High-throughput mutagenesis reveals functional determinants for DNA targeting by activation-induced deaminase

Nucleic Acids Research

Volumn 42, Issue 15, 2014, Pages 9964-9975

  Gajula, Kiran S ^a   Huwe, Peter J ^b   Mo, Charlie Y ^c   Crawford, Daniel J ^a   Stivers, James T ^d   Radhakrishnan, Ravi ^b   Kohli, Rahul M ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; ALANINE; PROTEIN VARIANT; AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); CYTIDINE DEAMINASE; DNA;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE TARGETING; HIGH THROUGHPUT SCREENING; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOLECULAR RECOGNITION; MUTAGENESIS; MUTATIONAL ANALYSIS; NEXT GENERATION SEQUENCING; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN FUNCTION; CHEMISTRY; DNA SEQUENCE; GENETICS; HIGH THROUGHPUT SEQUENCING; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION;

ALANINE; CYTIDINE DEAMINASE; DNA; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS; SEQUENCE ANALYSIS, DNA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84942361505     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gku689     Document Type: Article

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