Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases

DNA Repair

Volumn 38, Issue , 2016, Pages 110-116

  Zanotti, Kimberly J ^a   Gearhart, Patricia J ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Activation induced deaminase; Class switch recombination; DNA polymerase ; Mismatch repair; Somatic hypermutation

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; DNA POLYMERASE; PROTEIN MUTL; PROTEIN MUTL ALPHA; PROTEIN MUTS; PROTEIN MUTS ALPHA; UNCLASSIFIED DRUG; URACIL DNA GLYCOSIDASE; AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); ANTIBODY; CYTIDINE DEAMINASE; DNA DIRECTED DNA POLYMERASE;

ANTIBODY SPECIFICITY; ANTIGEN BINDING; B LYMPHOCYTE; CLASS SWITCH RECOMBINATION; DNA RECOMBINATION; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVATION; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; MISMATCH REPAIR; PRIORITY JOURNAL; REVIEW; SOMATIC HYPERMUTATION; ANIMAL; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE;

ANIMALS; ANTIBODIES; BASE SEQUENCE; CYTIDINE DEAMINASE; DNA MISMATCH REPAIR; DNA-DIRECTED DNA POLYMERASE; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 84956662519     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2015.11.011     Document Type: Review

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