefano, P.S.4    Curtis, R.5
  • 8
    • 78049402859 scopus 로고    scopus 로고
    • Molecular signals of epigenetic states
    • R. Bonasio, S. Tu, and D. Reinberg Molecular signals of epigenetic states Science 330 2010 612 616
    • (2010) Science , vol.330 , pp. 612-616
    • Bonasio, R.1    Tu, S.2    Reinberg, D.3
  • 9
    • 34547924424 scopus 로고    scopus 로고
    • Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
    • DOI 10.1126/science.1144090
    • A.S. Brack, M.J. Conboy, S. Roy, M. Lee, C.J. Kuo, C. Keller, and T.A. Rando Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis Science 317 2007 807 810 (Pubitemid 47257918)
    • (2007) Science , vol.317 , Issue.5839 , pp. 807-810
    • Brack, A.S.1    Conboy, M.J.2    Roy, S.3    Lee, M.4    Kuo, C.J.5    Keller, C.6    Rando, T.A.7
  • 10
    • 0000042464 scopus 로고
    • Transplantation of Living Nuclei from Blastula Cells into Enucleated Frogs' Eggs
    • R. Briggs, and T.J. King Transplantation of Living Nuclei From Blastula Cells into Enucleated Frogs' Eggs Proc. Natl. Acad. Sci. USA 38 1952 455 463
    • (1952) Proc. Natl. Acad. Sci. USA , vol.38 , pp. 455-463
    • Briggs, R.1    King, T.J.2
  • 11
    • 84981012984 scopus 로고
    • An improved method of parabiosis
    • E. Bunster, and R.K. Meyer An improved method of parabiosis Anat. Rec. 57 1933 339 343
    • (1933) Anat. Rec. , vol.57 , pp. 339-343
    • Bunster, E.1    Meyer, R.K.2
  • 13
    • 0029967424 scopus 로고    scopus 로고
    • Sheep cloned by nuclear transfer from a cultured cell line
    • DOI 10.1038/380064a0
    • K.H. Campbell, J. McWhir, W.A. Ritchie, and I. Wilmut Sheep cloned by nuclear transfer from a cultured cell line Nature 380 1996 64 66 (Pubitemid 26076237)
    • (1996) Nature , vol.380 , Issue.6569 , pp. 64-66
    • Campbell, K.H.S.1    McWhir, J.2    Ritchie, W.A.3    Wilmut, I.4
  • 14
    • 64949135819 scopus 로고    scopus 로고
    • Does damage to DNA and other macromolecules play a role in aging? if so, how?
    • J. Campisi, and J. Vijg Does damage to DNA and other macromolecules play a role in aging? If so, how? J. Gerontol. A Biol. Sci. Med. Sci. 64 2009 175 178
    • (2009) J. Gerontol. A Biol. Sci. Med. Sci. , vol.64 , pp. 175-178
    • Campisi, J.1    Vijg, J.2
  • 15
    • 0028975575 scopus 로고
    • Revival and identification of bacterial spores in 25- to 40-million-year-old Dominican amber
    • R.J. Cano, and M.K. Borucki Revival and identification of bacterial spores in 25- to 40-million-year-old Dominican amber Science 268 1995 1060 1064
    • (1995) Science , vol.268 , pp. 1060-1064
    • Cano, R.J.1    Borucki, M.K.2
  • 16
    • 47949097215 scopus 로고    scopus 로고
    • Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells
    • M.E. Carlson, M. Hsu, and I.M. Conboy Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells Nature 454 2008 528 532
    • (2008) Nature , vol.454 , pp. 528-532
    • Carlson, M.E.1    Hsu, M.2    Conboy, I.M.3
  • 18
    • 28844469898 scopus 로고    scopus 로고
    • Medicine: Increase in activity during calorie restriction requires Sirt1
    • DOI 10.1126/science.1118357
    • D. Chen, A.D. Steele, S. Lindquist, and L. Guarente Increase in activity during calorie restriction requires Sirt1 Science 310 2005 1641 (Pubitemid 41780779)
    • (2005) Science , vol.310 , Issue.5754 , pp. 1641
    • Chen, D.1    Steele, A.D.2    Lindquist, S.3    Guarente, L.4
  • 19
    • 75549090275 scopus 로고    scopus 로고
    • MTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
    • C. Chen, Y. Liu, Y. Liu, and P. Zheng mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells Sci. Signal. 2 2009 ra75
    • (2009) Sci. Signal. , vol.2 , pp. 75
    • Chen, C.1    Liu, Y.2    Liu, Y.3    Zheng, P.4
  • 20
    • 13944261231 scopus 로고    scopus 로고
    • Rejuvenation of aged progenitor cells by exposure to a young systemic environment
    • DOI 10.1038/nature03260
    • I.M. Conboy, M.J. Conboy, A.J. Wagers, E.R. Girma, I.L. Weissman, and T.A. Rando Rejuvenation of aged progenitor cells by exposure to a young systemic environment Nature 433 2005 760 764 (Pubitemid 40292986)
    • (2005) Nature , vol.433 , Issue.7027 , pp. 760-764
    • Conboy, I.M.1    Conboy, M.J.2    Wagers, A.J.3    Girma, E.R.4    Weismann, I.L.5    Rando, T.A.6
  • 21
    • 23944457397 scopus 로고    scopus 로고
    • Developmental Biology: Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells
    • DOI 10.1126/science.1116447
    • C.A. Cowan, J. Atienza, D.A. Melton, and K. Eggan Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells Science 309 2005 1369 1373 (Pubitemid 41209363)
    • (2005) Science , vol.309 , Issue.5739 , pp. 1369-1373
    • Cowan, C.A.1    Atienza, J.2    Melton, D.A.3    Eggan, K.4
  • 24
    • 34548644772 scopus 로고    scopus 로고
    • The Histone H3 Lysine-27 Demethylase Jmjd3 Links Inflammation to Inhibition of Polycomb-Mediated Gene Silencing
    • DOI 10.1016/j.cell.2007.08.019, PII S0092867407010823
    • F. De Santa, M.G. Totaro, E. Prosperini, S. Notarbartolo, G. Testa, and G. Natoli The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing Cell 130 2007 1083 1094 (Pubitemid 47410272)
    • (2007) Cell , vol.130 , Issue.6 , pp. 1083-1094
    • De Santa, F.1    Totaro, M.G.2    Prosperini, E.3    Notarbartolo, S.4    Testa, G.5    Natoli, G.6
  • 25
    • 65249121864 scopus 로고    scopus 로고
    • Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation
    • S. Dhawan, S.I. Tschen, and A. Bhushan Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation Genes Dev. 23 2009 906 911
    • (2009) Genes Dev. , vol.23 , pp. 906-911
    • Dhawan, S.1    Tschen, S.I.2    Bhushan, A.3
  • 26
    • 34249080596 scopus 로고    scopus 로고
    • Theoretical Analysis of Epigenetic Cell Memory by Nucleosome Modification
    • DOI 10.1016/j.cell.2007.02.053, PII S0092867407004588
    • I.B. Dodd, M.A. Micheelsen, K. Sneppen, and G. Thon Theoretical analysis of epigenetic cell memory by nucleosome modification Cell 129 2007 813 822 (Pubitemid 46802381)
    • (2007) Cell , vol.129 , Issue.4 , pp. 813-822
    • Dodd, I.B.1    Micheelsen, M.A.2    Sneppen, K.3    Thon, G.4
  • 27
    • 67650076211 scopus 로고    scopus 로고
    • The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting
    • M.E. Donohoe, S.S. Silva, S.F. Pinter, N. Xu, and J.T. Lee The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting Nature 460 2009 128 132
    • (2009) Nature , vol.460 , pp. 128-132
    • Donohoe, M.E.1    Silva, S.S.2    Pinter, S.F.3    Xu, N.4    Lee, J.T.5
  • 28
    • 77956362155 scopus 로고    scopus 로고
    • Protein homeostasis and aging in neurodegeneration
    • P.M. Douglas, and A. Dillin Protein homeostasis and aging in neurodegeneration J. Cell Biol. 190 2010 719 729
    • (2010) J. Cell Biol. , vol.190 , pp. 719-729
    • Douglas, P.M.1    Dillin, A.2
  • 29
    • 78049414227 scopus 로고    scopus 로고
    • Epigenetic reprogramming in plant and animal development
    • S. Feng, S.E. Jacobsen, and W. Reik Epigenetic reprogramming in plant and animal development Science 330 2010 622 627
    • (2010) Science , vol.330 , pp. 622-627
    • Feng, S.1    Jacobsen, S.E.2    Reik, W.3
  • 30
    • 50049116926 scopus 로고    scopus 로고
    • C. elegans dauer formation and the molecular basis of plasticity
    • N. Fielenbach, and A. Antebi C. elegans dauer formation and the molecular basis of plasticity Genes Dev. 22 2008 2149 2165
    • (2008) Genes Dev. , vol.22 , pp. 2149-2165
    • Fielenbach, N.1    Antebi, A.2
  • 31
    • 0013472626 scopus 로고
    • Parabiosis in physiological studies
    • J.C. Finerty Parabiosis in physiological studies Physiol. Rev. 32 1952 277 302
    • (1952) Physiol. Rev. , vol.32 , pp. 277-302
    • Finerty, J.C.1
  • 32
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span - From yeast to humans
    • L. Fontana, L. Partridge, and V.D. Longo Extending healthy life span - from yeast to humans Science 328 2010 321 326
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 34
    • 39049103917 scopus 로고    scopus 로고
    • Chromatin structure and the regulation of gene expression: The lessons of PEV in Drosophila
    • J.R. Girton, and K.M. Johansen Chromatin structure and the regulation of gene expression: the lessons of PEV in Drosophila Adv. Genet. 61 2008 1 43
    • (2008) Adv. Genet. , vol.61 , pp. 1-43
    • Girton, J.R.1    Johansen, K.M.2
  • 38
    • 0000331391 scopus 로고
    • Adult frogs derived from the nuclei of single somatic cells
    • J.B. Gurdon Adult frogs derived from the nuclei of single somatic cells Dev. Biol. 4 1962 256 273
    • (1962) Dev. Biol. , vol.4 , pp. 256-273
    • Gurdon, J.B.1
  • 39
    • 78649350746 scopus 로고    scopus 로고
    • The aging stress response
    • M.C. Haigis, and B.A. Yankner The aging stress response Mol. Cell 40 2010 333 344
    • (2010) Mol. Cell , vol.40 , pp. 333-344
    • Haigis, M.C.1    Yankner, B.A.2
  • 40
    • 78149487692 scopus 로고    scopus 로고
    • Pluripotency and cellular reprogramming: Facts, hypotheses, unresolved issues
    • J.H. Hanna, K. Saha, and R. Jaenisch Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues Cell 143 2010 508 525
    • (2010) Cell , vol.143 , pp. 508-525
    • Hanna, J.H.1    Saha, K.2    Jaenisch, R.3
  • 42
    • 34249672703 scopus 로고    scopus 로고
    • Biological aging is no longer an unsolved problem
    • DOI 10.1196/annals.1395.001, Biogerontology: Mechanisms and Interventions
    • L. Hayflick Biological aging is no longer an unsolved problem Ann. N Y Acad. Sci. 1100 2007 1 13 (Pubitemid 47092635)
    • (2007) Annals of the New York Academy of Sciences , vol.1100 , pp. 1-13
    • Hayflick, L.1
  • 44
    • 78649339069 scopus 로고    scopus 로고
    • Long noncoding RNA in genome regulation: Prospects and mechanisms
    • T. Hung, and H.Y. Chang Long noncoding RNA in genome regulation: prospects and mechanisms RNA Biol. 7 2010 582 585
    • (2010) RNA Biol. , vol.7 , pp. 582-585
    • Hung, T.1    Chang, H.Y.2
  • 47
    • 79955511101 scopus 로고    scopus 로고
    • Emerging models and paradigms for stem cell ageing
    • D.L. Jones, and T.A. Rando Emerging models and paradigms for stem cell ageing Nat. Cell Biol. 13 2011 506 512
    • (2011) Nat. Cell Biol. , vol.13 , pp. 506-512
    • Jones, D.L.1    Rando, T.A.2
  • 48
    • 0033214237 scopus 로고    scopus 로고
    • The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
    • DOI 10.1101/gad.13.19.2570
    • M. Kaeberlein, M. McVey, and L. Guarente The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms Genes Dev. 13 1999 2570 2580 (Pubitemid 29489648)
    • (1999) Genes and Development , vol.13 , Issue.19 , pp. 2570-2580
    • Kaeberlein, M.1    McVey, M.2    Guarente, L.3
  • 49
    • 3042648746 scopus 로고    scopus 로고
    • Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    • DOI 10.1016/j.cub.2004.03.059, PII S0960982204002386
    • P. Kapahi, B.M. Zid, T. Harper, D. Koslover, V. Sapin, and S. Benzer Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway Curr. Biol. 14 2004 885 890 (Pubitemid 38800910)
    • (2004) Current Biology , vol.14 , Issue.10 , pp. 885-890
    • Kapahi, P.1    Zid, B.M.2    Harper, T.3    Koslover, D.4    Sapin, V.5    Benzer, S.6
  • 50
    • 77952923018 scopus 로고    scopus 로고
    • Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age
    • A.L. Kauffman, J.M. Ashraf, M.R. Corces-Zimmerman, J.N. Landis, and C.T. Murphy Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age PLoS Biol. 8 2010 e1000372
    • (2010) PLoS Biol. , vol.8 , pp. 1000372
    • Kauffman, A.L.1    Ashraf, J.M.2    Corces-Zimmerman, M.R.3    Landis, J.N.4    Murphy, C.T.5
  • 52
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • C.J. Kenyon The genetics of ageing Nature 464 2010 504 512
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 53
    • 0030813398 scopus 로고    scopus 로고
    • Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    • DOI 10.1126/science.277.5328.942
    • K.D. Kimura, H.A. Tissenbaum, Y. Liu, and G. Ruvkun daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans Science 277 1997 942 946 (Pubitemid 27366677)
    • (1997) Science , vol.277 , Issue.5328 , pp. 942-946
    • Kimura, K.D.1    Tissenbaum, H.A.2    Liu, Y.3    Ruvkun, G.4
  • 54
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • DOI 10.1016/j.cell.2005.01.027
    • T.B. Kirkwood Understanding the odd science of aging Cell 120 2005 437 447 (Pubitemid 40269759)
    • (2005) Cell , vol.120 , Issue.4 , pp. 437-447
    • Kirkwood, T.B.L.1
  • 55
    • 77956238806 scopus 로고    scopus 로고
    • The connections between general and reproductive senescence and the evolutionary basis of menopause
    • T.B. Kirkwood, and D.P. Shanley The connections between general and reproductive senescence and the evolutionary basis of menopause Ann. N Y Acad. Sci. 1204 2010 21 29
    • (2010) Ann. N y Acad. Sci. , vol.1204 , pp. 21-29
    • Kirkwood, T.B.1    Shanley, D.P.2
  • 56
    • 79251498807 scopus 로고    scopus 로고
    • Protein homeostasis and aging: The importance of exquisite quality control
    • H. Koga, S. Kaushik, and A.M. Cuervo Protein homeostasis and aging: The importance of exquisite quality control Ageing Res. Rev. 10 2011 205 215
    • (2011) Ageing Res. Rev. , vol.10 , pp. 205-215
    • Koga, H.1    Kaushik, S.2    Cuervo, A.M.3
  • 58
    • 69349098834 scopus 로고    scopus 로고
    • Stem cells: The promises and perils of p53
    • V. Krizhanovsky, and S.W. Lowe Stem cells: The promises and perils of p53 Nature 460 2009 1085 1086
    • (2009) Nature , vol.460 , pp. 1085-1086
    • Krizhanovsky, V.1    Lowe, S.W.2
  • 60
    • 27744555810 scopus 로고    scopus 로고
    • Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs
    • DOI 10.1038/nature04120, PII N04120
    • N. Lee, C. Maurange, L. Ringrose, and R. Paro Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs Nature 438 2005 234 237 (Pubitemid 41599876)
    • (2005) Nature , vol.438 , Issue.7065 , pp. 234-237
    • Lee, N.1    Maurange, C.2    Ringrose, L.3    Paro, R.4
  • 63
    • 0034703217 scopus 로고    scopus 로고
    • Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
    • S.J. Lin, P.A. Defossez, and L. Guarente Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae Science 289 2000 2126 2128
    • (2000) Science , vol.289 , pp. 2126-2128
    • Lin, S.J.1    Defossez, P.A.2    Guarente, L.3
  • 64
    • 79955513612 scopus 로고    scopus 로고
    • Manifestations and mechanisms of stem cell aging
    • L. Liu, and T.A. Rando Manifestations and mechanisms of stem cell aging J. Cell Biol. 193 2011 257 266
    • (2011) J. Cell Biol. , vol.193 , pp. 257-266
    • Liu, L.1    Rando, T.A.2
  • 65
    • 77956261391 scopus 로고    scopus 로고
    • Recreating pluripotency?
    • K.M. Loh, and B. Lim Recreating pluripotency? Cell Stem Cell 7 2010 137 139
    • (2010) Cell Stem Cell , vol.7 , pp. 137-139
    • Loh, K.M.1    Lim, B.2
  • 66
    • 77957797819 scopus 로고    scopus 로고
    • TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance
    • S. Luo, G.A. Kleemann, J.M. Ashraf, W.M. Shaw, and C.T. Murphy TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance Cell 143 2010 299 312
    • (2010) Cell , vol.143 , pp. 299-312
    • Luo, S.1    Kleemann, G.A.2    Ashraf, J.M.3    Shaw, W.M.4    Murphy, C.T.5
  • 68
    • 78751662908 scopus 로고    scopus 로고
    • The Polycomb complex PRC2 and its mark in life
    • R. Margueron, and D. Reinberg The Polycomb complex PRC2 and its mark in life Nature 469 2011 343 349
    • (2011) Nature , vol.469 , pp. 343-349
    • Margueron, R.1    Reinberg, D.2
  • 69
    • 77952240404 scopus 로고    scopus 로고
    • Telomere rejuvenation during nuclear reprogramming
    • R.M. Marión, and M.A. Blasco Telomere rejuvenation during nuclear reprogramming Curr. Opin. Genet. Dev. 20 2010 190 196
    • (2010) Curr. Opin. Genet. Dev. , vol.20 , pp. 190-196
    • Marión, R.M.1    Blasco, M.A.2
  • 70
    • 74049087181 scopus 로고    scopus 로고
    • Epigenetic gambling and epigenetic drift as an antagonistic pleiotropic mechanism of aging
    • G.M. Martin Epigenetic gambling and epigenetic drift as an antagonistic pleiotropic mechanism of aging Aging Cell 8 2009 761 764
    • (2009) Aging Cell , vol.8 , pp. 761-764
    • Martin, G.M.1
  • 72
    • 77957970498 scopus 로고    scopus 로고
    • Epigenetic modifications in pluripotent and differentiated cells
    • A. Meissner Epigenetic modifications in pluripotent and differentiated cells Nat. Biotechnol. 28 2010 1079 1088
    • (2010) Nat. Biotechnol. , vol.28 , pp. 1079-1088
    • Meissner, A.1
  • 78
    • 34548150187 scopus 로고    scopus 로고
    • The role of nuclear architecture in genomic instability and ageing
    • DOI 10.1038/nrm2238, PII NRM2238
    • P. Oberdoerffer, and D.A. Sinclair The role of nuclear architecture in genomic instability and ageing Nat. Rev. Mol. Cell Biol. 8 2007 692 702 (Pubitemid 47312825)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.9 , pp. 692-702
    • Oberdoerffer, P.1    Sinclair, D.A.2
  • 80
    • 34249880066 scopus 로고    scopus 로고
    • Generation of germline-competent induced pluripotent stem cells
    • DOI 10.1038/nature05934, PII NATURE05934
    • K. Okita, T. Ichisaka, and S. Yamanaka Generation of germline-competent induced pluripotent stem cells Nature 448 2007 313 317 (Pubitemid 47080336)
    • (2007) Nature , vol.448 , Issue.7151 , pp. 313-317
    • Okita, K.1    Ichisaka, T.2    Yamanaka, S.3
  • 81
    • 78649650475 scopus 로고    scopus 로고
    • Noncoding RNA landmarks of pluripotency and reprogramming
    • Z. Ouyang, G.X. Zheng, and H.Y. Chang Noncoding RNA landmarks of pluripotency and reprogramming Cell Stem Cell 7 2010 649 650
    • (2010) Cell Stem Cell , vol.7 , pp. 649-650
    • Ouyang, Z.1    Zheng, G.X.2    Chang, H.Y.3
  • 84
    • 33745614062 scopus 로고    scopus 로고
    • Stem cells, ageing and the quest for immortality
    • DOI 10.1038/nature04958, PII N04958
    • T.A. Rando Stem cells, ageing and the quest for immortality Nature 441 2006 1080 1086 (Pubitemid 43990720)
    • (2006) Nature , vol.441 , Issue.7097 , pp. 1080-1086
    • Rando, T.A.1
  • 85
    • 67650711140 scopus 로고    scopus 로고
    • Genome-wide views of chromatin structure
    • O.J. Rando, and H.Y. Chang Genome-wide views of chromatin structure Annu. Rev. Biochem. 78 2009 245 271
    • (2009) Annu. Rev. Biochem. , vol.78 , pp. 245-271
    • Rando, O.J.1    Chang, H.Y.2
  • 86
    • 33847208871 scopus 로고    scopus 로고
    • Timescales of genetic and epigenetic inheritance
    • O.J. Rando, and K.J. Verstrepen Timescales of genetic and epigenetic inheritance Cell 128 2007 655 668
    • (2007) Cell , vol.128 , pp. 655-668
    • Rando, O.J.1    Verstrepen, K.J.2
  • 87
    • 0035839106 scopus 로고    scopus 로고
    • Nuclear cloning and epigenetic reprogramming of the genome
    • DOI 10.1126/science.1063206
    • W.M. Rideout III, K. Eggan, and R. Jaenisch Nuclear cloning and epigenetic reprogramming of the genome Science 293 2001 1093 1098 (Pubitemid 32758082)
    • (2001) Science , vol.293 , Issue.5532 , pp. 1093-1098
    • Rideout III, W.M.1    Eggan, K.2    Jaenisch, R.3
  • 89
    • 0035176425 scopus 로고    scopus 로고
    • Stem cells from the mammalian blastocyst
    • J. Rossant Stem cells from the Mammalian blastocyst Stem Cells 19 2001 477 482 (Pubitemid 33095842)
    • (2001) Stem Cells , vol.19 , Issue.6 , pp. 477-482
    • Rossant, J.1
  • 90
    • 33846019277 scopus 로고    scopus 로고
    • Methylation of Lysine 4 on Histone H3: Intricacy of Writing and Reading a Single Epigenetic Mark
    • DOI 10.1016/j.molcel.2006.12.014, PII S1097276506008720
    • A.J. Ruthenburg, C.D. Allis, and J. Wysocka Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark Mol. Cell 25 2007 15 30 (Pubitemid 46049068)
    • (2007) Molecular Cell , vol.25 , Issue.1 , pp. 15-30
    • Ruthenburg, A.J.1    Allis, C.D.2    Wysocka, J.3
  • 92
    • 75749104729 scopus 로고    scopus 로고
    • DNMT1 maintains progenitor function in self-renewing somatic tissue
    • G.L. Sen, J.A. Reuter, D.E. Webster, L. Zhu, and P.A. Khavari DNMT1 maintains progenitor function in self-renewing somatic tissue Nature 463 2010 563 567
    • (2010) Nature , vol.463 , pp. 563-567
    • Sen, G.L.1    Reuter, J.A.2    Webster, D.E.3    Zhu, L.4    Khavari, P.A.5
  • 93
    • 79952260454 scopus 로고    scopus 로고
    • The DNA damage response: Balancing the scale between cancer and ageing
    • E.G. Seviour, and S.Y. Lin The DNA damage response: Balancing the scale between cancer and ageing Aging (Albany NY) 2 2010 900 907
    • (2010) Aging (Albany NY) , vol.2 , pp. 900-907
    • Seviour, E.G.1    Lin, S.Y.2
  • 94
    • 34548153747 scopus 로고    scopus 로고
    • How stem cells age and why this makes us grow old
    • DOI 10.1038/nrm2241, PII NRM2241
    • N.E. Sharpless, and R.A. DePinho How stem cells age and why this makes us grow old Nat. Rev. Mol. Cell Biol. 8 2007 703 713 (Pubitemid 47312828)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.9 , pp. 703-713
    • Sharpless, N.E.1    DePinho, R.A.2
  • 95
    • 0031459980 scopus 로고    scopus 로고
    • Extrachromosomal rDNA circles - A cause of aging in yeast
    • DOI 10.1016/S0092-8674(00)80493-6
    • D.A. Sinclair, and L. Guarente Extrachromosomal rDNA circles - a cause of aging in yeast Cell 91 1997 1033 1042 (Pubitemid 28027835)
    • (1997) Cell , vol.91 , Issue.7 , pp. 1033-1042
    • Sinclair, D.A.1    Guarente, L.2
  • 96
    • 77958569435 scopus 로고    scopus 로고
    • Induced pluripotency: History, mechanisms, and applications
    • M. Stadtfeld, and K. Hochedlinger Induced pluripotency: history, mechanisms, and applications Genes Dev. 24 2010 2239 2263
    • (2010) Genes Dev. , vol.24 , pp. 2239-2263
    • Stadtfeld, M.1    Hochedlinger, K.2
  • 97
    • 0035797898 scopus 로고    scopus 로고
    • Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells
    • DOI 10.1016/S0960-9822(01)00459-6
    • M. Tada, Y. Takahama, K. Abe, N. Nakatsuji, and T. Tada Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells Curr. Biol. 11 2001 1553 1558 (Pubitemid 32931020)
    • (2001) Current Biology , vol.11 , Issue.19 , pp. 1553-1558
    • Tada, M.1    Takahama, Y.2    Abe, K.3    Nakatsuji, N.4    Tada, T.5
  • 98
    • 33747195353 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
    • DOI 10.1016/j.cell.2006.07.024, PII S0092867406009767
    • K. Takahashi, and S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676 (Pubitemid 44233629)
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 99
    • 0017725251 scopus 로고
    • Change of the hepatic cells in parabiosis between old and young rats
    • H. Tauchi, and K. Hasegawa Change of the hepatic cells in parabiosis between old and young rats Mech. Ageing Dev. 6 1977 333 339 (Pubitemid 8154581)
    • (1977) Mechanisms of Ageing and Development , vol.6 , Issue.5 , pp. 333-339
    • Tauchi, H.1    Hasegawa, K.2
  • 100
    • 78650889400 scopus 로고    scopus 로고
    • Chromatin regulation and genome maintenance by mammalian SIRT6
    • R.I. Tennen, and K.F. Chua Chromatin regulation and genome maintenance by mammalian SIRT6 Trends Biochem. Sci. 36 2011 39 46
    • (2011) Trends Biochem. Sci. , vol.36 , pp. 39-46
    • Tennen, R.I.1    Chua, K.F.2
  • 101
    • 33745186492 scopus 로고    scopus 로고
    • Acquisition and extinction of gene expression programs are separable events in heterokaryon reprogramming
    • DOI 10.1242/jcs.02945
    • R. Terranova, C.F. Pereira, C. Du Roure, M. Merkenschlager, and A.G. Fisher Acquisition and extinction of gene expression programs are separable events in heterokaryon reprogramming J. Cell Sci. 119 2006 2065 2072 (Pubitemid 43904961)
    • (2006) Journal of Cell Science , vol.119 , Issue.10 , pp. 2065-2072
    • Terranova, R.1    Pereira, C.F.2    Du Roure, C.3    Merkenschlager, M.4    Fisher, A.G.5
  • 102
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • DOI 10.1038/35065638
    • H.A. Tissenbaum, and L. Guarente Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans Nature 410 2001 227 230 (Pubitemid 32216597)
    • (2001) Nature , vol.410 , Issue.6825 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 104
    • 70349469788 scopus 로고    scopus 로고
    • DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells
    • J.J. Trowbridge, J.W. Snow, J. Kim, and S.H. Orkin DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells Cell Stem Cell 5 2009 442 449
    • (2009) Cell Stem Cell , vol.5 , pp. 442-449
    • Trowbridge, J.J.1    Snow, J.W.2    Kim, J.3    Orkin, S.H.4
  • 105
    • 69249235740 scopus 로고    scopus 로고
    • Calorie restriction and the exercise of chromatin
    • A. Vaquero, and D. Reinberg Calorie restriction and the exercise of chromatin Genes Dev. 23 2009 1849 1869
    • (2009) Genes Dev. , vol.23 , pp. 1849-1869
    • Vaquero, A.1    Reinberg, D.2
  • 109
    • 0034687374 scopus 로고    scopus 로고
    • Isolation of a 250 million-year-old halotolerant bacterium from a primary salt crystal
    • R.H. Vreeland, W.D. Rosenzweig, and D.W. Powers Isolation of a 250 million-year-old halotolerant bacterium from a primary salt crystal Nature 407 2000 897 900
    • (2000) Nature , vol.407 , pp. 897-900
    • Vreeland, R.H.1    Rosenzweig, W.D.2    Powers, D.W.3
  • 110
    • 55849101681 scopus 로고    scopus 로고
    • Fat metabolism links germline stem cells and longevity in C. elegans
    • M.C. Wang, E.J. O'Rourke, and G. Ruvkun Fat metabolism links germline stem cells and longevity in C. elegans Science 322 2008 957 960
    • (2008) Science , vol.322 , pp. 957-960
    • Wang, M.C.1    O'Rourke, E.J.2    Ruvkun, G.3
  • 112
    • 79952660821 scopus 로고    scopus 로고
    • Control of the embryonic stem cell state
    • R.A. Young Control of the embryonic stem cell state Cell 144 2011 940 954
    • (2011) Cell , vol.144 , pp. 940-954
    • Young, R.A.1
  • 113
    • 38949212767 scopus 로고    scopus 로고
    • Human embryonic stem cells: Mechanisms to escape replicative senescence?
    • DOI 10.1007/s12015-007-9005-x
    • X. Zeng Human embryonic stem cells: mechanisms to escape replicative senescence? Stem Cell Rev. 3 2007 270 279 (Pubitemid 351526204)
    • (2007) Stem Cell Reviews , vol.3 , Issue.4 , pp. 270-279
    • Zeng, X.1


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