-
1
-
-
84859265162
-
Senescence: a new weapon for cancer therapy
-
Acosta, J.C., and Gil, J. (2012). Senescence: a new weapon for cancer therapy. Trends Cell Biol. 22, 211-219.
-
(2012)
Trends Cell Biol.
, vol.22
, pp. 211-219
-
-
Acosta, J.C.1
Gil, J.2
-
2
-
-
84877001084
-
Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence
-
Aird, K.M., Zhang, G., Li, H. et al. (2013). Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence. Cell Rep. 3, 1252-1265.
-
(2013)
Cell Rep.
, vol.3
, pp. 1252-1265
-
-
Aird, K.M.1
Zhang, G.2
Li, H.3
-
3
-
-
84858207885
-
Vemurafenib: the road to personalized medicine in melanoma
-
Amaria, R.N., Lewis, K.D., and Jimeno, A. (2012). Vemurafenib: the road to personalized medicine in melanoma. Drugs Today (Barc.) 48, 109-118.
-
(2012)
Drugs Today (Barc.)
, vol.48
, pp. 109-118
-
-
Amaria, R.N.1
Lewis, K.D.2
Jimeno, A.3
-
4
-
-
84903754178
-
Wnt5A enhances resistance of melanoma cells to targeted BRAF inhibitors
-
Anastas, J.N., Kulikauskas, R.M., Tamir, T. et al. (2014). Wnt5A enhances resistance of melanoma cells to targeted BRAF inhibitors. J. Clin. Invest. 124, 2877-2890.
-
(2014)
J. Clin. Invest.
, vol.124
, pp. 2877-2890
-
-
Anastas, J.N.1
Kulikauskas, R.M.2
Tamir, T.3
-
5
-
-
84855696067
-
Wnt/beta-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma
-
Biechele, T.L., Kulikauskas, R.M., Toroni, R.A., Lucero, O.M., Swift, R.D., James, R.G., Robin, N.C., Dawson, D.W., Moon, R.T., and Chien, A.J. (2012). Wnt/beta-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma. Sci. Signal. 5, ra3.
-
(2012)
Sci. Signal.
, vol.5
, pp. ra3
-
-
Biechele, T.L.1
Kulikauskas, R.M.2
Toroni, R.A.3
Lucero, O.M.4
Swift, R.D.5
James, R.G.6
Robin, N.C.7
Dawson, D.W.8
Moon, R.T.9
Chien, A.J.10
-
6
-
-
65649132391
-
Mina Bissell: context is everything. [An interview by Ben Short]
-
Bissell, M. (2009). Mina Bissell: context is everything. [An interview by Ben Short]. J. Cell Biol. 185, 374-375.
-
(2009)
J. Cell Biol.
, vol.185
, pp. 374-375
-
-
Bissell, M.1
-
7
-
-
80053361798
-
Wnt5A suppresses epithelial ovarian cancer by promoting cellular senescence
-
Bitler, B.G., Nicodemus, J.P., Li, H. et al. (2011). Wnt5A suppresses epithelial ovarian cancer by promoting cellular senescence. Cancer Res. 71, 6184-6194.
-
(2011)
Cancer Res.
, vol.71
, pp. 6184-6194
-
-
Bitler, B.G.1
Nicodemus, J.P.2
Li, H.3
-
8
-
-
33845711166
-
Mitf regulation of Dia1 controls melanoma proliferation and invasiveness
-
Carreira, S., Goodall, J., Denat, L., Rodriguez, M., Nuciforo, P., Hoek, K.S., Testori, A., Larue, L., and Goding, C.R. (2006). Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. Genes Dev. 20, 3426-3439.
-
(2006)
Genes Dev.
, vol.20
, pp. 3426-3439
-
-
Carreira, S.1
Goodall, J.2
Denat, L.3
Rodriguez, M.4
Nuciforo, P.5
Hoek, K.S.6
Testori, A.7
Larue, L.8
Goding, C.R.9
-
9
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman, P.B., Hauschild, A., Robert, C. et al. (2011). Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N. Engl. J. Med. 364, 2507-2516.
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
10
-
-
77949881221
-
The senescence-associated secretory phenotype: the dark side of tumor suppression
-
Coppe, J.P., Desprez, P.Y., Krtolica, A., and Campisi, J. (2010). The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol. 5, 99-118.
-
(2010)
Annu. Rev. Pathol.
, vol.5
, pp. 99-118
-
-
Coppe, J.P.1
Desprez, P.Y.2
Krtolica, A.3
Campisi, J.4
-
11
-
-
34447131518
-
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition
-
Dissanayake, S.K., Wade, M., Johnson, C.E. et al. (2007). The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J. Biol. Chem. 282, 17259-17271.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 17259-17271
-
-
Dissanayake, S.K.1
Wade, M.2
Johnson, C.E.3
-
12
-
-
57749098673
-
Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation
-
Dissanayake, S.K., Olkhanud, P.B., O'Connell, M.P. et al. (2008). Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation. Cancer Res. 68, 10205-10214.
-
(2008)
Cancer Res.
, vol.68
, pp. 10205-10214
-
-
Dissanayake, S.K.1
Olkhanud, P.B.2
O'Connell, M.P.3
-
13
-
-
84884417141
-
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
-
Dorr, J.R., Yu, Y., Milanovic, M. et al. (2013). Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. Nature 501, 421-425.
-
(2013)
Nature
, vol.501
, pp. 421-425
-
-
Dorr, J.R.1
Yu, Y.2
Milanovic, M.3
-
14
-
-
80051875971
-
Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switching
-
Eichhoff, O.M., Weeraratna, A., Zipser, M.C. et al. (2011). Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switching. Pigment Cell Melanoma Res. 24, 631-642.
-
(2011)
Pigment Cell Melanoma Res.
, vol.24
, pp. 631-642
-
-
Eichhoff, O.M.1
Weeraratna, A.2
Zipser, M.C.3
-
15
-
-
77951743475
-
Microphthalmia-associated transcription factor controls the DNA damage response and a lineage-specific senescence program in melanomas
-
Giuliano, S., Cheli, Y., Ohanna, M. et al. (2010). Microphthalmia-associated transcription factor controls the DNA damage response and a lineage-specific senescence program in melanomas. Cancer Res. 70, 3813-3822.
-
(2010)
Cancer Res.
, vol.70
, pp. 3813-3822
-
-
Giuliano, S.1
Cheli, Y.2
Ohanna, M.3
-
16
-
-
33747192833
-
Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
-
Gray-Schopfer, V.C., Cheong, S.C., Chong, H., Chow, J., Moss, T., Abdel-Malek, Z.A., Marais, R., Wynford-Thomas, D., and Bennett, D.C. (2006). Cellular senescence in naevi and immortalisation in melanoma: a role for p16? Br. J. Cancer 95, 496-505.
-
(2006)
Br. J. Cancer
, vol.95
, pp. 496-505
-
-
Gray-Schopfer, V.C.1
Cheong, S.C.2
Chong, H.3
Chow, J.4
Moss, T.5
Abdel-Malek, Z.A.6
Marais, R.7
Wynford-Thomas, D.8
Bennett, D.C.9
-
17
-
-
52449115597
-
p16INK4a-induced senescence is disabled by melanoma-associated mutations
-
Haferkamp, S., Becker, T.M., Scurr, L.L., Kefford, R.F., and Rizos, H. (2008). p16INK4a-induced senescence is disabled by melanoma-associated mutations. Aging Cell 7, 733-745.
-
(2008)
Aging Cell
, vol.7
, pp. 733-745
-
-
Haferkamp, S.1
Becker, T.M.2
Scurr, L.L.3
Kefford, R.F.4
Rizos, H.5
-
18
-
-
84878556423
-
Vemurafenib induces senescence features in melanoma cells
-
Haferkamp, S., Borst, A., Adam, C., Becker, T.M., Motschenbacher, S., Windhovel, S., Hufnagel, A.L., Houben, R., and Meierjohann, S. (2013). Vemurafenib induces senescence features in melanoma cells. J. Invest. Dermatol. 133, 1601-1609.
-
(2013)
J. Invest. Dermatol.
, vol.133
, pp. 1601-1609
-
-
Haferkamp, S.1
Borst, A.2
Adam, C.3
Becker, T.M.4
Motschenbacher, S.5
Windhovel, S.6
Hufnagel, A.L.7
Houben, R.8
Meierjohann, S.9
-
19
-
-
84899730313
-
Molecular pathways: BRAF induces bioenergetic adaptation by attenuating oxidative phosphorylation
-
Haq, R., Fisher, D.E., and Widlund, H.R. (2014). Molecular pathways: BRAF induces bioenergetic adaptation by attenuating oxidative phosphorylation. Clin. Cancer Res. 20, 2257-2263.
-
(2014)
Clin. Cancer Res.
, vol.20
, pp. 2257-2263
-
-
Haq, R.1
Fisher, D.E.2
Widlund, H.R.3
-
20
-
-
0016028982
-
The strategy of senescence
-
Hayflick, L. (1974). The strategy of senescence. Gerontologist 14, 37-45.
-
(1974)
Gerontologist
, vol.14
, pp. 37-45
-
-
Hayflick, L.1
-
21
-
-
77954762934
-
FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence
-
Krejci, P., Prochazkova, J., Smutny, J., Chlebova, K., Lin, P., Aklian, A., Bryja, V., Kozubik, A., and Wilcox, W.R. (2010). FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence. Bone 47, 102-110.
-
(2010)
Bone
, vol.47
, pp. 102-110
-
-
Krejci, P.1
Prochazkova, J.2
Smutny, J.3
Chlebova, K.4
Lin, P.5
Aklian, A.6
Bryja, V.7
Kozubik, A.8
Wilcox, W.R.9
-
22
-
-
60649100864
-
Senescence induction; a possible cancer therapy
-
Lleonart, M.E., Artero-Castro, A., and Kondoh, H. (2009). Senescence induction; a possible cancer therapy. Mol. Cancer. 8, 3.
-
(2009)
Mol. Cancer.
, vol.8
, pp. 3
-
-
Lleonart, M.E.1
Artero-Castro, A.2
Kondoh, H.3
-
23
-
-
0036566326
-
Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence
-
Macip, S., Igarashi, M., Fang, L., Chen, A., Pan, Z.Q., Lee, S.W., and Aaronson, S.A. (2002). Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence. EMBO J. 21, 2180-2188.
-
(2002)
EMBO J.
, vol.21
, pp. 2180-2188
-
-
Macip, S.1
Igarashi, M.2
Fang, L.3
Chen, A.4
Pan, Z.Q.5
Lee, S.W.6
Aaronson, S.A.7
-
24
-
-
23244447037
-
BRAFE600-associated senescence-like cell cycle arrest of human naevi
-
Michaloglou, C., Vredeveld, L.C., Soengas, M.S., Denoyelle, C., Kuilman, T., van der Horst, C.M., Majoor, D.M., Shay, J.W., Mooi, W.J., and Peeper, D.S. (2005). BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436, 720-724.
-
(2005)
Nature
, vol.436
, pp. 720-724
-
-
Michaloglou, C.1
Vredeveld, L.C.2
Soengas, M.S.3
Denoyelle, C.4
Kuilman, T.5
van der Horst, C.M.6
Majoor, D.M.7
Shay, J.W.8
Mooi, W.J.9
Peeper, D.S.10
-
25
-
-
67449128692
-
Wnt5A activates the calpain-mediated cleavage of filamin A
-
O'Connell, M.P., Fiori, J.L., Baugher, K.M. et al. (2009a). Wnt5A activates the calpain-mediated cleavage of filamin A. J. Invest. Dermatol. 129, 1782-1789.
-
(2009)
J. Invest. Dermatol.
, vol.129
, pp. 1782-1789
-
-
O'Connell, M.P.1
Fiori, J.L.2
Baugher, K.M.3
-
26
-
-
73849123750
-
The Orphan Tyrosine Kinase Receptor, ROR2, Mediates Wnt5A Signaling in Metastatic Melanoma
-
O'Connell, M.P., Fiori, J.L., Xu, M. et al. (2009b). The Orphan Tyrosine Kinase Receptor, ROR2, Mediates Wnt5A Signaling in Metastatic Melanoma. Oncogene 29, 34-44.
-
(2009)
Oncogene
, vol.29
, pp. 34-44
-
-
O'Connell, M.P.1
Fiori, J.L.2
Xu, M.3
-
27
-
-
84890063283
-
Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2
-
O'Connell, M.P., Marchbank, K., Webster, M.R. et al. (2013). Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2. Cancer Discov. 3, 1378-1393.
-
(2013)
Cancer Discov.
, vol.3
, pp. 1378-1393
-
-
O'Connell, M.P.1
Marchbank, K.2
Webster, M.R.3
-
28
-
-
0038013875
-
Senescence, apoptosis and therapy-cutting the lifelines of cancer
-
Schmitt, C.A. (2003). Senescence, apoptosis and therapy-cutting the lifelines of cancer. Nat. Rev. Cancer 3, 286-295.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 286-295
-
-
Schmitt, C.A.1
-
29
-
-
0037013154
-
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
-
Schmitt, C.A., Fridman, J.S., Yang, M., Lee, S., Baranov, E., Hoffman, R.M., and Lowe, S.W. (2002). A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 109, 335-346.
-
(2002)
Cell
, vol.109
, pp. 335-346
-
-
Schmitt, C.A.1
Fridman, J.S.2
Yang, M.3
Lee, S.4
Baranov, E.5
Hoffman, R.M.6
Lowe, S.W.7
-
30
-
-
0042424602
-
Statistical significance for genomewide studies
-
Storey, J.D., and Tibshirani, R. (2003). Statistical significance for genomewide studies. Proc. Natl Acad. Sci. U.S.A. 100, 9440-9445.
-
(2003)
Proc. Natl Acad. Sci. U.S.A.
, vol.100
, pp. 9440-9445
-
-
Storey, J.D.1
Tibshirani, R.2
-
31
-
-
84897531613
-
Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma
-
Sun, C., Wang, L., Huang, S. et al. (2014). Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma. Nature 508, 118-122.
-
(2014)
Nature
, vol.508
, pp. 118-122
-
-
Sun, C.1
Wang, L.2
Huang, S.3
-
32
-
-
34547552888
-
p53 restoration leads to tumor senescence and regression: implications for cancer therapy
-
Tai, A.W., and Chung, R.T. (2007). p53 restoration leads to tumor senescence and regression: implications for cancer therapy. Gastroenterology 133, 722-723.
-
(2007)
Gastroenterology
, vol.133
, pp. 722-723
-
-
Tai, A.W.1
Chung, R.T.2
-
33
-
-
0036528247
-
Wnt5A signaling directly affects cell motility and invasion of metastatic melanoma
-
Weeraratna, A.T., Jiang, Y., Hostetter, G., Rosenblatt, K., Duray, P., Bittner, M., and Trent, J.M. (2002). Wnt5A signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 1, 279-288.
-
(2002)
Cancer Cell
, vol.1
, pp. 279-288
-
-
Weeraratna, A.T.1
Jiang, Y.2
Hostetter, G.3
Rosenblatt, K.4
Duray, P.5
Bittner, M.6
Trent, J.M.7
-
34
-
-
34547684291
-
A comprehensive evaluation of SAM, the SAM R-package and a simple modification to improve its performance
-
Zhang, S. (2007). A comprehensive evaluation of SAM, the SAM R-package and a simple modification to improve its performance. BMC Bioinformatics 8, 230.
-
(2007)
BMC Bioinformatics
, vol.8
, pp. 230
-
-
Zhang, S.1
|