Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

Immunity

Volumn 9, Issue 1, 1998, Pages 127-134

  Frey, Stéphane ^a   Bertocci, Barbara ^a   Delbos, Frédéric ^a   Quint, Laurent ^a   Weill, Jean Claude ^a   Reynaud, Claude Agnès ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; DNA DAMAGE; GENE MUTATION; GERMINAL CENTER; KNOCKOUT MOUSE; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL;

EID: 0032127811     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80594-4     Document Type: Article

References (31)

1. Baker, S.M., Bronner, C.E., Zhang, L., Plug, A.W., Robatzek, M., Warren, G., Elliott, E.A., Yu, J., Ashley, T., Arnheim, N., et al. (1995). Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell 82, 309-319.
2. Baker, S.M., Plug, A.W., Prolla, T.A., Bronner, C.E., Harris, A.C., Yao, X., Christie, D.-A., Monell, C., Arnheim, N., Bradley, A., et al. (1996). Involvement of mouse MLH1 in DNA mismatch repair and meiotic crossing over. Nat. Genet. 13, 336-342.
3. Betz, A.G., Milstein, C., Gonzalez-Fernandez, A., Pannell, R., Larson, T., and Neuberger, M.S. (1994). Elements regulating somatic hypermutation of an immunoglobulin K gene: critical role for the intron enhancer/matrix attachment region. Cell 77, 239-248.
4. Brenner, S., and Milstein, C. (1996). Origin of antibody variation. Nature 211, 242-243.
5. Cascalho, M., Wong, J., Steinberg, C., and Wabl, M. (1998). Mismatch repair co-opted by hypermutation. Science 279, 1207-1210.
6. de Wind, N., Dekker, M., Berns, A., Radman, M., and te Riele, H. (1995). Inactivation of the mouse MSH2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell 82, 321-330.
7. Edelmann, W., Cohen, P.E., Kane, M.F., Lau, K., Morrow, B., Bennett, S., Umar, A., Kunkel, T., Cattoretti, G., Chaganti, R., et al. (1995). Meiotic pachytene arrest in MLH1-deficient mice. Cell 85, 1125-1134.
8. Fishel, R., and Wilson, T. (1997). MutS homologs in mammalian cells. Cur. Op. Genet. Dev. 7, 105-113.
9. Gonzalez-Fernandez, A., Gilmore, D., and Milstein, C. (1994). Age-related decrease in the proportion of germinal center B cells from mouse Peyer's patches is accompanied by an accumulation of somatic mutations in their immunoglobulin genes. Eur. J. Immunol. 24, 2918-2921.
10. Goyenechea, B., Klix, N., Yélamos, J., Williams, G.T., Riddell, A., Neuberger, M.S., and Milstein, C. (1997). Cells strongly expressing Igκ transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers. EMBO J. 16, 3987-3994.
11. Griffiths, G.M., Berek, C., and Milstein, C. (1984). Somatic mutation and the maturation of immune response to 2-phenyl oxazolone. Nature 312, 271-275.
12. Jacobs, H., Fukita, Y., van der Horst, G.T.L., de Boer, J., Weeda, G., Esser, J., de Wind, N., Engelward, B.P., Samson, L., Verbeek, S., et al. (1998). Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice. J. Exp. Med. 187, 1735-1743.
13. Jolly, C.J., Klix, N., and Neuberger, M.S. (1997). Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice. Nucleic Acids Res. 25, 1913-1919.
14. Kim, N., and Storb, U. (1998). The role of DNA repair in somatic hypermutation of immunoglobulin genes. J. Exp. Med. 187, 1729-1733.
15. Kim, N., Kage, K., Matsuda, F., Lefranc, M.-P., and Storb, U. (1997). B lymphocytes of Xeroderma Pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes. J. Exp. Med. 186, 413-419.
16. Kunkel, T.A. (1991). Hypermutation during DNA synthesis in vitro. In Somatic Hypermutation in V-Regions, E.J. Steele, ed. (Boca Raton, FL: CRC Press), pp. 159-178.
17. MacLennan, I.C.M., Gulbranson-Judge, A., Toellner, K.M., Casamayor-Palleja, M., Chan, E., Sze, D.M.Y., Luther, S.A., and Orbea, H.A. (1997). The changing preference of T and B cells for partners as T-dependent antibody responses develop, Immunol. Rev. 156, 53-66.
18. Makela, O., Kaartinen, M., Pelkonen, J.L.T., and Karjalainen, K. (1978). Inheritance of antibody specificity. V. Anti-2-phenyloxazolone in the mouse. J. Exp. Med. 148, 1644-1660.
19. Neuberger, M.S., and Milstein, C. (1995). Somatic hypermutation. Cur. Op. Immunol. 7, 248-254.
20. Peters, A., and Storb, U. (1996). Somatic hypermutation of immunoglobulin genesis linked to transcription initiation. Immunity 4, 57-65.
21. Phung, Q.H., Winter, D.B., Cranston, A., Tarone, R.E., Bohr, V.A., Fishel, R., and Gearhart, P.J. (1998). Increased hypermutation at G and C nucleotides in immunoglobulin genes from mice deficient in the MSH2 mismatch repair protein. J. Exp. Med. 187, 1-7.
22. Prolla, T.A., Baker, S.M., Harris, A.C., Tsao, J.-L., Yao, X., Bronner, C.E., Zheng, B., Gordon, M., Reneker, J., Arnheim, N., et al. (1998). Tumour susceptibility and spontaneous mutation in mice deficient in MLH1, PMS1 and PMS2 DNA mismatch repair. Nat. Genet. 18, 276-279.
23. Reitmair, A.H., Schmits, R., Ewel, A., Bapat, B., Redston, M., Mitri, A., Waterhouse, P., Mittrücker, H.-W., Wakeham, A., Liu, B., et al. (1995). MSH2 deficient mice are viable and susceptible to lymphoid tumors. Nat. Genet. 11, 64-70.
24. Reitmair, A.H., Redston, M., Cai, J.C., Chuang, T.C.Y., Bjerknes, M., Cheng, H., Hay, K., Gallinger, S., Bapat, B., and Mak, T.W. (1996). Spontaneous carcinomas and skin neoplasms in MSH2-deficient mice. Cancer Res. 56, 3842-3849.
25. Rogozin, I.B., and Kolchanov, N.A. (1992). Somatic hypermutagenesis in immunoglobulin genes. II. influence of neighbouring base sequence on mutagenesis. Biochim. Biophys. Acta 1171, 11-18.
26. Shen, H.M., Cheo, D.L., Friedberg, E., and Storb, U. (1997). The inactivation of the XP-Cgene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes. Mol. Immunol. 34, 527-533.
27. Storb, U., Peters, A., Klotz, E., Rogerson, B., and Hackett, J. (1996). The mechanism of somatic hypermutation studied with transgenic and transfected target genes. Semin. Immunol. 8, 131-140.
28. Strand, M., Prolla, T.A., Liskay, R.M., and Petes, T.D. (1993). Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature 365, 274-276.
29. Wagner, S.D., Elvin, J.G., Norris, P., McGregor, J.M., and Neuberger, M.S. (1996). Somatic hypermutation of Ig genes in patients with Xeroderma Pigmentosum (XP-D). Int. Immunol. 8, 701-705.
30. Weigert, M.G., Cesari, I.M., Yonkovich, S.J., and Cohn, M. (1970). Variability in the lambda light chain sequences of mouse antibody. Nature 228, 1045-1047.
31. Winter, D.B., Phung, Q.H., Umar, A., Baker, S.M., Tarone, R.E., Tanaka, K., Liskay, R.M., Kunkel, T.A., Bohr, V.A., and Gearhart, P.J. (1998). Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2. Proc. Natl. Acad. Sci. USA 95, 6953-6958.