Tumor suppressor and aging biomarker p16 INK4a induces cellular senescence without the associated inflammatory secretory phenotype

Journal of Biological Chemistry

Volumn 286, Issue 42, 2011, Pages 36396-36403

  Coppé, Jean Philippe ^a,b   Rodier, Francis ^a,b,c   Patil, Christopher K ^a,b   Freund, Adam ^a,b   Desprez, Pierre Yves ^a,d   Campisi, Judith ^a,b  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^c Institut du Cancer de Montreal   (Canada)

^d CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE-RELATED; CELLULAR SENESCENCE; COMPLEX PHENOTYPE; CYCLIN-DEPENDENT KINASE INHIBITORS; CYTOKINE SECRETIONS; CYTOKINES; DNA DAMAGES; ECTOPIC EXPRESSIONS; EPITHELIAL CELLS; GROWTH ARREST; GROWTH FACTOR; HUMAN FIBROBLAST; IN-VIVO; PARACRINE; REPLICATIVE SENESCENCE; TUMOR SUPPRESSORS;

CELL CULTURE; DISEASES; ENZYMES; IONIZING RADIATION; PHYSIOLOGY; TUMORS;

CELLS;

CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; RAS PROTEIN; SECRETORY PROTEIN; SENESCENCE ASSOCIATED SECRETORY PHENOTYPE; UNCLASSIFIED DRUG;

AGING; ARTICLE; CANCER INHIBITION; CELL GROWTH; CONTROLLED STUDY; CYTOKINE RELEASE; DNA DAMAGE; EPITHELIUM CELL; FIBROBLAST; GROWTH DISORDER; HUMAN; HUMAN CELL; IONIZING RADIATION; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENESCENCE;

CELL AGING; CELLS, CULTURED; COCULTURE TECHNIQUES; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; EPITHELIAL CELLS; FIBROBLASTS; HUMANS; PARACRINE COMMUNICATION; RADIATION, IONIZING;

EID: 80054682555     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.257071     Document Type: Article

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