Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 12, 1998, Pages 6953-6958

  Winter, David B ^a   Phung, Quy H ^a,b   Umar, Asad ^c   Baker, Sean M ^d   Tarone, Robert E ^e   Tanaka, Kiyoji ^f   Liskay, R Michael ^g   Kunkel, Thomas A ^c   Bohr, Vilhelm A ^a   Gearhart, Patricia J ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f OSAKA UNIVERSITY   (Japan)

^g OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASE MISPAIRING; BASE PAIRING; CONTROLLED STUDY; DNA REPAIR; EXCISION REPAIR; GENE MUTATION; GENE REARRANGEMENT; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ANTIBODIES; BASE SEQUENCE; DNA REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTATION; PROTEINS;

ANIMALIA; MURINAE;

EID: 13144250122     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.12.6953     Document Type: Article

References (43)

1. Pech, M., Hochtl, J., Schnell, H. & Zachau, H. G. (1981) Nature (London) 291, 668-670.
2. Kim, S., Davis, M., Sinn, E., Patten, P. & Hood, L. (1981) Cell 27, 573-581.
3. Gearhart, P. J. & Bogenhagen, D. F. (1983) Proc. Natl. Acad. Sci. USA 80, 3439-3443.
4. Lebecque, S. G. & Gearhart, P. J. (1990) J. Exp. Med. 172, 1717-1727.
5. Goyenechea, B., Klix, N., Yelamos, J., Williams, G. T., Riddell, A., Neuberger, M. S. & Milstein, C. (1997) EMBO J. 16, 3987-3994.
6. Peters, A. & Storb, U. (1996) Immunity 4, 57-65.
7. Tumas-Brundage, K. & Manser, T. (1997) J. Exp. Med. 185, 239-250.
8. Betz, A. G., Milstein, C., Gonzalez-Fernandez, A., Pannell, R., Larson, T. & Neuberger, M. S. (1994) Cell 77, 239-248.
9. Wilson, P. C., de Bouteiller, O., Liu, Y.-L., Potter, K., Banchereau, J., Capra, J. D. & Pascual V. (1998) J. Exp. Med. 187, 59-70.
10. Smith, D. S., Creadon, G., Jena, P. K., Portanova, J. P., Kotzin, B. L. & Wysocki, L. J. (1996) J. Immunol. 156, 2642-2652.
11. Golding, G. B., Gearhart, P. J. & Glickman, B. W. (1987) Genetics 115, 169-176.
12. Friedberg, E. C. (1996) Annu. Rev. Biochem. 65, 15-42.
13. Korogodin, V. I., Korogodina, V. L., Fajszi, C., Chepurnoy, A., Mikhova-Tsenova, N. & Simonyan, N. V. (1991) Yeast 7, 105-117.
14. Nakane, H., Takeuchi, S., Yuba, S., Saijo, M., Nakatsu, Y., Murai, H., Nakatsuru, Y., Ishikawa, T., Hirota, S., Kitamura, Y., et al. (1995) Nature (London) 377, 165-168.
15. Modrich, P. & Lahue, R. (1996) Annu. Rev. Biochem. 65, 101-133.
16. Kolodner, R. (1996) Genes Dev. 10, 1433-1442.
17. Umar, A. & Kunkel, T. A. (1996) Eur. J. Biochem. 238, 297-307.
18. Umar, A., Buermeyer, A. B., Simon, J. A., Thomas, D. C., Clark, A. B., Liskay, R. M. & Kunkel, T. A. (1996) Cell 87, 65-73.
19. Baker, S. M., Bronner, C. E., Zhang, L., Plug, A. W., Robatzek, M., Warren, G., Elliott, E. A., Yu, J., Ashley, T., Arnheim, N., et al. (1995) Cell 82, 309-319.
20. Thomas, D. C., Umar, A. & Kunkel, T. A. (1995) in Methods: A Companion to Methods in Enzymology, ed. Friedberg, E. C. (Academic, New York), pp. 187-197.
21. Kaartinen, M., Griffiths, G. M., Markham, A. F. & Milstein, C. (1983) Nature (London) 304, 320-324.
22. Rada, C., Gonzalez-Fernandez, A., Jarvis, J. M. & Milstein, C. (1994) Eur. J. Immunol. 24, 1453-1457.
23. Milstein, C., Even, J., Jarvis, J. M., Gonzalez-Fernandez, A. & Gherardi, E. (1992) Eur. J. Immunol. 22, 1627-1634.
24. Griffiths, G. M., Berek, C., Kaartinen, M. & Milstein, C. (1984) Nature (London) 312, 271-275.
25. Alzari, P. M., Spinelli, S., Mariuzza, R. A., Boulot, G., Poljak, R. J., Jarvis, J. M. & Milstein, C. (1990) EMBO J. 9, 3807-3814.
26. Gonzalez-Fernandez, A. & Milstein, C. (1993) Proc. Natl. Acad. Sci. USA 90, 9862-9866.
27. Berek, C., Jarvis, J. M. & Milstein, C. (1987) Eur. J. Immunol. 17, 1121-1129.
28. Lozano, F., Rada, C., Jarvis, J. M. & Milstein, C. (1993) Nature (London) 363, 271-273.
29. Brownlee, K. A. (1965) in Statistical Theory and Methodology in Science and Engineering (Wiley, New York), pp. 183-185.
30. Thomas, D. C., Roberts, J. D. & Kunkel, T. A. (1991) J. Biol. Chem. 266, 3744-3751.
31. Risinger, J. I., Umar, A., Barrett, J. C. & Kunkel, T. A. (1995) J. Biol. Chem. 270, 18183-18186.
32. Wagner, S. D., Elvin, J. G., Norris, P., McGregor, J. M. & Neuberger, M. S. (1996) Int. Immunol. 8, 701-705.
33. Kim, N., Kage, K., Matsuda, F., Lefranc, M.-P. & Storb, U. (1997) J. Exp. Med. 186, 413-419.
34. Shen, H. M., Cheo, D. L., Friedberg, E. & Storb, U. (1997) Mol. Immunol. 34, 527-533.
35. Jacobs, H., Fukita, Y., van der Horst, G. T. J., de Boer, J., Weeda, G., Essers, J., de Wind, N., Engelward, B. P., Samson, L., Verbeek, S., et al. (1998) J. Exp. Med., in press.
36. Li, G. M. & Modrich, P. (1995) Proc. Natl. Acad. Sci. USA 92, 1950-1954.
37. Vidmar, J. J. & Cupples, C. G. (1993) Can. J. Microbiol. 39, 892-894.
38. Cascalho, M., Wong, J., Steinberg, C. & Wabl, M. (1998) Science 279, 1207-1210.
39. Phung, Q. H., Winter, D. B., Cranston, A., Tarone, R. E., Bohr, V. A., Fishel, R. & Gearhart, P. J. (1998) J. Exp. Med., in press.
40. Roberts, J. D. & Kunkel, T. A. (1996) in DNA Replication in Eukaryotic Cells, ed. DePamphilis, M. L. (Cold Spring Harbor Lab. Press, Plainview, NY), pp. 217-247.
41. Seidman, M. M., Bredberg, A., Seetharam, S. & Kraemer, K. H. (1987) Proc. Natl. Acad. Sci. USA 84, 4944-4948.
42. Beard, W. A., Osheroff, W. P., Prasad, R., Sawaya, M. R., Jaju, M., Wood, T. G., Kraut, J., Kunkel, T. A. & Wilson, A. H. (1996) J. Biol. Chem. 271, 12141-12144.
43. Klein, R., Jaenichen, R. & Zachau, H. G. (1993) Eur. J. Immunol. 23, 3248-3271.