Cell autonomous and non-autonomous effects of senescent cells in the skin

Journal of Investigative Dermatology

Volumn 135, Issue 7, 2015, Pages 1722-1726

  Demaria, Marco ^a   Desprez, Pierre Yves ^a,b   Campisi, Judith ^a,c   Velarde, Michael C ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DAMAGE; CELL FUNCTION; CHRONIC WOUND; CUTANEOUS PARAMETERS; CYTOKINE RELEASE; DERMOEPIDERMAL JUNCTION; EXTRACELLULAR MATRIX; GRANULATION TISSUE; HUMAN; NONHUMAN; PHOTOAGING; PRIORITY JOURNAL; REVIEW; SENESCENCE; SKIN; WOUND HEALING; ANIMAL; CELL AGING; CELL DIFFERENTIATION; CELL DIVISION; CYTOLOGY; EPIDERMIS; FEMALE; FIBROBLAST; GENETICS; HOMEOSTASIS; MALE; METABOLISM; MOUSE; PHYSIOLOGY; SENSITIVITY AND SPECIFICITY;

ANIMALS; CELL AGING; CELL DIFFERENTIATION; CELL DIVISION; EPIDERMIS; FEMALE; FIBROBLASTS; HOMEOSTASIS; HUMANS; MALE; MICE; SENSITIVITY AND SPECIFICITY; SKIN; SKIN AGING; WOUND HEALING;

EID: 84931031396     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2015.108     Document Type: Review

References (68)

1. Adamus J, Aho S, Meldrum H, et al. (2014) p16INK4A influences the aging phenotype in the living skin equivalent. J Invest Dermatol 134:1131-3
2. Baker DJ, Wijshake T, Tchkonia T, et al. (2011) Clearance of p16Ink4a-positive senescent cells delays ageing-Associated disorders. Nature 479:232-6
3. Berneburg M, Gattermann N, Stege H, et al. (1997) Chronically ultravioletexposed human skin shows a higher mutation frequency of mitochondrial DNA as compared to unexposed skin and the hematopoietic system. Photochem Photobiol 66:271-5
4. Berneburg M, Gremmel T, Kurten V, et al. (2005) Creatine supplementation normalizes mutagenesis of mitochondrial DNA as well as functional consequences. J Invest Dermatol 125:213-20
5. Bernstein EF, Chen YQ, Tamai K, et al. (1994) Enhanced elastin and fibrillin gene expression in chronically photodamaged skin. J Invest Dermatol 103: 182-6
6. Birch-Machin MA, Tindall M, Turner R, et al. (1998) Mitochondrial DNA deletions in human skin reflect photo-rather than chronologic aging. J Invest Dermatol 110:149-52
7. Campisi J (2001) Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol 11:27-31
8. Campisi J (2013) Aging, cellular senescence, and cancer. Annu Rev Physiol 75: 685-705
9. Chen L, Tredget EE, Wu PY, et al. (2008) Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 3:e1886
10. Coppe JP, Patil CK, Rodier F, et al. (2010) A human-like senescence-Associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS One 5:e9188
11. Coppe JP, Patil CK, Rodier F, et al. (2008) Senescence-Associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6:2853-68
12. Davis T, Wyllie FS, Rokicki MJ, et al. (2007) The role of cellular senescence in Werner syndrome: toward therapeutic intervention in human premature aging. Ann N Y Acad Sci 1100:455-69
13. Demaria M, Ohtani N, Youssef SA, et al. (2014) An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev Cell 31:722-33
14. Dimri GP, Lee X, Basile G, et al. (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92:9363-7
15. Dorr JR, Yu Y, Milanovic M, et al. (2013) Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. Nature 501:421-5
16. Dvorak HF (1986) Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 315:1650-9
17. Farage MA, Miller KW, Elsner P, et al. (2013) Characteristics of the aging skin. Adv Wound Care 2:5-10
18. Feng Y, Santoriello C, Mione M, et al. (2010) Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: parallels between tumor initiation and wound inflammation. PLoS Biol 8:e1000562
19. Freund A, Patil CK, Campisi J (2011) p38MAPK is a novel DNA damage response-independent regulator of the senescence-Associated secretory phenotype. EMBO J 30:1536-48
20. Fuhrman B, Brook GJ, Aviram M (1991) Activated platelets secrete a protein-like factor that stimulates oxidized-LDL receptor activity in macrophages. J Lipid Res 32:1113-23
21. Guo S, Dipietro LA (2010) Factors affecting wound healing. J Dental Res 89: 219-29
22. Harada YN, Shiomi N, Koike M, et al. (1999) Postnatal growth failure, short life span, and early onset of cellular senescence and subsequent immortalization in mice lacking the xeroderma pigmentosum group G gene. Mol Cell Biol 19:2366-72
23. Imokawa G (2009) Mechanism of UVB-induced wrinkling of the skin: paracrine cytokine linkage between keratinocytes and fibroblasts leading to the stimulation of elastase. J Investig Dermatol Symp Proc 14:36-43
24. Jariashvili K, Madhan B, Brodsky B, et al. (2012) UV damage of collagen: insights from model collagen peptides. Biopolymers 97:189-98
25. Jun JI, Lau LF (2010) The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol 12:676-85
26. Kim KH, Chen CC, Monzon RI, et al. (2013) Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts. Mol Cell Biol 33:2078-90
27. Kim MH, Liu W, Borjesson DL, et al. (2008) Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging. J Invest Dermatol 128:1812-20
28. Krishnamurthy J, Torrice C, Ramsey MR, et al. (2004) Ink4a/Arf expression is a biomarker of aging. J Clin Invest 114:1299-307
29. Krizhanovsky V, Yon M, Dickins RA, et al. (2008) Senescence of activated stellate cells limits liver fibrosis. Cell 134:657-67
30. Krutmann J, Schroeder P (2009) Role of mitochondria in photoaging of human skin: the defective powerhouse model. J Investig Dermatol Symp Proc 14: 44-9
31. Liu Y, Rusinol A, Sinensky M, et al. (2006) DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. J Cell Sci 119: 4644-9
32. Madden JW, Peacock EE Jr. (1971) Studies on the biology of collagen during wound healing. 3. Dynamic metabolism of scar collagen and remodeling of dermal wounds. Ann Surg 174:511-20
33. Makrantonaki E, Zouboulis CC (2007) Molecular mechanisms of skin aging: state of the art. Ann N Y Acad Sci 1119:40-50
34. Martins VL, Caley M, O'Toole EA (2013) Matrix metalloproteinases and epidermal wound repair. Cell Tissue Res 351:255-68
35. Mendez MV, Stanley A, Park HY, et al. (1998) Fibroblasts cultured from venous ulcers display cellular characteristics of senescence. J Vasc Surg 28:876-83
36. Menter JM, Patta AM, Sayre RM, et al. (2001) Effect of UV irradiation on type I collagen fibril formation in neutral collagen solutions. Photodermatol Photoimmunol Photomed 17:114-20
37. Midwood KS, Williams LV, Schwarzbauer JE (2004) Tissue repair and the dynamics of the extracellular matrix. Inter J Biochem Cell Biol 36:1031-7
38. Mitchell RE (1967) Chronic solar dermatosis: a light and electron microscopic study of the dermis. J Invest Dermatol 48:203-20
39. Passos JF, von Zglinicki T, Saretzki G (2006) Mitochondrial dysfunction and cell senescence: cause or consequence?. Rejuvenation Res 9:64-8
40. Postlethwaite AE, Keski-Oja J, Moses HL, et al. (1987) Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta. J Exp Med 165:251-6
41. Quan T, He T, Kang S, et al. (2004) Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signaling. Am J Pathol 165:741-51
42. Quan T, Qin Z, Xia W, et al. (2009) Matrix-degrading metalloproteinases in photoaging. J Investig Dermatol Symp Proc 14:20-4
43. Quan T, Shao Y, He T, et al. (2010) Reduced expression of connective tissue growth factor (CTGF/CCN2) mediates collagen loss in chronologically aged human skin. J Invest Dermatol 130:415-24
44. Ressler S, Bartkova J, Niederegger H, et al. (2006) p16INK4A is a robust in vivo biomarker of cellular aging in human skin. Aging Cell 5:379-89
45. Rodier F, Campisi J (2011) Four faces of cellular senescence. J Cell Biol 192: 547-56
46. Sen CK, Gordillo GM, Roy S, et al. (2009) Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen 17:763-71
47. Shallo H, Plackett TP, Heinrich SA, et al. (2003) Monocyte chemoattractant protein-1 (MCP-1) and macrophage infiltration into the skin after burn injury in aged mice. Burns 29:641-7
48. Sherratt MJ, Bayley CP, Reilly SM, et al. (2010) Low-dose ultraviolet radiation selectively degrades chromophore-rich extracellular matrix components. J Pathol 222:32-40
49. Shin J, Kim JH, Kim EK (2012) Repeated exposure of human fibroblasts to UVR induces secretion of stem cell factor and senescence. J Eur Acad Dermatol Venereol 26:1577-80
50. Shuster S, Black MM, McVitie E (1975) The influence of age and sex on skin thickness, skin collagen and density. Br J Dermatol 93:639-43
51. Signer RA, Morrison SJ (2013) Mechanisms that regulate stem cell aging and life span. Cell Stem Cell 12:152-65
52. Singer AJ, Clark RA (1999) Cutaneous wound healing. N Engl J Med 341: 738-46
53. Sunderkotter C, Steinbrink K, Goebeler M, et al. (1994) Macrophages and angiogenesis. J Leukoc Biol 55:410-22
54. Takeuchi S, Takahashi A, Motoi N, et al. (2010) Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo. Cancer Res 70:9381-90
55. Telgenhoff D, Shroot B (2005) Cellular senescence mechanisms in chronic wound healing. Cell Death Differ 12:695-8
56. Tomasek JJ, Gabbiani G, Hinz B, et al. (2002) Myofibroblasts and mechanoregulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3: 349-63
57. van Deursen JM (2014) The role of senescent cells in ageing. Nature 509: 439-46
58. Vande Berg JS, Robson MC (2003) Arresting cell cycles and the effect on wound healing. Surg Clin North Am 83:509-20
59. Vande Berg JS, Rose MA, Haywood-Reid PL, et al. (2005) Cultured pressure ulcer fibroblasts show replicative senescence with elevated production of plasmin, plasminogen activator inhibitor-1, and transforming growth factor-beta1. Wound Repair Regener 13:76-83
60. Varani J, Dame MK, Rittie L, et al. (2006) Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am J Pathol 168:1861-8
61. Varani J, Schuger L, Dame MK, et al. (2004) Reduced fibroblast interaction with intact collagen as a mechanism for depressed collagen synthesis in photodamaged skin. J Invest Dermatol 122:1471-9
62. Velarde MC, Flynn JM, Day NU, et al. (2012) Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging 4:3-12
63. von Zglinicki T, Saretzki G, Ladhoff J, et al. (2005) Human cell senescence as a DNA damage response. Mech Ageing Dev 126:111-7
64. Waaijer ME, Parish WE, Strongitharm BH, et al. (2012) The number of p16INK4a positive cells in human skin reflects biological age. Aging Cell 11: 722-5
65. Watson RE, Craven NM, Kang S, et al. (2001) A short-Term screening protocol, using fibrillin-1 as a reporter molecule, for photoaging repair agents. J Invest Dermatol 116:672-8
66. Woenne EC, Lederle W, Zwick S, et al. (2010) MMP inhibition blocks fibroblastdependent skin cancer invasion, reduces vascularization and alters VEGFA and PDGF-BB expression. Anticancer Res 30:703-11
67. Yang GY, Zhang CL, Liu XC, et al. (2013) Effects of cigarette smoke extracts on the growth and senescence of skin fibroblasts in vitro. Int J Biol Sci 9: 613-23
68. Ziegler DV, Wiley CD, Velarde MC (2015) Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging. Aging Cell 14:1-7