-
1
-
-
34249790004
-
Molecular mechanisms of antibody somatic hypermutation
-
Di Noia JM, Neuberger MS (2007) Molecular mechanisms of antibody somatic hypermutation. Annu Rev Biochem 76:1-22.
-
(2007)
Annu Rev Biochem
, vol.76
, pp. 1-22
-
-
Di Noia, J.M.1
Neuberger, M.S.2
-
2
-
-
42649124572
-
The biochemistry of somatic hypermutation
-
Peled JU, et al. (2008) The biochemistry of somatic hypermutation. Annu Rev Immunol 26:481-511.
-
(2008)
Annu Rev Immunol
, vol.26
, pp. 481-511
-
-
Peled, J.U.1
-
3
-
-
0034268780
-
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
-
Muramatsu M, et al. (2000) Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102:553-563.
-
(2000)
Cell
, vol.102
, pp. 553-563
-
-
Muramatsu, M.1
-
5
-
-
0037026482
-
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
-
Di Noia J, Neuberger MS (2002) Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature 419:43-48.
-
(2002)
Nature
, vol.419
, pp. 43-48
-
-
Di Noia, J.1
Neuberger, M.S.2
-
6
-
-
33846404877
-
DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse
-
Delbos F, Aoufouchi S, Faili A, Weill JC, Reynaud CA (2007) DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse. J Exp Med 204:17-23.
-
(2007)
J Exp Med
, vol.204
, pp. 17-23
-
-
Delbos, F.1
Aoufouchi, S.2
Faili, A.3
Weill, J.C.4
Reynaud, C.A.5
-
7
-
-
34547114028
-
DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes
-
Masuda K, et al. (2007) DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes. J Biol Chem 282:17387-17394.
-
(2007)
J Biol Chem
, vol.282
, pp. 17387-17394
-
-
Masuda, K.1
-
8
-
-
48149091758
-
Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes
-
Martomo SA, Saribasak H, Yokoi M, Hanaoka F, Gearhart PJ (2008) Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes. DNA Repair (Amsterdam) 7:1603-1608.
-
(2008)
DNA Repair (Amsterdam)
, vol.7
, pp. 1603-1608
-
-
Martomo, S.A.1
Saribasak, H.2
Yokoi, M.3
Hanaoka, F.4
Gearhart, P.J.5
-
9
-
-
39149099085
-
Two levels of protection for the B cell genome during somatic hypermutation
-
Liu M, et al. (2008) Two levels of protection for the B cell genome during somatic hypermutation. Nature 451:841-845.
-
(2008)
Nature
, vol.451
, pp. 841-845
-
-
Liu, M.1
-
10
-
-
0037068455
-
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
-
Hoege C, Pfander B, Moldovan GL, Pyrowolakis G, Jentsch S (2002) RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419:135-141.
-
(2002)
Nature
, vol.419
, pp. 135-141
-
-
Hoege, C.1
Pfander, B.2
Moldovan, G.L.3
Pyrowolakis, G.4
Jentsch, S.5
-
11
-
-
2442417331
-
Interaction of human DNA polymerase eta with monoubiquitinated PCNA: A possible mechanism for the polymerase switch in response to DNA damage
-
Kannouche PL, Wing J, Lehmann AR (2004) Interaction of human DNA polymerase eta with monoubiquitinated PCNA: A possible mechanism for the polymerase switch in response to DNA damage. Mol Cell 14:491-500.
-
(2004)
Mol Cell
, vol.14
, pp. 491-500
-
-
Kannouche, P.L.1
Wing, J.2
Lehmann, A.R.3
-
12
-
-
29444454665
-
Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases eta and REV1
-
Garg P, Burgers PM (2005) Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases eta and REV1. Proc Natl Acad Sci USA 102:18361-18366.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 18361-18366
-
-
Garg, P.1
Burgers, P.M.2
-
13
-
-
34249066085
-
PCNA, the maestro of the replication fork
-
Moldovan GL, Pfander B, Jentsch S (2007) PCNA, the maestro of the replication fork. Cell 129:665-679.
-
(2007)
Cell
, vol.129
, pp. 665-679
-
-
Moldovan, G.L.1
Pfander, B.2
Jentsch, S.3
-
15
-
-
33645727204
-
Deubiquitinating PCNA: A downside to DNA damage tolerance
-
Ulrich HD (2006) Deubiquitinating PCNA: A downside to DNA damage tolerance. Nat Cell Biol 8:303-305.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 303-305
-
-
Ulrich, H.D.1
-
17
-
-
33751050806
-
A role for PCNA ubiquitination in immunoglobulin hypermutation
-
Arakawa H, et al. (2006) A role for PCNA ubiquitination in immunoglobulin hypermutation. PLoS Biol 4:e366.
-
(2006)
PLoS Biol
, vol.4
-
-
Arakawa, H.1
-
18
-
-
34547797940
-
A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification
-
Langerak P, Nygren AO, Krijger PH, van den Berk PC, Jacobs H (2007) A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification. J Exp Med 204:1989-1998.
-
(2007)
J Exp Med
, vol.204
, pp. 1989-1998
-
-
Langerak, P.1
Nygren, A.O.2
Krijger, P.H.3
van den Berk, P.C.4
Jacobs, H.5
-
19
-
-
33749510488
-
RAD18-independent ubiquitination of proliferating-cell nuclear antigen in the avian cell line DT40
-
Simpson LJ, et al. (2006) RAD18-independent ubiquitination of proliferating-cell nuclear antigen in the avian cell line DT40. EMBO Rep 7:927-932.
-
(2006)
EMBO Rep
, vol.7
, pp. 927-932
-
-
Simpson, L.J.1
-
20
-
-
33744932980
-
Genetic analysis of chromosome pairing, recombination, and cell cycle control during first meiotic prophase in mammals
-
Cohen PE, Pollack SE, Pollard JW (2006) Genetic analysis of chromosome pairing, recombination, and cell cycle control during first meiotic prophase in mammals. Endocr Rev 27:398-426.
-
(2006)
Endocr Rev
, vol.27
, pp. 398-426
-
-
Cohen, P.E.1
Pollack, S.E.2
Pollard, J.W.3
-
21
-
-
0033517129
-
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes
-
Schrader CE, Edelmann W, Kucherlapati R, Stavnezer J (1999) Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. J Exp Med 190:323-330.
-
(1999)
J Exp Med
, vol.190
, pp. 323-330
-
-
Schrader, C.E.1
Edelmann, W.2
Kucherlapati, R.3
Stavnezer, J.4
-
22
-
-
0025601012
-
The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response
-
Weiss U, Rajewsky K (1990) The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response. J Exp Med 172:1681-1689.
-
(1990)
J Exp Med
, vol.172
, pp. 1681-1689
-
-
Weiss, U.1
Rajewsky, K.2
-
23
-
-
0035379581
-
Somatic mutation hotspots correlate with DNA polymerase eta error spectrum
-
Rogozin IB, Pavlov YI, Bebenek K, Matsuda T, Kunkel TA (2001) Somatic mutation hotspots correlate with DNA polymerase eta error spectrum. Nat Immunol 2:530-536.
-
(2001)
Nat Immunol
, vol.2
, pp. 530-536
-
-
Rogozin, I.B.1
Pavlov, Y.I.2
Bebenek, K.3
Matsuda, T.4
Kunkel, T.A.5
-
24
-
-
0035860310
-
Error rate and specificity of human and murine DNA polymerase eta
-
Matsuda T, et al. (2001) Error rate and specificity of human and murine DNA polymerase eta. J Mol Biol 312:335-346.
-
(2001)
J Mol Biol
, vol.312
, pp. 335-346
-
-
Matsuda, T.1
-
25
-
-
20444427642
-
DNA polymerase eta contributes to strand bias of mutations of A versus T in immunoglobulin genes
-
Mayorov VI, Rogozin IB, Adkison LR, Gearhart PJ (2005) DNA polymerase eta contributes to strand bias of mutations of A versus T in immunoglobulin genes. J Immunol 174:7781-7786.
-
(2005)
J Immunol
, vol.174
, pp. 7781-7786
-
-
Mayorov, V.I.1
Rogozin, I.B.2
Adkison, L.R.3
Gearhart, P.J.4
-
26
-
-
0037926476
-
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
-
Pham P, Bransteitter R, Petruska J, Goodman MF (2003) Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature 424:103-107.
-
(2003)
Nature
, vol.424
, pp. 103-107
-
-
Pham, P.1
Bransteitter, R.2
Petruska, J.3
Goodman, M.F.4
-
27
-
-
0026443954
-
Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis
-
Rogozin IB, Kolchanov NA (1992) Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochim Biophy Acta 1171:11-18.
-
(1992)
Biochim Biophy Acta
, vol.1171
, pp. 11-18
-
-
Rogozin, I.B.1
Kolchanov, N.A.2
-
28
-
-
1842732235
-
Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions
-
Zeng X, Negrete GA, Kasmer C, Yang WW, Gearhart PJ (2004) Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions. J Exp Med 199:917-924.
-
(2004)
J Exp Med
, vol.199
, pp. 917-924
-
-
Zeng, X.1
Negrete, G.A.2
Kasmer, C.3
Yang, W.W.4
Gearhart, P.J.5
-
29
-
-
1642499721
-
DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination
-
Faili A, et al. (2004) DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination. J Exp Med 199:265-270.
-
(2004)
J Exp Med
, vol.199
, pp. 265-270
-
-
Faili, A.1
-
30
-
-
33646254420
-
Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis
-
Haracska L, Unk I, Prakash L, Prakash S (2006) Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis. Proc Natl Acad Sci USA 103:6477-6482.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 6477-6482
-
-
Haracska, L.1
Unk, I.2
Prakash, L.3
Prakash, S.4
-
31
-
-
14244250387
-
MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes
-
Wilson TM, et al. (2005) MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes. J Exp Med 201:637-645.
-
(2005)
J Exp Med
, vol.201
, pp. 637-645
-
-
Wilson, T.M.1
-
32
-
-
33847381960
-
Contributions of ubiquitin-and PCNA-binding domains to the activity of polymerase eta in Saccharomyces cerevisiae
-
Parker JL, Bielen AB, Dikic I, Ulrich HD (2007) Contributions of ubiquitin-and PCNA-binding domains to the activity of polymerase eta in Saccharomyces cerevisiae. Nucleic Acids Res 35:881-889.
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 881-889
-
-
Parker, J.L.1
Bielen, A.B.2
Dikic, I.3
Ulrich, H.D.4
-
33
-
-
41449101673
-
Ubiquitylation of proliferating cell nuclear antigen and recruitment of human DNA polymerase eta
-
Nikolaishvili-Feinberg N, et al. (2008) Ubiquitylation of proliferating cell nuclear antigen and recruitment of human DNA polymerase eta. Biochemistry 47:4141-4150.
-
(2008)
Biochemistry
, vol.47
, pp. 4141-4150
-
-
Nikolaishvili-Feinberg, N.1
-
34
-
-
34548526067
-
Strand-biased spreading of mutations during somatic hypermutation
-
Unniraman S, Schatz DG (2007) Strand-biased spreading of mutations during somatic hypermutation. Science 317:1227-1230.
-
(2007)
Science
, vol.317
, pp. 1227-1230
-
-
Unniraman, S.1
Schatz, D.G.2
-
35
-
-
20844452399
-
Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification
-
Martomo SA, et al. (2005) Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification. Proc Natl Acad Sci USA 102:8656-8661.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 8656-8661
-
-
Martomo, S.A.1
-
36
-
-
33344468484
-
Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice
-
Jansen JG, et al. (2006) Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice. J Exp Med 203:319-323.
-
(2006)
J Exp Med
, vol.203
, pp. 319-323
-
-
Jansen, J.G.1
-
37
-
-
33644543730
-
The catalytic activity of REV1 is employed during immunoglobulin gene diversification in DT40
-
Ross AL, Sale JE (2006) The catalytic activity of REV1 is employed during immunoglobulin gene diversification in DT40. Mol Immunol 43:1587-1594.
-
(2006)
Mol Immunol
, vol.43
, pp. 1587-1594
-
-
Ross, A.L.1
Sale, J.E.2
-
38
-
-
41149132841
-
Fixing DNA breaks during class switch recombination
-
Jolly CJ, Cook AJ, Manis JP (2008) Fixing DNA breaks during class switch recombination. J Exp Med 205:509-513.
-
(2008)
J Exp Med
, vol.205
, pp. 509-513
-
-
Jolly, C.J.1
Cook, A.J.2
Manis, J.P.3
-
39
-
-
34748863465
-
IgH class switching and translocations use a robust non-classical end-joining pathway
-
Yan CT, et al. (2007) IgH class switching and translocations use a robust non-classical end-joining pathway. Nature 449:478-482.
-
(2007)
Nature
, vol.449
, pp. 478-482
-
-
Yan, C.T.1
-
40
-
-
1142299546
-
Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice
-
Bardwell PD, et al. (2004) Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice. Nat Immunol 5:224-229.
-
(2004)
Nat Immunol
, vol.5
, pp. 224-229
-
-
Bardwell, P.D.1
-
41
-
-
0037017390
-
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions
-
Schrader CE, Vardo J, Stavnezer J (2002) Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions. J Exp Med 195:367-373.
-
(2002)
J Exp Med
, vol.195
, pp. 367-373
-
-
Schrader, C.E.1
Vardo, J.2
Stavnezer, J.3
-
42
-
-
0038190805
-
Mlh1 can function in antibody class switch recombination independently of Msh2
-
Schrader CE, Vardo J, Stavnezer J (2003) Mlh1 can function in antibody class switch recombination independently of Msh2. J Exp Med 197:1377-1383.
-
(2003)
J Exp Med
, vol.197
, pp. 1377-1383
-
-
Schrader, C.E.1
Vardo, J.2
Stavnezer, J.3
-
43
-
-
0033564878
-
Deficiency in msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: Parallels with somatic hypermutation
-
Ehrenstein MR, Neuberger MS (1999) Deficiency in msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: Parallels with somatic hypermutation. EMBO J 18:3484-3490.
-
(1999)
EMBO J
, vol.18
, pp. 3484-3490
-
-
Ehrenstein, M.R.1
Neuberger, M.S.2
-
44
-
-
34447279017
-
DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination
-
Wu X, Stavnezer J (2007) DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination. J Exp Med 204:1677-1689.
-
(2007)
J Exp Med
, vol.204
, pp. 1677-1689
-
-
Wu, X.1
Stavnezer, J.2
-
45
-
-
0033974775
-
Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally
-
Esposito G, et al. (2000) Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally. Proc Natl Acad Sci USA 97:1166-1171.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1166-1171
-
-
Esposito, G.1
-
46
-
-
27744579794
-
Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I
-
Kolas NK, et al. (2005) Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I. J Cell Biol 171:447-458.
-
(2005)
J Cell Biol
, vol.171
, pp. 447-458
-
-
Kolas, N.K.1
-
47
-
-
33646015672
-
The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus
-
Li Z, et al. (2006) The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus. Immunity 24:393-403.
-
(2006)
Immunity
, vol.24
, pp. 393-403
-
-
Li, Z.1
-
48
-
-
33646018048
-
A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation
-
Wu X, et al. (2006) A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation. J Immunol 176:5426-5437.
-
(2006)
J Immunol
, vol.176
, pp. 5426-5437
-
-
Wu, X.1
-
49
-
-
0035807955
-
Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination
-
Ehrenstein MR, Rada C, Jones AM, Milstein C, Neuberger MS (2001) Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination. Proc Natl Acad Sci USA 98:14553-14558.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 14553-14558
-
-
Ehrenstein, M.R.1
Rada, C.2
Jones, A.M.3
Milstein, C.4
Neuberger, M.S.5
|