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Volumn 22, Issue 6, 2010, Pages 337-345

RAGs' eye view of the immunoglobulin heavy chain gene locus

Author keywords

Accessibility; Enhancer; Epigenetics; Immunoglobulin

Indexed keywords

HISTONE METHYLTRANSFERASE; PROTEIN H3K4ME2; PROTEIN H3K4ME3; RAG1 PROTEIN; RAG2 PROTEIN; TRICHOSTATIN A; UNCLASSIFIED DRUG;

EID: 78249282286     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.smim.2010.08.003     Document Type: Review
Times cited : (13)

References (110)
  • 1
    • 58049218889 scopus 로고    scopus 로고
    • Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus
    • Perlot T., Alt F.W. Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus. Adv Immunol 2008, 99:1-32.
    • (2008) Adv Immunol , vol.99 , pp. 1-32
    • Perlot, T.1    Alt, F.W.2
  • 2
    • 70349570163 scopus 로고    scopus 로고
    • Germline transcription: a key regulator of accessibility and recombination
    • Abarrategui I., Krangel M.S. Germline transcription: a key regulator of accessibility and recombination. Adv Exp Med Biol 2009, 650:93-102.
    • (2009) Adv Exp Med Biol , vol.650 , pp. 93-102
    • Abarrategui, I.1    Krangel, M.S.2
  • 3
    • 0021983551 scopus 로고
    • Developmentally controlled and tissue-specific expression of unrearranged VH gene segments
    • Yancopoulos G.D., Alt F.W. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell 1985, 40:271-281.
    • (1985) Cell , vol.40 , pp. 271-281
    • Yancopoulos, G.D.1    Alt, F.W.2
  • 4
    • 0023002697 scopus 로고
    • Recombination between immunoglobulin variable region gene segments is enhanced by transcription
    • Blackwell T.K., Moore M.W., Yancopoulos G.D., Suh H., Lutzker S., Selsing E., et al. Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature 1986, 324:585-589.
    • (1986) Nature , vol.324 , pp. 585-589
    • Blackwell, T.K.1    Moore, M.W.2    Yancopoulos, G.D.3    Suh, H.4    Lutzker, S.5    Selsing, E.6
  • 5
    • 0024433760 scopus 로고
    • T cell receptor DJ but not VDJ rearrangement within a recombination substrate introduced into a pre-B cell line
    • Ferrier P., Covey L.R., Suh H., Winoto A., Hood L., Alt F.W. T cell receptor DJ but not VDJ rearrangement within a recombination substrate introduced into a pre-B cell line. Int Immunol 1989, 1:66-74.
    • (1989) Int Immunol , vol.1 , pp. 66-74
    • Ferrier, P.1    Covey, L.R.2    Suh, H.3    Winoto, A.4    Hood, L.5    Alt, F.W.6
  • 6
    • 0022374773 scopus 로고
    • C mu-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5'-nontranslatable exon
    • Lennon G.G., Perry R.P. C mu-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5'-nontranslatable exon. Nature 1985, 318:475-478.
    • (1985) Nature , vol.318 , pp. 475-478
    • Lennon, G.G.1    Perry, R.P.2
  • 7
    • 0019856949 scopus 로고
    • Transcription of the unrearranged mouse C kappa locus: sequence of the initiation region and comparison of activity with a rearranged V kappa-C kappa gene
    • Van Ness B.G., Weigert M., Coleclough C., Mather E.L., Kelley D.E., Perry R.P. Transcription of the unrearranged mouse C kappa locus: sequence of the initiation region and comparison of activity with a rearranged V kappa-C kappa gene. Cell 1981, 27:593-602.
    • (1981) Cell , vol.27 , pp. 593-602
    • Van Ness, B.G.1    Weigert, M.2    Coleclough, C.3    Mather, E.L.4    Kelley, D.E.5    Perry, R.P.6
  • 8
    • 0021730596 scopus 로고
    • Unrearranged immunoglobulin lambda variable region is transcribed in kappa-producing myelomas
    • Picard D., Schaffner W. Unrearranged immunoglobulin lambda variable region is transcribed in kappa-producing myelomas. EMBO J 1984, 3:3031-3035.
    • (1984) EMBO J , vol.3 , pp. 3031-3035
    • Picard, D.1    Schaffner, W.2
  • 9
    • 13444268486 scopus 로고    scopus 로고
    • Regulation of T cell receptor beta allelic exclusion at a level beyond accessibility
    • Jackson A., Kondilis H.D., Khor B., Sleckman B.P., Krangel M.S. Regulation of T cell receptor beta allelic exclusion at a level beyond accessibility. Nat Immunol 2005, 6:189-197.
    • (2005) Nat Immunol , vol.6 , pp. 189-197
    • Jackson, A.1    Kondilis, H.D.2    Khor, B.3    Sleckman, B.P.4    Krangel, M.S.5
  • 10
    • 0038783581 scopus 로고    scopus 로고
    • Increase of TCR V beta accessibility within E beta regulatory region influences its recombination frequency but not allelic exclusion
    • Senoo M., Wang L., Suzuki D., Takeda N., Shinkai Y., Habu S. Increase of TCR V beta accessibility within E beta regulatory region influences its recombination frequency but not allelic exclusion. J Immunol 2003, 171:829-835.
    • (2003) J Immunol , vol.171 , pp. 829-835
    • Senoo, M.1    Wang, L.2    Suzuki, D.3    Takeda, N.4    Shinkai, Y.5    Habu, S.6
  • 11
    • 0028223482 scopus 로고
    • Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells
    • Okada A., Mendelsohn M., Alt F. Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells. J Exp Med 1994, 180:261-272.
    • (1994) J Exp Med , vol.180 , pp. 261-272
    • Okada, A.1    Mendelsohn, M.2    Alt, F.3
  • 12
    • 0031595346 scopus 로고    scopus 로고
    • Evidence that immunoglobulin VH-DJ recombination does not require germ line transcription of the recombining variable gene segment
    • Angelin-Duclos C., Calame K. Evidence that immunoglobulin VH-DJ recombination does not require germ line transcription of the recombining variable gene segment. Mol Cell Biol 1998, 18:6253-6264.
    • (1998) Mol Cell Biol , vol.18 , pp. 6253-6264
    • Angelin-Duclos, C.1    Calame, K.2
  • 13
    • 0019457034 scopus 로고
    • Activation of globin genes during chicken development
    • Groudine M., Weintraub H. Activation of globin genes during chicken development. Cell 1981, 24:393-401.
    • (1981) Cell , vol.24 , pp. 393-401
    • Groudine, M.1    Weintraub, H.2
  • 14
    • 0019401409 scopus 로고
    • DNase I hypersensitive sites in Drosophila chromatin occur at the 5' ends of regions of transcription
    • Keene M.A., Corces V., Lowenhaupt K., Elgin S.C. DNase I hypersensitive sites in Drosophila chromatin occur at the 5' ends of regions of transcription. Proc Natl Acad Sci USA 1981, 78:143-146.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 143-146
    • Keene, M.A.1    Corces, V.2    Lowenhaupt, K.3    Elgin, S.C.4
  • 15
    • 0019542744 scopus 로고
    • Tissue-specific exposure of chromatin structure at the 5' terminus of the rat preproinsulin II gene
    • Wu C., Gilbert W. Tissue-specific exposure of chromatin structure at the 5' terminus of the rat preproinsulin II gene. Proc Natl Acad Sci USA 1981, 78:1577-1580.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 1577-1580
    • Wu, C.1    Gilbert, W.2
  • 16
    • 0023371968 scopus 로고
    • Analysis of the tissue-specific enhancer at the 3' end of the chicken adult beta-globin gene
    • Emerson B.M., Nickol J.M., Jackson P.D., Felsenfeld G. Analysis of the tissue-specific enhancer at the 3' end of the chicken adult beta-globin gene. Proc Natl Acad Sci USA 1987, 84:4786-4790.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 4786-4790
    • Emerson, B.M.1    Nickol, J.M.2    Jackson, P.D.3    Felsenfeld, G.4
  • 17
    • 0026467244 scopus 로고
    • A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer
    • Henkel G., Weiss D.L., McCoy R., Deloughery T., Tara D., Brown M.A. A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer. J Immunol 1992, 149:3239-3246.
    • (1992) J Immunol , vol.149 , pp. 3239-3246
    • Henkel, G.1    Weiss, D.L.2    McCoy, R.3    Deloughery, T.4    Tara, D.5    Brown, M.A.6
  • 18
    • 0023899769 scopus 로고
    • Nuclease hypersensitive sites in chromatin
    • Gross D.S., Garrard W.T. Nuclease hypersensitive sites in chromatin. Annu Rev Biochem 1988, 57:159-197.
    • (1988) Annu Rev Biochem , vol.57 , pp. 159-197
    • Gross, D.S.1    Garrard, W.T.2
  • 19
    • 0027487392 scopus 로고
    • The immunoglobulin mu enhancer core establishes local factor access in nuclear chromatin independent of transcriptional stimulation
    • Jenuwein T., Forrester W.C., Qiu R.G., Grosschedl R. The immunoglobulin mu enhancer core establishes local factor access in nuclear chromatin independent of transcriptional stimulation. Genes Dev 1993, 7:2016-2032.
    • (1993) Genes Dev , vol.7 , pp. 2016-2032
    • Jenuwein, T.1    Forrester, W.C.2    Qiu, R.G.3    Grosschedl, R.4
  • 20
    • 0025177032 scopus 로고
    • Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate
    • Ferrier P., Krippl B., Blackwell T.K., Furley A.J., Suh H., Winoto A., et al. Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. EMBO J 1990, 9:117-125.
    • (1990) EMBO J , vol.9 , pp. 117-125
    • Ferrier, P.1    Krippl, B.2    Blackwell, T.K.3    Furley, A.J.4    Suh, H.5    Winoto, A.6
  • 21
    • 0027508340 scopus 로고
    • TCR beta and TCR alpha gene enhancers confer tissue- and stage-specificity on V(D)J recombination events
    • Capone M., Watrin F., Fernex C., Horvat B., Krippl B., Wu L., et al. TCR beta and TCR alpha gene enhancers confer tissue- and stage-specificity on V(D)J recombination events. EMBO J 1993, 12:4335-4346.
    • (1993) EMBO J , vol.12 , pp. 4335-4346
    • Capone, M.1    Watrin, F.2    Fernex, C.3    Horvat, B.4    Krippl, B.5    Wu, L.6
  • 22
    • 0033988495 scopus 로고    scopus 로고
    • Definition of a T-cell receptor beta gene core enhancer of V(D)J recombination by transgenic mapping
    • Tripathi R.K., Mathieu N., Spicuglia S., Payet D., Verthuy C., Bouvier G., et al. Definition of a T-cell receptor beta gene core enhancer of V(D)J recombination by transgenic mapping. Mol Cell Biol 2000, 20:42-53.
    • (2000) Mol Cell Biol , vol.20 , pp. 42-53
    • Tripathi, R.K.1    Mathieu, N.2    Spicuglia, S.3    Payet, D.4    Verthuy, C.5    Bouvier, G.6
  • 23
    • 0028012025 scopus 로고
    • Enhancer-dependent and -independent steps in the rearrangement of a human T cell receptor delta transgene
    • Lauzurica P., Krangel M.S. Enhancer-dependent and -independent steps in the rearrangement of a human T cell receptor delta transgene. J Exp Med 1994, 179:43-55.
    • (1994) J Exp Med , vol.179 , pp. 43-55
    • Lauzurica, P.1    Krangel, M.S.2
  • 24
    • 0028276377 scopus 로고
    • Temporal and lineage-specific control of T cell receptor alpha/delta gene rearrangement by T cell receptor alpha and delta enhancers
    • Lauzurica P., Krangel M.S. Temporal and lineage-specific control of T cell receptor alpha/delta gene rearrangement by T cell receptor alpha and delta enhancers. J Exp Med 1994, 179:1913-1921.
    • (1994) J Exp Med , vol.179 , pp. 1913-1921
    • Lauzurica, P.1    Krangel, M.S.2
  • 25
    • 0029819322 scopus 로고    scopus 로고
    • Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility
    • Bories J.C., Demengeot J., Davidson L., Alt F.W. Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility. Proc Natl Acad Sci USA 1996, 93:7871-7876.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7871-7876
    • Bories, J.C.1    Demengeot, J.2    Davidson, L.3    Alt, F.W.4
  • 26
    • 0030663194 scopus 로고    scopus 로고
    • Function of the TCR alpha enhancer in alphabeta and gammadelta T cells
    • Sleckman B.P., Bardon C.G., Ferrini R., Davidson L., Alt F.W. Function of the TCR alpha enhancer in alphabeta and gammadelta T cells. Immunity 1997, 7:505-515.
    • (1997) Immunity , vol.7 , pp. 505-515
    • Sleckman, B.P.1    Bardon, C.G.2    Ferrini, R.3    Davidson, L.4    Alt, F.W.5
  • 27
    • 0029842562 scopus 로고    scopus 로고
    • Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development
    • Bouvier G., Watrin F., Naspetti M., Verthuy C., Naquet P., Ferrier P. Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development. Proc Natl Acad Sci USA 1996, 93:7877-7881.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7877-7881
    • Bouvier, G.1    Watrin, F.2    Naspetti, M.3    Verthuy, C.4    Naquet, P.5    Ferrier, P.6
  • 28
    • 32044444420 scopus 로고    scopus 로고
    • Regulation of IgH gene assembly: role of the intronic enhancer and 5'DQ52 region in targeting DHJH recombination
    • Afshar R., Pierce S., Bolland D.J., Corcoran A., Oltz E.M. Regulation of IgH gene assembly: role of the intronic enhancer and 5'DQ52 region in targeting DHJH recombination. J Immunol 2006, 176:2439-2447.
    • (2006) J Immunol , vol.176 , pp. 2439-2447
    • Afshar, R.1    Pierce, S.2    Bolland, D.J.3    Corcoran, A.4    Oltz, E.M.5
  • 29
    • 26444515533 scopus 로고    scopus 로고
    • Elucidation of IgH intronic enhancer functions via germ-line deletion
    • Perlot T., Alt F.W., Bassing C.H., Suh H., Pinaud E. Elucidation of IgH intronic enhancer functions via germ-line deletion. Proc Natl Acad Sci USA 2005, 102:14362-14367.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 14362-14367
    • Perlot, T.1    Alt, F.W.2    Bassing, C.H.3    Suh, H.4    Pinaud, E.5
  • 30
    • 0033574062 scopus 로고    scopus 로고
    • Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions
    • Sakai E., Bottaro A., Davidson L., Sleckman B.P., Alt F.W. Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions. Proc Natl Acad Sci USA 1999, 96:1526-1531.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1526-1531
    • Sakai, E.1    Bottaro, A.2    Davidson, L.3    Sleckman, B.P.4    Alt, F.W.5
  • 31
    • 0027192988 scopus 로고
    • V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer
    • Serwe M., Sablitzky F. V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer. EMBO J 1993, 12:2321-2327.
    • (1993) EMBO J , vol.12 , pp. 2321-2327
    • Serwe, M.1    Sablitzky, F.2
  • 32
    • 0036097492 scopus 로고    scopus 로고
    • Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation
    • Inlay M., Alt F.W., Baltimore D., Xu Y. Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation. Nat Immunol 2002, 3:463-468.
    • (2002) Nat Immunol , vol.3 , pp. 463-468
    • Inlay, M.1    Alt, F.W.2    Baltimore, D.3    Xu, Y.4
  • 33
    • 0029967078 scopus 로고    scopus 로고
    • Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement
    • Xu Y., Davidson L., Alt F.W., Baltimore D. Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement. Immunity 1996, 4:377-385.
    • (1996) Immunity , vol.4 , pp. 377-385
    • Xu, Y.1    Davidson, L.2    Alt, F.W.3    Baltimore, D.4
  • 35
  • 36
    • 0033103012 scopus 로고    scopus 로고
    • Control of V(D)J recombinational accessibility of the D beta 1 gene segment at the TCR beta locus by a germline promoter
    • Whitehurst C.E., Chattopadhyay S., Chen J. Control of V(D)J recombinational accessibility of the D beta 1 gene segment at the TCR beta locus by a germline promoter. Immunity 1999, 10:313-322.
    • (1999) Immunity , vol.10 , pp. 313-322
    • Whitehurst, C.E.1    Chattopadhyay, S.2    Chen, J.3
  • 37
    • 0030273709 scopus 로고    scopus 로고
    • Defect in rearrangement of the most 5' TCR-J alpha following targeted deletion of T early alpha (TEA): implications for TCR alpha locus accessibility
    • Villey I., Caillol D., Selz F., Ferrier P., de Villartay J.P. Defect in rearrangement of the most 5' TCR-J alpha following targeted deletion of T early alpha (TEA): implications for TCR alpha locus accessibility. Immunity 1996, 5:331-342.
    • (1996) Immunity , vol.5 , pp. 331-342
    • Villey, I.1    Caillol, D.2    Selz, F.3    Ferrier, P.4    de Villartay, J.P.5
  • 38
    • 0035890244 scopus 로고    scopus 로고
    • Stepwise activation of the immunoglobulin mu heavy chain gene locus
    • Chowdhury D., Sen R. Stepwise activation of the immunoglobulin mu heavy chain gene locus. EMBO J 2001, 20:6394-6403.
    • (2001) EMBO J , vol.20 , pp. 6394-6403
    • Chowdhury, D.1    Sen, R.2
  • 39
    • 0021077011 scopus 로고
    • DNase I hypersensitive sites in the chromatin of human mu immunoglobulin heavy-chain genes
    • Mills F.C., Fisher L.M., Kuroda R., Ford A.M., Gould H.J. DNase I hypersensitive sites in the chromatin of human mu immunoglobulin heavy-chain genes. Nature 1983, 306:809-812.
    • (1983) Nature , vol.306 , pp. 809-812
    • Mills, F.C.1    Fisher, L.M.2    Kuroda, R.3    Ford, A.M.4    Gould, H.J.5
  • 40
    • 0027173505 scopus 로고
    • DNA regions flanking the mouse Ig 3' alpha enhancer are differentially methylated and DNAase I hypersensitive during B cell differentiation
    • Giannini S.L., Singh M., Calvo C.F., Ding G., Birshtein B.K. DNA regions flanking the mouse Ig 3' alpha enhancer are differentially methylated and DNAase I hypersensitive during B cell differentiation. J Immunol 1993, 150:1772-1780.
    • (1993) J Immunol , vol.150 , pp. 1772-1780
    • Giannini, S.L.1    Singh, M.2    Calvo, C.F.3    Ding, G.4    Birshtein, B.K.5
  • 41
    • 0028988293 scopus 로고
    • Identification of 3' alpha-hs4, a novel Ig heavy chain enhancer element regulated at multiple stages of B cell differentiation
    • Michaelson J.S., Giannini S.L., Birshtein B.K. Identification of 3' alpha-hs4, a novel Ig heavy chain enhancer element regulated at multiple stages of B cell differentiation. Nucleic Acids Res 1995, 23:975-981.
    • (1995) Nucleic Acids Res , vol.23 , pp. 975-981
    • Michaelson, J.S.1    Giannini, S.L.2    Birshtein, B.K.3
  • 42
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T., Allis C.D. Translating the histone code. Science 2001, 293:1074-1080.
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 43
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • Strahl B.D., Allis C.D. The language of covalent histone modifications. Nature 2000, 403:41-45.
    • (2000) Nature , vol.403 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 44
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation during transcription
    • Berger S.L. The complex language of chromatin regulation during transcription. Nature 2007, 447:407-412.
    • (2007) Nature , vol.447 , pp. 407-412
    • Berger, S.L.1
  • 45
    • 0141705373 scopus 로고    scopus 로고
    • Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4
    • Morshead K.B., Ciccone D.N., Taverna S.D., Allis C.D., Oettinger M.A. Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4. Proc Natl Acad Sci USA 2003, 100:11577-11582.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11577-11582
    • Morshead, K.B.1    Ciccone, D.N.2    Taverna, S.D.3    Allis, C.D.4    Oettinger, M.A.5
  • 46
    • 34548247115 scopus 로고    scopus 로고
    • Repeat organization and epigenetic regulation of the DH-Cmu domain of the immunoglobulin heavy-chain gene locus
    • Chakraborty T., Chowdhury D., Keyes A., Jani A., Subrahmanyam R., Ivanova I., et al. Repeat organization and epigenetic regulation of the DH-Cmu domain of the immunoglobulin heavy-chain gene locus. Mol Cell 2007, 27:842-850.
    • (2007) Mol Cell , vol.27 , pp. 842-850
    • Chakraborty, T.1    Chowdhury, D.2    Keyes, A.3    Jani, A.4    Subrahmanyam, R.5    Ivanova, I.6
  • 47
    • 66049116723 scopus 로고    scopus 로고
    • A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation
    • Chakraborty T., Perlot T., Subrahmanyam R., Jani A., Goff P.H., Zhang Y., et al. A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation. J Exp Med 2009, 206:1019-1027.
    • (2009) J Exp Med , vol.206 , pp. 1019-1027
    • Chakraborty, T.1    Perlot, T.2    Subrahmanyam, R.3    Jani, A.4    Goff, P.H.5    Zhang, Y.6
  • 48
    • 33645980634 scopus 로고    scopus 로고
    • Activation of V(D)J recombination at the IgH chain JH locus occurs within a 6-kilobase chromatin domain and is associated with nucleosomal remodeling
    • Maes J., Chappaz S., Cavelier P., O'Neill L., Turner B., Rougeon F., et al. Activation of V(D)J recombination at the IgH chain JH locus occurs within a 6-kilobase chromatin domain and is associated with nucleosomal remodeling. J Immunol 2006, 176:5409-5417.
    • (2006) J Immunol , vol.176 , pp. 5409-5417
    • Maes, J.1    Chappaz, S.2    Cavelier, P.3    O'Neill, L.4    Turner, B.5    Rougeon, F.6
  • 49
    • 3042750473 scopus 로고    scopus 로고
    • Histone 3 lysine 4 methylation during the pre-B to immature B-cell transition
    • Perkins E.J., Kee B.L., Ramsden D.A. Histone 3 lysine 4 methylation during the pre-B to immature B-cell transition. Nucleic Acids Res 2004, 32:1942-1947.
    • (2004) Nucleic Acids Res , vol.32 , pp. 1942-1947
    • Perkins, E.J.1    Kee, B.L.2    Ramsden, D.A.3
  • 50
    • 63149116657 scopus 로고    scopus 로고
    • The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling
    • Xu C.R., Feeney A.J. The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling. J Immunol 2009, 182:1362-1369.
    • (2009) J Immunol , vol.182 , pp. 1362-1369
    • Xu, C.R.1    Feeney, A.J.2
  • 51
    • 0025922273 scopus 로고
    • Comparison of D, JH, and junctional diversity in the fetal, adult, and aged B cell repertoires
    • Bangs L.A., Sanz I.E., Teale J.M. Comparison of D, JH, and junctional diversity in the fetal, adult, and aged B cell repertoires. J Immunol 1991, 146:1996-2004.
    • (1991) J Immunol , vol.146 , pp. 1996-2004
    • Bangs, L.A.1    Sanz, I.E.2    Teale, J.M.3
  • 52
    • 0026538739 scopus 로고
    • Enumeration and characterization of DJH structures in mouse fetal liver
    • Chang Y., Paige C.J., Wu G.E. Enumeration and characterization of DJH structures in mouse fetal liver. EMBO J 1992, 11:1891-1899.
    • (1992) EMBO J , vol.11 , pp. 1891-1899
    • Chang, Y.1    Paige, C.J.2    Wu, G.E.3
  • 53
    • 0025184095 scopus 로고
    • Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences
    • Feeney A.J. Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences. J Exp Med 1990, 172:1377-1390.
    • (1990) J Exp Med , vol.172 , pp. 1377-1390
    • Feeney, A.J.1
  • 54
    • 0035865342 scopus 로고    scopus 로고
    • Deletion of the DQ52 element within the Ig heavy chain locus leads to a selective reduction in VDJ recombination and altered D gene usage
    • Nitschke L., Kestler J., Tallone T., Pelkonen S., Pelkonen J. Deletion of the DQ52 element within the Ig heavy chain locus leads to a selective reduction in VDJ recombination and altered D gene usage. J Immunol 2001, 166:2540-2552.
    • (2001) J Immunol , vol.166 , pp. 2540-2552
    • Nitschke, L.1    Kestler, J.2    Tallone, T.3    Pelkonen, S.4    Pelkonen, J.5
  • 55
    • 0025335831 scopus 로고
    • Estimation of D segment usage in initial D to JH joinings in a murine immature B cell line. Preferential usage of DFL16. 1, the most 5' D segment and DQ52, the most JH-proximal D segment
    • Tsukada S., Sugiyama H., Oka Y., Kishimoto S. Estimation of D segment usage in initial D to JH joinings in a murine immature B cell line. Preferential usage of DFL16. 1, the most 5' D segment and DQ52, the most JH-proximal D segment. J Immunol 1990, 144:4053-4059.
    • (1990) J Immunol , vol.144 , pp. 4053-4059
    • Tsukada, S.1    Sugiyama, H.2    Oka, Y.3    Kishimoto, S.4
  • 56
    • 0037072661 scopus 로고    scopus 로고
    • Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi
    • Volpe T.A., Kidner C., Hall I.M., Teng G., Grewal S.I., Martienssen R.A. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 2002, 297:1833-1837.
    • (2002) Science , vol.297 , pp. 1833-1837
    • Volpe, T.A.1    Kidner, C.2    Hall, I.M.3    Teng, G.4    Grewal, S.I.5    Martienssen, R.A.6
  • 57
    • 26944434789 scopus 로고    scopus 로고
    • The nucleation and maintenance of heterochromatin by a histone deacetylase in fission yeast
    • Yamada T., Fischle W., Sugiyama T., Allis C.D., Grewal S.I. The nucleation and maintenance of heterochromatin by a histone deacetylase in fission yeast. Mol Cell 2005, 20:173-185.
    • (2005) Mol Cell , vol.20 , pp. 173-185
    • Yamada, T.1    Fischle, W.2    Sugiyama, T.3    Allis, C.D.4    Grewal, S.I.5
  • 58
    • 10944248935 scopus 로고    scopus 로고
    • Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs
    • Motamedi M.R., Verdel A., Colmenares S.U., Gerber S.A., Gygi S.P., Moazed D. Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell 2004, 119:789-802.
    • (2004) Cell , vol.119 , pp. 789-802
    • Motamedi, M.R.1    Verdel, A.2    Colmenares, S.U.3    Gerber, S.A.4    Gygi, S.P.5    Moazed, D.6
  • 59
    • 34548784928 scopus 로고    scopus 로고
    • Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline
    • Klenov M.S., Lavrov S.A., Stolyarenko A.D., Ryazansky S.S., Aravin A.A., Tuschl T., et al. Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline. Nucleic Acids Res 2007, 35:5430-5438.
    • (2007) Nucleic Acids Res , vol.35 , pp. 5430-5438
    • Klenov, M.S.1    Lavrov, S.A.2    Stolyarenko, A.D.3    Ryazansky, S.S.4    Aravin, A.A.5    Tuschl, T.6
  • 60
    • 23044508951 scopus 로고    scopus 로고
    • Interrelationship of RNA interference and transcriptional gene silencing in Drosophila
    • Pal-Bhadra M., Bhadra U., Birchler J.A. Interrelationship of RNA interference and transcriptional gene silencing in Drosophila. Cold Spring Harb Symp Quant Biol 2004, 69:433-438.
    • (2004) Cold Spring Harb Symp Quant Biol , vol.69 , pp. 433-438
    • Pal-Bhadra, M.1    Bhadra, U.2    Birchler, J.A.3
  • 61
    • 0942279635 scopus 로고    scopus 로고
    • RNAi-mediated targeting of heterochromatin by the RITS complex
    • Verdel A., Jia S., Gerber S., Sugiyama T., Gygi S., Grewal S.I., et al. RNAi-mediated targeting of heterochromatin by the RITS complex. Science 2004, 303:672-676.
    • (2004) Science , vol.303 , pp. 672-676
    • Verdel, A.1    Jia, S.2    Gerber, S.3    Sugiyama, T.4    Gygi, S.5    Grewal, S.I.6
  • 62
    • 23044498502 scopus 로고    scopus 로고
    • Comprehensive analysis of heterochromatin- and RNAi-mediated epigenetic control of the fission yeast genome
    • Cam H.P., Sugiyama T., Chen E.S., Chen X., FitzGerald P.C., Grewal S.I. Comprehensive analysis of heterochromatin- and RNAi-mediated epigenetic control of the fission yeast genome. Nat Genet 2005, 37:809-819.
    • (2005) Nat Genet , vol.37 , pp. 809-819
    • Cam, H.P.1    Sugiyama, T.2    Chen, E.S.3    Chen, X.4    FitzGerald, P.C.5    Grewal, S.I.6
  • 63
    • 40649112903 scopus 로고    scopus 로고
    • RNAi-mediated chromatin silencing in fission yeast
    • White S.A., Allshire R.C. RNAi-mediated chromatin silencing in fission yeast. Curr Top Microbiol Immunol 2008, 320:157-183.
    • (2008) Curr Top Microbiol Immunol , vol.320 , pp. 157-183
    • White, S.A.1    Allshire, R.C.2
  • 64
    • 33947303168 scopus 로고    scopus 로고
    • Transposable elements and the epigenetic regulation of the genome
    • Slotkin R.K., Martienssen R. Transposable elements and the epigenetic regulation of the genome. Nat Rev Genet 2007, 8:272-285.
    • (2007) Nat Rev Genet , vol.8 , pp. 272-285
    • Slotkin, R.K.1    Martienssen, R.2
  • 65
    • 33845755946 scopus 로고    scopus 로고
    • Heterochromatin revisited
    • Grewal S.I., Jia S. Heterochromatin revisited. Nat Rev Genet 2007, 8:35-46.
    • (2007) Nat Rev Genet , vol.8 , pp. 35-46
    • Grewal, S.I.1    Jia, S.2
  • 66
    • 34547180324 scopus 로고    scopus 로고
    • Antisense intergenic transcription precedes Igh D-to-J recombination and is controlled by the intronic enhancer Emu
    • Bolland D.J., Wood A.L., Afshar R., Featherstone K., Oltz E.M., Corcoran A.E. Antisense intergenic transcription precedes Igh D-to-J recombination and is controlled by the intronic enhancer Emu. Mol Cell Biol 2007, 27:5523-5533.
    • (2007) Mol Cell Biol , vol.27 , pp. 5523-5533
    • Bolland, D.J.1    Wood, A.L.2    Afshar, R.3    Featherstone, K.4    Oltz, E.M.5    Corcoran, A.E.6
  • 67
    • 39749101294 scopus 로고    scopus 로고
    • Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage
    • Koralov S.B., Muljo S.A., Galler G.R., Krek A., Chakraborty T., Kanellopoulou C., et al. Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell 2008, 132:860-874.
    • (2008) Cell , vol.132 , pp. 860-874
    • Koralov, S.B.1    Muljo, S.A.2    Galler, G.R.3    Krek, A.4    Chakraborty, T.5    Kanellopoulou, C.6
  • 68
    • 77951893700 scopus 로고    scopus 로고
    • The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci
    • Ji Y., Resch W., Corbett E., Yamane A., Casellas R., Schatz D.G. The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci. Cell 2010, 141:419-431.
    • (2010) Cell , vol.141 , pp. 419-431
    • Ji, Y.1    Resch, W.2    Corbett, E.3    Yamane, A.4    Casellas, R.5    Schatz, D.G.6
  • 69
    • 37549065849 scopus 로고    scopus 로고
    • Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination
    • Bates J.G., Cado D., Nolla H., Schlissel M.S. Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination. J Exp Med 2007, 204:3247-3256.
    • (2007) J Exp Med , vol.204 , pp. 3247-3256
    • Bates, J.G.1    Cado, D.2    Nolla, H.3    Schlissel, M.S.4
  • 70
    • 0026045243 scopus 로고
    • Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line
    • Schlissel M., Voronova A., Baltimore D. Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line. Genes Dev 1991, 5:1367-1376.
    • (1991) Genes Dev , vol.5 , pp. 1367-1376
    • Schlissel, M.1    Voronova, A.2    Baltimore, D.3
  • 71
    • 33645224956 scopus 로고    scopus 로고
    • Genome-wide relationships between TAF1 and histone acetyltransferases in Saccharomyces cerevisiae
    • Durant M., Pugh B.F. Genome-wide relationships between TAF1 and histone acetyltransferases in Saccharomyces cerevisiae. Mol Cell Biol 2006, 26:2791-2802.
    • (2006) Mol Cell Biol , vol.26 , pp. 2791-2802
    • Durant, M.1    Pugh, B.F.2
  • 72
    • 0034508137 scopus 로고    scopus 로고
    • Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription
    • Kuo M.H., vom Baur E., Struhl K., Allis C.D. Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription. Mol Cell 2000, 6:1309-1320.
    • (2000) Mol Cell , vol.6 , pp. 1309-1320
    • Kuo, M.H.1    vom Baur, E.2    Struhl, K.3    Allis, C.D.4
  • 73
    • 33644866509 scopus 로고    scopus 로고
    • Leaving a mark: the many footprints of the elongating RNA polymerase II
    • Eissenberg J.C., Shilatifard A. Leaving a mark: the many footprints of the elongating RNA polymerase II. Curr Opin Genet Dev 2006, 16:184-190.
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 184-190
    • Eissenberg, J.C.1    Shilatifard, A.2
  • 74
    • 35349024178 scopus 로고    scopus 로고
    • A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement
    • Liu Y., Subrahmanyam R., Chakraborty T., Sen R., Desiderio S. A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement. Immunity 2007, 27:561-571.
    • (2007) Immunity , vol.27 , pp. 561-571
    • Liu, Y.1    Subrahmanyam, R.2    Chakraborty, T.3    Sen, R.4    Desiderio, S.5
  • 75
    • 37249041657 scopus 로고    scopus 로고
    • RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination
    • Matthews A.G., Kuo A.J., Ramon-Maiques S., Han S., Champagne K.S., Ivanov D., et al. RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature 2007, 450:1106-1110.
    • (2007) Nature , vol.450 , pp. 1106-1110
    • Matthews, A.G.1    Kuo, A.J.2    Ramon-Maiques, S.3    Han, S.4    Champagne, K.S.5    Ivanov, D.6
  • 76
    • 37649026007 scopus 로고    scopus 로고
    • The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2
    • Ramon-Maiques S., Kuo A.J., Carney D., Matthews A.G., Oettinger M.A., Gozani O., et al. The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Proc Natl Acad Sci USA 2007, 104:18993-18998.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 18993-18998
    • Ramon-Maiques, S.1    Kuo, A.J.2    Carney, D.3    Matthews, A.G.4    Oettinger, M.A.5    Gozani, O.6
  • 78
    • 0023654621 scopus 로고
    • The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements
    • Cockerill P.N., Yuen M.H., Garrard W.T. The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements. J Biol Chem 1987, 262:5394-5397.
    • (1987) J Biol Chem , vol.262 , pp. 5394-5397
    • Cockerill, P.N.1    Yuen, M.H.2    Garrard, W.T.3
  • 79
    • 0242610985 scopus 로고    scopus 로고
    • Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice
    • Dudley D.D., Sekiguchi J., Zhu C., Sadofsky M.J., Whitlow S., DeVido J., et al. Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice. J Exp Med 2003, 198:1439-1450.
    • (2003) J Exp Med , vol.198 , pp. 1439-1450
    • Dudley, D.D.1    Sekiguchi, J.2    Zhu, C.3    Sadofsky, M.J.4    Whitlow, S.5    DeVido, J.6
  • 80
    • 0034605064 scopus 로고    scopus 로고
    • Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: Implications for the control of TCR-beta locus recombination
    • Mathieu N., Hempel W.M., Spicuglia S., Verthuy C., Ferrier P. Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: Implications for the control of TCR-beta locus recombination. J Exp Med 2000, 192:625-636.
    • (2000) J Exp Med , vol.192 , pp. 625-636
    • Mathieu, N.1    Hempel, W.M.2    Spicuglia, S.3    Verthuy, C.4    Ferrier, P.5
  • 81
    • 0034695501 scopus 로고    scopus 로고
    • A role for histone acetylation in the developmental regulation of VDJ recombination
    • McMurry M.T., Krangel M.S. A role for histone acetylation in the developmental regulation of VDJ recombination. Science 2000, 287:495-498.
    • (2000) Science , vol.287 , pp. 495-498
    • McMurry, M.T.1    Krangel, M.S.2
  • 82
    • 0035949586 scopus 로고    scopus 로고
    • The murine beta-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes
    • Schubeler D., Groudine M., Bender M.A. The murine beta-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes. Proc Natl Acad Sci USA 2001, 98:11432-11437.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11432-11437
    • Schubeler, D.1    Groudine, M.2    Bender, M.A.3
  • 83
    • 47249158480 scopus 로고    scopus 로고
    • Reciprocal patterns of methylation of H3K36 and H3K27 on proximal vs. distal IgVH genes are modulated by IL-7 and Pax5
    • Xu C.R., Schaffer L., Head S.R., Feeney A.J. Reciprocal patterns of methylation of H3K36 and H3K27 on proximal vs. distal IgVH genes are modulated by IL-7 and Pax5. Proc Natl Acad Sci USA 2008, 105:8685-8690.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 8685-8690
    • Xu, C.R.1    Schaffer, L.2    Head, S.R.3    Feeney, A.J.4
  • 84
    • 13444267442 scopus 로고    scopus 로고
    • Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation
    • Pray-Grant M.G., Daniel J.A., Schieltz D., Yates J.R., Grant P.A. Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation. Nature 2005, 433:434-438.
    • (2005) Nature , vol.433 , pp. 434-438
    • Pray-Grant, M.G.1    Daniel, J.A.2    Schieltz, D.3    Yates, J.R.4    Grant, P.A.5
  • 85
    • 0032539691 scopus 로고    scopus 로고
    • Use of D gene segments with irregular spacers in terminal deoxynucleotidyltransferase (TdT)+/+ and TdT-/- mice carrying a human Ig heavy chain transgenic minilocus
    • Tuaillon N., Capra J.D. Use of D gene segments with irregular spacers in terminal deoxynucleotidyltransferase (TdT)+/+ and TdT-/- mice carrying a human Ig heavy chain transgenic minilocus. Proc Natl Acad Sci USA 1998, 95:1703-1708.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 1703-1708
    • Tuaillon, N.1    Capra, J.D.2
  • 86
    • 0033623388 scopus 로고    scopus 로고
    • VHD rearrangements in human immunoglobulin heavy chain minilocus transgenic mice
    • Tuaillon N., Capra J.D. VHD rearrangements in human immunoglobulin heavy chain minilocus transgenic mice. Eur J Immunol 2000, 30:2998-3005.
    • (2000) Eur J Immunol , vol.30 , pp. 2998-3005
    • Tuaillon, N.1    Capra, J.D.2
  • 87
    • 0037332014 scopus 로고    scopus 로고
    • Transient IL-7/IL-7R signaling provides a mechanism for feedback inhibition of immunoglobulin heavy chain gene rearrangements
    • Chowdhury D., Sen R. Transient IL-7/IL-7R signaling provides a mechanism for feedback inhibition of immunoglobulin heavy chain gene rearrangements. Immunity 2003, 18:229-241.
    • (2003) Immunity , vol.18 , pp. 229-241
    • Chowdhury, D.1    Sen, R.2
  • 88
    • 14844345051 scopus 로고    scopus 로고
    • Stat5 mediates the IL-7-induced accessibility of a representative D-Distal VH gene
    • Stanton M.L., Brodeur P.H. Stat5 mediates the IL-7-induced accessibility of a representative D-Distal VH gene. J Immunol 2005, 174:3164-3168.
    • (2005) J Immunol , vol.174 , pp. 3164-3168
    • Stanton, M.L.1    Brodeur, P.H.2
  • 89
    • 0034651566 scopus 로고    scopus 로고
    • Murine pro-B cells require IL-7 and its receptor complex to up-regulate IL-7R alpha, terminal deoxynucleotidyltransferase, and c mu expression
    • Wei C., Zeff R., Goldschneider I. Murine pro-B cells require IL-7 and its receptor complex to up-regulate IL-7R alpha, terminal deoxynucleotidyltransferase, and c mu expression. J Immunol 2000, 164:1961-1970.
    • (2000) J Immunol , vol.164 , pp. 1961-1970
    • Wei, C.1    Zeff, R.2    Goldschneider, I.3
  • 90
    • 3242878308 scopus 로고    scopus 로고
    • Regulation of immunoglobulin heavy-chain gene rearrangements
    • Chowdhury D., Sen R. Regulation of immunoglobulin heavy-chain gene rearrangements. Immunol Rev 2004, 200:182-196.
    • (2004) Immunol Rev , vol.200 , pp. 182-196
    • Chowdhury, D.1    Sen, R.2
  • 92
    • 0023722178 scopus 로고
    • Comparison of the fetal and adult functional B cell repertoires by analysis of VH gene family expression
    • Jeong H.D., Teale J.M. Comparison of the fetal and adult functional B cell repertoires by analysis of VH gene family expression. J Exp Med 1988, 168:589-603.
    • (1988) J Exp Med , vol.168 , pp. 589-603
    • Jeong, H.D.1    Teale, J.M.2
  • 93
    • 0021951340 scopus 로고
    • Developmentally controlled expression of immunoglobulin VH genes
    • Perlmutter R.M., Kearney J.F., Chang S.P., Hood L.E. Developmentally controlled expression of immunoglobulin VH genes. Science 1985, 227:1597-1601.
    • (1985) Science , vol.227 , pp. 1597-1601
    • Perlmutter, R.M.1    Kearney, J.F.2    Chang, S.P.3    Hood, L.E.4
  • 94
    • 0030765923 scopus 로고    scopus 로고
    • Changes in the V(H) gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor
    • ten Boekel E., Melchers F., Rolink A.G. Changes in the V(H) gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor. Immunity 1997, 7:357-368.
    • (1997) Immunity , vol.7 , pp. 357-368
    • ten Boekel, E.1    Melchers, F.2    Rolink, A.G.3
  • 95
    • 0025193019 scopus 로고
    • Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice
    • Malynn B.A., Yancopoulos G.D., Barth J.E., Bona C.A., Alt F.W. Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice. J Exp Med 1990, 171:843-859.
    • (1990) J Exp Med , vol.171 , pp. 843-859
    • Malynn, B.A.1    Yancopoulos, G.D.2    Barth, J.E.3    Bona, C.A.4    Alt, F.W.5
  • 97
    • 0037320925 scopus 로고    scopus 로고
    • Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement
    • Su I.H., Basavaraj A., Krutchinsky A.N., Hobert O., Ullrich A., Chait B.T., et al. Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol 2003, 4:124-131.
    • (2003) Nat Immunol , vol.4 , pp. 124-131
    • Su, I.H.1    Basavaraj, A.2    Krutchinsky, A.N.3    Hobert, O.4    Ullrich, A.5    Chait, B.T.6
  • 99
    • 1642323620 scopus 로고    scopus 로고
    • Pax5 activates immunoglobulin heavy chain V to DJ rearrangement in transgenic thymocytes
    • Hsu L.Y., Liang H.E., Johnson K., Kang C., Schlissel M.S. Pax5 activates immunoglobulin heavy chain V to DJ rearrangement in transgenic thymocytes. J Exp Med 2004, 199:825-830.
    • (2004) J Exp Med , vol.199 , pp. 825-830
    • Hsu, L.Y.1    Liang, H.E.2    Johnson, K.3    Kang, C.4    Schlissel, M.S.5
  • 100
    • 23944495647 scopus 로고    scopus 로고
    • Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5
    • Bertolino E., Reddy K., Medina K.L., Parganas E., Ihle J., Singh H. Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5. Nat Immunol 2005, 6:836-843.
    • (2005) Nat Immunol , vol.6 , pp. 836-843
    • Bertolino, E.1    Reddy, K.2    Medina, K.L.3    Parganas, E.4    Ihle, J.5    Singh, H.6
  • 101
    • 75649093758 scopus 로고    scopus 로고
    • Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development
    • Malin S., McManus S., Cobaleda C., Novatchkova M., Delogu A., Bouillet P., et al. Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat Immunol 2010, 11:171-179.
    • (2010) Nat Immunol , vol.11 , pp. 171-179
    • Malin, S.1    McManus, S.2    Cobaleda, C.3    Novatchkova, M.4    Delogu, A.5    Bouillet, P.6
  • 102
    • 45449089640 scopus 로고    scopus 로고
    • Choreography of Ig allelic exclusion
    • Cedar H., Bergman Y. Choreography of Ig allelic exclusion. Curr Opin Immunol 2008, 20:308-317.
    • (2008) Curr Opin Immunol , vol.20 , pp. 308-317
    • Cedar, H.1    Bergman, Y.2
  • 103
    • 14244264313 scopus 로고    scopus 로고
    • Immunoglobulin locus silencing and allelic exclusion
    • Corcoran A.E. Immunoglobulin locus silencing and allelic exclusion. Semin Immunol 2005, 17:141-154.
    • (2005) Semin Immunol , vol.17 , pp. 141-154
    • Corcoran, A.E.1
  • 105
    • 0022385230 scopus 로고
    • A transgenic immunoglobulin mu gene prevents rearrangement of endogenous genes
    • Weaver D., Costantini F., Imanishi-Kari T., Baltimore D. A transgenic immunoglobulin mu gene prevents rearrangement of endogenous genes. Cell 1985, 42:117-127.
    • (1985) Cell , vol.42 , pp. 117-127
    • Weaver, D.1    Costantini, F.2    Imanishi-Kari, T.3    Baltimore, D.4
  • 106
    • 0023189116 scopus 로고
    • Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu
    • Nussenzweig M.C., Shaw A.C., Sinn E., Danner D.B., Holmes K.L., Morse H.C., et al. Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu. Science 1987, 236:816-819.
    • (1987) Science , vol.236 , pp. 816-819
    • Nussenzweig, M.C.1    Shaw, A.C.2    Sinn, E.3    Danner, D.B.4    Holmes, K.L.5    Morse, H.C.6
  • 107
    • 0026534145 scopus 로고
    • Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice
    • Costa T.E., Suh H., Nussenzweig M.C. Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice. Proc Natl Acad Sci USA 1992, 89:2205-2208.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2205-2208
    • Costa, T.E.1    Suh, H.2    Nussenzweig, M.C.3
  • 108
    • 1542381073 scopus 로고    scopus 로고
    • Mechanisms for feedback inhibition of the immunoglobulin heavy chain locus
    • Chowdhury D., Sen R. Mechanisms for feedback inhibition of the immunoglobulin heavy chain locus. Curr Opin Immunol 2004, 16:235-240.
    • (2004) Curr Opin Immunol , vol.16 , pp. 235-240
    • Chowdhury, D.1    Sen, R.2
  • 109
    • 12344270023 scopus 로고    scopus 로고
    • Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene
    • Roldan E., Fuxa M., Chong W., Martinez D., Novatchkova M., Busslinger M., et al. Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene. Nat Immunol 2005, 6:31-41.
    • (2005) Nat Immunol , vol.6 , pp. 31-41
    • Roldan, E.1    Fuxa, M.2    Chong, W.3    Martinez, D.4    Novatchkova, M.5    Busslinger, M.6
  • 110
    • 47249122132 scopus 로고    scopus 로고
    • Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation
    • Kuzin I.I., Bagaeva L., Young F.M., Bottaro A. Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation. J Immunol 2008, 180:7443-7450.
    • (2008) J Immunol , vol.180 , pp. 7443-7450
    • Kuzin, I.I.1    Bagaeva, L.2    Young, F.M.3    Bottaro, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.