BMS-345541 is a highly selective inhibitor of IκB kinase that binds at an allosteric site of the enzyme and blocks NF-κB-dependent transcription in mice

Journal of Biological Chemistry

Volumn 278, Issue 3, 2003, Pages 1450-1456

  Burke, James R ^a   Pattoli, Mark A ^a   Gregor, Kurt R ^a   Brassil, Patrick J ^a   MacMaster, John F ^a   McIntyre, Kim W ^a   Yang, Xiaoxia ^a   Iotzova, Violetta S ^a   Clarke, Wendy ^a   Strnad, Joann ^a   Qiu, Yuping ^a   Zusi, F Christopher ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYME INHIBITION; PHARMACOKINETICS; POLYSACCHARIDES; TUMORS;

PHOSPHORYLATION;

ENZYMES;

4 (2' AMINOETHYL)AMINO 1,8 DIMETHYLIMIDAZO[1,2 A]QUINOXALINE; BMS 345541; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; QUINOXALINE DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 4(2' AMINOETHYL)AMINO 1,8 DIMETHYLIMIDAZO(1,2 A)QUINOXALINE; 4(2'-AMINOETHYL)AMINO-1,8-DIMETHYLIMIDAZO(1,2-A)QUINOXALINE; CHUK PROTEIN, MOUSE; ENZYME INHIBITOR; IKBKB PROTEIN, MOUSE; IKBKE PROTEIN, MOUSE; IMIDAZOLE DERIVATIVE; PROTEIN SERINE THREONINE KINASE;

ALLOSTERISM; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG BINDING; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME SUBUNIT; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; KINETICS; METABOLISM; PHYSIOLOGY;

ANIMALIA;

ALLOSTERIC SITE; ANIMALS; CATALYTIC DOMAIN; ENZYME INHIBITORS; FEMALE; I-KAPPA B KINASE; IMIDAZOLES; KINETICS; MICE; MICE, INBRED BALB C; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; QUINOXALINES; TRANSCRIPTION, GENETIC;

EID: 0037449711     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209677200     Document Type: Article

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