Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 25, 2014, Pages 9217-9222

  Stavnezer, Janet ^a   Linehan, Erin K ^a   Thompson, Mikayla R ^a   Habboub, Ghaith ^a,c   Ucher, Anna J ^a   Kadungure, Tatenda ^a   Tsuchimoto, Daisuke ^b   Nakabeppu, Yusaku ^b   Schrader, Carol E ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b KYUSHU UNIVERSITY   (Japan)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; AP ENDONUCLEASE 1; AP ENDONUCLEASE 2; BASE; CYCLINE; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA POLYMERASE; EXONUCLEASE; PROTEIN MSH2; PROTEIN MSH6; UNCLASSIFIED DRUG; URACIL DNA GLYCOSIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CELL TYPE; CONTROLLED STUDY; DNA BASE COMPOSITION; DNA REPAIR; GENE EXPRESSION; GENE FREQUENCY; GERMINAL CENTER; HAPLOINSUFFICIENCY; IN VITRO STUDY; IN VIVO STUDY; INDEL MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SINGLE STRANDED DNA BREAK; SOMATIC HYPERMUTATION;

ANIMALS; B-LYMPHOCYTES; DNA GLYCOSYLASES; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DNA-BINDING PROTEINS; ENDONUCLEASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GERMINAL CENTER; MICE; MICE, KNOCKOUT; MUTATION; MUTS HOMOLOG 2 PROTEIN; PROLIFERATING CELL NUCLEAR ANTIGEN; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 84903474268     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1405590111     Document Type: Article

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