DNA polymerases η and θ function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes

Journal of Biological Chemistry

Volumn 282, Issue 24, 2007, Pages 17387-17394

  Masuda, Keiji ^a   Ouchida, Rika ^a   Hikida, Masaki ^a   Kurosaki, Tomohiro ^a   Yokoi, Masayuki ^b   Masutani, Chikahide ^b   Seki, Mineaki ^c   Wood, Richard D ^c   Hanaoka, Fumio ^b   O Wang, Jiyang ^a  

^a RIKEN YOKOHAMA INSTITUTE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASES; GENETIC PATHWAY;

CATALYSIS; DNA; ENZYME ACTIVITY; MUTAGENESIS; NUCLEOTIDES; REDUCTION;

GENES;

DNA DIRECTED DNA POLYMERASE ETA; DNA POLYMERASE THETA; ENZYME; NUCLEOTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA TEMPLATE; GENE INTERACTION; GENE MUTATION; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SOMATIC HYPERMUTATION;

ADENINE; ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA-DIRECTED DNA POLYMERASE; GENES, IMMUNOGLOBULIN; IMMUNOGLOBULIN CLASS SWITCHING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; T-LYMPHOCYTES; THYMINE;

MUS;

EID: 34547114028     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611849200     Document Type: Article

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