129-Derived strains of mice are deficient in DNA polymerase ι and have normal immunoglobulin hypermutation

Journal of Experimental Medicine

Volumn 198, Issue 4, 2003, Pages 635-643

  McDonald, John P ^a   Frank, Ekaterina G ^a   Plosky, Brian S ^a   Rogozin, Igor B ^b   Masutani, Chikahide ^c   Hanaoka, Fumio ^c,d   Woodgate, Roger ^a   Gearhart, Patricia J ^e  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c OSAKA UNIVERSITY   (Japan)

^d INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^e NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Base excision repair; Cytosine deamination; DNA polymerase ; Genomic organization; Immunoglobulin variable genes

Indexed keywords

DNA POLYMERASE;

AMINO ACID SUBSTITUTION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASE PAIRING; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS; ENZYME ACTIVE SITE; ENZYME DEFICIENCY; EXCISION REPAIR; GENE SEQUENCE; GENOTYPE; IMMUNOGLOBULIN VARIABLE REGION; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SOMATIC HYPERMUTATION; STOP CODON; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; GENOTYPE; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; MUTATION; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; TEMPLATES, GENETIC;

EID: 0042422042     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030767     Document Type: Article

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