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Volumn 89, Issue 5, 2015, Pages 711-731

NF-κB in cancer therapy

Author keywords

Angiogenesis; Apoptosis; Cancer; NF B; Proliferation

Indexed keywords

ANTINEOPLASTIC AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

EID: 84939967245     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-015-1470-4     Document Type: Review
Times cited : (178)

References (270)
  • 1
    • 2342613652 scopus 로고    scopus 로고
    • The proteasome: a suitable antineoplastic target
    • COI: 1:CAS:528:DC%2BD2cXjsFSlu7k%3D, PID: 15122206
    • Adams J (2004) The proteasome: a suitable antineoplastic target. Nat Rev Cancer 4(5):349–360. doi:10.1038/Nrc1361
    • (2004) Nat Rev Cancer , vol.4 , Issue.5 , pp. 349-360
    • Adams, J.1
  • 2
    • 4544342570 scopus 로고    scopus 로고
    • Nuclear factor-kappa-B: the enemy within
    • COI: 1:CAS:528:DC%2BD2cXot1Kis78%3D, PID: 15380510
    • Aggarwal BB (2004) Nuclear factor-kappa-B: the enemy within. Cancer Cell 6(3):203–208. doi:10.1016/j.ccr.2004.09.003
    • (2004) Cancer Cell , vol.6 , Issue.3 , pp. 203-208
    • Aggarwal, B.B.1
  • 3
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • COI: 1:CAS:528:DC%2BD28Xjs1Gls74%3D, PID: 16563357
    • Aggarwal BB, Shishodia S (2006) Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71(10):1397–1421. doi:10.1016/j.bcp.2006.02.009
    • (2006) Biochem Pharmacol , vol.71 , Issue.10 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 4
    • 6344274849 scopus 로고    scopus 로고
    • Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis
    • COI: 1:CAS:528:DC%2BD2cXos1GhsLc%3D, PID: 15494532
    • Aktas O, Prozorovski T, Smorodchenko A et al (2004) Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis. J Immunol 173(9):5794–5800
    • (2004) J Immunol , vol.173 , Issue.9 , pp. 5794-5800
    • Aktas, O.1    Prozorovski, T.2    Smorodchenko, A.3
  • 5
    • 0037329233 scopus 로고    scopus 로고
    • IKK alpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf
    • COI: 1:CAS:528:DC%2BD3sXitFWmurs%3D, PID: 12589056
    • Albanese C, Wu KM, D’Amico M et al (2003) IKK alpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf. Mol Biol Cell 14(2):585–599. doi:10.1091/mbc.02-06-0101
    • (2003) Mol Biol Cell , vol.14 , Issue.2 , pp. 585-599
    • Albanese, C.1    Wu, K.M.2    D’Amico, M.3
  • 6
    • 38449103501 scopus 로고    scopus 로고
    • Role of activated nuclear factor-kappa B in the pathogenesis and therapy of squamous cell carcinoma of the head and neck
    • Allen CT, Ricker JL, Chen Z, Van Waes C (2007) Role of activated nuclear factor-kappa B in the pathogenesis and therapy of squamous cell carcinoma of the head and neck. Head Neck J Sci Spec 29(10):959–971. doi:10.1002/Hed.20615
    • (2007) Head Neck J Sci Spec , vol.29 , Issue.10 , pp. 959-971
    • Allen, C.T.1    Ricker, J.L.2    Chen, Z.3    Van Waes, C.4
  • 7
    • 77949379050 scopus 로고    scopus 로고
    • B-cell-derived lymphotoxin promotes castration-resistant prostate cancer
    • COI: 1:CAS:528:DC%2BC3cXjtFSnurs%3D, PID: 20220849
    • Ammirante M, Luo JL, Grivennikov S, Nedospasov S, Karin M (2010) B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature 464(7286):302–305. doi:10.1038/Nature08782
    • (2010) Nature , vol.464 , Issue.7286 , pp. 302-305
    • Ammirante, M.1    Luo, J.L.2    Grivennikov, S.3    Nedospasov, S.4    Karin, M.5
  • 8
    • 79751501772 scopus 로고    scopus 로고
    • Pathogenesis of myeloma
    • COI: 1:CAS:528:DC%2BC3MXjtVWrsrY%3D
    • Anderson KC, Carrasco RD (2011) Pathogenesis of myeloma. Annu Rev Pathol Mech 6:249–274. doi:10.1146/annurev-pathol-011110-130249
    • (2011) Annu Rev Pathol Mech , vol.6 , pp. 249-274
    • Anderson, K.C.1    Carrasco, R.D.2
  • 9
    • 34547562418 scopus 로고    scopus 로고
    • Frequent engagement of the classical and alternative NF-kappa B pathways by diverse genetic abnormalities in multiple myeloma
    • COI: 1:CAS:528:DC%2BD2sXps1art74%3D, PID: 17692804
    • Annunziata CM, Davis RE, Demchenko Y et al (2007) Frequent engagement of the classical and alternative NF-kappa B pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell 12(2):115–130. doi:10.1016/j.ccr.2007.07.004
    • (2007) Cancer Cell , vol.12 , Issue.2 , pp. 115-130
    • Annunziata, C.M.1    Davis, R.E.2    Demchenko, Y.3
  • 10
    • 0036714882 scopus 로고    scopus 로고
    • Cigarette smoke condensate activates nuclear transcription factor-kappa B through phosphorylation and degradation of I kappa B alpha: correlation with induction of cyclooxygenase-2
    • COI: 1:CAS:528:DC%2BD38Xms1Knt70%3D, PID: 12189195
    • Anto RJ, Mukhopadhyay A, Shishodia S, Gairola CG, Aggarwal BB (2002) Cigarette smoke condensate activates nuclear transcription factor-kappa B through phosphorylation and degradation of I kappa B alpha: correlation with induction of cyclooxygenase-2. Carcinogenesis 23(9):1511–1518. doi:10.1093/carcin/23.9.1511
    • (2002) Carcinogenesis , vol.23 , Issue.9 , pp. 1511-1518
    • Anto, R.J.1    Mukhopadhyay, A.2    Shishodia, S.3    Gairola, C.G.4    Aggarwal, B.B.5
  • 11
    • 0030949419 scopus 로고    scopus 로고
    • Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells
    • COI: 1:CAS:528:DyaK2sXis12lsLs%3D, PID: 9108461
    • Arber N, Doki Y, Han EKH et al (1997) Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells. Cancer Res 57(8):1569–1574
    • (1997) Cancer Res , vol.57 , Issue.8 , pp. 1569-1574
    • Arber, N.1    Doki, Y.2    Han, E.K.H.3
  • 12
    • 26444584958 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and liver carcinogenesis
    • COI: 1:CAS:528:DC%2BD2MXhtFWms7fP, PID: 16125305
    • Arsura M, Cavin LG (2005) Nuclear factor-kappaB and liver carcinogenesis. Cancer Lett 229(2):157–169. doi:10.1016/j.canlet.2005.07.008
    • (2005) Cancer Lett , vol.229 , Issue.2 , pp. 157-169
    • Arsura, M.1    Cavin, L.G.2
  • 13
    • 0033623830 scopus 로고    scopus 로고
    • Role of the I kappa B kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells
    • COI: 1:CAS:528:DC%2BD3cXlt1SntLg%3D, PID: 10891479
    • Arsura M, Mercurio F, Oliver AL, Thorgeirsson SS, Sonenshein GE (2000) Role of the I kappa B kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells. Mol Cell Biol 20(15):5381–5391. doi:10.1128/Mcb.20.15.5381-5391.2000
    • (2000) Mol Cell Biol , vol.20 , Issue.15 , pp. 5381-5391
    • Arsura, M.1    Mercurio, F.2    Oliver, A.L.3    Thorgeirsson, S.S.4    Sonenshein, G.E.5
  • 14
    • 0037461958 scopus 로고    scopus 로고
    • Transient activation of NF-kappa B through a TAK1/IKK kinase pathway by TGF-beta 1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation
    • COI: 1:CAS:528:DC%2BD3sXlsV2lug%3D%3D, PID: 12545162
    • Arsura M, Panta GR, Bilyeu JD et al (2003) Transient activation of NF-kappa B through a TAK1/IKK kinase pathway by TGF-beta 1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation. Oncogene 22(3):412–425. doi:10.1038/sj.onc.1206132
    • (2003) Oncogene , vol.22 , Issue.3 , pp. 412-425
    • Arsura, M.1    Panta, G.R.2    Bilyeu, J.D.3
  • 15
    • 9644253003 scopus 로고    scopus 로고
    • The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappa B and c-Myc in pancreatic cancer cells
    • COI: 1:CAS:528:DC%2BD2cXpsF2msrk%3D, PID: 15467756
    • Asano T, Yao YX, Zhu JJ, Li DH, Abbruzzese JL, Reddy SAG (2004) The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappa B and c-Myc in pancreatic cancer cells. Oncogene 23(53):8571–8580. doi:10.1038/sj.onc.1207902
    • (2004) Oncogene , vol.23 , Issue.53 , pp. 8571-8580
    • Asano, T.1    Yao, Y.X.2    Zhu, J.J.3    Li, D.H.4    Abbruzzese, J.L.5    Reddy, S.A.G.6
  • 16
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis
    • COI: 1:CAS:528:DyaK2MXoslehs7g%3D, PID: 7569976
    • Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M (1995) Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 270(5234):286–290
    • (1995) Science , vol.270 , Issue.5234 , pp. 286-290
    • Auphan, N.1    DiDonato, J.A.2    Rosette, C.3    Helmberg, A.4    Karin, M.5
  • 17
    • 0029874138 scopus 로고    scopus 로고
    • The NF-kappa B and I kappa B proteins: new discoveries and insights
    • COI: 1:CAS:528:DyaK28XitlCgtbc%3D, PID: 8717528
    • Baldwin AS (1996) The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14:649–683. doi:10.1146/annurev.immunol.14.1.649
    • (1996) Annu Rev Immunol , vol.14 , pp. 649-683
    • Baldwin, A.S.1
  • 18
    • 84858726313 scopus 로고    scopus 로고
    • Regulation of cell death and autophagy by IKK and NF-kappa B: critical mechanisms in immune function and cancer
    • PID: 22435564
    • Baldwin AS (2012) Regulation of cell death and autophagy by IKK and NF-kappa B: critical mechanisms in immune function and cancer. Immunol Rev 246:327–345. doi:10.1111/j.1600-065X.2012.01095.x
    • (2012) Immunol Rev , vol.246 , pp. 327-345
    • Baldwin, A.S.1
  • 19
    • 0035124085 scopus 로고    scopus 로고
    • Coexpression of proangiogenic factors IL-8 and VEGF by human head and neck squamous cell carcinoma involves coactivation by MEK-MAPK and IKK-NF-kappaB signal pathways
    • COI: 1:CAS:528:DC%2BD3MXhvFKntrs%3D, PID: 11234901
    • Bancroft CC, Chen Z, Dong G et al (2001) Coexpression of proangiogenic factors IL-8 and VEGF by human head and neck squamous cell carcinoma involves coactivation by MEK-MAPK and IKK-NF-kappaB signal pathways. Clin Cancer Res 7(2):435–442
    • (2001) Clin Cancer Res , vol.7 , Issue.2 , pp. 435-442
    • Bancroft, C.C.1    Chen, Z.2    Dong, G.3
  • 20
    • 0036605053 scopus 로고    scopus 로고
    • Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines
    • COI: 1:CAS:528:DC%2BD38XjsFansLw%3D, PID: 11992543
    • Bancroft CC, Chen Z, Yeh J et al (2002) Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines. Int J Cancer 99(4):538–548. doi:10.1002/ijc.10398
    • (2002) Int J Cancer , vol.99 , Issue.4 , pp. 538-548
    • Bancroft, C.C.1    Chen, Z.2    Yeh, J.3
  • 21
    • 18844465632 scopus 로고    scopus 로고
    • Constitutive nuclear factor-kappa B-RelA activation is required for proliferation and survival of Hodgkin’s disease tumor cells
    • COI: 1:CAS:528:DyaK2sXotVyku70%3D, PID: 9399941
    • Bargou RC, Emmerich F, Krappmann D et al (1997) Constitutive nuclear factor-kappa B-RelA activation is required for proliferation and survival of Hodgkin’s disease tumor cells. J Clin Invest 100(12):2961–2969. doi:10.1172/Jci119849
    • (1997) J Clin Invest , vol.100 , Issue.12 , pp. 2961-2969
    • Bargou, R.C.1    Emmerich, F.2    Krappmann, D.3
  • 22
    • 0037421985 scopus 로고    scopus 로고
    • A randomized trial of aspirin to prevent colorectal adenomas
    • COI: 1:CAS:528:DC%2BD3sXhvVOitrw%3D, PID: 12621133
    • Baron JA, Cole BF, Sandler RS et al (2003) A randomized trial of aspirin to prevent colorectal adenomas. N Engl J Med 348(10):891–899. doi:10.1056/NEJMoa021735
    • (2003) N Engl J Med , vol.348 , Issue.10 , pp. 891-899
    • Baron, J.A.1    Cole, B.F.2    Sandler, R.S.3
  • 23
    • 33750432183 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression
    • COI: 1:CAS:528:DC%2BD28XhtFektL7N, PID: 17072330
    • Basseres DS, Baldwin AS (2006) Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression. Oncogene 25(51):6817–6830. doi:10.1038/sj.onc.1209942
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6817-6830
    • Basseres, D.S.1    Baldwin, A.S.2
  • 24
    • 3042716638 scopus 로고    scopus 로고
    • NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis
    • COI: 1:CAS:528:DC%2BD2cXlvFOhsL4%3D, PID: 15220474
    • Biswas DK, Shi Q, Baily S et al (2004) NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis. Proc Natl Acad Sci USA 101(27):10137–10142. doi:10.1073/pnas.0403621101
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.27 , pp. 10137-10142
    • Biswas, D.K.1    Shi, Q.2    Baily, S.3
  • 25
    • 0042968962 scopus 로고    scopus 로고
    • Molecular viral oncology of hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BD3sXmtFahu74%3D, PID: 12910247
    • Block TM, Mehta AS, Fimmel CJ, Jordan R (2003) Molecular viral oncology of hepatocellular carcinoma. Oncogene 22(33):5093–5107. doi:10.1038/sj.onc.1206557
    • (2003) Oncogene , vol.22 , Issue.33 , pp. 5093-5107
    • Block, T.M.1    Mehta, A.S.2    Fimmel, C.J.3    Jordan, R.4
  • 26
    • 73849090217 scopus 로고    scopus 로고
    • IKK/NF-kappa B and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis
    • COI: 1:CAS:528:DC%2BD1MXhtlKqurrN, PID: 19893576
    • Bollrath J, Greten FR (2009) IKK/NF-kappa B and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis. EMBO Rep 10(12):1314–1319. doi:10.1038/embor.2009.243
    • (2009) EMBO Rep , vol.10 , Issue.12 , pp. 1314-1319
    • Bollrath, J.1    Greten, F.R.2
  • 27
    • 2342464085 scopus 로고    scopus 로고
    • The two NF-kappa B activation pathways and their role in innate and adaptive immunity
    • COI: 1:CAS:528:DC%2BD2cXktVKqs7s%3D, PID: 15145317
    • Bonizzi G, Karin M (2004) The two NF-kappa B activation pathways and their role in innate and adaptive immunity. Trends Immunol 25(6):280–288. doi:10.1016/J.It.2004.03.008
    • (2004) Trends Immunol , vol.25 , Issue.6 , pp. 280-288
    • Bonizzi, G.1    Karin, M.2
  • 28
    • 8644274040 scopus 로고    scopus 로고
    • The enigmatic X gene of hepatitis B virus
    • COI: 1:CAS:528:DC%2BD2cXhtVaqtbrL, PID: 15542625
    • Bouchard MJ, Schneider RJ (2004) The enigmatic X gene of hepatitis B virus. J Virol 78(23):12725–12734. doi:10.1128/Jvi.78.23.12725-12734.2004
    • (2004) J Virol , vol.78 , Issue.23 , pp. 12725-12734
    • Bouchard, M.J.1    Schneider, R.J.2
  • 29
    • 0037449711 scopus 로고    scopus 로고
    • BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice
    • COI: 1:CAS:528:DC%2BD3sXisFyisw%3D%3D, PID: 12403772
    • Burke JR, Pattoli MA, Gregor KR et al (2003) BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem 278(3):1450–1456. doi:10.1074/jbc.M209677200
    • (2003) J Biol Chem , vol.278 , Issue.3 , pp. 1450-1456
    • Burke, J.R.1    Pattoli, M.A.2    Gregor, K.R.3
  • 30
    • 0035861314 scopus 로고    scopus 로고
    • IKK alpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development
    • COI: 1:CAS:528:DC%2BD38XhtFymtQ%3D%3D, PID: 11747812
    • Cao YX, Bonizzi G, Seagroves TN et al (2001) IKK alpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell 107(6):763–775. doi:10.1016/S0092-8674(01)00599-2
    • (2001) Cell , vol.107 , Issue.6 , pp. 763-775
    • Cao, Y.X.1    Bonizzi, G.2    Seagroves, T.N.3
  • 31
    • 35648970074 scopus 로고    scopus 로고
    • I kappa B kinase a kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells
    • COI: 1:CAS:528:DC%2BD2sXhtFGit73P, PID: 17890319
    • Cao YX, Luo JL, Karin M (2007) I kappa B kinase a kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Proc Natl Acad Sci USA 104(40):15852–15857. doi:10.1073/pnas.0706728104
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.40 , pp. 15852-15857
    • Cao, Y.X.1    Luo, J.L.2    Karin, M.3
  • 32
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • COI: 1:CAS:528:DC%2BD3cXmvVSls74%3D, PID: 11001068
    • Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407(6801):249–257. doi:10.1038/35025220
    • (2000) Nature , vol.407 , Issue.6801 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 33
    • 0029994434 scopus 로고    scopus 로고
    • The v-rel oncogene promotes malignant T-cell leukemia/lymphoma in transgenic mice
    • COI: 1:CAS:528:DyaK28Xksl2mtbk%3D, PID: 8670867
    • Carrasco D, Rizzo CA, Dorfman K, Bravo R (1996) The v-rel oncogene promotes malignant T-cell leukemia/lymphoma in transgenic mice. EMBO J 15(14):3640–3650
    • (1996) EMBO J , vol.15 , Issue.14 , pp. 3640-3650
    • Carrasco, D.1    Rizzo, C.A.2    Dorfman, K.3    Bravo, R.4
  • 34
    • 12444296120 scopus 로고    scopus 로고
    • Novel IKK inhibitors: beta-carbolines
    • COI: 1:CAS:528:DC%2BD3sXkvVGqsr0%3D, PID: 12824047
    • Castro AC, Dang LC, Soucy F et al (2003) Novel IKK inhibitors: beta-carbolines. Bioorg Med Chem Lett 13(14):2419–2422. doi:10.1016/S0960-894x(03)00408-6
    • (2003) Bioorg Med Chem Lett , vol.13 , Issue.14 , pp. 2419-2422
    • Castro, A.C.1    Dang, L.C.2    Soucy, F.3
  • 35
    • 0035504081 scopus 로고    scopus 로고
    • Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer
    • COI: 1:CAS:528:DC%2BD3MXovVOntLg%3D, PID: 11704864
    • Catz SD, Johnson JL (2001) Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer. Oncogene 20(50):7342–7351. doi:10.1038/sj.onc.1204926
    • (2001) Oncogene , vol.20 , Issue.50 , pp. 7342-7351
    • Catz, S.D.1    Johnson, J.L.2
  • 36
    • 22944470236 scopus 로고    scopus 로고
    • Transforming growth factor-alpha inhibits the intrinsic pathway of c-myc-induced apoptosis through activation of nuclear factor-kappa B in murine hepatocellular carcinomas
    • COI: 1:CAS:528:DC%2BD2MXmsFSmt7w%3D, PID: 16046551
    • Cavin LG, Wang F, Factor VM et al (2005) Transforming growth factor-alpha inhibits the intrinsic pathway of c-myc-induced apoptosis through activation of nuclear factor-kappa B in murine hepatocellular carcinomas. Mol Cancer Res 3(7):403–412. doi:10.1158/1541-7786.Mcr-04-0186
    • (2005) Mol Cancer Res , vol.3 , Issue.7 , pp. 403-412
    • Cavin, L.G.1    Wang, F.2    Factor, V.M.3
  • 37
    • 0037810249 scopus 로고    scopus 로고
    • Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention
    • COI: 1:CAS:528:DC%2BD3sXkvFeqsro%3D, PID: 12835716
    • Chang F, Steelman LS, Lee JT et al (2003) Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia 17(7):1263–1293. doi:10.1038/sj.leu.2402945
    • (2003) Leukemia , vol.17 , Issue.7 , pp. 1263-1293
    • Chang, F.1    Steelman, L.S.2    Lee, J.T.3
  • 38
    • 2342522110 scopus 로고    scopus 로고
    • Shaping the nuclear action of NF-kappa B
    • COI: 1:CAS:528:DC%2BD2cXjsFSltL0%3D
    • Chen LF, Greene WC (2004) Shaping the nuclear action of NF-kappa B. Nat Rev Mol Cell Bio 5(5):392–401. doi:10.1038/Nrm1368
    • (2004) Nat Rev Mol Cell Bio , vol.5 , Issue.5 , pp. 392-401
    • Chen, L.F.1    Greene, W.C.2
  • 39
    • 0033621956 scopus 로고    scopus 로고
    • The Rel/NF-kappa B family directly activates expression of the apoptosis inhibitor Bcl-x(L)
    • PID: 10733571
    • Chen CL, Edelstein LC, Gelinas C (2000) The Rel/NF-kappa B family directly activates expression of the apoptosis inhibitor Bcl-x(L). Mol Cell Biol 20(8):2687–2695. doi:10.1128/Mcb.20.8.2687-2695.2000
    • (2000) Mol Cell Biol , vol.20 , Issue.8 , pp. 2687-2695
    • Chen, C.L.1    Edelstein, L.C.2    Gelinas, C.3
  • 40
    • 0030885421 scopus 로고    scopus 로고
    • Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappa B control
    • COI: 1:CAS:528:DyaK2sXmt1Cquro%3D, PID: 9294162
    • Chu ZL, McKinsey TA, Liu L, Gentry JJ, Malim MH, Ballard DW (1997) Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappa B control. Proc Natl Acad Sci USA 94(19):10057–10062. doi:10.1073/pnas.94.19.10057
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.19 , pp. 10057-10062
    • Chu, Z.L.1    McKinsey, T.A.2    Liu, L.3    Gentry, J.J.4    Malim, M.H.5    Ballard, D.W.6
  • 41
    • 33748057486 scopus 로고    scopus 로고
    • Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kappa B signaling as characteristics of a high-risk head and neck squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BD28XotFWqtbY%3D, PID: 16912200
    • Chung CH, Parker JS, Ely K et al (2006) Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kappa B signaling as characteristics of a high-risk head and neck squamous cell carcinoma. Cancer Res 66(16):8210–8218. doi:10.1158/0008-5472.Can-06-1213
    • (2006) Cancer Res , vol.66 , Issue.16 , pp. 8210-8218
    • Chung, C.H.1    Parker, J.S.2    Ely, K.3
  • 42
    • 0034708132 scopus 로고    scopus 로고
    • Selective activation of NF-kappa B subunits in human breast cancer: potential roles for NF-kappa B2/p52 and for Bcl-3
    • COI: 1:CAS:528:DC%2BD3cXitFeqt7c%3D, PID: 10713699
    • Cogswell PC, Guttridge DC, Funkhouser WK, Baldwin AS (2000) Selective activation of NF-kappa B subunits in human breast cancer: potential roles for NF-kappa B2/p52 and for Bcl-3. Oncogene 19(9):1123–1131. doi:10.1038/sj.onc.1203412
    • (2000) Oncogene , vol.19 , Issue.9 , pp. 1123-1131
    • Cogswell, P.C.1    Guttridge, D.C.2    Funkhouser, W.K.3    Baldwin, A.S.4
  • 43
    • 0029101772 scopus 로고
    • Transcriptional regulation of endothelial-cell adhesion molecules—Nf-Kappa-B and cytokine-inducible enhancers
    • COI: 1:CAS:528:DyaK2MXntFyrsb4%3D, PID: 7542214
    • Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T (1995) Transcriptional regulation of endothelial-cell adhesion molecules—Nf-Kappa-B and cytokine-inducible enhancers. Faseb J 9(10):899–909
    • (1995) Faseb J , vol.9 , Issue.10 , pp. 899-909
    • Collins, T.1    Read, M.A.2    Neish, A.S.3    Whitley, M.Z.4    Thanos, D.5    Maniatis, T.6
  • 44
    • 33750454819 scopus 로고    scopus 로고
    • Mutations in the NF-kappaB signaling pathway: implications for human disease
    • COI: 1:CAS:528:DC%2BD28XhtFekt7fJ, PID: 17072331
    • Courtois G, Gilmore TD (2006) Mutations in the NF-kappaB signaling pathway: implications for human disease. Oncogene 25(51):6831–6843. doi:10.1038/sj.onc.1209939
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6831-6843
    • Courtois, G.1    Gilmore, T.D.2
  • 45
    • 0035328584 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappa B inhibition
    • COI: 1:CAS:528:DC%2BD3MXjsFCgt7o%3D, PID: 11325813
    • Cusack JC, Liu R, Houston M et al (2001) Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappa B inhibition. Cancer Res 61(9):3535–3540
    • (2001) Cancer Res , vol.61 , Issue.9 , pp. 3535-3540
    • Cusack, J.C.1    Liu, R.2    Houston, M.3
  • 46
    • 44849117768 scopus 로고    scopus 로고
    • Akt-dependent regulation of NF-kappa B is controlled by mTOR and raptor in association with IKK
    • COI: 1:CAS:528:DC%2BD1cXnsVOlu7o%3D, PID: 18519641
    • Dan HC, Cooper MJ, Cogswell PC, Duncan JA, Ting JPY, Baldwin AS (2008) Akt-dependent regulation of NF-kappa B is controlled by mTOR and raptor in association with IKK. Genes Dev 22(11):1490–1500. doi:10.1101/Gad.1662308
    • (2008) Genes Dev , vol.22 , Issue.11 , pp. 1490-1500
    • Dan, H.C.1    Cooper, M.J.2    Cogswell, P.C.3    Duncan, J.A.4    Ting, J.P.Y.5    Baldwin, A.S.6
  • 47
    • 18644380058 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibitor celecoxib augments chemotherapeutic drug-induced apoptosis by enhancing activation of caspase-3 and-9 in prostate cancer cells
    • COI: 1:CAS:528:DC%2BD2MXkt1Clu7o%3D, PID: 15688368
    • Dandekar DS, Lopez M, Carey RI, Lokeshwar BL (2005) Cyclooxygenase-2 inhibitor celecoxib augments chemotherapeutic drug-induced apoptosis by enhancing activation of caspase-3 and-9 in prostate cancer cells. Int J Cancer 115(3):484–492. doi:10.1002/Ijc.20878
    • (2005) Int J Cancer , vol.115 , Issue.3 , pp. 484-492
    • Dandekar, D.S.1    Lopez, M.2    Carey, R.I.3    Lokeshwar, B.L.4
  • 48
    • 0035905313 scopus 로고    scopus 로고
    • Constitutive nuclear factor kappa B activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells
    • COI: 1:CAS:528:DC%2BD38Xpt1ar, PID: 11748286
    • Davis RE, Brown KD, Siebenlist U, Staudt LM (2001) Constitutive nuclear factor kappa B activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells. J Exp Med 194(12):1861–1874. doi:10.1084/jem.194.12.1861
    • (2001) J Exp Med , vol.194 , Issue.12 , pp. 1861-1874
    • Davis, R.E.1    Brown, K.D.2    Siebenlist, U.3    Staudt, L.M.4
  • 49
    • 0035889252 scopus 로고    scopus 로고
    • Induction of gadd45 beta by NF-kappa B downregulates pro-apoptotic JNK signalling
    • PID: 11713530
    • De Smaele E, Zazzeroni F, Papa S et al (2001) Induction of gadd45 beta by NF-kappa B downregulates pro-apoptotic JNK signalling. Nature 414(6861):308–313. doi:10.1038/35104560
    • (2001) Nature , vol.414 , Issue.6861 , pp. 308-313
    • De Smaele, E.1    Zazzeroni, F.2    Papa, S.3
  • 50
    • 77951719556 scopus 로고    scopus 로고
    • Classical and/or alternative NF-kappa B pathway activation in multiple myeloma
    • COI: 1:CAS:528:DC%2BC3cXmtFylur0%3D, PID: 20053756
    • Demchenko YN, Glebov OK, Zingone A, Keats JJ, Bergsagel PL, Kuehl WM (2010) Classical and/or alternative NF-kappa B pathway activation in multiple myeloma. Blood 115(17):3541–3552. doi:10.1182/blood-2009-09-243535
    • (2010) Blood , vol.115 , Issue.17 , pp. 3541-3552
    • Demchenko, Y.N.1    Glebov, O.K.2    Zingone, A.3    Keats, J.J.4    Bergsagel, P.L.5    Kuehl, W.M.6
  • 51
    • 0033082995 scopus 로고    scopus 로고
    • IAP family proteins—suppressors of apoptosis
    • COI: 1:CAS:528:DyaK1MXht1KgsL0%3D, PID: 9990849
    • Deveraux QL, Reed TC (1999) IAP family proteins—suppressors of apoptosis. Genes Dev 13(3):239–252. doi:10.1101/Gad.13.3.239
    • (1999) Genes Dev , vol.13 , Issue.3 , pp. 239-252
    • Deveraux, Q.L.1    Reed, T.C.2
  • 52
    • 51649118928 scopus 로고    scopus 로고
    • Phase II trial of curcumin in patients with advanced pancreatic cancer
    • COI: 1:CAS:528:DC%2BD1cXosFGitLw%3D, PID: 18628464
    • Dhillon N, Aggarwal BB, Newman RA et al (2008) Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 14(14):4491–4499. doi:10.1158/1078-0432.Ccr-08-0024
    • (2008) Clin Cancer Res , vol.14 , Issue.14 , pp. 4491-4499
    • Dhillon, N.1    Aggarwal, B.B.2    Newman, R.A.3
  • 53
    • 0034954277 scopus 로고    scopus 로고
    • X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesis
    • COI: 1:CAS:528:DC%2BD3MXltVWitb4%3D
    • Diao JY, Garces R, Richardson CD (2001) X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesis. Cytokine Growth Fact Rev 12(2–3):189–205. doi:10.1016/S1359-6101(00)00034-4
    • (2001) Cytokine Growth Fact Rev , vol.12 , Issue.2-3 , pp. 189-205
    • Diao, J.Y.1    Garces, R.2    Richardson, C.D.3
  • 54
    • 33645906539 scopus 로고    scopus 로고
    • Curcumin induces stress response, neurite outgrowth and prevent NF-kappa B activation by inhibiting the proteasome function
    • COI: 1:CAS:528:DC%2BD28XhtFKqsbjI, PID: 16464750
    • Dikshit P, Goswami A, Mishra A, Chatterjee M, Jana NR (2006) Curcumin induces stress response, neurite outgrowth and prevent NF-kappa B activation by inhibiting the proteasome function. Neurotox Res 9(1):29–37
    • (2006) Neurotox Res , vol.9 , Issue.1 , pp. 29-37
    • Dikshit, P.1    Goswami, A.2    Mishra, A.3    Chatterjee, M.4    Jana, N.R.5
  • 55
    • 0035874877 scopus 로고    scopus 로고
    • Molecular profiling of transformed and metastatic murine squamous carcinoma cells by differential display and cDNA microarray reveals altered expression of multiple genes related to growth, apoptosis, angiogenesis, and the NF-kappaB signal pathway
    • COI: 1:CAS:528:DC%2BD3MXks1Grur0%3D, PID: 11406555
    • Dong G, Loukinova E, Chen Z et al (2001) Molecular profiling of transformed and metastatic murine squamous carcinoma cells by differential display and cDNA microarray reveals altered expression of multiple genes related to growth, apoptosis, angiogenesis, and the NF-kappaB signal pathway. Cancer Res 61(12):4797–4808
    • (2001) Cancer Res , vol.61 , Issue.12 , pp. 4797-4808
    • Dong, G.1    Loukinova, E.2    Chen, Z.3
  • 56
    • 0031895560 scopus 로고    scopus 로고
    • Cyclin D1 and human neoplasia
    • COI: 1:STN:280:DyaK1c3oslCqtw%3D%3D
    • Donnellan R, Chetty R (1998) Cyclin D1 and human neoplasia. J Clin Pathol Mol Pathol 51(1):1–7
    • (1998) J Clin Pathol Mol Pathol , vol.51 , Issue.1 , pp. 1-7
    • Donnellan, R.1    Chetty, R.2
  • 57
    • 0037388183 scopus 로고    scopus 로고
    • The nuclear localization of NF kappa B and p53 is positively correlated with HPV16 E7 level in laryngeal squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BD3sXivVerurY%3D, PID: 12642632
    • Du J, Chen GG, Vlantis AC, Xu H, Tsang RKY, van Hasselt AC (2003) The nuclear localization of NF kappa B and p53 is positively correlated with HPV16 E7 level in laryngeal squamous cell carcinoma. J Histochem Cytochem 51(4):533–539
    • (2003) J Histochem Cytochem , vol.51 , Issue.4 , pp. 533-539
    • Du, J.1    Chen, G.G.2    Vlantis, A.C.3    Xu, H.4    Tsang, R.K.Y.5    van Hasselt, A.C.6
  • 58
    • 0033565217 scopus 로고    scopus 로고
    • Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo
    • COI: 1:CAS:528:DyaK1MXks1Omsb4%3D, PID: 10416612
    • Duffey DC, Chen Z, Dong G et al (1999) Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo. Cancer Res 59(14):3468–3474
    • (1999) Cancer Res , vol.59 , Issue.14 , pp. 3468-3474
    • Duffey, D.C.1    Chen, Z.2    Dong, G.3
  • 59
    • 67650398258 scopus 로고    scopus 로고
    • Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma
    • COI: 1:CAS:528:DC%2BD1MXnslSmurs%3D, PID: 19380866
    • Dunleavy K, Pittaluga S, Czuczman MS et al (2009) Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma. Blood 113(24):6069–6076. doi:10.1182/blood-2009-01-199679
    • (2009) Blood , vol.113 , Issue.24 , pp. 6069-6076
    • Dunleavy, K.1    Pittaluga, S.2    Czuczman, M.S.3
  • 60
    • 0142182047 scopus 로고    scopus 로고
    • 5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis
    • COI: 1:CAS:528:DC%2BD3sXpt1Kis7w%3D, PID: 12842827
    • Farah M, Parhar K, Moussavi M, Eivemark S, Salh B (2003) 5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis. Am J Physiol Gastrointest Liver Physiol 285(5):G919–G928. doi:10.1152/ajpgi.00205.2003
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.285 , Issue.5 , pp. 919-928
    • Farah, M.1    Parhar, K.2    Moussavi, M.3    Eivemark, S.4    Salh, B.5
  • 61
    • 0030882666 scopus 로고    scopus 로고
    • Oncogenic Ha-Ras-induced signaling activates NF-kappa B transcriptional activity, which is required for cellular transformation
    • COI: 1:CAS:528:DyaK2sXmsFantbc%3D, PID: 9305854
    • Finco TS, Westwick JK, Norris JL, Beg AA, Der CJ, Baldwin AS (1997) Oncogenic Ha-Ras-induced signaling activates NF-kappa B transcriptional activity, which is required for cellular transformation. J Biol Chem 272(39):24113–24116. doi:10.1074/jbc.272.39.24113
    • (1997) J Biol Chem , vol.272 , Issue.39 , pp. 24113-24116
    • Finco, T.S.1    Westwick, J.K.2    Norris, J.L.3    Beg, A.A.4    Der, C.J.5    Baldwin, A.S.6
  • 62
    • 0034471496 scopus 로고    scopus 로고
    • Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia
    • COI: 1:CAS:528:DC%2BD3cXosVejsro%3D
    • Fosslien E (2000) Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. Crit Rev Cl Lab Sci 37(5):431–502. doi:10.1080/10408360091174286
    • (2000) Crit Rev Cl Lab Sci , vol.37 , Issue.5 , pp. 431-502
    • Fosslien, E.1
  • 63
    • 11144237891 scopus 로고    scopus 로고
    • Nuclear factor-kappa B nuclear localization is predictive of biochemical recurrence in patients with positive margin prostate cancer
    • COI: 1:CAS:528:DC%2BD2cXhtFGjs7rL, PID: 15623625
    • Fradet V, Lessard L, Begin LR, Karakiewicz P, Masson AMM, Saad F (2004) Nuclear factor-kappa B nuclear localization is predictive of biochemical recurrence in patients with positive margin prostate cancer. Clin Cancer Res 10(24):8460–8464. doi:10.1158/1078-0432.Ccr-04-0764
    • (2004) Clin Cancer Res , vol.10 , Issue.24 , pp. 8460-8464
    • Fradet, V.1    Lessard, L.2    Begin, L.R.3    Karakiewicz, P.4    Masson, A.M.M.5    Saad, F.6
  • 64
    • 4344660420 scopus 로고    scopus 로고
    • NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity
    • COI: 1:CAS:528:DC%2BD2cXntVKgsr8%3D, PID: 15314185
    • Fujioka S, Niu J, Schmidt C et al (2004) NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity. Mol Cell Biol 24(17):7806–7819. doi:10.1128/MCB.24.17.7806-7819.2004
    • (2004) Mol Cell Biol , vol.24 , Issue.17 , pp. 7806-7819
    • Fujioka, S.1    Niu, J.2    Schmidt, C.3
  • 65
    • 0036150911 scopus 로고    scopus 로고
    • The role of IKK in constitutive activation of NF-kappaB transcription factor in prostate carcinoma cells
    • COI: 1:CAS:528:DC%2BD38XovVeitA%3D%3D, PID: 11801732
    • Gasparian AV, Yao YJ, Kowalczyk D et al (2002) The role of IKK in constitutive activation of NF-kappaB transcription factor in prostate carcinoma cells. J Cell Sci 115(Pt 1):141–151
    • (2002) J Cell Sci , vol.115 , pp. 141-151
    • Gasparian, A.V.1    Yao, Y.J.2    Kowalczyk, D.3
  • 66
    • 0031897632 scopus 로고    scopus 로고
    • NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
    • COI: 1:CAS:528:DyaK1cXislygtL0%3D, PID: 9597130
    • Ghosh S, May MJ, Kopp EB (1998) NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16:225–260. doi:10.1146/annurev.immunol.16.1.225
    • (1998) Annu Rev Immunol , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 67
    • 0033596128 scopus 로고    scopus 로고
    • Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel
    • COI: 1:CAS:528:DyaK1MXotVyhtLc%3D, PID: 10602467
    • Gilmore TD (1999) Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel. Oncogene 18(49):6925–6937. doi:10.1038/sj.onc.1203222
    • (1999) Oncogene , vol.18 , Issue.49 , pp. 6925-6937
    • Gilmore, T.D.1
  • 68
    • 1842432464 scopus 로고    scopus 로고
    • The c-Rel transcription factor and B-cell proliferation: a deal with the devil
    • COI: 1:CAS:528:DC%2BD2cXisVGksb0%3D, PID: 14755244
    • Gilmore TD, Kalaitzidis D, Liang MC, Starczynowski DT (2004) The c-Rel transcription factor and B-cell proliferation: a deal with the devil. Oncogene 23(13):2275–2286. doi:10.1038/sj.onc.1207410
    • (2004) Oncogene , vol.23 , Issue.13 , pp. 2275-2286
    • Gilmore, T.D.1    Kalaitzidis, D.2    Liang, M.C.3    Starczynowski, D.T.4
  • 69
    • 0015611872 scopus 로고
    • Thymidine kinase activity in Burkitt lymphoblastoid somatic cell hybrids after induction of the EB virus
    • COI: 1:CAS:528:DyaE3sXhtV2jtrw%3D, PID: 4348579
    • Glaser R, Ogino T, Zimmerman J Jr, Rapp F (1973) Thymidine kinase activity in Burkitt lymphoblastoid somatic cell hybrids after induction of the EB virus. Proc Soc Exp Biol Med 142(4):1059–1062
    • (1973) Proc Soc Exp Biol Med , vol.142 , Issue.4 , pp. 1059-1062
    • Glaser, R.1    Ogino, T.2    Zimmerman, J.3    Rapp, F.4
  • 70
    • 4043088499 scopus 로고    scopus 로고
    • IKK beta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • COI: 1:CAS:528:DC%2BD2cXmslKrs7o%3D, PID: 15294155
    • Greten FR, Eckmann L, Greten TF et al (2004) IKK beta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118(3):285–296. doi:10.1016/j.cell.2004.07.013
    • (2004) Cell , vol.118 , Issue.3 , pp. 285-296
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3
  • 71
    • 77549083560 scopus 로고    scopus 로고
    • Dangerous liaisons: STAT3 and NF-kappa B collaboration and crosstalk in cancer
    • COI: 1:CAS:528:DC%2BC3cXivFKgsrs%3D, PID: 20018552
    • Grivennikov SI, Karin M (2010) Dangerous liaisons: STAT3 and NF-kappa B collaboration and crosstalk in cancer. Cytokine Growth Factor Rev 21(1):11–19. doi:10.1016/j.cytogfr.2009.11.005
    • (2010) Cytokine Growth Factor Rev , vol.21 , Issue.1 , pp. 11-19
    • Grivennikov, S.I.1    Karin, M.2
  • 72
    • 0035104119 scopus 로고    scopus 로고
    • LPS induction of gene expression in human monocytes
    • COI: 1:CAS:528:DC%2BD3MXitVOmtb0%3D, PID: 11257452
    • Guha M, Mackman N (2001) LPS induction of gene expression in human monocytes. Cell Signal 13(2):85–94. doi:10.1016/S0898-6568(00)00149-2
    • (2001) Cell Signal , vol.13 , Issue.2 , pp. 85-94
    • Guha, M.1    Mackman, N.2
  • 73
    • 2542449068 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to irinotecan by RNA interference mediated down-regulation of the nuclear factor-kappa B p65 subunit
    • COI: 1:CAS:528:DC%2BD2cXkt1Ghs7c%3D, PID: 15161687
    • Guo J, Verma UN, Gaynor RB, Frenkel EP, Becerra CR (2004) Enhanced chemosensitivity to irinotecan by RNA interference mediated down-regulation of the nuclear factor-kappa B p65 subunit. Clin Cancer Res 10(10):3333–3341. doi:10.1158/1078-0432.Ccr-03-0366
    • (2004) Clin Cancer Res , vol.10 , Issue.10 , pp. 3333-3341
    • Guo, J.1    Verma, U.N.2    Gaynor, R.B.3    Frenkel, E.P.4    Becerra, C.R.5
  • 74
    • 0032588186 scopus 로고    scopus 로고
    • NF-kappa B controls cell growth and differentiation through transcriptional regulation of cyclin D1
    • COI: 1:CAS:528:DyaK1MXkvVKjtrc%3D, PID: 10409765
    • Guttridge DC, Albanese C, Reuther JY, Pestell RG, Baldwin AS (1999) NF-kappa B controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol 19(8):5785–5799
    • (1999) Mol Cell Biol , vol.19 , Issue.8 , pp. 5785-5799
    • Guttridge, D.C.1    Albanese, C.2    Reuther, J.Y.3    Pestell, R.G.4    Baldwin, A.S.5
  • 75
    • 77954930632 scopus 로고    scopus 로고
    • IAPs: from caspase inhibitors to modulators of NF-kappa B, inflammation and cancer
    • COI: 1:CAS:528:DC%2BC3cXpt1Gjtbw%3D, PID: 20651737
    • Gyrd-Hansen M, Meier P (2010) IAPs: from caspase inhibitors to modulators of NF-kappa B, inflammation and cancer. Nat Rev Cancer 10(8):561–574. doi:10.1038/Nrc2889
    • (2010) Nat Rev Cancer , vol.10 , Issue.8 , pp. 561-574
    • Gyrd-Hansen, M.1    Meier, P.2
  • 76
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • COI: 1:CAS:528:DC%2BC3MXjsFeqtrk%3D, PID: 21376230
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646–674. doi:10.1016/j.cell.2011.02.013
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 77
    • 5644264889 scopus 로고    scopus 로고
    • The nuclear factor kappa B subunits RelA/p65 and c-Rel potentiate but are not required for Ras-induced cellular transformation
    • COI: 1:CAS:528:DC%2BD2cXosFynt7o%3D, PID: 15492243
    • Hanson JL, Hawke NA, Kashatus D, Baldwin AS (2004) The nuclear factor kappa B subunits RelA/p65 and c-Rel potentiate but are not required for Ras-induced cellular transformation. Cancer Res 64(20):7248–7255. doi:10.1158/0008-5472.Can-03-3898
    • (2004) Cancer Res , vol.64 , Issue.20 , pp. 7248-7255
    • Hanson, J.L.1    Hawke, N.A.2    Kashatus, D.3    Baldwin, A.S.4
  • 78
    • 0035864733 scopus 로고    scopus 로고
    • NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps
    • COI: 1:CAS:528:DC%2BD3MXhvVers7g%3D, PID: 11314016
    • Hardwick JCH, van den Brink GR, Offerhaus GJ, van Deventer SJH, Peppelenbosch MP (2001) NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps. Oncogene 20(7):819–827. doi:10.1038/sj.onc.1204162
    • (2001) Oncogene , vol.20 , Issue.7 , pp. 819-827
    • Hardwick, J.C.H.1    van den Brink, G.R.2    Offerhaus, G.J.3    van Deventer, S.J.H.4    Peppelenbosch, M.P.5
  • 79
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-kappa B
    • COI: 1:CAS:528:DC%2BD2cXnslCntbY%3D, PID: 15371334
    • Hayden MS, Ghosh S (2004) Signaling to NF-kappa B. Genes Dev 18(18):2195–2224. doi:10.1101/Gad.1228704
    • (2004) Genes Dev , vol.18 , Issue.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 80
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappa B signaling
    • COI: 1:CAS:528:DC%2BD1cXivVahtbY%3D, PID: 18267068
    • Hayden MS, Ghosh S (2008) Shared principles in NF-kappa B signaling. Cell 132(3):344–362. doi:10.1016/j.cell.2008.01.020
    • (2008) Cell , vol.132 , Issue.3 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 81
    • 0038498102 scopus 로고    scopus 로고
    • NF-kappa B promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4
    • COI: 1:CAS:528:DC%2BD3sXksVemsL8%3D, PID: 12690099
    • Helbig G, Christopherson KW, Bhat-Nakshatri P et al (2003) NF-kappa B promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J Biol Chem 278(24):21631–21638. doi:10.1074/jbc.M300609200
    • (2003) J Biol Chem , vol.278 , Issue.24 , pp. 21631-21638
    • Helbig, G.1    Christopherson, K.W.2    Bhat-Nakshatri, P.3
  • 82
    • 0035525733 scopus 로고    scopus 로고
    • Cellular stress response and apoptosis in cancer therapy
    • COI: 1:CAS:528:DC%2BD3MXotVegs7o%3D, PID: 11675328
    • Herr I, Debatin KM (2001) Cellular stress response and apoptosis in cancer therapy. Blood 98(9):2603–2614. doi:10.1182/blood.V98.9.2603
    • (2001) Blood , vol.98 , Issue.9 , pp. 2603-2614
    • Herr, I.1    Debatin, K.M.2
  • 83
    • 0031586606 scopus 로고    scopus 로고
    • Bcl-2 suppresses apoptosis resulting from disruption of the NF-kappa B survival pathway
    • COI: 1:CAS:528:DyaK2sXnvFWmu7w%3D, PID: 9417872
    • Herrmann JL, Beham AW, Sarkiss M et al (1997) Bcl-2 suppresses apoptosis resulting from disruption of the NF-kappa B survival pathway. Exp Cell Res 237(1):101–109. doi:10.1006/excr.1997.3737
    • (1997) Exp Cell Res , vol.237 , Issue.1 , pp. 101-109
    • Herrmann, J.L.1    Beham, A.W.2    Sarkiss, M.3
  • 84
    • 0031657807 scopus 로고    scopus 로고
    • The ubiquitin system
    • COI: 1:CAS:528:DyaK1cXlsFOmsLc%3D, PID: 9759494
    • Hershko A, Ciechanover A (1998) The ubiquitin system. Annu Rev Biochem 67:425–479. doi:10.1146/annurev.biochem.67.1.425
    • (1998) Annu Rev Biochem , vol.67 , pp. 425-479
    • Hershko, A.1    Ciechanover, A.2
  • 85
    • 18544367201 scopus 로고    scopus 로고
    • NF-kappa B as a therapeutic target in multiple myeloma
    • COI: 1:CAS:528:DC%2BD38XjslWhtrw%3D, PID: 11872748
    • Hideshima T, Chauhan D, Richardson P et al (2002) NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem 277(19):16639–16647. doi:10.1074/jbc.M200360200
    • (2002) J Biol Chem , vol.277 , Issue.19 , pp. 16639-16647
    • Hideshima, T.1    Chauhan, D.2    Richardson, P.3
  • 86
    • 0037441760 scopus 로고    scopus 로고
    • Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341
    • COI: 1:CAS:528:DC%2BD3sXht1ansr4%3D, PID: 12393500
    • Hideshima T, Mitsiades C, Akiyama M et al (2003) Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. Blood 101(4):1530–1534. doi:10.1182/blood-2002-08-2543
    • (2003) Blood , vol.101 , Issue.4 , pp. 1530-1534
    • Hideshima, T.1    Mitsiades, C.2    Akiyama, M.3
  • 87
    • 3242777803 scopus 로고    scopus 로고
    • Advances in biology of multiple myeloma: clinical applications
    • COI: 1:CAS:528:DC%2BD2cXmtlCkt7s%3D, PID: 15090448
    • Hideshima T, Bergsagel PL, Kuehl WM, Anderson KC (2004) Advances in biology of multiple myeloma: clinical applications. Blood 104(3):607–618. doi:10.1182/blood-2004-01-0037
    • (2004) Blood , vol.104 , Issue.3 , pp. 607-618
    • Hideshima, T.1    Bergsagel, P.L.2    Kuehl, W.M.3    Anderson, K.C.4
  • 88
    • 0032588170 scopus 로고    scopus 로고
    • NF-kappa B function in growth control: regulation of cyclin D1 expression and G(0)G(1)-to-S-Phase transition
    • COI: 1:CAS:528:DyaK1MXit1amt7s%3D, PID: 10082535
    • Hinz M, Krappmann D, Eichten A, Heder A, Scheidereit C, Strauss M (1999) NF-kappa B function in growth control: regulation of cyclin D1 expression and G(0)G(1)-to-S-Phase transition. Mol Cell Biol 19(4):2690–2698
    • (1999) Mol Cell Biol , vol.19 , Issue.4 , pp. 2690-2698
    • Hinz, M.1    Krappmann, D.2    Eichten, A.3    Heder, A.4    Scheidereit, C.5    Strauss, M.6
  • 89
    • 0033571407 scopus 로고    scopus 로고
    • CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo
    • COI: 1:CAS:528:DyaK1MXnslyhurw%3D, PID: 10582695
    • Hjarnaa PJV, Jonsson E, Latini S et al (1999) CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo. Cancer Res 59(22):5751–5757
    • (1999) Cancer Res , vol.59 , Issue.22 , pp. 5751-5757
    • Hjarnaa, P.J.V.1    Jonsson, E.2    Latini, S.3
  • 90
    • 27544476971 scopus 로고    scopus 로고
    • The role of IL-6 and STAT3 in inflammation and cancer
    • COI: 1:CAS:528:DC%2BD2MXhtFyks73E, PID: 16199153
    • Hodge DR, Hurt EM, Farrar WL (2005) The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 41(16):2502–2512. doi:10.1016/j.ejca.2005.08.016
    • (2005) Eur J Cancer , vol.41 , Issue.16 , pp. 2502-2512
    • Hodge, D.R.1    Hurt, E.M.2    Farrar, W.L.3
  • 91
    • 0034698053 scopus 로고    scopus 로고
    • Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1
    • COI: 1:CAS:528:DC%2BD3cXlt1ehtLY%3D, PID: 10807933
    • Hofer-Warbinek R, Schmid JA, Stehlik C, Binder BR, Lipp J, de Martin R (2000) Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1. J Biol Chem 275(29):22064–22068. doi:10.1074/jbc.M910346199
    • (2000) J Biol Chem , vol.275 , Issue.29 , pp. 22064-22068
    • Hofer-Warbinek, R.1    Schmid, J.A.2    Stehlik, C.3    Binder, B.R.4    Lipp, J.5    de Martin, R.6
  • 92
    • 0036716986 scopus 로고    scopus 로고
    • A phase I study of CHS 828 in patients with solid tumor malignancy
    • COI: 1:CAS:528:DC%2BD38XnvVWisb8%3D, PID: 12231525
    • Hovstadius P, Larsson R, Jonsson E et al (2002) A phase I study of CHS 828 in patients with solid tumor malignancy. Clin Cancer Res 8(9):2843–2850
    • (2002) Clin Cancer Res , vol.8 , Issue.9 , pp. 2843-2850
    • Hovstadius, P.1    Larsson, R.2    Jonsson, E.3
  • 93
    • 0033623902 scopus 로고    scopus 로고
    • Nuclear factor-kappa B activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice
    • COI: 1:CAS:528:DC%2BD3cXksVGhtrk%3D, PID: 10873114
    • Huang S, DeGuzman A, Bucana CD, Fidler IJ (2000a) Nuclear factor-kappa B activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice. Clin Cancer Res 6(6):2573–2581
    • (2000) Clin Cancer Res , vol.6 , Issue.6 , pp. 2573-2581
    • Huang, S.1    DeGuzman, A.2    Bucana, C.D.3    Fidler, I.J.4
  • 94
    • 0034306969 scopus 로고    scopus 로고
    • Blockade of nuclear factor-kappa B signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8
    • COI: 1:CAS:528:DC%2BD3cXns1ehsL8%3D, PID: 11034066
    • Huang S, Robinson JB, DeGuzman A, Bucana CD, Fidler IJ (2000b) Blockade of nuclear factor-kappa B signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res 60(19):5334–5339
    • (2000) Cancer Res , vol.60 , Issue.19 , pp. 5334-5339
    • Huang, S.1    Robinson, J.B.2    DeGuzman, A.3    Bucana, C.D.4    Fidler, I.J.5
  • 95
    • 0035849720 scopus 로고    scopus 로고
    • Blockade of NF-kappa B activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
    • COI: 1:CAS:528:DC%2BD3MXls1WltbY%3D, PID: 11464285
    • Huang SY, Pettaway CA, Uehara H, Bucana CD, Fidler IJ (2001) Blockade of NF-kappa B activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 20(31):4188–4197. doi:10.1038/sj.onc.1204535
    • (2001) Oncogene , vol.20 , Issue.31 , pp. 4188-4197
    • Huang, S.Y.1    Pettaway, C.A.2    Uehara, H.3    Bucana, C.D.4    Fidler, I.J.5
  • 96
    • 4344612243 scopus 로고    scopus 로고
    • NF-kappa B is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
    • COI: 1:CAS:528:DC%2BD2cXmvVelsrY%3D, PID: 15314694
    • Huber MA, Azoitei N, Baumann B et al (2004) NF-kappa B is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 114(4):569–581. doi:10.1172/Jci200421358
    • (2004) J Clin Invest , vol.114 , Issue.4 , pp. 569-581
    • Huber, M.A.1    Azoitei, N.2    Baumann, B.3
  • 97
    • 0027938209 scopus 로고
    • Cyclins and cancer. 2. Cyclin-D and Cdk inhibitors come of age
    • COI: 1:CAS:528:DyaK2MXit1Glu7k%3D, PID: 7954824
    • Hunter T, Pines J (1994) Cyclins and cancer. 2. Cyclin-D and Cdk inhibitors come of age. Cell 79(4):573–582. doi:10.1016/0092-8674(94)90543-6
    • (1994) Cell , vol.79 , Issue.4 , pp. 573-582
    • Hunter, T.1    Pines, J.2
  • 98
    • 34547126428 scopus 로고    scopus 로고
    • The inhibitors of apoptosis (IAPs) as cancer targets
    • COI: 1:CAS:528:DC%2BD2sXotFWru7c%3D, PID: 17573556
    • Hunter AM, LaCasse EC, Korneluk RG (2007) The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis 12(9):1543–1568. doi:10.1007/s10495-007-0087-3
    • (2007) Apoptosis , vol.12 , Issue.9 , pp. 1543-1568
    • Hunter, A.M.1    LaCasse, E.C.2    Korneluk, R.G.3
  • 99
    • 0842327809 scopus 로고    scopus 로고
    • Expression of NF-kappa B in prostate cancer lymph node metastases
    • PID: 14743471
    • Ismail H, Lessard L, Mes-Masson AM, Saad F (2004) Expression of NF-kappa B in prostate cancer lymph node metastases. Prostate 58(3):308–313. doi:10.1002/Pros.10335
    • (2004) Prostate , vol.58 , Issue.3 , pp. 308-313
    • Ismail, H.1    Lessard, L.2    Mes-Masson, A.M.3    Saad, F.4
  • 100
    • 33847394078 scopus 로고    scopus 로고
    • Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappa B activation and proliferation in human head and neck squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BD2sXit12rsLs%3D, PID: 16953224
    • Jackson-Bernitsas DG, Ichikawa H, Takada Y et al (2007) Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappa B activation and proliferation in human head and neck squamous cell carcinoma. Oncogene 26(10):1385–1397. doi:10.1038/sj.onc.1209945
    • (2007) Oncogene , vol.26 , Issue.10 , pp. 1385-1397
    • Jackson-Bernitsas, D.G.1    Ichikawa, H.2    Takada, Y.3
  • 101
    • 33947586159 scopus 로고    scopus 로고
    • Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications
    • COI: 1:CAS:528:DC%2BD2sXjvVygu7Y%3D, PID: 17119127
    • Jost PJ, Ruland J (2007) Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications. Blood 109(7):2700–2707. doi:10.1182/blood-2006-07-025809
    • (2007) Blood , vol.109 , Issue.7 , pp. 2700-2707
    • Jost, P.J.1    Ruland, J.2
  • 102
    • 0347334750 scopus 로고    scopus 로고
    • IL-1 beta mediated up-regulation of HIF-1 alpha via an NFkB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis
    • COI: 1:CAS:528:DC%2BD3sXovFOhsb0%3D, PID: 12958148
    • Jung YJ, Isaacs JS, Lee SM, Trepel J, Neckers L (2003) IL-1 beta mediated up-regulation of HIF-1 alpha via an NFkB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. Faseb J 17(12):2115–2117. doi:10.1096/fj.03-0329fje
    • (2003) Faseb J , vol.17 , Issue.12 , pp. 2115-2117
    • Jung, Y.J.1    Isaacs, J.S.2    Lee, S.M.3    Trepel, J.4    Neckers, L.5
  • 103
    • 67650973761 scopus 로고    scopus 로고
    • Anti-inflammatory properties of curcumin, a major constituent of curcuma longa: a review of preclinical and clinical research
    • PID: 19594223
    • Jurenka JS (2009) Anti-inflammatory properties of curcumin, a major constituent of curcuma longa: a review of preclinical and clinical research. Altern Med Rev 14(2):141–153
    • (2009) Altern Med Rev , vol.14 , Issue.2 , pp. 141-153
    • Jurenka, J.S.1
  • 104
    • 14844327760 scopus 로고    scopus 로고
    • Reactive oxygen species promote TNF alpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
    • COI: 1:CAS:528:DC%2BD2MXis1yhsbg%3D, PID: 15766528
    • Kamata H, Honda S, Maeda S, Chang LF, Hirata H, Karin M (2005) Reactive oxygen species promote TNF alpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120(5):649–661. doi:10.1016/j.cell.2004.12.041
    • (2005) Cell , vol.120 , Issue.5 , pp. 649-661
    • Kamata, H.1    Honda, S.2    Maeda, S.3    Chang, L.F.4    Hirata, H.5    Karin, M.6
  • 105
    • 0036316344 scopus 로고    scopus 로고
    • Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription
    • COI: 1:CAS:528:DC%2BD38Xlslyjtbk%3D, PID: 12138205
    • Kane LP, Mollenauer MN, Xu Z, Turck CW, Weiss A (2002) Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription. Mol Cell Biol 22(16):5962–5974. doi:10.1128/Mcb.22.16.5962-5974.2002
    • (2002) Mol Cell Biol , vol.22 , Issue.16 , pp. 5962-5974
    • Kane, L.P.1    Mollenauer, M.N.2    Xu, Z.3    Turck, C.W.4    Weiss, A.5
  • 106
    • 0345447210 scopus 로고    scopus 로고
    • Velcade: U.S. FDA approval for the treatment of multiple myeloma progressing on prior therapy
    • PID: 14657528
    • Kane RC, Bross PF, Farrell AT, Pazdur R (2003) Velcade: U.S. FDA approval for the treatment of multiple myeloma progressing on prior therapy. Oncologist 8(6):508–513
    • (2003) Oncologist , vol.8 , Issue.6 , pp. 508-513
    • Kane, R.C.1    Bross, P.F.2    Farrell, A.T.3    Pazdur, R.4
  • 107
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappa B in cancer development and progression
    • COI: 1:CAS:528:DC%2BD28XkvVyrsrw%3D, PID: 16724054
    • Karin M (2006) Nuclear factor-kappa B in cancer development and progression. Nature 441(7092):431–436. doi:10.1038/Nature04870
    • (2006) Nature , vol.441 , Issue.7092 , pp. 431-436
    • Karin, M.1
  • 108
    • 0036009115 scopus 로고    scopus 로고
    • NF-kappa B at the crossroads of life and death
    • COI: 1:CAS:528:DC%2BD38XitVWlt7g%3D, PID: 11875461
    • Karin M, Lin A (2002) NF-kappa B at the crossroads of life and death. Nat Immunol 3(3):221–227. doi:10.1038/Ni0302-221
    • (2002) Nat Immunol , vol.3 , Issue.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 109
    • 0036546501 scopus 로고    scopus 로고
    • NF-kappaB in cancer: from innocent bystander to major culprit
    • COI: 1:CAS:528:DC%2BD38XivFGqt7k%3D, PID: 12001991
    • Karin M, Cao Y, Greten FR, Li ZW (2002) NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2(4):301–310. doi:10.1038/nrc780
    • (2002) Nat Rev Cancer , vol.2 , Issue.4 , pp. 301-310
    • Karin, M.1    Cao, Y.2    Greten, F.R.3    Li, Z.W.4
  • 110
    • 0346505340 scopus 로고    scopus 로고
    • The IKKNF-kappa B system: a treasure trove for drug development
    • COI: 1:CAS:528:DC%2BD2cXpvFKqug%3D%3D, PID: 14708018
    • Karin M, Yamamoto Y, Wang QM (2004) The IKKNF-kappa B system: a treasure trove for drug development. Nat Rev Drug Discov 3(1):17–26. doi:10.1038/Nrd1279
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.1 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 111
    • 20344379174 scopus 로고    scopus 로고
    • Transcriptional activation of survivin through the NF-kappa B pathway by human T-cell leukemia virus type I Tax
    • COI: 1:CAS:528:DC%2BD2MXltlWrsb8%3D, PID: 15729715
    • Kawakami H, Tomita M, Matsuda T et al (2005) Transcriptional activation of survivin through the NF-kappa B pathway by human T-cell leukemia virus type I Tax. Int J Cancer 115(6):967–974. doi:10.1002/Ijc.20954
    • (2005) Int J Cancer , vol.115 , Issue.6 , pp. 967-974
    • Kawakami, H.1    Tomita, M.2    Matsuda, T.3
  • 112
    • 0032533494 scopus 로고    scopus 로고
    • Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer
    • COI: 1:CAS:528:DyaK1cXnsFSmt78%3D, PID: 9823313
    • Kawasaki H, Altieri DC, Lu CD, Toyoda M, Tenjo T, Tanigawa N (1998) Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer. Cancer Res 58(22):5071–5074
    • (1998) Cancer Res , vol.58 , Issue.22 , pp. 5071-5074
    • Kawasaki, H.1    Altieri, D.C.2    Lu, C.D.3    Toyoda, M.4    Tenjo, T.5    Tanigawa, N.6
  • 113
    • 34547660308 scopus 로고    scopus 로고
    • Promiscuous mutations activate the noncanonical NF-kappa B pathway in multiple myeloma
    • COI: 1:CAS:528:DC%2BD2sXps1art78%3D, PID: 17692805
    • Keats JJ, Fonseca R, Chesi M et al (2007) Promiscuous mutations activate the noncanonical NF-kappa B pathway in multiple myeloma. Cancer Cell 12(2):131–144. doi:10.1016/j.ccr.2007.07.003
    • (2007) Cancer Cell , vol.12 , Issue.2 , pp. 131-144
    • Keats, J.J.1    Fonseca, R.2    Chesi, M.3
  • 114
    • 0035933772 scopus 로고    scopus 로고
    • Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity
    • COI: 1:CAS:528:DC%2BD3MXkvVamsro%3D, PID: 11297551
    • Keifer JA, Guttridge DC, Ashburner BP, Baldwin AS Jr (2001) Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity. J Biol Chem 276(25):22382–22387. doi:10.1074/jbc.M100938200
    • (2001) J Biol Chem , vol.276 , Issue.25 , pp. 22382-22387
    • Keifer, J.A.1    Guttridge, D.C.2    Ashburner, B.P.3    Baldwin, A.S.4
  • 115
    • 0035831465 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells
    • COI: 1:CAS:528:DC%2BD3MXisl2qs7k%3D, PID: 11108718
    • Kim I, Moon SO, Kim SH, Kim HJ, Koh YS, Koh GY (2001) Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells. J Biol Chem 276(10):7614–7620. doi:10.1074/jbc.M009705200
    • (2001) J Biol Chem , vol.276 , Issue.10 , pp. 7614-7620
    • Kim, I.1    Moon, S.O.2    Kim, S.H.3    Kim, H.J.4    Koh, Y.S.5    Koh, G.Y.6
  • 116
    • 0037019172 scopus 로고    scopus 로고
    • Constitutive activation of NF-kappaB in Ki-ras-transformed prostate epithelial cells
    • COI: 1:CAS:528:DC%2BD38Xksl2mt7s%3D, PID: 12085227
    • Kim BY, Gaynor RB, Song K, Dritschilo A, Jung M (2002) Constitutive activation of NF-kappaB in Ki-ras-transformed prostate epithelial cells. Oncogene 21(29):4490–4497. doi:10.1038/sj.onc.1205547
    • (2002) Oncogene , vol.21 , Issue.29 , pp. 4490-4497
    • Kim, B.Y.1    Gaynor, R.B.2    Song, K.3    Dritschilo, A.4    Jung, M.5
  • 117
    • 0037711690 scopus 로고    scopus 로고
    • Mechanisms of Bcr-Abl-mediated NF-kappaB/Rel activation
    • COI: 1:CAS:528:DC%2BD3sXkvVKnsL0%3D, PID: 12829026
    • Kirchner D, Duyster J, Ottmann O, Schmid RM, Bergmann L, Munzert G (2003) Mechanisms of Bcr-Abl-mediated NF-kappaB/Rel activation. Exp Hematol 31(6):504–511
    • (2003) Exp Hematol , vol.31 , Issue.6 , pp. 504-511
    • Kirchner, D.1    Duyster, J.2    Ottmann, O.3    Schmid, R.M.4    Bergmann, L.5    Munzert, G.6
  • 118
    • 0034162780 scopus 로고    scopus 로고
    • Preferential enhancement of tumor radioresponse by a cyclooxygenase-2 inhibitor
    • COI: 1:CAS:528:DC%2BD3cXhvFWrt70%3D, PID: 10728694
    • Kishi K, Petersen S, Petersen C et al (2000) Preferential enhancement of tumor radioresponse by a cyclooxygenase-2 inhibitor. Cancer Res 60(5):1326–1331
    • (2000) Cancer Res , vol.60 , Issue.5 , pp. 1326-1331
    • Kishi, K.1    Petersen, S.2    Petersen, C.3
  • 119
    • 33847216148 scopus 로고    scopus 로고
    • Endothelial cell adhesion molecules and cancer progression
    • COI: 1:CAS:528:DC%2BD2sXhs1yhur0%3D, PID: 17305540
    • Kobayashi H, Boelte KC, Lin PC (2007) Endothelial cell adhesion molecules and cancer progression. Curr Med Chem 14(4):377–386. doi:10.2174/092986707779941032
    • (2007) Curr Med Chem , vol.14 , Issue.4 , pp. 377-386
    • Kobayashi, H.1    Boelte, K.C.2    Lin, P.C.3
  • 120
    • 2442455744 scopus 로고    scopus 로고
    • Increased nuclear factor-kappa B activation in human colorectal carcinoma and its correlation with tumor progression
    • COI: 1:CAS:528:DC%2BD2cXkvVens74%3D, PID: 15161011
    • Kojima M, Morisaki T, Sasaki N et al (2004) Increased nuclear factor-kappa B activation in human colorectal carcinoma and its correlation with tumor progression. Anticancer Res 24(2B):675–681
    • (2004) Anticancer Res , vol.24 , Issue.2B , pp. 675-681
    • Kojima, M.1    Morisaki, T.2    Sasaki, N.3
  • 121
    • 0032518616 scopus 로고    scopus 로고
    • Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum
    • COI: 1:CAS:528:DyaK1cXmtF2isA%3D%3D, PID: 9435306
    • Kornmann M, Arber N, Korc M (1998) Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum. J Clin Invest 101(2):344–352. doi:10.1172/Jci1323
    • (1998) J Clin Invest , vol.101 , Issue.2 , pp. 344-352
    • Kornmann, M.1    Arber, N.2    Korc, M.3
  • 122
    • 0033565625 scopus 로고    scopus 로고
    • Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes
    • COI: 1:CAS:528:DyaK1MXks1Omsbs%3D, PID: 10416617
    • Kornmann M, Danenberg KD, Arber N, Beger HG, Danenberg PV, Korc M (1999) Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes. Cancer Res 59(14):3505–3511
    • (1999) Cancer Res , vol.59 , Issue.14 , pp. 3505-3511
    • Kornmann, M.1    Danenberg, K.D.2    Arber, N.3    Beger, H.G.4    Danenberg, P.V.5    Korc, M.6
  • 123
    • 3042834382 scopus 로고    scopus 로고
    • The I kappa B kinase complex and NF-kappa B act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1
    • COI: 1:CAS:528:DC%2BD2cXlslentrY%3D, PID: 15226448
    • Krappmann D, Wegener E, Sunami Y et al (2004) The I kappa B kinase complex and NF-kappa B act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1. Mol Cell Biol 24(14):6488–6500. doi:10.1128/Mcb.24.14.6488-6500.2004
    • (2004) Mol Cell Biol , vol.24 , Issue.14 , pp. 6488-6500
    • Krappmann, D.1    Wegener, E.2    Sunami, Y.3
  • 124
    • 3843052483 scopus 로고    scopus 로고
    • Nuclear factor-kappa B: its role in health and disease
    • COI: 1:CAS:528:DC%2BD2cXlsVCqsb4%3D, PID: 15175863
    • Kumar A, Takada Y, Boriek AM, Aggarwal BB (2004) Nuclear factor-kappa B: its role in health and disease. J Mol Med 82(7):434–448. doi:10.1007/s00109-004-0555-y
    • (2004) J Mol Med , vol.82 , Issue.7 , pp. 434-448
    • Kumar, A.1    Takada, Y.2    Boriek, A.M.3    Aggarwal, B.B.4
  • 125
    • 6944235003 scopus 로고    scopus 로고
    • Multiple myeloma
    • COI: 1:CAS:528:DC%2BD2cXptFChtLk%3D, PID: 15509819
    • Kyle RA, Rajkumar SV (2004) Multiple myeloma. N Engl J Med 351(18):1860–1873. doi:10.1056/NEJMra041875
    • (2004) N Engl J Med , vol.351 , Issue.18 , pp. 1860-1873
    • Kyle, R.A.1    Rajkumar, S.V.2
  • 126
    • 0032410818 scopus 로고    scopus 로고
    • The inhibitors of apoptosis (IAPs) and their emerging role in cancer
    • PID: 9916987
    • LaCasse EC, Baird S, Korneluk RG, MacKenzie AE (1998) The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene 17(25):3247–3259
    • (1998) Oncogene , vol.17 , Issue.25 , pp. 3247-3259
    • LaCasse, E.C.1    Baird, S.2    Korneluk, R.G.3    MacKenzie, A.E.4
  • 128
    • 19944428834 scopus 로고    scopus 로고
    • Small molecule inhibitors of I kappa B kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling
    • COI: 1:CAS:528:DC%2BD2MXhtVehtbo%3D, PID: 15671525
    • Lam LT, Davis RE, Pierce J et al (2005) Small molecule inhibitors of I kappa B kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling. Clin Cancer Res 11(1):28–40
    • (2005) Clin Cancer Res , vol.11 , Issue.1 , pp. 28-40
    • Lam, L.T.1    Davis, R.E.2    Pierce, J.3
  • 130
    • 25444494484 scopus 로고    scopus 로고
    • EGFR and Her-2 regulate the constitutive activation of NF-kappaB in PC-3 prostate cancer cells
    • PID: 15880609
    • Le Page C, Koumakpayi IH, Lessard L, Mes-Masson AM, Saad F (2005) EGFR and Her-2 regulate the constitutive activation of NF-kappaB in PC-3 prostate cancer cells. Prostate 65(2):130–140. doi:10.1002/pros.20234
    • (2005) Prostate , vol.65 , Issue.2 , pp. 130-140
    • Le Page, C.1    Koumakpayi, I.H.2    Lessard, L.3    Mes-Masson, A.M.4    Saad, F.5
  • 131
    • 63249092765 scopus 로고    scopus 로고
    • Persistently activated Stat3 maintains constitutive NF-kappa B activity in tumors
    • COI: 1:CAS:528:DC%2BD1MXlsFyrtL8%3D, PID: 19345327
    • Lee H, Herrmann A, Deng JH et al (2009) Persistently activated Stat3 maintains constitutive NF-kappa B activity in tumors. Cancer Cell 15(4):283–293. doi:10.1016/j.ccr.2009.02.015
    • (2009) Cancer Cell , vol.15 , Issue.4 , pp. 283-293
    • Lee, H.1    Herrmann, A.2    Deng, J.H.3
  • 132
    • 0038079838 scopus 로고    scopus 로고
    • Bombesin stimulates nuclear factor kappa B activation and expression of proangiogenic factors in prostate cancer cells
    • COI: 1:CAS:528:DC%2BD3sXltVGrtLc%3D, PID: 12839933
    • Levine L, Lucci JA, Pazdrak B et al (2003) Bombesin stimulates nuclear factor kappa B activation and expression of proangiogenic factors in prostate cancer cells. Cancer Res 63(13):3495–3502
    • (2003) Cancer Res , vol.63 , Issue.13 , pp. 3495-3502
    • Levine, L.1    Lucci, J.A.2    Pazdrak, B.3
  • 133
    • 77649341172 scopus 로고    scopus 로고
    • Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy
    • COI: 1:CAS:528:DC%2BC3cXjt1Kqsrk%3D, PID: 20079806
    • Li F, Sethi G (2010) Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy. Biochim Biophys Acta 1805(2):167–180. doi:10.1016/j.bbcan.2010.01.002
    • (2010) Biochim Biophys Acta , vol.1805 , Issue.2 , pp. 167-180
    • Li, F.1    Sethi, G.2
  • 134
    • 0036781052 scopus 로고    scopus 로고
    • NF-kappaB regulation in the immune system
    • COI: 1:CAS:528:DC%2BD38XnsVGqsbg%3D, PID: 12360211
    • Li Q, Verma IM (2002) NF-kappaB regulation in the immune system. Nat Rev Immunol 2(10):725–734. doi:10.1038/nri910
    • (2002) Nat Rev Immunol , vol.2 , Issue.10 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 135
    • 0034896686 scopus 로고    scopus 로고
    • Nuclear factor-kappa B is upregulated in colorectal cancer
    • COI: 1:STN:280:DC%2BD3MvksVegtg%3D%3D, PID: 11490372
    • Lind DS, Hochwald SN, Malaty J et al (2001) Nuclear factor-kappa B is upregulated in colorectal cancer. Surgery 130(2):363–369. doi:10.1067/msy.2001.116672
    • (2001) Surgery , vol.130 , Issue.2 , pp. 363-369
    • Lind, D.S.1    Hochwald, S.N.2    Malaty, J.3
  • 136
    • 0036009411 scopus 로고    scopus 로고
    • NF-kappa B inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun
    • COI: 1:CAS:528:DC%2BD38XjtFSlu7Y%3D, PID: 11915022
    • Liu HL, Lo CR, Czaja MJ (2002) NF-kappa B inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun. Hepatology 35(4):772–778. doi:10.1053/jhep.2002.32534
    • (2002) Hepatology , vol.35 , Issue.4 , pp. 772-778
    • Liu, H.L.1    Lo, C.R.2    Czaja, M.J.3
  • 137
    • 4644313276 scopus 로고    scopus 로고
    • Nuclear factor-kappa B is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BD2cXnsFOltbk%3D, PID: 15374962
    • Loercher A, Lee TL, Ricker JL et al (2004) Nuclear factor-kappa B is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma. Cancer Res 64(18):6511–6523. doi:10.1158/0008-5472.Can-04-0852
    • (2004) Cancer Res , vol.64 , Issue.18 , pp. 6511-6523
    • Loercher, A.1    Lee, T.L.2    Ricker, J.L.3
  • 138
    • 70450142560 scopus 로고    scopus 로고
    • Inflammation and EMT: an alliance towards organ fibrosis and cancer progression
    • COI: 1:CAS:528:DC%2BD1MXhsVSltL%2FJ, PID: 20049734
    • Lopez-Novoa JM, Nieto MA (2009) Inflammation and EMT: an alliance towards organ fibrosis and cancer progression. EMBO Mol Med 1(6–7):303–314. doi:10.1002/emmm.200900043
    • (2009) EMBO Mol Med , vol.1 , Issue.6-7 , pp. 303-314
    • Lopez-Novoa, J.M.1    Nieto, M.A.2
  • 139
    • 0032080378 scopus 로고    scopus 로고
    • Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas
    • COI: 1:CAS:528:DyaK1cXislensbs%3D, PID: 9581817
    • Lu CD, Altieri DC, Tanigawa N (1998) Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas. Cancer Res 58(9):1808–1812
    • (1998) Cancer Res , vol.58 , Issue.9 , pp. 1808-1812
    • Lu, C.D.1    Altieri, D.C.2    Tanigawa, N.3
  • 140
    • 4544224979 scopus 로고    scopus 로고
    • Inhibition of NF-kappa B in cancer cells converts inflammation-induced tumor growth mediated by TNF alpha to TRAIL-mediated tumor regression
    • COI: 1:CAS:528:DC%2BD2cXot1KisL8%3D, PID: 15380520
    • Luo JL, Maeda S, Hsu LC, Yagita H, Karin M (2004) Inhibition of NF-kappa B in cancer cells converts inflammation-induced tumor growth mediated by TNF alpha to TRAIL-mediated tumor regression. Cancer Cell 6(3):297–305. doi:10.1016/j.ccr.2004.08.012
    • (2004) Cancer Cell , vol.6 , Issue.3 , pp. 297-305
    • Luo, J.L.1    Maeda, S.2    Hsu, L.C.3    Yagita, H.4    Karin, M.5
  • 141
    • 34247274248 scopus 로고    scopus 로고
    • Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin
    • COI: 1:CAS:528:DC%2BD2sXjslOlsLk%3D, PID: 17377533
    • Luo JL, Tan W, Ricono JM et al (2007) Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature 446(7136):690–694. doi:10.1038/nature05656
    • (2007) Nature , vol.446 , Issue.7136 , pp. 690-694
    • Luo, J.L.1    Tan, W.2    Ricono, J.M.3
  • 142
    • 0001112989 scopus 로고    scopus 로고
    • The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65
    • COI: 1:CAS:528:DyaK1MXms1I%3D, PID: 9837931
    • Lyss G, Knorre A, Schmidt TJ, Pahl HL, Merfort I (1998) The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65. J Biol Chem 273(50):33508–33516
    • (1998) J Biol Chem , vol.273 , Issue.50 , pp. 33508-33516
    • Lyss, G.1    Knorre, A.2    Schmidt, T.J.3    Pahl, H.L.4    Merfort, I.5
  • 143
    • 0033961280 scopus 로고    scopus 로고
    • Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappa B
    • COI: 1:CAS:528:DC%2BD3cXhtF2nt74%3D, PID: 10669740
    • Madrid LV, Wang CY, Guttridge DC, Schottelius AJG, Baldwin AS, Mayo MW (2000) Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappa B. Mol Cell Biol 20(5):1626–1638. doi:10.1128/Mcb.20.5.1626-1638.2000
    • (2000) Mol Cell Biol , vol.20 , Issue.5 , pp. 1626-1638
    • Madrid, L.V.1    Wang, C.Y.2    Guttridge, D.C.3    Schottelius, A.J.G.4    Baldwin, A.S.5    Mayo, M.W.6
  • 144
    • 0035379555 scopus 로고    scopus 로고
    • Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-kappa B through utilization of the I kappa B kinase and activation of the mitogen-activated protein kinase p38
    • COI: 1:CAS:528:DC%2BD3MXkt12kur8%3D, PID: 11259436
    • Madrid LV, Mayo MW, Reuther JY, Baldwin AS (2001) Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-kappa B through utilization of the I kappa B kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem 276(22):18934–18940. doi:10.1074/jbc.M101103200
    • (2001) J Biol Chem , vol.276 , Issue.22 , pp. 18934-18940
    • Madrid, L.V.1    Mayo, M.W.2    Reuther, J.Y.3    Baldwin, A.S.4
  • 145
    • 21244472975 scopus 로고    scopus 로고
    • IKK beta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • COI: 1:CAS:528:DC%2BD2MXmtF2nsbo%3D, PID: 15989949
    • Maeda S, Kamata H, Luo JL, Leffert H, Karin M (2005) IKK beta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121(7):977–990. doi:10.1016/j.cell.2005.04.014
    • (2005) Cell , vol.121 , Issue.7 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 146
    • 0037087402 scopus 로고    scopus 로고
    • 2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester
    • COI: 1:CAS:528:DC%2BD38XitFSksbY%3D, PID: 11884428
    • 2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester. J Immunol 168(6):2644–2651
    • (2002) J Immunol , vol.168 , Issue.6 , pp. 2644-2651
    • Majumdar, S.1    Lamothe, B.2    Aggarwal, B.B.3
  • 147
    • 33947578030 scopus 로고    scopus 로고
    • Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation
    • COI: 1:CAS:528:DC%2BD2sXjtlyhtLk%3D, PID: 17384582
    • Matsuoka M, Jeang KT (2007) Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer 7(4):270–280. doi:10.1038/Nrc2111
    • (2007) Nat Rev Cancer , vol.7 , Issue.4 , pp. 270-280
    • Matsuoka, M.1    Jeang, K.T.2
  • 148
    • 0030612937 scopus 로고    scopus 로고
    • Requirement of NF-kappa B activation to suppress p53-independent apoptosis induced by oncogenic Ras
    • COI: 1:CAS:528:DyaK2sXnvFCksLo%3D, PID: 9388187
    • Mayo MW, Wang CY, Cogswell PC et al (1997) Requirement of NF-kappa B activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science 278(5344):1812–1815. doi:10.1126/science.278.5344.1812
    • (1997) Science , vol.278 , Issue.5344 , pp. 1812-1815
    • Mayo, M.W.1    Wang, C.Y.2    Cogswell, P.C.3
  • 149
    • 79955485187 scopus 로고    scopus 로고
    • Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer
    • COI: 1:CAS:528:DC%2BC3MXps1aitg%3D%3D, PID: 21258404
    • McGivern DR, Lemon SM (2011) Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer. Oncogene 30(17):1969–1983. doi:10.1038/Onc.2010.594
    • (2011) Oncogene , vol.30 , Issue.17 , pp. 1969-1983
    • McGivern, D.R.1    Lemon, S.M.2
  • 150
    • 33751585152 scopus 로고    scopus 로고
    • Differential expression and activation of NF-kappaB family proteins during oral carcinogenesis: role of high risk human papillomavirus infection
    • COI: 1:CAS:528:DC%2BD28Xht1yqt7jP, PID: 16998793
    • Mishra A, Bharti AC, Varghese P, Saluja D, Das BC (2006) Differential expression and activation of NF-kappaB family proteins during oral carcinogenesis: role of high risk human papillomavirus infection. Int J Cancer 119(12):2840–2850. doi:10.1002/ijc.22262
    • (2006) Int J Cancer , vol.119 , Issue.12 , pp. 2840-2850
    • Mishra, A.1    Bharti, A.C.2    Varghese, P.3    Saluja, D.4    Das, B.C.5
  • 151
    • 52649172153 scopus 로고    scopus 로고
    • Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics
    • COI: 1:CAS:528:DC%2BD1cXpslKgsbs%3D, PID: 18698017
    • Mita AC, Mita MM, Nawrocki ST, Giles FJ (2008) Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics. Clin Cancer Res 14(16):5000–5005. doi:10.1158/1078-0432.Ccr-08-0746
    • (2008) Clin Cancer Res , vol.14 , Issue.16 , pp. 5000-5005
    • Mita, A.C.1    Mita, M.M.2    Nawrocki, S.T.3    Giles, F.J.4
  • 152
    • 0242496212 scopus 로고    scopus 로고
    • Molecular sequelae of proteasome inhibition in human multiple myeloma cells
    • COI: 1:CAS:528:DC%2BD38XosF2iu7Y%3D, PID: 12391322
    • Mitsiades N, Mitsiades CS, Poulaki V et al (2002a) Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc Natl Acad Sci USA 99(22):14374–14379. doi:10.1073/pnas.202445099
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.22 , pp. 14374-14379
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3
  • 153
    • 0037097595 scopus 로고    scopus 로고
    • Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications
    • COI: 1:CAS:528:DC%2BD38XksFGksL4%3D, PID: 12036884
    • Mitsiades N, Mitsiades CS, Poulaki V et al (2002b) Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood 99(12):4525–4530
    • (2002) Blood , vol.99 , Issue.12 , pp. 4525-4530
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3
  • 154
    • 67349108318 scopus 로고    scopus 로고
    • Dysregulated molecular networks in head and neck carcinogenesis
    • COI: 1:CAS:528:DC%2BD1MXlsVaitbo%3D, PID: 18805044
    • Molinolo AA, Amornphimoltham P, Squarize CH, Castilho RM, Patel V, Gutkind JS (2009) Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol 45(4–5):324–334. doi:10.1016/j.oraloncology.2008.07.011
    • (2009) Oral Oncol , vol.45 , Issue.4-5 , pp. 324-334
    • Molinolo, A.A.1    Amornphimoltham, P.2    Squarize, C.H.3    Castilho, R.M.4    Patel, V.5    Gutkind, J.S.6
  • 155
    • 0036007194 scopus 로고    scopus 로고
    • Activation of NF-kappa B is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis
    • COI: 1:CAS:528:DC%2BD38XovVWrtg%3D%3D, PID: 11809798
    • Muller M, Morotti A, Ponzetto C (2002) Activation of NF-kappa B is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis. Mol Cell Biol 22(4):1060–1072. doi:10.1128/Mcb.22.4.1060-1072.2002
    • (2002) Mol Cell Biol , vol.22 , Issue.4 , pp. 1060-1072
    • Muller, M.1    Morotti, A.2    Ponzetto, C.3
  • 156
    • 16844366650 scopus 로고    scopus 로고
    • Nuclear factor-kappa B inhibitors as sensitizers to anticancer drugs
    • COI: 1:CAS:528:DC%2BD2MXivVars7Y%3D, PID: 15803156
    • Nakanishi C, Toi M (2005) Nuclear factor-kappa B inhibitors as sensitizers to anticancer drugs. Nat Rev Cancer 5(4):297–309. doi:10.1038/Nrc1588
    • (2005) Nat Rev Cancer , vol.5 , Issue.4 , pp. 297-309
    • Nakanishi, C.1    Toi, M.2
  • 157
    • 33645965616 scopus 로고    scopus 로고
    • Reactive oxygen species mediate crosstalk between NF-kappa B and JNK
    • COI: 1:CAS:528:DC%2BD28XjsFWisLY%3D, PID: 16341124
    • Nakano H, Nakajima A, Sakon-Komazawa S, Piao JH, Xue X, Okumura K (2006) Reactive oxygen species mediate crosstalk between NF-kappa B and JNK. Cell Death Differ 13(5):730–737. doi:10.1038/sj.cdd.4401830
    • (2006) Cell Death Differ , vol.13 , Issue.5 , pp. 730-737
    • Nakano, H.1    Nakajima, A.2    Sakon-Komazawa, S.3    Piao, J.H.4    Xue, X.5    Okumura, K.6
  • 158
    • 0033840219 scopus 로고    scopus 로고
    • Antisense inhibition of cyclin D1 in human head and neck squamous cell carcinoma
    • COI: 1:STN:280:DC%2BD3cvhslaqtA%3D%3D
    • Nakashima T, Clayman GL (2000) Antisense inhibition of cyclin D1 in human head and neck squamous cell carcinoma. Arch Otolaryngol 126(8):957–961
    • (2000) Arch Otolaryngol , vol.126 , Issue.8 , pp. 957-961
    • Nakashima, T.1    Clayman, G.L.2
  • 159
    • 0942278941 scopus 로고    scopus 로고
    • Potentiation of tumor response to radiation or chemoradiation by selective cyclooxygenase-2 enzyme inhibitors
    • COI: 1:CAS:528:DC%2BD2cXnvVKmsQ%3D%3D
    • Nakata E, Mason KA, Hunter N et al (2004) Potentiation of tumor response to radiation or chemoradiation by selective cyclooxygenase-2 enzyme inhibitors. Int J Radiat Oncol 58(2):369–375. doi:10.1016/j.ijrobp.2003.09.061
    • (2004) Int J Radiat Oncol , vol.58 , Issue.2 , pp. 369-375
    • Nakata, E.1    Mason, K.A.2    Hunter, N.3
  • 160
    • 0035892777 scopus 로고    scopus 로고
    • High expression levels of nuclear factor kappaB, IkappaB kinase alpha and Akt kinase in squamous cell carcinoma of the oral cavity
    • COI: 1:CAS:528:DC%2BD38XjvVejsQ%3D%3D, PID: 11753981
    • Nakayama H, Ikebe T, Beppu M, Shirasuna K (2001) High expression levels of nuclear factor kappaB, IkappaB kinase alpha and Akt kinase in squamous cell carcinoma of the oral cavity. Cancer 92(12):3037–3044
    • (2001) Cancer , vol.92 , Issue.12 , pp. 3037-3044
    • Nakayama, H.1    Ikebe, T.2    Beppu, M.3    Shirasuna, K.4
  • 161
    • 0030927167 scopus 로고    scopus 로고
    • Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth
    • COI: 1:CAS:528:DyaK2sXktFOhtLY%3D, PID: 9199297
    • Nakshatri H, Bhat-Nakshatri P, Martin DA, Goulet RJ Jr, Sledge GW Jr (1997) Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth. Mol Cell Biol 17(7):3629–3639
    • (1997) Mol Cell Biol , vol.17 , Issue.7 , pp. 3629-3639
    • Nakshatri, H.1    Bhat-Nakshatri, P.2    Martin, D.A.3    Goulet, R.J.4    Sledge, G.W.5
  • 162
    • 6044240634 scopus 로고    scopus 로고
    • Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase
    • COI: 1:CAS:528:DC%2BD2cXnsleltLY%3D, PID: 15286701
    • Nakshatri H, Rice SE, Bhat-Nakshatri P (2004) Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase. Oncogene 23(44):7330–7344. doi:10.1038/sj.onc.1207995
    • (2004) Oncogene , vol.23 , Issue.44 , pp. 7330-7344
    • Nakshatri, H.1    Rice, S.E.2    Bhat-Nakshatri, P.3
  • 163
    • 0035918278 scopus 로고    scopus 로고
    • Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo
    • COI: 1:CAS:528:DC%2BD3MXjtFymtrY%3D, PID: 11278274
    • Nam S, Smith DM, Dou QP (2001) Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo. J Biol Chem 276(16):13322–13330. doi:10.1074/jbc.M004209200
    • (2001) J Biol Chem , vol.276 , Issue.16 , pp. 13322-13330
    • Nam, S.1    Smith, D.M.2    Dou, Q.P.3
  • 164
    • 32044464123 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) signaling in cancer
    • COI: 1:CAS:528:DC%2BD28Xht1Crs7k%3D, PID: 16377102
    • Normanno N, De Luca A, Bianco C et al (2006) Epidermal growth factor receptor (EGFR) signaling in cancer. Gene 366(1):2–16. doi:10.1016/j.gene.2005.10.018
    • (2006) Gene , vol.366 , Issue.1 , pp. 2-16
    • Normanno, N.1    De Luca, A.2    Bianco, C.3
  • 165
    • 3142767508 scopus 로고    scopus 로고
    • Anticancer agent CHS 828 suppresses nuclear factor-kappa B activity in cancer cells through downregulation of ikk activity
    • COI: 1:CAS:528:DC%2BD2cXlvFWnsLo%3D, PID: 15197771
    • Olsen LS, Hjarnaa PJV, Latini S et al (2004) Anticancer agent CHS 828 suppresses nuclear factor-kappa B activity in cancer cells through downregulation of ikk activity. Int J Cancer 111(2):198–205. doi:10.1002/Ijc.20255
    • (2004) Int J Cancer , vol.111 , Issue.2 , pp. 198-205
    • Olsen, L.S.1    Hjarnaa, P.J.V.2    Latini, S.3
  • 166
    • 0032885434 scopus 로고    scopus 로고
    • Constitutive activation of transcription factors NF-kappa B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines
    • COI: 1:CAS:528:DyaK1MXms1ahsb8%3D
    • Ondrey FG, Dong G, Sunwoo J et al (1999) Constitutive activation of transcription factors NF-kappa B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines. Mol Carcinogen 26(2):119–129. doi:10.1002/(Sici)1098-2744(199910)26:2<119:Aid-Mc6>3.0.Co;2-N
    • (1999) Mol Carcinogen , vol.26 , Issue.2 , pp. 119-129
    • Ondrey, F.G.1    Dong, G.2    Sunwoo, J.3
  • 167
    • 0033517189 scopus 로고    scopus 로고
    • NF-kappa B activation by tumour necrosis factor requires the Akt serine-threonine kinase
    • COI: 1:CAS:528:DyaK1MXlvVGmsbY%3D, PID: 10485710
    • Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB (1999) NF-kappa B activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401(6748):82–85
    • (1999) Nature , vol.401 , Issue.6748 , pp. 82-85
    • Ozes, O.N.1    Mayo, L.D.2    Gustin, J.A.3    Pfeffer, S.R.4    Pfeffer, L.M.5    Donner, D.B.6
  • 168
    • 0033517999 scopus 로고    scopus 로고
    • Constitutive activation of I kappa B kinase alpha and NF-kappa B in prostate cancer cells is inhibited by ibuprofen
    • COI: 1:CAS:528:DC%2BD3cXpvVyn, PID: 10602496
    • Palayoor ST, Youmell MY, Calderwood SK, Coleman CN, Price BD (1999) Constitutive activation of I kappa B kinase alpha and NF-kappa B in prostate cancer cells is inhibited by ibuprofen. Oncogene 18(51):7389–7394. doi:10.1038/sj.onc.1203160
    • (1999) Oncogene , vol.18 , Issue.51 , pp. 7389-7394
    • Palayoor, S.T.1    Youmell, M.Y.2    Calderwood, S.K.3    Coleman, C.N.4    Price, B.D.5
  • 169
    • 9444245015 scopus 로고    scopus 로고
    • Linking JNK signaling to NF-kappa B: a key to survival
    • COI: 1:CAS:528:DC%2BD2cXhtVCjsrzL, PID: 15483317
    • Papa S, Zazzeroni F, Pham CG, Bubici C, Franzoso G (2004) Linking JNK signaling to NF-kappa B: a key to survival. J Cell Sci 117(22):5197–5208. doi:10.1242/Jcs.01483
    • (2004) J Cell Sci , vol.117 , Issue.22 , pp. 5197-5208
    • Papa, S.1    Zazzeroni, F.2    Pham, C.G.3    Bubici, C.4    Franzoso, G.5
  • 170
    • 33645983982 scopus 로고    scopus 로고
    • The NF-kappa B-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease
    • COI: 1:CAS:528:DC%2BD28XjsFWisbg%3D, PID: 16456579
    • Papa S, Bubici C, Zazzeroni F et al (2006) The NF-kappa B-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease. Cell Death Differ 13(5):712–729. doi:10.1038/sj.cdd.4401865
    • (2006) Cell Death Differ , vol.13 , Issue.5 , pp. 712-729
    • Papa, S.1    Bubici, C.2    Zazzeroni, F.3
  • 171
    • 15944379896 scopus 로고    scopus 로고
    • Formation of an IKK alpha-dependent transcription complex is required for estrogen receptor-mediated gene activation
    • COI: 1:CAS:528:DC%2BD2MXjt1Oit7k%3D, PID: 15808510
    • Park KJ, Krishnan V, O’Malley BW, Yamamoto Y, Gaynor RB (2005) Formation of an IKK alpha-dependent transcription complex is required for estrogen receptor-mediated gene activation. Mol Cell 18(1):71–82. doi:10.1016/j.molcel.2005.03.006
    • (2005) Mol Cell , vol.18 , Issue.1 , pp. 71-82
    • Park, K.J.1    Krishnan, V.2    O’Malley, B.W.3    Yamamoto, Y.4    Gaynor, R.B.5
  • 172
    • 0031461976 scopus 로고    scopus 로고
    • Achieving transcriptional specificity with NF-kappa B
    • COI: 1:CAS:528:DyaK1cXitlOgsrs%3D
    • Perkins ND (1997) Achieving transcriptional specificity with NF-kappa B. Int J Biochem Cell B 29(12):1433–1448. doi:10.1016/S1357-2725(97)00088-5
    • (1997) Int J Biochem Cell B , vol.29 , Issue.12 , pp. 1433-1448
    • Perkins, N.D.1
  • 173
    • 0442323562 scopus 로고    scopus 로고
    • NF-kappa B: tumor promoter or suppressor?
    • COI: 1:CAS:528:DC%2BD2cXhtVOrt7c%3D, PID: 15102437
    • Perkins ND (2004) NF-kappa B: tumor promoter or suppressor? Trends Cell Biol 14(2):64–69. doi:10.1016/j.tcb.2003.12.004
    • (2004) Trends Cell Biol , vol.14 , Issue.2 , pp. 64-69
    • Perkins, N.D.1
  • 174
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-kappa B and IKK function
    • COI: 1:CAS:528:DC%2BD28XhtlCjt7bK
    • Perkins ND (2007) Integrating cell-signalling pathways with NF-kappa B and IKK function. Nat Rev Mol Cell Bio 8(1):49–62. doi:10.1038/Nrm2083
    • (2007) Nat Rev Mol Cell Bio , vol.8 , Issue.1 , pp. 49-62
    • Perkins, N.D.1
  • 175
    • 0034124894 scopus 로고    scopus 로고
    • Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor
    • COI: 1:CAS:528:DC%2BD3cXksVGhtr8%3D, PID: 10873107
    • Petersen C, Petersen S, Milas L, Lang FF, Tofilon PJ (2000) Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor. Clin Cancer Res 6(6):2513–2520
    • (2000) Clin Cancer Res , vol.6 , Issue.6 , pp. 2513-2520
    • Petersen, C.1    Petersen, S.2    Milas, L.3    Lang, F.F.4    Tofilon, P.J.5
  • 176
    • 8344260568 scopus 로고    scopus 로고
    • Ferritin heavy chain upregulation by NF-kappa B inhibits TNF alpha-induced apoptosis by suppressing reactive oxygen species
    • COI: 1:CAS:528:DC%2BD2cXhtVCjt7fL, PID: 15537542
    • Pham CG, Bubici C, Zazzeroni F et al (2004) Ferritin heavy chain upregulation by NF-kappa B inhibits TNF alpha-induced apoptosis by suppressing reactive oxygen species. Cell 119(4):529–542. doi:10.1016/j.cell.2004.10.017
    • (2004) Cell , vol.119 , Issue.4 , pp. 529-542
    • Pham, C.G.1    Bubici, C.2    Zazzeroni, F.3
  • 177
    • 0035868342 scopus 로고    scopus 로고
    • Her-2/neu overexpression induces NF-kappa B via a PI3-kinase/Akt pathway involving calpain-mediated degradation of I kappa-B-alpha that can be inhibited by the tumor suppressor PTEN
    • COI: 1:CAS:528:DC%2BD3MXisFWhu7k%3D, PID: 11313873
    • Pianetti S, Arsura M, Romieu-Mourez R, Coffey RJ, Sonenshein GE (2001) Her-2/neu overexpression induces NF-kappa B via a PI3-kinase/Akt pathway involving calpain-mediated degradation of I kappa-B-alpha that can be inhibited by the tumor suppressor PTEN. Oncogene 20(11):1287–1299. doi:10.1038/sj.onc.1204257
    • (2001) Oncogene , vol.20 , Issue.11 , pp. 1287-1299
    • Pianetti, S.1    Arsura, M.2    Romieu-Mourez, R.3    Coffey, R.J.4    Sonenshein, G.E.5
  • 178
    • 4644324186 scopus 로고    scopus 로고
    • NF-kappa B functions as a tumour promoter in inflammation-associated cancer
    • COI: 1:CAS:528:DC%2BD2cXnslelsrc%3D, PID: 15329734
    • Pikarsky E, Porat RM, Stein I et al (2004) NF-kappa B functions as a tumour promoter in inflammation-associated cancer. Nature 431(7007):461–466. doi:10.1038/Nature02924
    • (2004) Nature , vol.431 , Issue.7007 , pp. 461-466
    • Pikarsky, E.1    Porat, R.M.2    Stein, I.3
  • 179
    • 0033613436 scopus 로고    scopus 로고
    • Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex
    • COI: 1:CAS:528:DyaK1MXntlGitb8%3D, PID: 10557090
    • Plummer SM, Holloway KA, Manson MM et al (1999) Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex. Oncogene 18(44):6013–6020. doi:10.1038/sj.onc.1202980
    • (1999) Oncogene , vol.18 , Issue.44 , pp. 6013-6020
    • Plummer, S.M.1    Holloway, K.A.2    Manson, M.M.3
  • 180
    • 0035914407 scopus 로고    scopus 로고
    • Positive and negative regulation of NF-kappa B by COX-2-Roles of different prostaglandins
    • COI: 1:CAS:528:DC%2BD3MXnvVent70%3D, PID: 11509575
    • Poligone B, Baldwin AS (2001) Positive and negative regulation of NF-kappa B by COX-2-Roles of different prostaglandins. J Biol Chem 276(42):38658–38664. doi:10.1074/jbc.M106599200
    • (2001) J Biol Chem , vol.276 , Issue.42 , pp. 38658-38664
    • Poligone, B.1    Baldwin, A.S.2
  • 181
    • 33645457576 scopus 로고    scopus 로고
    • Constitutive activation of NF-kappaB in human hepatocellular carcinoma: evidence of a cytoprotective role
    • COI: 1:CAS:528:DC%2BD28XisFWgu7s%3D, PID: 16544977
    • Qiao L, Zhang H, Yu J et al (2006) Constitutive activation of NF-kappaB in human hepatocellular carcinoma: evidence of a cytoprotective role. Hum Gene Ther 17(3):280–290. doi:10.1089/hum.2006.17.280
    • (2006) Hum Gene Ther , vol.17 , Issue.3 , pp. 280-290
    • Qiao, L.1    Zhang, H.2    Yu, J.3
  • 182
    • 14844291424 scopus 로고    scopus 로고
    • Phase I study and pharmacokinetic of CHS-828, a guanidino-containing compound, administered orally as a single dose every 3 weeks in solid tumours: an ECSG/EORTC study
    • COI: 1:CAS:528:DC%2BD2MXitF2isLc%3D, PID: 15763645
    • Ravaud A, Cerny T, Terret C et al (2005) Phase I study and pharmacokinetic of CHS-828, a guanidino-containing compound, administered orally as a single dose every 3 weeks in solid tumours: an ECSG/EORTC study. Eur J Cancer 41(5):702–707. doi:10.1016/j.ejca.2004.12.023
    • (2005) Eur J Cancer , vol.41 , Issue.5 , pp. 702-707
    • Ravaud, A.1    Cerny, T.2    Terret, C.3
  • 183
    • 0028107237 scopus 로고
    • Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor
    • COI: 1:CAS:528:DyaK2cXht1GgsLk%3D, PID: 8290595
    • Ray A, Prefontaine KE (1994) Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc Natl Acad Sci USA 91(2):752–756
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.2 , pp. 752-756
    • Ray, A.1    Prefontaine, K.E.2
  • 184
    • 0033596124 scopus 로고    scopus 로고
    • Aberrant rel/nfkb genes and activity in human cancer
    • COI: 1:CAS:528:DyaK1MXotVyhtb4%3D, PID: 10602468
    • Rayet B, Gelinas C (1999) Aberrant rel/nfkb genes and activity in human cancer. Oncogene 18(49):6938–6947. doi:10.1038/sj.onc.1203221
    • (1999) Oncogene , vol.18 , Issue.49 , pp. 6938-6947
    • Rayet, B.1    Gelinas, C.2
  • 185
    • 0032034216 scopus 로고    scopus 로고
    • A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation
    • COI: 1:CAS:528:DyaK1cXisl2hurg%3D, PID: 9531535
    • Reuther JY, Reuther GW, Cortez D, Pendergast AM, Baldwin AS Jr (1998) A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation. Genes Dev 12(7):968–981
    • (1998) Genes Dev , vol.12 , Issue.7 , pp. 968-981
    • Reuther, J.Y.1    Reuther, G.W.2    Cortez, D.3    Pendergast, A.M.4    Baldwin, A.S.5
  • 186
    • 0037973279 scopus 로고    scopus 로고
    • A phase 2 study of bortezomib in relapsed, refractory myeloma
    • COI: 1:CAS:528:DC%2BD3sXkvVSksLs%3D, PID: 12826635
    • Richardson PG, Barlogie B, Berenson J et al (2003) A phase 2 study of bortezomib in relapsed, refractory myeloma. New Engl J Med 348(26):2609–2617. doi:10.1056/Nejmoa030288
    • (2003) New Engl J Med , vol.348 , Issue.26 , pp. 2609-2617
    • Richardson, P.G.1    Barlogie, B.2    Berenson, J.3
  • 187
    • 0033591849 scopus 로고    scopus 로고
    • Effect of antioxidants on androgen-induced AP-1 and NF-kappa B DNA-binding activity in prostate carcinoma cells
    • COI: 1:CAS:528:DyaK1MXltVOhu7s%3D
    • Ripple MO, Henry WF, Schwarze SR, Wilding G, Weindruch R (1999) Effect of antioxidants on androgen-induced AP-1 and NF-kappa B DNA-binding activity in prostate carcinoma cells. J Natl Cancer I 91(14):1227–1232. doi:10.1093/jnci/91.14.1227
    • (1999) J Natl Cancer I , vol.91 , Issue.14 , pp. 1227-1232
    • Ripple, M.O.1    Henry, W.F.2    Schwarze, S.R.3    Wilding, G.4    Weindruch, R.5
  • 188
    • 44849100198 scopus 로고    scopus 로고
    • NF-kappa B links innate immunity to the hypoxic response through transcriptional regulation of HIF-1 alpha
    • Rius J, Guma M, Schachtrup C et al (2008) NF-kappa B links innate immunity to the hypoxic response through transcriptional regulation of HIF-1 alpha. Nature 453(7196):807-U9. doi:10.1038/Nature06905
    • (2008) Nature , vol.453 , Issue.7196
    • Rius, J.1    Guma, M.2    Schachtrup, C.3
  • 189
    • 0033517190 scopus 로고    scopus 로고
    • NF-kappa B is a target of AKT in anti-apoptotic PDGF signalling
    • COI: 1:CAS:528:DyaK1MXlvVGmtr8%3D, PID: 10485711
    • Romashkova JA, Makarov SS (1999) NF-kappa B is a target of AKT in anti-apoptotic PDGF signalling. Nature 401(6748):86–90
    • (1999) Nature , vol.401 , Issue.6748 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 190
    • 0035328531 scopus 로고    scopus 로고
    • Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-kappa B in breast cancer
    • COI: 1:CAS:528:DC%2BD3MXjsFCgu7Y%3D, PID: 11325857
    • Romieu-Mourez R, Landesman-Bollag E, Seldin DC, Traish AM, Mercurio F, Sonenshein GE (2001) Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-kappa B in breast cancer. Cancer Res 61(9):3810–3818
    • (2001) Cancer Res , vol.61 , Issue.9 , pp. 3810-3818
    • Romieu-Mourez, R.1    Landesman-Bollag, E.2    Seldin, D.C.3    Traish, A.M.4    Mercurio, F.5    Sonenshein, G.E.6
  • 191
    • 0041631005 scopus 로고    scopus 로고
    • Mouse mammary tumor virus c-rel transgenic mice develop mammary tumors
    • COI: 1:CAS:528:DC%2BD3sXmt1SrtL8%3D, PID: 12897145
    • Romieu-Mourez R, Kim DW, Shin SM et al (2003) Mouse mammary tumor virus c-rel transgenic mice develop mammary tumors. Mol Cell Biol 23(16):5738–5754
    • (2003) Mol Cell Biol , vol.23 , Issue.16 , pp. 5738-5754
    • Romieu-Mourez, R.1    Kim, D.W.2    Shin, S.M.3
  • 192
    • 1842479017 scopus 로고    scopus 로고
    • Expression of nuclear factor-kappa B and I kappa B alpha proteins in prostatic adenocarcinomas: correlation of nuclear factor-kappa B immunoreactivity with disease recurrence
    • COI: 1:CAS:528:DC%2BD2cXivFSqsLY%3D, PID: 15073126
    • Ross JS, Kallakury BVS, Sheehan CE et al (2004) Expression of nuclear factor-kappa B and I kappa B alpha proteins in prostatic adenocarcinomas: correlation of nuclear factor-kappa B immunoreactivity with disease recurrence. Clin Cancer Res 10(7):2466–2472. doi:10.1158/1078-0432.Ccr-0543-3
    • (2004) Clin Cancer Res , vol.10 , Issue.7 , pp. 2466-2472
    • Ross, J.S.1    Kallakury, B.V.S.2    Sheehan, C.E.3
  • 193
    • 0035341494 scopus 로고    scopus 로고
    • Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappa B
    • COI: 1:CAS:528:DC%2BD3MXislGqtbw%3D
    • Russo SM, Tepper JE, Baldwin AS et al (2001) Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappa B. Int J Radiat Oncol 50(1):183–193. doi:10.1016/S0360-3016(01)01446-8
    • (2001) Int J Radiat Oncol , vol.50 , Issue.1 , pp. 183-193
    • Russo, S.M.1    Tepper, J.E.2    Baldwin, A.S.3
  • 194
    • 0034021068 scopus 로고    scopus 로고
    • Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma
    • COI: 1:CAS:528:DC%2BD3cXjsVShu7Y%3D, PID: 10764707
    • Sarela AI, Macadam RCA, Farmery SM, Markham AF, Guillou PJ (2000) Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma. Gut 46(5):645–650. doi:10.1136/Gut.46.5.645
    • (2000) Gut , vol.46 , Issue.5 , pp. 645-650
    • Sarela, A.I.1    Macadam, R.C.A.2    Farmery, S.M.3    Markham, A.F.4    Guillou, P.J.5
  • 195
    • 53949090765 scopus 로고    scopus 로고
    • NF-kappa B signaling pathway and its therapeutic implications in human diseases
    • COI: 1:CAS:528:DC%2BD1cXht1eksbfF, PID: 18853341
    • Sarkar FH, Li YW, Wang ZW, Kong DJ (2008) NF-kappa B signaling pathway and its therapeutic implications in human diseases. Int Rev Immunol 27(5):293–319. doi:10.1080/08830180802276179
    • (2008) Int Rev Immunol , vol.27 , Issue.5 , pp. 293-319
    • Sarkar, F.H.1    Li, Y.W.2    Wang, Z.W.3    Kong, D.J.4
  • 196
    • 33845436329 scopus 로고    scopus 로고
    • Hepatitis C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming growth factor alpha expression via activation of nuclear factor-kappa B
    • COI: 1:CAS:528:DC%2BD2sXkvFOjug%3D%3D, PID: 16581947
    • Sato Y, Kato J, Takimoto R et al (2006) Hepatitis C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming growth factor alpha expression via activation of nuclear factor-kappa B. Gut 55(12):1801–1808. doi:10.1136/gut.2005.070417
    • (2006) Gut , vol.55 , Issue.12 , pp. 1801-1808
    • Sato, Y.1    Kato, J.2    Takimoto, R.3
  • 197
    • 0028879819 scopus 로고
    • Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids
    • COI: 1:CAS:528:DyaK2MXoslehs7s%3D, PID: 7569975
    • Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS Jr (1995) Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science 270(5234):283–286
    • (1995) Science , vol.270 , Issue.5234 , pp. 283-286
    • Scheinman, R.I.1    Cogswell, P.C.2    Lofquist, A.K.3    Baldwin, A.S.4
  • 198
    • 78149284013 scopus 로고    scopus 로고
    • Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer
    • COI: 1:CAS:528:DC%2BC3cXht1ajtbvI, PID: 20881962
    • Schramek D, Leibbrandt A, Sigl V et al (2010) Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature 468(7320):98–102. doi:10.1038/Nature09387
    • (2010) Nature , vol.468 , Issue.7320 , pp. 98-102
    • Schramek, D.1    Leibbrandt, A.2    Sigl, V.3
  • 199
    • 0028325496 scopus 로고
    • Aspirin use and lung, colon, and breast cancer incidence in a prospective study
    • COI: 1:STN:280:DyaK2c3islWmsw%3D%3D, PID: 8172988
    • Schreinemachers DM, Everson RB (1994) Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology 5(2):138–146
    • (1994) Epidemiology , vol.5 , Issue.2 , pp. 138-146
    • Schreinemachers, D.M.1    Everson, R.B.2
  • 200
    • 0030101829 scopus 로고    scopus 로고
    • Inhibition of lung cancer proliferation by antisense cyclin D
    • COI: 1:CAS:528:DyaK28XivVGkur0%3D, PID: 8729912
    • Schrump DS, Chen A, Consoli U (1996) Inhibition of lung cancer proliferation by antisense cyclin D. Cancer Gene Ther 3(2):131–135
    • (1996) Cancer Gene Ther , vol.3 , Issue.2 , pp. 131-135
    • Schrump, D.S.1    Chen, A.2    Consoli, U.3
  • 201
    • 0022481133 scopus 로고
    • Multiple Nuclear Factors Interact with the Immunoglobulin Enhancer Sequences
    • COI: 1:CAS:528:DyaL28XmtVCjs74%3D, PID: 3091258
    • Sen R, Baltimore D (1986) Multiple Nuclear Factors Interact with the Immunoglobulin Enhancer Sequences. Cell 46(5):705–716. doi:10.1016/0092-8674(86)90346-6
    • (1986) Cell , vol.46 , Issue.5 , pp. 705-716
    • Sen, R.1    Baltimore, D.2
  • 202
    • 17944378526 scopus 로고    scopus 로고
    • Activation by IKK alpha of a second, evolutionary conserved, NF-kappa B signaling pathway
    • COI: 1:CAS:528:DC%2BD3MXmsVeqs7s%3D, PID: 11520989
    • Senftleben U, Cao YX, Xiao GT et al (2001) Activation by IKK alpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293(5534):1495–1499. doi:10.1126/science.1062677
    • (2001) Science , vol.293 , Issue.5534 , pp. 1495-1499
    • Senftleben, U.1    Cao, Y.X.2    Xiao, G.T.3
  • 203
    • 68649091235 scopus 로고    scopus 로고
    • Potential pharmacological control of the NF-kappa B pathway
    • COI: 1:CAS:528:DC%2BD1MXntVKmsb0%3D, PID: 19446347
    • Sethi G, Tergaonkar V (2009) Potential pharmacological control of the NF-kappa B pathway. Trends Pharmacol Sci 30(6):313–321. doi:10.1016/j.tips.2009.03.004
    • (2009) Trends Pharmacol Sci , vol.30 , Issue.6 , pp. 313-321
    • Sethi, G.1    Tergaonkar, V.2
  • 204
    • 36149000984 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF) activates nuclear factor-kappa B through I kappa B alpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of I kappa B alpha
    • COI: 1:CAS:528:DC%2BD2sXhtlWjtrzO, PID: 17533369
    • Sethi G, Ahn KS, Chaturvedi MM, Aggarwal BB (2007) Epidermal growth factor (EGF) activates nuclear factor-kappa B through I kappa B alpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of I kappa B alpha. Oncogene 26(52):7324–7332. doi:10.1038/sj.onc.1210544
    • (2007) Oncogene , vol.26 , Issue.52 , pp. 7324-7332
    • Sethi, G.1    Ahn, K.S.2    Chaturvedi, M.M.3    Aggarwal, B.B.4
  • 205
    • 84863012160 scopus 로고    scopus 로고
    • Multifaceted link between cancer and inflammation
    • COI: 1:CAS:528:DC%2BC3MXht1yksrzL, PID: 21981137
    • Sethi G, Shanmugam MK, Ramachandran L, Kumar AP, Tergaonkar V (2012) Multifaceted link between cancer and inflammation. Biosci Rep 32(1):1–15. doi:10.1042/Bsr20100136
    • (2012) Biosci Rep , vol.32 , Issue.1 , pp. 1-15
    • Sethi, G.1    Shanmugam, M.K.2    Ramachandran, L.3    Kumar, A.P.4    Tergaonkar, V.5
  • 206
    • 62449233322 scopus 로고    scopus 로고
    • NF kappa B signaling in carcinogenesis and as a potential molecular target for cancer therapy
    • COI: 1:CAS:528:DC%2BD1MXivFSnsLY%3D, PID: 19212815
    • Shen HM, Tergaonkar V (2009) NF kappa B signaling in carcinogenesis and as a potential molecular target for cancer therapy. Apoptosis 14(4):348–363. doi:10.1007/s10495-009-0315-0
    • (2009) Apoptosis , vol.14 , Issue.4 , pp. 348-363
    • Shen, H.M.1    Tergaonkar, V.2
  • 207
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • COI: 1:CAS:528:DyaK28XntlyktLs%3D, PID: 8939849
    • Sherr CJ (1996) Cancer cell cycles. Science 274(5293):1672–1677. doi:10.1126/science.274.5293.1672
    • (1996) Science , vol.274 , Issue.5293 , pp. 1672-1677
    • Sherr, C.J.1
  • 208
    • 4143134494 scopus 로고    scopus 로고
    • Nuclear factor-KB: a friend or a foe in cancer?
    • COI: 1:CAS:528:DC%2BD2cXmslOnsr0%3D, PID: 15313403
    • Shishodia S, Aggarwal BB (2004) Nuclear factor-KB: a friend or a foe in cancer? Biochem Pharmacol 68(6):1071–1080. doi:10.1016/j.bcp.2004.04.026
    • (2004) Biochem Pharmacol , vol.68 , Issue.6 , pp. 1071-1080
    • Shishodia, S.1    Aggarwal, B.B.2
  • 209
    • 0031797725 scopus 로고    scopus 로고
    • Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors
    • COI: 1:CAS:528:DyaK1cXnsF2ms70%3D, PID: 9811706
    • Shrivastava A, Manna SK, Ray R, Aggarwal BB (1998) Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors. J Virol 72(12):9722–9728
    • (1998) J Virol , vol.72 , Issue.12 , pp. 9722-9728
    • Shrivastava, A.1    Manna, S.K.2    Ray, R.3    Aggarwal, B.B.4
  • 210
    • 3142770405 scopus 로고    scopus 로고
    • Nuclear factor-kappa B/p65 (Rel A) is constitutively activated in human prostate adenocarcinoma and correlates with disease progression
    • COI: 1:CAS:528:DC%2BD2cXmslWlu70%3D, PID: 15256061
    • Shukla S, MacLennan GT, Fu PF et al (2004) Nuclear factor-kappa B/p65 (Rel A) is constitutively activated in human prostate adenocarcinoma and correlates with disease progression. Neoplasia 6(4):390–400. doi:10.1593/Neo.04112
    • (2004) Neoplasia , vol.6 , Issue.4 , pp. 390-400
    • Shukla, S.1    MacLennan, G.T.2    Fu, P.F.3
  • 211
    • 22144449607 scopus 로고    scopus 로고
    • Constitutive activation of P I3 K-Akt and NF-kappaB during prostate cancer progression in autochthonous transgenic mouse model
    • COI: 1:CAS:528:DC%2BD2MXotFSmt7Y%3D, PID: 15712212
    • Shukla S, Maclennan GT, Marengo SR, Resnick MI, Gupta S (2005) Constitutive activation of P I3 K-Akt and NF-kappaB during prostate cancer progression in autochthonous transgenic mouse model. Prostate 64(3):224–239. doi:10.1002/pros.20217
    • (2005) Prostate , vol.64 , Issue.3 , pp. 224-239
    • Shukla, S.1    Maclennan, G.T.2    Marengo, S.R.3    Resnick, M.I.4    Gupta, S.5
  • 212
    • 34447333110 scopus 로고    scopus 로고
    • Nuclear factor-kappaB activation: a molecular therapeutic target for estrogen receptor-negative and epidermal growth factor receptor family receptor-positive human breast cancer
    • COI: 1:CAS:528:DC%2BD2sXnsV2jsr0%3D, PID: 17620428
    • Singh S, Shi Q, Bailey ST et al (2007) Nuclear factor-kappaB activation: a molecular therapeutic target for estrogen receptor-negative and epidermal growth factor receptor family receptor-positive human breast cancer. Mol Cancer Ther 6(7):1973–1982. doi:10.1158/1535-7163.MCT-07-0063
    • (2007) Mol Cancer Ther , vol.6 , Issue.7 , pp. 1973-1982
    • Singh, S.1    Shi, Q.2    Bailey, S.T.3
  • 213
    • 0032748385 scopus 로고    scopus 로고
    • Antitumor activity of thalidomide in refractory multiple myeloma
    • COI: 1:CAS:528:DyaK1MXotVSgs78%3D, PID: 10564685
    • Singhal S, Mehta J, Desikan R et al (1999) Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med 341(21):1565–1571. doi:10.1056/NEJM199911183412102
    • (1999) N Engl J Med , vol.341 , Issue.21 , pp. 1565-1571
    • Singhal, S.1    Mehta, J.2    Desikan, R.3
  • 214
    • 0033791318 scopus 로고    scopus 로고
    • Cyclooxygenases: structural, cellular, and molecular biology
    • COI: 1:CAS:528:DC%2BD3cXnt1ajtLg%3D, PID: 10966456
    • Smith WL, DeWitt DL, Garavito RM (2000) Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 69:145–182. doi:10.1146/annurev.biochem.69.1.145
    • (2000) Annu Rev Biochem , vol.69 , pp. 145-182
    • Smith, W.L.1    DeWitt, D.L.2    Garavito, R.M.3
  • 215
    • 0031440245 scopus 로고    scopus 로고
    • Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer
    • COI: 1:CAS:528:DyaK2sXotVyku7w%3D, PID: 9399940
    • Sovak MA, Bellas RE, Kim DW et al (1997) Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer. J Clin Invest 100(12):2952–2960. doi:10.1172/JCI119848
    • (1997) J Clin Invest , vol.100 , Issue.12 , pp. 2952-2960
    • Sovak, M.A.1    Bellas, R.E.2    Kim, D.W.3
  • 216
    • 77956396829 scopus 로고    scopus 로고
    • Oncogenic activation of NF-kappa B
    • Staudt LM (2010) Oncogenic activation of NF-kappa B. Csh Perspect Biol. doi:10.1101/cshperspect.a000109
    • (2010) Csh Perspect Biol
    • Staudt, L.M.1
  • 217
    • 0032490670 scopus 로고    scopus 로고
    • Nuclear factor (NF)-kappa B-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis
    • COI: 1:CAS:528:DyaK1cXksFyjsLw%3D, PID: 9653098
    • Stehlik C, de Martin R, Kumabashiri I, Schmid JA, Binder BR, Lipp J (1998) Nuclear factor (NF)-kappa B-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis. J Exp Med 188(1):211–216. doi:10.1084/jem.188.1.211
    • (1998) J Exp Med , vol.188 , Issue.1 , pp. 211-216
    • Stehlik, C.1    de Martin, R.2    Kumabashiri, I.3    Schmid, J.A.4    Binder, B.R.5    Lipp, J.6
  • 218
    • 0027379055 scopus 로고
    • Distinct Mechanisms for Regulation of the Interleukin-8 Gene Involve Synergism and Cooperativity between C/Ebp and Nf-Kappa-B
    • COI: 1:CAS:528:DyaK2cXpvVSktA%3D%3D, PID: 8413306
    • Stein B, Baldwin AS (1993) Distinct Mechanisms for Regulation of the Interleukin-8 Gene Involve Synergism and Cooperativity between C/Ebp and Nf-Kappa-B. Mol Cell Biol 13(11):7191–7198
    • (1993) Mol Cell Biol , vol.13 , Issue.11 , pp. 7191-7198
    • Stein, B.1    Baldwin, A.S.2
  • 219
    • 0027224017 scopus 로고
    • Cross-coupling of the Nf-Theta-B P65 and Fos Jun transcription factors produces potentiated biological function
    • COI: 1:CAS:528:DyaK3sXmtF2jtLk%3D, PID: 8404856
    • Stein B, Baldwin AS, Ballard DW, Greene WC, Angel P, Herrlich P (1993) Cross-coupling of the Nf-Theta-B P65 and Fos Jun transcription factors produces potentiated biological function. EMBO J 12(10):3879–3891
    • (1993) EMBO J , vol.12 , Issue.10 , pp. 3879-3891
    • Stein, B.1    Baldwin, A.S.2    Ballard, D.W.3    Greene, W.C.4    Angel, P.5    Herrlich, P.6
  • 220
    • 0034685876 scopus 로고    scopus 로고
    • Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2—evidence for involvement of ERK1/2 and p38 mitogen-activated protein kinase pathways
    • COI: 1:CAS:528:DC%2BD3cXjsFantrg%3D, PID: 10809726
    • Subbaramaiah K, Hart JC, Norton L, Dannenberg AJ (2000) Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2—evidence for involvement of ERK1/2 and p38 mitogen-activated protein kinase pathways. J Biol Chem 275(20):14838–14845. doi:10.1074/jbc.275.20.14838
    • (2000) J Biol Chem , vol.275 , Issue.20 , pp. 14838-14845
    • Subbaramaiah, K.1    Hart, J.C.2    Norton, L.3    Dannenberg, A.J.4
  • 221
    • 0141844522 scopus 로고    scopus 로고
    • Regulation of cyclooxgenase-2 mRNA stability by taxanes—evidence for involvement of p38, MAPKAPK-2, and HuR
    • COI: 1:CAS:528:DC%2BD3sXnsV2lsbk%3D, PID: 12826679
    • Subbaramaiah K, Marmo TP, Dixon DA, Dannenberg AJ (2003) Regulation of cyclooxgenase-2 mRNA stability by taxanes—evidence for involvement of p38, MAPKAPK-2, and HuR. J Biol Chem 278(39):37637–37647. doi:10.1074/jbc.M301481200
    • (2003) J Biol Chem , vol.278 , Issue.39 , pp. 37637-37647
    • Subbaramaiah, K.1    Marmo, T.P.2    Dixon, D.A.3    Dannenberg, A.J.4
  • 222
    • 0036680137 scopus 로고    scopus 로고
    • Mechanisms of constitutive NF-kappaB activation in human prostate cancer cells
    • COI: 1:CAS:528:DC%2BD38XmsVWqtbw%3D, PID: 12111695
    • Suh J, Payvandi F, Edelstein LC et al (2002) Mechanisms of constitutive NF-kappaB activation in human prostate cancer cells. Prostate 52(3):183–200. doi:10.1002/pros.10082
    • (2002) Prostate , vol.52 , Issue.3 , pp. 183-200
    • Suh, J.1    Payvandi, F.2    Edelstein, L.C.3
  • 223
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • COI: 1:CAS:528:DC%2BD3sXotFChsLw%3D, PID: 14570043
    • Surh YJ (2003) Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3(10):768–780. doi:10.1038/nrc1189
    • (2003) Nat Rev Cancer , vol.3 , Issue.10 , pp. 768-780
    • Surh, Y.J.1
  • 224
    • 0035451363 scopus 로고    scopus 로고
    • Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation
    • Surh YJ, Chun KS, Cha HH et al (2001) Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res Fundam Mol M 480:243–268. doi:10.1016/S0027-5107(01)00183-X
    • (2001) Mutat Res Fundam Mol M , vol.480 , pp. 243-268
    • Surh, Y.J.1    Chun, K.S.2    Cha, H.H.3
  • 225
    • 0034544619 scopus 로고    scopus 로고
    • Constitutive activation of nuclear factor kappa B in hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BD3cXptVaqsbg%3D, PID: 11147598
    • Tai DI, Tsai SL, Chang YH et al (2000) Constitutive activation of nuclear factor kappa B in hepatocellular carcinoma. Cancer 89(11):2274–2281. doi:10.1002/1097-0142(20001201)89:11<2274:Aid-Cncr16>3.3.Co;2-U
    • (2000) Cancer , vol.89 , Issue.11 , pp. 2274-2281
    • Tai, D.I.1    Tsai, S.L.2    Chang, Y.H.3
  • 226
    • 0034746919 scopus 로고    scopus 로고
    • NF-kappa B: a key role in inflammatory diseases
    • COI: 1:CAS:528:DC%2BD3MXitVOhtg%3D%3D, PID: 11134171
    • Tak PP, Firestein GS (2001) NF-kappa B: a key role in inflammatory diseases. J Clin Invest 107(1):7–11. doi:10.1172/Jci11830
    • (2001) J Clin Invest , vol.107 , Issue.1 , pp. 7-11
    • Tak, P.P.1    Firestein, G.S.2
  • 227
    • 1042278138 scopus 로고    scopus 로고
    • Flavopiridol inhibits NF-kappa B activation induced by various carcinogens and inflammatory agents through inhibition of I kappa B alpha kinase and p65 phosphorylation—abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9
    • COI: 1:CAS:528:DC%2BD2cXps12rtQ%3D%3D, PID: 14630924
    • Takada Y, Aggarwal BB (2004) Flavopiridol inhibits NF-kappa B activation induced by various carcinogens and inflammatory agents through inhibition of I kappa B alpha kinase and p65 phosphorylation—abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. J Biol Chem 279(6):4750–4759. doi:10.1074/jbc.M304546200
    • (2004) J Biol Chem , vol.279 , Issue.6 , pp. 4750-4759
    • Takada, Y.1    Aggarwal, B.B.2
  • 228
    • 11244334168 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation
    • COI: 1:CAS:528:DC%2BD2cXhtVGmtbnE, PID: 15489888
    • Takada Y, Bhardwaj A, Potdar P, Aggarwal BB (2004) Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23(57):9247–9258. doi:10.1038/sj.onc.1208169
    • (2004) Oncogene , vol.23 , Issue.57 , pp. 9247-9258
    • Takada, Y.1    Bhardwaj, A.2    Potdar, P.3    Aggarwal, B.B.4
  • 229
    • 0032403126 scopus 로고    scopus 로고
    • IAP-family protein Survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs
    • COI: 1:CAS:528:DyaK1cXotVSkt7w%3D, PID: 9850056
    • Tamm I, Wang Y, Sausville E et al (1998) IAP-family protein Survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res 58(23):5315–5320
    • (1998) Cancer Res , vol.58 , Issue.23 , pp. 5315-5320
    • Tamm, I.1    Wang, Y.2    Sausville, E.3
  • 230
    • 79952193038 scopus 로고    scopus 로고
    • Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling
    • COI: 1:CAS:528:DC%2BC3MXhvFKltL8%3D, PID: 21326202
    • Tan W, Zhang WZ, Strasner A et al (2011) Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature 470(7335):548–553. doi:10.1038/Nature09707
    • (2011) Nature , vol.470 , Issue.7335 , pp. 548-553
    • Tan, W.1    Zhang, W.Z.2    Strasner, A.3
  • 231
    • 0035891320 scopus 로고    scopus 로고
    • Inhibition of JNK activation through NF-kappa B target genes
    • COI: 1:CAS:528:DC%2BD3MXovFGisr8%3D, PID: 11713531
    • Tang GL, Minemoto Y, Dibling B et al (2001) Inhibition of JNK activation through NF-kappa B target genes. Nature 414(6861):313–317. doi:10.1038/35104568
    • (2001) Nature , vol.414 , Issue.6861 , pp. 313-317
    • Tang, G.L.1    Minemoto, Y.2    Dibling, B.3
  • 232
    • 1242338040 scopus 로고    scopus 로고
    • Overexpression of cyclooxygenase-2 is associated with radioresistance in oral squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BD2cXht12jsL8%3D, PID: 14969817
    • Terakado N, Shintani S, Yano JY et al (2004) Overexpression of cyclooxygenase-2 is associated with radioresistance in oral squamous cell carcinoma. Oral Oncol 40(4):383–389. doi:10.1016/j.oraloncology.2003.09.005
    • (2004) Oral Oncol , vol.40 , Issue.4 , pp. 383-389
    • Terakado, N.1    Shintani, S.2    Yano, J.Y.3
  • 233
    • 33745342580 scopus 로고    scopus 로고
    • NF kappa B pathway: a good signaling paradigm and therapeutic target
    • COI: 1:CAS:528:DC%2BD28Xms1ans70%3D
    • Tergaonkar V (2006) NF kappa B pathway: a good signaling paradigm and therapeutic target. Int J Biochem Cell B 38(10):1647–1653. doi:10.1016/j.biocel.2006.03.023
    • (2006) Int J Biochem Cell B , vol.38 , Issue.10 , pp. 1647-1653
    • Tergaonkar, V.1
  • 235
    • 0037108880 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition with celecoxib enhances antitumor efficacy and reduces diarrhea side effect of CPT-11
    • COI: 1:CAS:528:DC%2BD38XotFyktrs%3D, PID: 12384538
    • Trifan OC, Durham WF, Salazar VS et al (2002) Cyclooxygenase-2 inhibition with celecoxib enhances antitumor efficacy and reduces diarrhea side effect of CPT-11. Cancer Res 62(20):5778–5784
    • (2002) Cancer Res , vol.62 , Issue.20 , pp. 5778-5784
    • Trifan, O.C.1    Durham, W.F.2    Salazar, V.S.3
  • 236
    • 0003504049 scopus 로고    scopus 로고
    • Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    • COI: 1:CAS:528:DyaK1cXjsl2ksbw%3D, PID: 9630216
    • Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN (1998) Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93(5):705–716. doi:10.1016/S0092-8674(00)81433-6
    • (1998) Cell , vol.93 , Issue.5 , pp. 705-716
    • Tsujii, M.1    Kawano, S.2    Tsuji, S.3    Sawaoka, H.4    Hori, M.5    DuBois, R.N.6
  • 237
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-kappa B transcription factors in the immune system
    • COI: 1:CAS:528:DC%2BD1MXlsFSlt7o%3D, PID: 19302050
    • Vallabhapurapu S, Karin M (2009) Regulation and function of NF-kappa B transcription factors in the immune system. Annu Rev Immunol 27:693–733. doi:10.1146/annurev.immunol.021908.132641
    • (2009) Annu Rev Immunol , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 238
    • 33947202249 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in development, prevention, and therapy of cancer
    • PID: 17317814
    • Van Waes C (2007) Nuclear factor-kappaB in development, prevention, and therapy of cancer. Clin Cancer Res 13(4):1076–1082. doi:10.1158/1078-0432.CCR-06-2221
    • (2007) Clin Cancer Res , vol.13 , Issue.4 , pp. 1076-1082
    • Van Waes, C.1
  • 239
    • 11844269840 scopus 로고    scopus 로고
    • Phosphorylation of NF-kappa B and I kappa B proteins: implications in cancer and inflammation
    • COI: 1:CAS:528:DC%2BD2MXkslOkuw%3D%3D, PID: 15653325
    • Viatour P, Merville MP, Bours V, Chariot A (2005) Phosphorylation of NF-kappa B and I kappa B proteins: implications in cancer and inflammation. Trends Biochem Sci 30(1):43–52. doi:10.1016/j.tiba.2004.11.009
    • (2005) Trends Biochem Sci , vol.30 , Issue.1 , pp. 43-52
    • Viatour, P.1    Merville, M.P.2    Bours, V.3    Chariot, A.4
  • 240
    • 33144469102 scopus 로고    scopus 로고
    • The proteasome and proteasome inhibitors in cancer therapy
    • COI: 1:CAS:528:DC%2BD28XisFKltLc%3D
    • Voorhees PM, Orlowski RZ (2006) The proteasome and proteasome inhibitors in cancer therapy. Annu Rev Pharmacol 46:189–213. doi:10.1146/annurev.pharmtox.46.120604.141300
    • (2006) Annu Rev Pharmacol , vol.46 , pp. 189-213
    • Voorhees, P.M.1    Orlowski, R.Z.2
  • 241
    • 67749117934 scopus 로고    scopus 로고
    • Signal integration by JNK and p38 MAPK pathways in cancer development
    • COI: 1:CAS:528:DC%2BD1MXovFymu7w%3D, PID: 19629069
    • Wagner EF, Nebreda AR (2009) Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 9(8):537–549. doi:10.1038/Nrc2694
    • (2009) Nat Rev Cancer , vol.9 , Issue.8 , pp. 537-549
    • Wagner, E.F.1    Nebreda, A.R.2
  • 242
    • 29244449354 scopus 로고    scopus 로고
    • Prostaglandins and cancer
    • COI: 1:CAS:528:DC%2BD28Xnt1yquw%3D%3D, PID: 16118353
    • Wang D, DuBois RN (2006) Prostaglandins and cancer. Gut 55(1):115–122. doi:10.1136/gut.2004.047100
    • (2006) Gut , vol.55 , Issue.1 , pp. 115-122
    • Wang, D.1    DuBois, R.N.2
  • 243
    • 0032508414 scopus 로고    scopus 로고
    • NF-kappa B antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
    • COI: 1:CAS:528:DyaK1cXmtVWhurk%3D, PID: 9733516
    • Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS (1998) NF-kappa B antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281(5383):1680–1683. doi:10.1126/science.281.5383.1680
    • (1998) Science , vol.281 , Issue.5383 , pp. 1680-1683
    • Wang, C.Y.1    Mayo, M.W.2    Korneluk, R.G.3    Goeddel, D.V.4    Baldwin, A.S.5
  • 244
    • 0032588317 scopus 로고    scopus 로고
    • NF-kappa B induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis
    • COI: 1:CAS:528:DyaK1MXlslSqurw%3D, PID: 10454539
    • Wang CY, Guttridge DC, Mayo MW, Baldwin AS (1999) NF-kappa B induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol Cell Biol 19(9):5923–5929
    • (1999) Mol Cell Biol , vol.19 , Issue.9 , pp. 5923-5929
    • Wang, C.Y.1    Guttridge, D.C.2    Mayo, M.W.3    Baldwin, A.S.4
  • 245
    • 33646877856 scopus 로고    scopus 로고
    • Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells
    • COI: 1:CAS:528:DC%2BD28Xls1Sru7s%3D, PID: 16628653
    • Wang ZW, Zhang YX, Banerjee S, Li YW, Sarkar FH (2006) Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells. Cancer 106(11):2503–2513. doi:10.1002/Cncr.21904
    • (2006) Cancer , vol.106 , Issue.11 , pp. 2503-2513
    • Wang, Z.W.1    Zhang, Y.X.2    Banerjee, S.3    Li, Y.W.4    Sarkar, F.H.5
  • 246
    • 68849108871 scopus 로고    scopus 로고
    • Current and potential inflammation targeted therapies in head and neck cancer
    • COI: 1:CAS:528:DC%2BD1MXhtVenurnE, PID: 19570715
    • Wang F, Arun P, Friedman J, Chen Z, Van Waes C (2009) Current and potential inflammation targeted therapies in head and neck cancer. Curr Opin Pharmacol 9(4):389–395. doi:10.1016/j.coph.2009.06.005
    • (2009) Curr Opin Pharmacol , vol.9 , Issue.4 , pp. 389-395
    • Wang, F.1    Arun, P.2    Friedman, J.3    Chen, Z.4    Van Waes, C.5
  • 247
    • 0142039960 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A and subgenomic replicon activate NF-kappa B via tyrosine phosphorylation of I kappa B alpha and its degradation by calpain protease
    • COI: 1:CAS:528:DC%2BD3sXotFWgsLg%3D, PID: 12909638
    • Waris G, Livolsi A, Imbert V, Peyron JF, Siddiqui A (2003) Hepatitis C virus NS5A and subgenomic replicon activate NF-kappa B via tyrosine phosphorylation of I kappa B alpha and its degradation by calpain protease. J Biol Chem 278(42):40778–40787. doi:10.1074/jbc.M303248200
    • (2003) J Biol Chem , vol.278 , Issue.42 , pp. 40778-40787
    • Waris, G.1    Livolsi, A.2    Imbert, V.3    Peyron, J.F.4    Siddiqui, A.5
  • 248
    • 0035196739 scopus 로고    scopus 로고
    • The putative oncoprotein Bcl-3 induces cyclin d1 to stimulate G(1) transition
    • COI: 1:CAS:528:DC%2BD3MXovVegsb4%3D, PID: 11713278
    • Westerheide SD, Mayo MW, Anest V, Hanson JL, Baldwin AS (2001) The putative oncoprotein Bcl-3 induces cyclin d1 to stimulate G(1) transition. Mol Cell Biol 21(24):8428–8436. doi:10.1128/Mcb.21.24.8428-8436.2001
    • (2001) Mol Cell Biol , vol.21 , Issue.24 , pp. 8428-8436
    • Westerheide, S.D.1    Mayo, M.W.2    Anest, V.3    Hanson, J.L.4    Baldwin, A.S.5
  • 249
    • 0034742512 scopus 로고    scopus 로고
    • IL (interleukin)-1alpha promotes nuclear factor-kappaB and AP-1-induced IL-8 expression, cell survival, and proliferation in head and neck squamous cell carcinomas
    • COI: 1:CAS:528:DC%2BD3MXltV2hsLk%3D, PID: 11410524
    • Wolf JS, Chen Z, Dong G et al (2001) IL (interleukin)-1alpha promotes nuclear factor-kappaB and AP-1-induced IL-8 expression, cell survival, and proliferation in head and neck squamous cell carcinomas. Clin Cancer Res 7(6):1812–1820
    • (2001) Clin Cancer Res , vol.7 , Issue.6 , pp. 1812-1820
    • Wolf, J.S.1    Chen, Z.2    Dong, G.3
  • 250
    • 65549164068 scopus 로고    scopus 로고
    • Roles of NF-kappa B in health and disease: mechanisms and therapeutic potential
    • COI: 1:CAS:528:DC%2BD1MXhslSit7g%3D, PID: 19200055
    • Wong ET, Tergaonkar V (2009) Roles of NF-kappa B in health and disease: mechanisms and therapeutic potential. Clin Sci 116(5–6):451–465. doi:10.1042/Cs20080502
    • (2009) Clin Sci , vol.116 , Issue.5-6 , pp. 451-465
    • Wong, E.T.1    Tergaonkar, V.2
  • 251
    • 0031432620 scopus 로고    scopus 로고
    • Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes
    • COI: 1:CAS:528:DyaK1cXitlOltrc%3D
    • Xia CL, Cheshire JK, Patel H, Woo P (1997) Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes. Int J Biochem Cell B 29(12):1525–1539. doi:10.1016/S1357-2725(97)00083-6
    • (1997) Int J Biochem Cell B , vol.29 , Issue.12 , pp. 1525-1539
    • Xia, C.L.1    Cheshire, J.K.2    Patel, H.3    Woo, P.4
  • 252
    • 4644241127 scopus 로고    scopus 로고
    • Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50
    • COI: 1:CAS:528:DC%2BD2cXnsVWrs7Y%3D, PID: 15356172
    • Xia YF, Ye BQ, Li YD et al (2004) Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50. J Immunol 173(6):4207–4217
    • (2004) J Immunol , vol.173 , Issue.6 , pp. 4207-4217
    • Xia, Y.F.1    Ye, B.Q.2    Li, Y.D.3
  • 253
    • 0029595394 scopus 로고
    • Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells
    • COI: 1:CAS:528:DyaK28XivFWhtQ%3D%3D, PID: 8537402
    • Yamamoto K, Arakawa T, Ueda N, Yamamoto S (1995) Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J Biol Chem 270(52):31315–31320
    • (1995) J Biol Chem , vol.270 , Issue.52 , pp. 31315-31320
    • Yamamoto, K.1    Arakawa, T.2    Ueda, N.3    Yamamoto, S.4
  • 254
    • 0033578879 scopus 로고    scopus 로고
    • Sulindac inhibits activation of the NF-kappaB pathway
    • COI: 1:CAS:528:DyaK1MXmt1aktbc%3D, PID: 10480951
    • Yamamoto Y, Yin MJ, Lin KM, Gaynor RB (1999) Sulindac inhibits activation of the NF-kappaB pathway. J Biol Chem 274(38):27307–27314
    • (1999) J Biol Chem , vol.274 , Issue.38 , pp. 27307-27314
    • Yamamoto, Y.1    Yin, M.J.2    Lin, K.M.3    Gaynor, R.B.4
  • 255
    • 0029670843 scopus 로고    scopus 로고
    • Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein
    • COI: 1:CAS:528:DyaK28XhsFGgtLs%3D, PID: 8631308
    • Yamaoka S, Inoue H, Sakurai M et al (1996) Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein. EMBO J 15(4):873–887
    • (1996) EMBO J , vol.15 , Issue.4 , pp. 873-887
    • Yamaoka, S.1    Inoue, H.2    Sakurai, M.3
  • 256
    • 32944468414 scopus 로고    scopus 로고
    • BMS-345541 targets inhibitor of kappa B kinase and induces apoptosis in melanoma: involvement of nuclear factor kappa B and mitochondria pathways
    • COI: 1:CAS:528:DC%2BD28XhtFehsr4%3D, PID: 16467110
    • Yang JM, Amiri KI, Burke JR, Schmid JA, Richmond A (2006) BMS-345541 targets inhibitor of kappa B kinase and induces apoptosis in melanoma: involvement of nuclear factor kappa B and mitochondria pathways. Clin Cancer Res 12(3):950–960. doi:10.1158/1078-0432.Ccr-05-1220
    • (2006) Clin Cancer Res , vol.12 , Issue.3 , pp. 950-960
    • Yang, J.M.1    Amiri, K.I.2    Burke, J.R.3    Schmid, J.A.4    Richmond, A.5
  • 257
    • 0034773992 scopus 로고    scopus 로고
    • The EGFR family and its ligands in human cancer: signalling mechanisms and therapeutic opportunities
    • COI: 1:CAS:528:DC%2BD3MXntlOku78%3D, PID: 11597398
    • Yarden Y (2001) The EGFR family and its ligands in human cancer: signalling mechanisms and therapeutic opportunities. Eur J Cancer 37:S3–S8
    • (2001) Eur J Cancer , vol.37 , pp. 3-8
    • Yarden, Y.1
  • 258
    • 3242719545 scopus 로고    scopus 로고
    • Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    • COI: 1:CAS:528:DC%2BD2cXkvVeku7Y%3D, PID: 15152190
    • Yeung F, Hoberg JE, Ramsey CS et al (2004) Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 23(12):2369–2380. doi:10.1038/sj.emboj.7600244
    • (2004) EMBO J , vol.23 , Issue.12 , pp. 2369-2380
    • Yeung, F.1    Hoberg, J.E.2    Ramsey, C.S.3
  • 259
    • 0032487857 scopus 로고    scopus 로고
    • The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta
    • COI: 1:CAS:528:DyaK1cXnsVSjur0%3D, PID: 9817203
    • Yin MJ, Yamamoto Y, Gaynor RB (1998) The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature 396(6706):77–80. doi:10.1038/23948
    • (1998) Nature , vol.396 , Issue.6706 , pp. 77-80
    • Yin, M.J.1    Yamamoto, Y.2    Gaynor, R.B.3
  • 260
    • 0031009807 scopus 로고    scopus 로고
    • Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis
    • COI: 1:CAS:528:DyaK2sXktFOisrg%3D, PID: 9199336
    • Yoshida S, Ono M, Shono T et al (1997) Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis. Mol Cell Biol 17(7):4015–4023
    • (1997) Mol Cell Biol , vol.17 , Issue.7 , pp. 4015-4023
    • Yoshida, S.1    Ono, M.2    Shono, T.3
  • 261
    • 4944266319 scopus 로고    scopus 로고
    • Epstein-Barr virus: 40 years on
    • COI: 1:CAS:528:DC%2BD2cXos1ymu78%3D, PID: 15510157
    • Young LS, Rickinson AB (2004) Epstein-Barr virus: 40 years on. Nat Rev Cancer 4(10):757–768. doi:10.1038/Nrc1452
    • (2004) Nat Rev Cancer , vol.4 , Issue.10 , pp. 757-768
    • Young, L.S.1    Rickinson, A.B.2
  • 262
    • 0037972018 scopus 로고    scopus 로고
    • Increased expression of RelA/nuclear factor-kappa B protein correlates with colorectal tumorigenesis
    • COI: 1:CAS:528:DC%2BD3sXltlChtbc%3D
    • Yu HG, Yu LL, Yang YN et al (2003) Increased expression of RelA/nuclear factor-kappa B protein correlates with colorectal tumorigenesis. Oncology-Basel 65(1):37–45. doi:10.1159/000071203
    • (2003) Oncology-Basel , vol.65 , Issue.1 , pp. 37-45
    • Yu, H.G.1    Yu, L.L.2    Yang, Y.N.3
  • 263
    • 33746160746 scopus 로고    scopus 로고
    • Protein kinase casein kinase 2 mediates inhibitor-kappa B kinase and aberrant nuclear factor-kappa B activation by serum factor(s) in head and neck squamous carcinoma cells
    • COI: 1:CAS:528:DC%2BD28XmsVamu7g%3D, PID: 16818647
    • Yu M, Yeh J, Van Waes C (2006) Protein kinase casein kinase 2 mediates inhibitor-kappa B kinase and aberrant nuclear factor-kappa B activation by serum factor(s) in head and neck squamous carcinoma cells. Cancer Res 66(13):6722–6731. doi:10.1158/0008-5472.Can-05-3758
    • (2006) Cancer Res , vol.66 , Issue.13 , pp. 6722-6731
    • Yu, M.1    Yeh, J.2    Van Waes, C.3
  • 264
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: a leading role for STAT3
    • COI: 1:CAS:528:DC%2BD1MXhtlSjur%2FP, PID: 19851315
    • Yu H, Pardoll D, Jove R (2009) STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9(11):798–809. doi:10.1038/Nrc2734
    • (2009) Nat Rev Cancer , vol.9 , Issue.11 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 265
    • 4544327894 scopus 로고    scopus 로고
    • Cyclooxygenases in cancer: progress and perspective
    • COI: 1:CAS:528:DC%2BD2cXnslGhsr0%3D, PID: 15374627
    • Zha S, Yegnasubramanian V, Nelson WG, Isaacs WB, De Marzo AM (2004) Cyclooxygenases in cancer: progress and perspective. Cancer Lett 215(1):1–20. doi:10.1016/j.canlet.2004.06.014
    • (2004) Cancer Lett , vol.215 , Issue.1 , pp. 1-20
    • Zha, S.1    Yegnasubramanian, V.2    Nelson, W.G.3    Isaacs, W.B.4    De Marzo, A.M.5
  • 266
    • 23044488525 scopus 로고    scopus 로고
    • Overexpression of phosphorylated nuclear factor-kappa B in tonsillar squamous cell carcinoma and high-grade dysplasia is associated with poor prognosis
    • COI: 1:CAS:528:DC%2BD2MXltlCitrc%3D, PID: 15920558
    • Zhang PL, Pellitteri PK, Law A et al (2005) Overexpression of phosphorylated nuclear factor-kappa B in tonsillar squamous cell carcinoma and high-grade dysplasia is associated with poor prognosis. Mod Pathol 18(7):924–932. doi:10.1038/modpathol.3800372
    • (2005) Mod Pathol , vol.18 , Issue.7 , pp. 924-932
    • Zhang, P.L.1    Pellitteri, P.K.2    Law, A.3
  • 267
    • 68449103870 scopus 로고    scopus 로고
    • NF-kappa B regulates androgen receptor expression and prostate cancer growth
    • COI: 1:CAS:528:DC%2BD1MXhtVGqtrvE, PID: 19628766
    • Zhang LY, Altuwaijri S, Deng FM et al (2009) NF-kappa B regulates androgen receptor expression and prostate cancer growth. Am J Pathol 175(2):489–499. doi:10.2353/ajpath.2009.080727
    • (2009) Am J Pathol , vol.175 , Issue.2 , pp. 489-499
    • Zhang, L.Y.1    Altuwaijri, S.2    Deng, F.M.3
  • 268
    • 0029080861 scopus 로고
    • Antisense to Cyclin D1 inhibits growth and reverses the transformed phenotype of human esophageal cancer-cells
    • COI: 1:CAS:528:DyaK2MXnsFyht70%3D, PID: 7630641
    • Zhou P, Jiang W, Zhang YJ et al (1995) Antisense to Cyclin D1 inhibits growth and reverses the transformed phenotype of human esophageal cancer-cells. Oncogene 11(3):571–580
    • (1995) Oncogene , vol.11 , Issue.3 , pp. 571-580
    • Zhou, P.1    Jiang, W.2    Zhang, Y.J.3
  • 269
    • 0034677776 scopus 로고    scopus 로고
    • HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway
    • COI: 1:CAS:528:DC%2BD3cXitVyltL8%3D, PID: 10713122
    • Zhou BP, Hu MC, Miller SA et al (2000) HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway. J Biol Chem 275(11):8027–8031
    • (2000) J Biol Chem , vol.275 , Issue.11 , pp. 8027-8031
    • Zhou, B.P.1    Hu, M.C.2    Miller, S.A.3
  • 270
    • 0033558215 scopus 로고    scopus 로고
    • The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNF alpha-induced apoptosis
    • COI: 1:CAS:528:DyaK1MXhs1Wrt7o%3D, PID: 10049353
    • Zong WX, Edelstein LC, Chen CL, Bash J, Gelinas C (1999) The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNF alpha-induced apoptosis. Genes Dev 13(4):382–387. doi:10.1101/Gad.13.4.382
    • (1999) Genes Dev , vol.13 , Issue.4 , pp. 382-387
    • Zong, W.X.1    Edelstein, L.C.2    Chen, C.L.3    Bash, J.4    Gelinas, C.5


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