Different mutation signatures in DNA polymerase η- and MSH6-deficient mice suggest separate roles in antibody diversification

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 24, 2005, Pages 8656-8661

  Martomo, Stella A ^a   Yang, William W ^a   Wersto, Robert P ^a   Ohkumo, Tsuyoshi ^b   Kondo, Yuji ^b   Yokoi, Masayuki ^b   Masutani, Chikahide ^b   Hanaoka, Fumio ^b,c   Gearhart, Patricia J ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b OSAKA UNIVERSITY   (Japan)

^c Japan Science and Technology Agency   (Japan)

Author keywords

Class switch recombination; Low fidelity DNA polymerase; Mismatch repair; Somatic hypermutation

Indexed keywords

DNA; DNA POLYMERASE; IMMUNOGLOBULIN HEAVY CHAIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; GENE MUTATION; IMMUNOGLOBULIN GENE; MISMATCH REPAIR; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOMATIC HYPERMUTATION; SPLEEN CELL; T LYMPHOCYTE;

ANIMALS; B-LYMPHOCYTES; DNA MUTATIONAL ANALYSIS; DNA PRIMERS; DNA REPAIR; DNA-BINDING PROTEINS; DNA-DIRECTED DNA POLYMERASE; FLOW CYTOMETRY; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN G; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION;

EID: 20844452399     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0501852102     Document Type: Article

References (46)

1. Chaudhuri, J. & Alt, F. A. (2004) Nat. Rev. Immunol. 4, 541-552.
2. Goodman, M. F. & Scharff, M. D. (2005) J. Exp. Med. 201, 493-496.
3. Pham, P., Bransteitter, R. & Goodman, M. F. (2005) Biochemistry 44, 2703-2715.
4. Muramatsu, M., Kinoshita, K., Faragasan, S., Yamada, S., Shinkai, Y. & Honjo, T. (2000) Cell 102, 553-563.
5. Revy, P., Muto, T., Levy, Y., Geissmann, F., Piebani, A., Sanal, O., Catalan, N., Forveille, M., Dufourcq-Lagelouse, R., Gennery, A., et al. (2000) Cell 102, 565-575.
6. Petersen-Mahrt, S. K., Harris, R. S. & Neuberger, M. S. (2002) Nature 418, 99-103.
7. Di Noia, J. & Neuberger, M. S. (2002) Nature 419, 43-48.
8. Rada, C., Williams, G. T., Nilsen, H., Barnes, D. E., Lindahl, T. & Neuberger, M. S. (2002) Curr. Biol. 12, 1748-1755.
9. Wiesendanger, M., Kneitz, B., Edelmann, W. & Scharff, M. D. (2000) J. Exp. Med. 191, 579-584.
10. Li, Z., Scherer, S. J., Ronai, D., Iglesias-Ussel, M. D., Peled, J. U., Bardwell, P. D., Zhuang, M., Lee, K., Martin, A., Edelmann, W., et al. (2004) J. Exp. Med. 200, 47-59.
11. Martomo, S. A., Yang, W. W. & Gearhart, P. J. (2004) J. Exp. Med. 200, 61-68.
12. Gu, L., Wu, J., Qiu, L., Jennings, C. D. & Li, G. M. (2002) J. Nutr. Biochem. 13, 355-363.
13. Wilson, T. M., Vaisman, A., Martomo, S. A., Sullivan, P., Lan, L., Hanaoka, F., Yasui, A., Woodgate, R. & Gearhart, P. J. (2005) J. Exp. Med. 201, 637-645.
14. Bardwell, P. D., Woo, C. J., Wei, K., Li, Z., Martin, A., Sack, S. Z., Parris, T., Edelmann, W. & Scharff, M. D. (2004) Nat. Immunol. 5, 224-229.
15. Esposito, G., Texido, G., Betz, U. A. K., Gu, H., Müller, W., Klein, U. & Rajewsky, K. (2000) Proc. Natl. Acad. Sci. USA 97, 1166-1171.
16. Longacre, A., Sun, T., Goldsby, T. E., Preston, B. D. & Storb, U. (2003) Int. Immunol. 15, 477-481.
17. Zan, H., Komori, A., Li, Z., Cerutti, A., Schaffer, A., Flajnik, M. F., Diaz, M. & Casali, P. (2001) Immunity 14, 643-653.
18. Diaz, M., Verkoczy, L. K., Flajnik, M. F. & Klinman, N. R. (2001) J. Immunol. 167, 327-335.
19. Zeng, X., Winter, D. B., Kasmer, C., Kraemer, K. H., Lehmann, A. R. & Gearhart, P. J. (2001) Nat. Immunol. 2, 537-541.
20. Faili, A., Aoufouchi, S., Weller, S., Vuillier, F., Stary, A., Sarasin, A., Reynaud, C. A. & Weill, J. C. (2004) J. Exp. Med. 199, 265-270.
21. Zeng, X., Negrete, G. A., Kasmer, C., Yang, W. W. & Gearhart, P. J. (2004) J. Exp. Med. 199, 917-924.
22. Faili, A., Aoufouchi, S., Flatter, E., Guéranger, Q., Reynaud, C. A. & Weill, J. C. (2002) Nature 419, 944-947.
23. McDonald, J. P., Frank, E. G., Plosky, B. S., Rogozin, I. B., Masutani, C., Hanaoka, F., Woodgate, R. & Gearhart, P. J. (2003) J. Exp. Med. 198, 635-643.
24. Schenten, D., Gerlach, V. L., Guo, C., Velasco-Miguel, S., Hladik, C. L., White, C. L., Friedberg, E. C., Rajewsky, K. & Esposito, G. (2002) Eur. J. Immunol. 32, 3152-3160.
25. Shimizu, T., Shinkai, Y., Ogi, T., Ohmori, H. & Azuma, T. (2003) Immunol. Lett. 86, 265-270.
26. Bertocci, B., de Smet, A., Flatter, E., Dahan, A., Bories, J. C., Landreau, C., Weill, J. C. & Reynaud, C. A. (2002) J. Immunol. 168, 3702-3706.
27. Ruiz, J. F., Lucas, D., Garcia-Palomero, E., Saez, A. I., González, M. A., Piris, M. A., Bernad, A. & Blanco, L. (2004) Nucleic Acids Res. 32, 5861-5873.
28. Simpson, L. J. & Sale, J. E. (2003) EMBO J. 22, 1654-1664.
29. Jansen, J. G., Tsaalbi-Shtylik, A., Langerak, P., Calléja, F., Meijers, C. M., Jacobs, H. & de Wind, N. (2005) Nucleic Acids Res. 33, 356-365.
30. Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K. & Hanaoka, F. (1999) Nature 399, 700-704.
31. Rogozin, I. B., Pavlov, Y. I., Bebenek, K., Matsuda, T. & Kunkel, T. A. (2001) Nat. Immunol. 2, 530-536.
32. Reina-San-Martin, B., Defilippantonio, S., Hanitsch, L., Masilamani, R. F., Nussenzweig, A. & Nussenzweig, M. C. (2003) J. Exp. Med. 197, 1767-1778.
33. Reina-San-Martin, B., Chen, H. T., Nussenzweig, A. & Nussenzweig, M. C. (2004) J. Exp. Med. 200, 1103-1110.
34. Lumsden, J. M., McCarty, T., Petiniot, L. K., Shen, R., Barlow, C., Wynn, T. A., Morse, H. C., III, Gearhart, P. J., Wynshaw-Boris, A., Max, E. E., et al. (2004) J. Exp. Med. 200, 1111-1121.
35. Mayorov, V. I., Rogozin, I. B., Adkison, L. R. & Gearhart, P. J. (2005) J. Immunol., in press.
36. Matsuda, T., Bebenek, K., Masutani, C., Rogozin, I. B., Hanaoka, F. & Kunkel, T. A. (2001) J. Mol. Biol. 312, 335-346.
37. Yu, K., Chedin, F., Hsieh, C. L., Wilson, T. E. & Lieber, M. R. (2003) Nat. Immunol. 4, 442-451.
38. Steele, E. J. (2004) DNA Repair (Amsterdam) 3, 687-692.
39. Neuberger, M. S., DiNoia, J. M., Beale, R. C. L., Williams, G. T., Yang, Z. & Rada, C. (2005) Nat. Rev. Immunol. 5, 171-178.
40. Phung, Q. H., Winter, D. B., Cranston, A., Tarone, R. E., Bohr, V. A., Fishel, R. & Gearhart, P. J. (1998) J. Exp. Med. 187, 1745-1751.
41. Frey, S., Bertocci, B., Delbos, F., Quint, L., Weill, J. C. & Reynaud, C. A. (1998) Immunity 9, 127-134.
42. Rada, C., Ehrenstein, M. R., Neuberger, M. S. & Milstein, C. (1998) Immunity 9, 135-141.
43. Pham, P., Bransteitter, R., Petruska, J. & Goodman, M. F. (2003) Nature 424, 103-107.
44. Beale, R. C. L., Petersen-Mahrt, S. K., Watt, I. N., Harris, R. S., Rada, C. & Neuberger, M. S. (2004) J. Mol. Biol. 337, 585-596.
45. Zarrin, A. A., Alt, F. W., Chaudhuri, J., Stokes, N., Kaushal, D., Du Pasquier, L. & Tian, M. (2004) Nat. Immunol. 5, 1275-1281.
46. Delbos, F., De Smet, A., Faili, A., Aoufouchi, S., Weill, J. C. & Reynaud, C. A. (2005) J. Exp. Med. 201, 1191-1196.