Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

Genes and Development

Volumn 27, Issue 16, 2013, Pages 1787-1799

  Shah, Parisha P ^a   Donahue, Greg ^a   Otte, Gabriel L ^a   Capell, Brian C ^a   Nelson, David M ^b   Cao, Kajia ^a   Aggarwala, Varun ^a   Cruickshanks, Hazel A ^b   Rai, Taranjit Singh ^b   McBryan, Tony ^b   Gregory, Brian D ^c   Adams, Peter D ^b   Berger, Shelley L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Chromatin; Gene expression; Lamin B1; Senescence

Indexed keywords

DNA; HISTONE H3; IMMUNOGLOBULIN G; LAMIN; LAMIN B1; MUTANT PROTEIN; PUROMYCIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ARTICLE; CANCER GENETICS; CELL AGING; CELL PROLIFERATION; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; DNA METHYLATION; EPIGENETICS; FIBROBLAST; GENE EXPRESSION REGULATION; GENOME; HUMAN; HUMAN CELL; PRECANCER; PRIORITY JOURNAL; PROGERIA; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENESCENCE; WESTERN BLOTTING;

CHROMATIN; GENE EXPRESSION; LAMIN B1; SENESCENCE;

AGING; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; EPIGENESIS, GENETIC; FIBROBLASTS; GENE EXPRESSION REGULATION; HISTONES; HUMANS; LAMIN TYPE B; METHYLATION; PROGERIA; PROTEIN STRUCTURE, TERTIARY;

EID: 84882682843     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.223834.113     Document Type: Article

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