PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 30, 2010, Pages 13384-13389

  Van Oers, Johanna M M ^a   Roa, Sergio ^a   Werling, Uwe ^a   Liu, Yiyong ^b   Genschel, Jochen ^b   Hou Jr , Harry ^a   Sellers, Rani S ^a   Modrich, Paul ^b   Scharff, Matthew D ^a   Edelmann, Winfried ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

B cell lymphoma; Class switch recombination; DNA mismatch repair; Somatic hypermutation; Spermatogenesis

Indexed keywords

ENDONUCLEASE; MISMATCH REPAIR PROTEIN PMS2; ADENOSINE TRIPHOSPHATASE; DNA BINDING PROTEIN; IMMUNOGLOBULIN G; PMS2 PROTEIN, MOUSE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B CELL LYMPHOMA; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; GENE SWITCHING; GENOME; GENOME MAINTENANCE; GENOMIC INSTABILITY; MALE; MISMATCH REPAIR; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOMATIC HYPERMUTATION; SPERMATOGENESIS; ANIMAL; ANIMAL EMBRYO; CELL CULTURE; CYTOLOGY; FEMALE; FERTILITY; FIBROBLAST; GENE REARRANGEMENT; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; KNOCKOUT MOUSE; LYMPHOMA; METABOLISM; MUTATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CELLS, CULTURED; DNA MISMATCH REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; EMBRYO, MAMMALIAN; ENDONUCLEASES; FEMALE; FERTILITY; FIBROBLASTS; GENETIC PREDISPOSITION TO DISEASE; GENOMIC INSTABILITY; GENOTYPE; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN G; LYMPHOMA; MALE; MICE; MICE, KNOCKOUT; MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77955795716     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1008589107     Document Type: Article

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