Effects of sequence and structure on the hypermutability of immunoglobulin genes

Immunity

Volumn 16, Issue 1, 2002, Pages 123-134

  Michael, Nancy ^a   Martin, Terence E ^a   Nicolae, Dan ^a   Kim, Nayun ^a   Padjen, Kris ^a   Zhan, Ping ^a   Nguyen, Hanh ^a   Pinkert, Carl ^b   Storb, Ursula ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; RNA;

ARTICLE; CONTROLLED STUDY; GENE SEQUENCE; GENE STRUCTURE; IMMUNOGLOBULIN GENE; MUTATION; NONHUMAN; PEDIGREE; PRIORITY JOURNAL; SOMATIC CELL GENETICS; TRANSGENE;

EID: 0036169650     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(02)00261-3     Document Type: Article

References (46)

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4. Elements regulating somatic hypermutation of an immunoglobulin K gene: Critical role for the intron enhancer/matrix attachment region
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6. DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation
7. Single-molecule study of transcriptional pausing and arrest by E. coli RNA polymerase
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9. Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase zeta
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14. The germinal center reaction
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17. Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1
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19. Requirement of RSF and FACT for transcription of chromatin templates in vitro
20. Control of formation of two distinct classes of RNA polymerase II elongation complexes
21. An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array
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27. Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation
28. The 5′ boundary of somatic hypermutation in a Vk gene is in the leader intron
29. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighboring base sequences on mutagenesis
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31. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line
32. Predicting regional mutability in antibody V genes based solely on di- and trinucleotide sequence composition
33. The BCL6 gene in normal memory B cells is mutated by the process of somatic hypermutation of immunoglobulin genes
34. The TATA binding protein, c-myc, and survivin genes are not somatically hypermutated, while Ig and BCL-6 genes are hypermutated in human memory B cells
35. Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells
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39. A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript
40. Somatic hypermutation of immunoglobulin genes is linked to transcription
41. A histone octamer can step around a transcribing polymerase without leaving the template
42. The transcriptional promoter regulates hypermutation of the antibody heavy chain locus
43. The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation
44. DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
45. On finding all suboptimal folding of an RNA molecule