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Volumn 190, Issue 12, 2013, Pages 5949-5960

Separation of function between isotype switching and affinity maturation in vivo during acute immune responses and circulating autoantibodies in UNG-deficient mice

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; IMMUNOGLOBULIN SUBCLASS; PROTEIN MSH2; PROTEIN MSH6; URACIL DNA GLYCOSIDASE;

EID: 84879124762     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202711     Document Type: Article
Times cited : (29)

References (52)
  • 1
    • 0034094425 scopus 로고    scopus 로고
    • The RAG proteins and V(D)J recombination: Complexes, ends, and transposition
    • DOI 10.1146/annurev.immunol.18.1.495
    • Fugmann, S. D., A. I. Lee, P. E. Shockett, I. J. Villey, and D. G. Schatz. 2000. The RAG proteins and V(D)J recombination: complexes, ends, and transposition. Annu. Rev. Immunol. 18: 495-527. (Pubitemid 30365389)
    • (2000) Annual Review of Immunology , vol.18 , pp. 495-527
    • Fugmann, S.D.1    Lee, A.I.2    Shockett, P.E.3    Villey, I.J.4    Schatz, D.G.5
  • 2
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu, M., K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai, and T. Honjo. 2000. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102: 553-563.
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 4
    • 34249790004 scopus 로고    scopus 로고
    • Molecular mechanisms of antibody somatic hypermutation
    • Di Noia, J. M., and M. S. Neuberger. 2007. Molecular mechanisms of antibody somatic hypermutation. Annu. Rev. Biochem. 76: 1-22.
    • (2007) Annu. Rev. Biochem. , vol.76 , pp. 1-22
    • Di Noia, J.M.1    Neuberger, M.S.2
  • 6
    • 60049083259 scopus 로고    scopus 로고
    • The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch
    • Schrader, C. E., J. E. Guikema, X. Wu, and J. Stavnezer. 2009. The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch. Philos. Trans. R. Soc. Lond. B Biol. Sci. 364: 645-652.
    • (2009) Philos. Trans. R. Soc. Lond. B Biol. Sci. , vol.364 , pp. 645-652
    • Schrader, C.E.1    Guikema, J.E.2    Wu, X.3    Stavnezer, J.4
  • 7
    • 0037026482 scopus 로고    scopus 로고
    • Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
    • DOI 10.1038/nature00981
    • Di Noia, J., and M. S. Neuberger. 2002. Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature 419: 43-48. (Pubitemid 34987864)
    • (2002) Nature , vol.419 , Issue.6902 , pp. 43-48
    • Di, N.J.1    Neuberger, M.S.2
  • 8
    • 0037019315 scopus 로고    scopus 로고
    • AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
    • DOI 10.1038/nature00862
    • Petersen-Mahrt, S. K., R. S. Harris, and M. S. Neuberger. 2002. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 418: 99-103. (Pubitemid 34742579)
    • (2002) Nature , vol.418 , Issue.6893 , pp. 99-103
    • Petersen-Mahrt, S.K.1    Harris, R.S.2    Neuberger, M.S.3
  • 9
    • 0037108463 scopus 로고    scopus 로고
    • Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
    • DOI 10.1016/S0960-9822(02)01215-0, PII S0960982202012150
    • Rada, C., G. T. Williams, H. Nilsen, D. E. Barnes, T. Lindahl and M. S. Neuberger. 2002. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr. Biol. 12: 1748-1755. (Pubitemid 35169790)
    • (2002) Current Biology , vol.12 , Issue.20 , pp. 1748-1755
    • Rada, C.1    Williams, G.T.2    Nilsen, H.3    Barnes, D.E.4    Lindahl, T.5    Neuberger, M.S.6
  • 10
    • 6344256944 scopus 로고    scopus 로고
    • Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation
    • DOI 10.1016/j.molcel.2004.10.011, PII S1097276504006136
    • Rada, C., J. M. Di Noia, and M. S. Neuberger. 2004. Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol. Cell 16: 163-171. (Pubitemid 39388832)
    • (2004) Molecular Cell , vol.16 , Issue.2 , pp. 163-171
    • Rada, C.1    Di, N.J.M.2    Neuberger, M.S.3
  • 12
    • 0033564878 scopus 로고    scopus 로고
    • Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: Parallels with somatic hypermutation
    • DOI 10.1093/emboj/18.12.3484
    • Ehrenstein, M. R., and M. S. Neuberger. 1999. Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation. EMBO J. 18: 3484-3490. (Pubitemid 29276593)
    • (1999) EMBO Journal , vol.18 , Issue.12 , pp. 3484-3490
    • Ehrenstein, M.R.1    Neuberger, M.S.2
  • 13
    • 3142663166 scopus 로고    scopus 로고
    • A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination
    • DOI 10.1084/jem.20040691
    • Martomo, S. A., W. W. Yang, and P. J. Gearhart. 2004. A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination. J. Exp. Med. 200: 61-68. (Pubitemid 38924728)
    • (2004) Journal of Experimental Medicine , vol.200 , Issue.1 , pp. 61-68
    • Martomo, S.A.1    Yang, W.W.2    Gearhart, P.J.3
  • 14
    • 0033517129 scopus 로고    scopus 로고
    • Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes
    • DOI 10.1084/jem.190.3.323
    • Schrader, C. E., W. Edelmann, R. Kucherlapati, and J. Stavnezer. 1999. Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. J. Exp. Med. 190: 323-330. (Pubitemid 29374830)
    • (1999) Journal of Experimental Medicine , vol.190 , Issue.3 , pp. 323-330
    • Schrader, C.E.1    Edelmann, W.2    Kucherlapati, R.3    Stavnezer, J.4
  • 16
    • 0032127804 scopus 로고    scopus 로고
    • Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
    • DOI 10.1016/S1074-7613(00)80595-6
    • Rada, C., M. R. Ehrenstein, M. S. Neuberger, and C. Milstein. 1998. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity 9: 135-141. (Pubitemid 28361302)
    • (1998) Immunity , vol.9 , Issue.1 , pp. 135-141
    • Rada, C.1    Ehrenstein, M.R.2    Neuberger, M.S.3    Milstein, C.4
  • 17
    • 0032127811 scopus 로고    scopus 로고
    • Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process
    • DOI 10.1016/S1074-7613(00)80594-4
    • Frey, S., B. Bertocci, F. Delbos, L. Quint, J. C. Weill, and C. A. Reynaud. 1998. Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process. Immunity 9: 127-134. (Pubitemid 28361301)
    • (1998) Immunity , vol.9 , Issue.1 , pp. 127-134
    • Frey, S.1    Bertocci, B.2    Delbos, F.3    Quint, L.4    Weill, J.-C.5    Reynaud, C.-A.6
  • 18
    • 33646187811 scopus 로고    scopus 로고
    • The multifaceted mismatch-repair system
    • Jiricny, J. 2006. The multifaceted mismatch-repair system. Nat. Rev. Mol. Cell Biol. 7: 335-346.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 335-346
    • Jiricny, J.1
  • 20
    • 14944385521 scopus 로고    scopus 로고
    • Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome
    • DOI 10.1182/blood-2003-12-4420
    • Lee, W.-I., T. R. Torgerson, M. J. Schumacher, L. Yel, Q. Zhu, and H. D. Ochs. 2005. Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome. Blood 105: 1881-1890. (Pubitemid 40731768)
    • (2005) Blood , vol.105 , Issue.5 , pp. 1881-1890
    • Lee, W.-I.1    Torgerson, T.R.2    Schumacher, M.J.3    Yel, L.4    Zhu, Q.5    Ochs, H.D.6
  • 21
    • 77950862610 scopus 로고    scopus 로고
    • Immunoglobulin class switch recombination deficiencies
    • Kracker, S., P. Gardes, F. Mazerolles, and A. H. Durandy. 2010. Immunoglobulin class switch recombination deficiencies. Clin. Immunol. 135: 193-203.
    • (2010) Clin. Immunol. , vol.135 , pp. 193-203
    • Kracker, S.1    Gardes, P.2    Mazerolles, F.3    Durandy, A.H.4
  • 24
    • 84856472936 scopus 로고    scopus 로고
    • Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1
    • Orthwein, A., A. Zahn, S. P. Methot, D. Godin, S. G. Conticello, K. Terada, and J. M. Di Noia. 2012. Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1. EMBO J. 31: 679-691.
    • (2012) EMBO J. , vol.31 , pp. 679-691
    • Orthwein, A.1    Zahn, A.2    Methot, S.P.3    Godin, D.4    Conticello, S.G.5    Terada, K.6    Di Noia, J.M.7
  • 25
    • 0025875937 scopus 로고
    • A rapid method to determine the isotype and specificity of coproantibodies in mice infected with Trichinella or fed cholera toxin
    • deVos, T., and T. A. Dick. 1991. A rapid method to determine the isotype and specificity of coproantibodies in mice infected with Trichinella or fed cholera toxin. J. Immunol. Methods 141: 285-288.
    • (1991) J. Immunol. Methods , vol.141 , pp. 285-288
    • DeVos, T.1    Dick, T.A.2
  • 26
    • 0029931627 scopus 로고    scopus 로고
    • Affinity of anti-GM1 antibodies in Guillain-Barré syndrome patients
    • Deisenhammer, F., G. Keir, B. Pfausler, and E. J. Thompson. 1996. Affinity of anti-GM1 antibodies in Guillain-Barré syndrome patients. J. Neuroimmunol. 66: 85-93.
    • (1996) J. Neuroimmunol. , vol.66 , pp. 85-93
    • Deisenhammer, F.1    Keir, G.2    Pfausler, B.3    Thompson, E.J.4
  • 27
    • 0025331453 scopus 로고
    • Affinity distributions of antigen-specific IgG in patients with multiple sclerosis and in patients with viral encephalitis
    • DOI 10.1016/0022-1759(90)90199-6
    • Luxton, R. W., and E. J. Thompson. 1990. Affinity distributions of antigen-specific IgG in patients with multiple sclerosis and in patients with viral encephalitis. J. Immunol. Methods 131: 277-282. (Pubitemid 20241528)
    • (1990) Journal of Immunological Methods , vol.131 , Issue.2 , pp. 277-282
    • Luxton, R.W.1    Thompson, E.J.2
  • 28
    • 0022640936 scopus 로고
    • Antibody mediated suppression of secondary IgM response in nude mice against vesicular stomatitis virus
    • Charan, S., and R. M. Zinkernagel. 1986. Antibody mediated suppression of secondary IgM response in nude mice against vesicular stomatitis virus. J. Immunol. 136: 3057-3061. (Pubitemid 16107218)
    • (1986) Journal of Immunology , vol.136 , Issue.8 , pp. 3057-3061
    • Charan, S.1    Zinkernagel, R.M.2
  • 29
    • 78649404299 scopus 로고    scopus 로고
    • Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90
    • Orthwein, A., A. M. Patenaude, B. Affar, A. Lamarre, J. C. Young, and J. M. Di Noia. 2010. Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90. J. Exp. Med. 207: 2751-2765.
    • (2010) J. Exp. Med. , vol.207 , pp. 2751-2765
    • Orthwein, A.1    Patenaude, A.M.2    Affar, B.3    Lamarre, A.4    Young, J.C.5    Di Noia, J.M.6
  • 30
    • 0022802257 scopus 로고
    • Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP
    • Cumano, A., and K. Rajewsky. 1986. Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP. EMBO J. 5: 2459-2468.
    • (1986) EMBO J. , vol.5 , pp. 2459-2468
    • Cumano, A.1    Rajewsky, K.2
  • 31
    • 0021888368 scopus 로고
    • Structure of primary anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice
    • DOI 10.1002/eji.1830150517
    • Cumano, A., and K. Rajewsky. 1985. Structure of primary anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice. Eur. J. Immunol. 15: 512-520. (Pubitemid 15071585)
    • (1985) European Journal of Immunology , vol.15 , Issue.5 , pp. 512-520
    • Cumano, A.1    Rajewsky, K.2
  • 32
    • 0023856770 scopus 로고
    • The half-lives of serum immunoglobulins in adult mice
    • Vieira, P., and K. Rajewsky. 1988. The half-lives of serum immunoglobulins in adult mice. Eur. J. Immunol. 18: 313-316. (Pubitemid 18078861)
    • (1988) European Journal of Immunology , vol.18 , Issue.2 , pp. 313-316
    • Vieira, P.1    Rajewsky, K.2
  • 33
    • 33344479421 scopus 로고    scopus 로고
    • Antiviral antibody responses: The two extremes of a wide spectrum
    • DOI 10.1038/nri1783
    • Hangartner, L., R. M. Zinkernagel, and H. Hengartner. 2006. Antiviral antibody responses: the two extremes of a wide spectrum. Nat. Rev. Immunol. 6: 231-243. (Pubitemid 43290992)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.3 , pp. 231-243
    • Hangartner, L.1    Zinkernagel, R.M.2    Hengartner, H.3
  • 34
    • 0030483588 scopus 로고    scopus 로고
    • The role of somatic mutation in the generation of the protective humoral immune response against vesicular stomatitis virus
    • DOI 10.1016/S1074-7613(00)80277-0
    • Kalinke, U., E. M. Bucher, B. Ernst, A. Oxenius, H. P. Roost, S. Geley, R. Kofler, R. M. Zinkernagel, and H. Hengartner. 1996. The role of somatic mutation in the generation of the protective humoral immune response against vesicular stomatitis virus. Immunity 5: 639-652. (Pubitemid 27062072)
    • (1996) Immunity , vol.5 , Issue.6 , pp. 639-652
    • Kalinke, U.1    Bucher, E.M.2    Ernst, B.3    Oxenius, A.4    Roost, H.-P.5    Geley, S.6    Kofler, R.7    Zinkernagel, R.M.8    Hengartner, H.9
  • 36
    • 0035846113 scopus 로고    scopus 로고
    • In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
    • DOI 10.1038/35098100
    • Fagarasan, S., K. Kinoshita, M. Muramatsu, K. Ikuta, and T. Honjo. 2001. In situ class switching and differentiation to IgA-producing cells in the gut lamina propria. Nature 413: 639-643. (Pubitemid 32964064)
    • (2001) Nature , vol.413 , Issue.6856 , pp. 639-643
    • Fagarasan, S.1    Kinoshita, K.2    Muramatsu, M.3    Ikuta, K.4    Honjo, T.5
  • 37
    • 57749181557 scopus 로고    scopus 로고
    • Haploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivo
    • Sernández, I. V., V. G. de Yébenes, Y. Dorsett, and A. R. Ramiro. 2008. Haploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivo. PLoS ONE 3: e3927.
    • (2008) PLoS ONE , vol.3
    • Sernández, I.V.1    De Yébenes, V.G.2    Dorsett, Y.3    Ramiro, A.R.4
  • 38
  • 39
    • 80052678086 scopus 로고    scopus 로고
    • AID binds cooperatively with UNG and Msh2-Msh6 to Ig switch regions dependent upon the AID C terminus
    • Ranjit, S., L. Khair, E. K. Linehan, A. J. Ucher, M. Chakrabarti, C. E. Schrader, and J. Stavnezer. 2011. AID binds cooperatively with UNG and Msh2-Msh6 to Ig switch regions dependent upon the AID C terminus. J. Immunol. 187: 2464-2475.
    • (2011) J. Immunol. , vol.187 , pp. 2464-2475
    • Ranjit, S.1    Khair, L.2    Linehan, E.K.3    Ucher, A.J.4    Chakrabarti, M.5    Schrader, C.E.6    Stavnezer, J.7
  • 40
    • 27844591343 scopus 로고    scopus 로고
    • Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice
    • DOI 10.1016/j.dnarep.2005.08.004, PII S1568786405002077
    • Andersen, S., M. Ericsson, H. Y. Dai, J. Peña-Diaz, G. Slupphaug, H. Nilsen, H. Aarset, and H. E. Krokan. 2005. Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair (Amst.) 4: 1432-1441. (Pubitemid 41653304)
    • (2005) DNA Repair , vol.4 , Issue.12 , pp. 1432-1441
    • Andersen, S.1    Ericsson, M.2    Dai, H.Y.3    Pena-Diaz, J.4    Slupphaug, G.5    Nilsen, H.6    Aarset, H.7    Krokan, H.E.8
  • 41
    • 51849125587 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease
    • Hase, K., D. Takahashi, M. Ebisawa, S. Kawano, K. Itoh, and H. Ohno. 2008. Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease. PLoS ONE 3: e3033.
    • (2008) PLoS ONE , vol.3
    • Hase, K.1    Takahashi, D.2    Ebisawa, M.3    Kawano, S.4    Itoh, K.5    Ohno, H.6
  • 42
    • 79955571648 scopus 로고    scopus 로고
    • Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice
    • Hsu, H. C., P. Yang, Q. Wu, J. H. Wang, G. Job, T. Guentert, J. Li, C. R. Stockard, T. V. Le, D. D. Chaplin, et al. 2011. Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice. Arthritis Rheum. 63: 2038-2048.
    • (2011) Arthritis Rheum. , vol.63 , pp. 2038-2048
    • Hsu, H.C.1    Yang, P.2    Wu, Q.3    Wang, J.H.4    Job, G.5    Guentert, T.6    Li, J.7    Stockard, C.R.8    Le, T.V.9    Chaplin, D.D.10
  • 46
  • 48
    • 79951602552 scopus 로고    scopus 로고
    • Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense
    • Wei, M., R. Shinkura, Y. Doi, M. Maruya, S. Fagarasan, and T. Honjo. 2011. Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense. Nat. Immunol. 12: 264-270.
    • (2011) Nat. Immunol. , vol.12 , pp. 264-270
    • Wei, M.1    Shinkura, R.2    Doi, Y.3    Maruya, M.4    Fagarasan, S.5    Honjo, T.6
  • 49
    • 19044396637 scopus 로고    scopus 로고
    • Analysis of class switch recombination and somatic hypermutation in patients affected with autosomal dominant hyper-IgM syndrome type 2
    • DOI 10.1016/j.clim.2005.02.003, PII S1521661605000410
    • Imai, K., Y. Zhu, P. Revy, T. Morio, S. Mizutani, A. Fischer, S. Nonoyama, and A. Durandy. 2005. Analysis of class switch recombination and somatic hypermutation in patients affected with autosomal dominant hyper-IgM syndrome type 2. Clin. Immunol. 115: 277-285. (Pubitemid 40712323)
    • (2005) Clinical Immunology , vol.115 , Issue.3 , pp. 277-285
    • Imai, K.1    Zhu, Y.2    Revy, P.3    Morio, T.4    Mizutani, S.5    Fischer, A.6    Nonoyama, S.7    Durandy, A.8
  • 50
    • 0037529321 scopus 로고    scopus 로고
    • Unmutated immunoglobulin M can protect mice from death by influenza virus infection
    • DOI 10.1084/jem.20021457
    • Harada, Y., M. Muramatsu, T. Shibata, T. Honjo, and K. Kuroda. 2003. Unmutated immunoglobulin M can protect mice from death by influenza virus infection. J. Exp. Med. 197: 1779-1785. (Pubitemid 36745352)
    • (2003) Journal of Experimental Medicine , vol.197 , Issue.12 , pp. 1779-1785
    • Harada, Y.1    Muramatsu, M.2    Shibata, T.3    Honjo, T.4    Kuroda, K.5
  • 51
    • 77955907831 scopus 로고    scopus 로고
    • Inherited defects of immunoglobulin class switch recombination
    • Kracker, S., P.Gardës, and A. Durandy. 2010. Inherited defects of immunoglobulin class switch recombination. Adv. Exp. Med. Biol. 685: 166-174.
    • (2010) Adv. Exp. Med. Biol. , vol.685 , pp. 166-174
    • Kracker, S.1    Gardës, P.2    Durandy, A.3


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