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Volumn 104, Issue 3, 2004, Pages 607-618

Advances in biology of multiple myeloma: Clinical applications

Author keywords

[No Author keywords available]

Indexed keywords

17 AAG; 2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID; 2 METHOXYESTRADIOL; 4 [N (2 HYDROXYETHYL) N [2 (3 INDOLYL)ETHYL]AMINOMETHYL]CINNAMOHYDROXAMIC ACID; 5 (2,6 DICHLOROPHENYL) 2 (2,4 DIFLUOROPHENYLTHIO)PYRIMIDO[1,6 B]PYRIDAZIN 6 ONE; 6 CHLORO 8 NICOTINAMIDO BETA CARBOLINE; ACYLTRANSFERASE INHIBITOR; ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; ATIPRIMOD; BORTEZOMIB; CYCLIN D1; FIBROBLAST GROWTH FACTOR 3; GALDANAMYCIN; GELDANAMYCIN; GW 654652; HISTONE DEACETYLASE INHIBITOR; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN; INOSINATE DEHYDROGENASE; INTERLEUKIN 6; LENALIDOMIDE; LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE BETA INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; OBLIMERSEN; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAPAMYCIN; SCIO 469; SOMATOMEDIN C RECEPTOR INHIBITOR; TELOMERASE INHIBITOR; TELOMESTATIN; THALIDOMIDE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR INHIBITOR; TRITERPENOID; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; UNINDEXED DRUG; VATALANIB; VX 944;

EID: 3242777803     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-01-0037     Document Type: Review
Times cited : (561)

References (199)
  • 2
    • 7944223997 scopus 로고    scopus 로고
    • Prevalence of monoclonal gammopathy of undetermined significance (MGUS) among Olmsted County, MN residents over 50 years of age
    • Kyle RA, Therneau TM, Rajkumar SV, et al. Prevalence of monoclonal gammopathy of undetermined significance (MGUS) among Olmsted County, MN residents over 50 years of age [abstract]. Blood. 2003;102:3476a.
    • (2003) Blood , vol.102
    • Kyle, R.A.1    Therneau, T.M.2    Rajkumar, S.V.3
  • 3
    • 0038264427 scopus 로고    scopus 로고
    • Immunoglobulin light chain variable (V) region genes influence clinical presentation and outcome in light chain-associated amyloidosis (AL)
    • Abraham RS, Geyer SM, Price-Troska TL, et al. Immunoglobulin light chain variable (V) region genes influence clinical presentation and outcome in light chain-associated amyloidosis (AL). Blood. 2003;101:3801-3808.
    • (2003) Blood , vol.101 , pp. 3801-3808
    • Abraham, R.S.1    Geyer, S.M.2    Price-Troska, T.L.3
  • 4
    • 0037148921 scopus 로고    scopus 로고
    • A long-term study of prognosis in monoclonal gammopathy of undetermined significance
    • Kyle RA, Therneeu TM, Rajkumar SV, et al. A long-term study of prognosis in monoclonal gammopathy of undetermined significance. N Engl J Med. 2002;346:564-569.
    • (2002) N Engl J Med , vol.346 , pp. 564-569
    • Kyle, R.A.1    Therneeu, T.M.2    Rajkumar, S.V.3
  • 5
    • 0032076120 scopus 로고    scopus 로고
    • Racial differences in the prevalence of monoclonal gammopathy in a community-based sample of the elderly
    • Cohen HJ, Crawford J, Rao MK, Pieper CF, Currie MS. Racial differences in the prevalence of monoclonal gammopathy in a community-based sample of the elderly. Am J Med. 1998;104:439-444.
    • (1998) Am J Med , vol.104 , pp. 439-444
    • Cohen, H.J.1    Crawford, J.2    Rao, M.K.3    Pieper, C.F.4    Currie, M.S.5
  • 7
    • 0032819014 scopus 로고    scopus 로고
    • Cytogenetic abnormalities correlate with the plasma cell labeling index and extent of bone marrow involvement in myeloma
    • Rajkumar SV, Fonseca R, Dewald GW, et al. Cytogenetic abnormalities correlate with the plasma cell labeling index and extent of bone marrow involvement in myeloma. Cancer Genet Cytogenet. 1999;113:73-77.
    • (1999) Cancer Genet Cytogenet , vol.113 , pp. 73-77
    • Rajkumar, S.V.1    Fonseca, R.2    Dewald, G.W.3
  • 8
    • 0036512435 scopus 로고    scopus 로고
    • Multiple myeloma: Evolving genetic events and host interactions
    • Kuehl WM, Bergsagel PL. Multiple myeloma: evolving genetic events and host interactions. Nat Rev Cancer. 2002;2:175-187.
    • (2002) Nat Rev Cancer , vol.2 , pp. 175-187
    • Kuehl, W.M.1    Bergsagel, P.L.2
  • 9
    • 0035839841 scopus 로고    scopus 로고
    • Chromosome translocations in multiple myeloma
    • Bergsagel PL, Kuehl WM. Chromosome translocations in multiple myeloma. Oncogene. 2001;20:5611-5622.
    • (2001) Oncogene , vol.20 , pp. 5611-5622
    • Bergsagel, P.L.1    Kuehl, W.M.2
  • 10
    • 0032005528 scopus 로고    scopus 로고
    • A novel three-color, clone-specific fluorescence in situ hybridization procedure for monoclonal gammopathies
    • Ahmann GJ, Jalal SM, Juneau AL, et al. A novel three-color, clone-specific fluorescence in situ hybridization procedure for monoclonal gammopathies. Cancer Genet Cytogenet. 1998;101:7-11.
    • (1998) Cancer Genet Cytogenet , vol.101 , pp. 7-11
    • Ahmann, G.J.1    Jalal, S.M.2    Juneau, A.L.3
  • 11
    • 0033568514 scopus 로고    scopus 로고
    • 14q32 translocations and monosomy 13 observed in monoclonal gammopathy of undetermined significance delineate a multistep process for the oncogenesis of multiple myeloma
    • Intergroupe Francophone du Myelome
    • Avet-Loiseau H, Facon T, Daviet A, et al. 14q32 translocations and monosomy 13 observed in monoclonal gammopathy of undetermined significance delineate a multistep process for the oncogenesis of multiple myeloma. Intergroupe Francophone du Myelome. Cancer Res. 1999;59:4546-4550.
    • (1999) Cancer Res , vol.59 , pp. 4546-4550
    • Avet-Loiseau, H.1    Facon, T.2    Daviet, A.3
  • 12
    • 0037085787 scopus 로고    scopus 로고
    • Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation
    • Avet-Loiseau H, Facon T, Grosbois B, et al. Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation. Blood. 2002;99:2185-2191.
    • (2002) Blood , vol.99 , pp. 2185-2191
    • Avet-Loiseau, H.1    Facon, T.2    Grosbois, B.3
  • 13
    • 0038142356 scopus 로고    scopus 로고
    • Clinical and biologic implications of recurrent genomic aberrations in myeloma
    • Fonseca R, Blood E, Rue M, et al. Clinical and biologic implications of recurrent genomic aberrations in myeloma. Blood. 2003;101:4569-4575.
    • (2003) Blood , vol.101 , pp. 4569-4575
    • Fonseca, R.1    Blood, E.2    Rue, M.3
  • 14
    • 0037103287 scopus 로고    scopus 로고
    • Genomic abnormalities in monoclonal gammopathy of undetermined significance
    • Fonseca R, Bailey RJ, Ahmann GJ, et al. Genomic abnormalities in monoclonal gammopathy of undetermined significance. Blood. 2002;100:1417-1424.
    • (2002) Blood , vol.100 , pp. 1417-1424
    • Fonseca, R.1    Bailey, R.J.2    Ahmann, G.J.3
  • 16
    • 0036468246 scopus 로고    scopus 로고
    • Biological and prognostic significance of interphase fluorescence in situ hybridization detection of chromosome 13 abnormalities (deltal 3) in multiple myeloma: An Eastern Cooperative Oncology Group study
    • Fonseca R, Harrington D, Oken MM, et al. Biological and prognostic significance of interphase fluorescence in situ hybridization detection of chromosome 13 abnormalities (deltal 3) in multiple myeloma: an Eastern Cooperative Oncology Group study. Cancer Res. 2002;62:715-720.
    • (2002) Cancer Res , vol.62 , pp. 715-720
    • Fonseca, R.1    Harrington, D.2    Oken, M.M.3
  • 17
    • 0032402134 scopus 로고    scopus 로고
    • Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping
    • Sawyer JR, Lukacs JL, Munshi N, et al. Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping. Blood. 1998;92:4269-4278.
    • (1998) Blood , vol.92 , pp. 4269-4278
    • Sawyer, J.R.1    Lukacs, J.L.2    Munshi, N.3
  • 18
    • 0035133202 scopus 로고    scopus 로고
    • Multicolour spectral karyotyping identifies new translocations and a recurring pathway for chromosome loss in multiple myeloma
    • Sawyer JR, Lukacs JL, Thomas EL, et al. Multicolour spectral karyotyping identifies new translocations and a recurring pathway for chromosome loss in multiple myeloma. Br J Haematol. 2001;112:167-174.
    • (2001) Br J Haematol , vol.112 , pp. 167-174
    • Sawyer, J.R.1    Lukacs, J.L.2    Thomas, E.L.3
  • 19
    • 0030922231 scopus 로고    scopus 로고
    • Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma: Association with increased expression and activating mutations of fibroblast growth factor receptor 3
    • Chesi M, Nardini E, Brents LA, et al. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma: association with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genetics. 1997;16:260-264.
    • (1997) Nat Genetics , vol.16 , pp. 260-264
    • Chesi, M.1    Nardini, E.2    Brents, L.A.3
  • 20
    • 0032212243 scopus 로고    scopus 로고
    • The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts
    • Chesi M, Nardini E, Lim RSC, Smith KD, Kuehl WM, Bergsagel PL. The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts. Blood. 1998;92:3025-3034.
    • (1998) Blood , vol.92 , pp. 3025-3034
    • Chesi, M.1    Nardini, E.2    Lim, R.S.C.3    Smith, K.D.4    Kuehl, W.M.5    Bergsagel, P.L.6
  • 21
    • 0036014969 scopus 로고    scopus 로고
    • The enigma of ectopic expression of FGFR3 in multiple myeloma: A critical initiating event or just a target for mutational activation during tumor progression
    • Chesi M, Bergsagel PL, Kuehl WM. The enigma of ectopic expression of FGFR3 in multiple myeloma: a critical initiating event or just a target for mutational activation during tumor progression. Curr Opin Hematol. 2002;9:288-293.
    • (2002) Curr Opin Hematol , vol.9 , pp. 288-293
    • Chesi, M.1    Bergsagel, P.L.2    Kuehl, W.M.3
  • 22
    • 0037441747 scopus 로고    scopus 로고
    • In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression
    • Keats JJ, Reiman T, Maxwell CA, et al. In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression. Blood. 2003;101:1520-1529.
    • (2003) Blood , vol.101 , pp. 1520-1529
    • Keats, J.J.1    Reiman, T.2    Maxwell, C.A.3
  • 23
    • 0037443417 scopus 로고    scopus 로고
    • A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript
    • Santra M, Zhan F, Tian E, Barlogie B, Shaughnessy J Jr. A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript. Blood. 2003;101:2374-2376.
    • (2003) Blood , vol.101 , pp. 2374-2376
    • Santra, M.1    Zhan, F.2    Tian, E.3    Barlogie, B.4    Shaughnessy Jr., J.5
  • 24
    • 0036721371 scopus 로고    scopus 로고
    • Recurrent 14q32 translocations determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapy
    • Moreau P, Facon T, Leleu X, et al. Recurrent 14q32 translocations determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapy. Blood. 2002;100:1579-1583.
    • (2002) Blood , vol.100 , pp. 1579-1583
    • Moreau, P.1    Facon, T.2    Leleu, X.3
  • 25
    • 0035892119 scopus 로고    scopus 로고
    • Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors
    • Avet-Loiseau H, Gerson F, Magrangeas F, Minvielle S, Harousseau JL, Bataille R. Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors. Blood. 2001;98:3082-3086.
    • (2001) Blood , vol.98 , pp. 3082-3086
    • Avet-Loiseau, H.1    Gerson, F.2    Magrangeas, F.3    Minvielle, S.4    Harousseau, J.L.5    Bataille, R.6
  • 26
    • 0034602691 scopus 로고    scopus 로고
    • Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma
    • Shou Y, Martelli ML, Gabrea A, et al. Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma. Proc Natl Acad Sci U S A. 2000;97:228-233.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 228-233
    • Shou, Y.1    Martelli, M.L.2    Gabrea, A.3
  • 27
    • 0038675193 scopus 로고    scopus 로고
    • Critical roles for immunoglobulin translocations and cyclin D dysregulation in multiple myeloma
    • Bergsagel PL, Kuehl WM. Critical roles for immunoglobulin translocations and cyclin D dysregulation in multiple myeloma. Immunol Rev. 2003;194:96-104.
    • (2003) Immunol Rev , vol.194 , pp. 96-104
    • Bergsagel, P.L.1    Kuehl, W.M.2
  • 28
    • 0037103205 scopus 로고    scopus 로고
    • Generation of polyclonal plasmablasts from peripheral blood B cells: A normal counterpart of malignant plasmablasts
    • Tarte K, De Vos J, Thykjaer T, et al. Generation of polyclonal plasmablasts from peripheral blood B cells: a normal counterpart of malignant plasmablasts. Blood. 2002;100:1113-1122.
    • (2002) Blood , vol.100 , pp. 1113-1122
    • Tarte, K.1    De Vos, J.2    Thykjaer, T.3
  • 29
    • 0036493522 scopus 로고    scopus 로고
    • Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells
    • Zhan F, Hardin J, Kordsmeier B, et al. Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells. Blood. 2002;99:1745-1757.
    • (2002) Blood , vol.99 , pp. 1745-1757
    • Zhan, F.1    Hardin, J.2    Kordsmeier, B.3
  • 30
    • 0035412392 scopus 로고    scopus 로고
    • Cyclin D3 at 6p21 is dysregulated by recurrent chromosomal translocations to immunoglobulin loci in multiple myeloma
    • Shaughnessy J Jr, Gabrea A, Qi Y, et al. Cyclin D3 at 6p21 is dysregulated by recurrent chromosomal translocations to immunoglobulin loci in multiple myeloma. Blood. 2001;98:217-223.
    • (2001) Blood , vol.98 , pp. 217-223
    • Shaughnessy Jr., J.1    Gabrea, A.2    Qi, Y.3
  • 31
  • 32
    • 0141993685 scopus 로고    scopus 로고
    • Further cytogenetic characterization of multiple myeloma confirms that 14q32 translocations are a very rare event in hyperdiploid cases
    • Smadja NV, Leroux D, Soulier J, et al. Further cytogenetic characterization of multiple myeloma confirms that 14q32 translocations are a very rare event in hyperdiploid cases. Genes Chromosomes Cancer. 2003;38:234-239.
    • (2003) Genes Chromosomes Cancer , vol.38 , pp. 234-239
    • Smadja, N.V.1    Leroux, D.2    Soulier, J.3
  • 33
    • 0141481984 scopus 로고    scopus 로고
    • The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma
    • Fonseca R, Debes-Marun CS, Picken EB, et al. The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma. Blood. 2003;102:2562-2567.
    • (2003) Blood , vol.102 , pp. 2562-2567
    • Fonseca, R.1    Debes-Marun, C.S.2    Picken, E.B.3
  • 34
    • 0030694727 scopus 로고    scopus 로고
    • INK4A expression in multiple myeloma and plasma cell leukemia
    • INK4A expression in multiple myeloma and plasma cell leukemia. Clin Cancer Res. 1997;3:2173-2179.
    • (1997) Clin Cancer Res , vol.3 , pp. 2173-2179
    • Urashima, M.1    Teoh, G.2    Ogata, A.3
  • 35
    • 0035412365 scopus 로고    scopus 로고
    • p16(INK4a) and p15(INK4b) gene methylations in plasma cells from monoclonal gammopathy of undetermined significance
    • Guillerm G, Gyan E, Wolowiec D, et al. p16(INK4a) and p15(INK4b) gene methylations in plasma cells from monoclonal gammopathy of undetermined significance. Blood. 2001;98:244-246.
    • (2001) Blood , vol.98 , pp. 244-246
    • Guillerm, G.1    Gyan, E.2    Wolowiec, D.3
  • 36
    • 0034876702 scopus 로고    scopus 로고
    • High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis
    • Bezieau S, Devilder MC, Avet-Loiseau H, et al. High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis. Hum Mut. 2001;18:212-224.
    • (2001) Hum Mut , vol.18 , pp. 212-224
    • Bezieau, S.1    Devilder, M.C.2    Avet-Loiseau, H.3
  • 37
    • 0029819604 scopus 로고    scopus 로고
    • Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: Analysis of the Eastern Cooperative Oncology Group Phase III Trial
    • Liu P, Leong T, Quam L, et al. Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial. Blood. 1996;88:2699-2706.
    • (1996) Blood , vol.88 , pp. 2699-2706
    • Liu, P.1    Leong, T.2    Quam, L.3
  • 38
    • 24444435070 scopus 로고    scopus 로고
    • Implication of N-ras and K-ras mutation in clinical outcome and biology of multiple myeloma
    • Fonseaca R, Price-Troska T, Blood E, et al. Implication of N-ras and K-ras mutation in clinical outcome and biology of multiple myeloma [abstract]. Blood. 2003;102:113a.
    • (2003) Blood , vol.102
    • Fonseaca, R.1    Price-Troska, T.2    Blood, E.3
  • 39
    • 0032147210 scopus 로고    scopus 로고
    • Presence of a p53 gene deletion in patients with multiple myeloma predicts for short survival after conventional-dose chemotherapy
    • Drach J, Ackermann J, Fritz E, et al. Presence of a p53 gene deletion in patients with multiple myeloma predicts for short survival after conventional-dose chemotherapy. Blood. 1998;92:802-809.
    • (1998) Blood , vol.92 , pp. 802-809
    • Drach, J.1    Ackermann, J.2    Fritz, E.3
  • 41
    • 85009921564 scopus 로고    scopus 로고
    • Frequent inactivation of the cyclin-dependent kinase inhibitor p18 by homozygous deletion in multiple myeloma cell lines: Ectopic p18 expression inhibits growth and induces apoptosis
    • Kulkarni MS, Daggett JL, Bender TP, Kuehl WM, Bergsagel PL, Williams ME. Frequent inactivation of the cyclin-dependent kinase inhibitor p18 by homozygous deletion in multiple myeloma cell lines: ectopic p18 expression inhibits growth and induces apoptosis. Leukemia. 2002;16:127-134.
    • (2002) Leukemia , vol.16 , pp. 127-134
    • Kulkarni, M.S.1    Daggett, J.L.2    Bender, T.P.3    Kuehl, W.M.4    Bergsagel, P.L.5    Williams, M.E.6
  • 42
    • 0034669945 scopus 로고    scopus 로고
    • Loss of PTEN expression leading to high Akt activation in human multiple myelomas
    • Hyun T, Yam A, Pece S, et al. Loss of PTEN expression leading to high Akt activation in human multiple myelomas. Blood. 2000;96:3560-3568.
    • (2000) Blood , vol.96 , pp. 3560-3568
    • Hyun, T.1    Yam, A.2    Pece, S.3
  • 43
    • 0034710535 scopus 로고    scopus 로고
    • Expression of PTEN in PTEN-deficient multiple myeloma cells abolishes tumor growth in vivo
    • Ge NL, Rudikoff S. Expression of PTEN in PTEN-deficient multiple myeloma cells abolishes tumor growth in vivo. Oncogene. 2000;19:4091-4095.
    • (2000) Oncogene , vol.19 , pp. 4091-4095
    • Ge, N.L.1    Rudikoff, S.2
  • 44
    • 1442285889 scopus 로고    scopus 로고
    • Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma
    • Hurt EM, Wiestner A, Rosenwald A, et al. Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma. Cancer Cell. 2004;5:191-199.
    • (2004) Cancer Cell , vol.5 , pp. 191-199
    • Hurt, E.M.1    Wiestner, A.2    Rosenwald, A.3
  • 45
    • 0038495926 scopus 로고    scopus 로고
    • Continuous absence of metaphase-defined cytogenetic abnormalities, especially of chromosome 13 and hypodiploidy, ensures long-term survival in multiple myeloma treated with Total Therapy I: Interpretation in the context of global gene expression
    • Shaughnessy J, Jacobson J, Sawyer J, et al. Continuous absence of metaphase-defined cytogenetic abnormalities, especially of chromosome 13 and hypodiploidy, ensures long-term survival in multiple myeloma treated with Total Therapy I: interpretation in the context of global gene expression. Blood. 2003;101:3849-3856.
    • (2003) Blood , vol.101 , pp. 3849-3856
    • Shaughnessy, J.1    Jacobson, J.2    Sawyer, J.3
  • 46
    • 0042943201 scopus 로고    scopus 로고
    • Cyclin D1 overexpression is a favorable prognostic variable for newly diagnosed multiple myeloma patients treated with high-dose chemotherapy and single or double autologous transplantation
    • Soverini S, Cavo M, Cellini C, et al. Cyclin D1 overexpression is a favorable prognostic variable for newly diagnosed multiple myeloma patients treated with high-dose chemotherapy and single or double autologous transplantation. Blood. 2003;102:1588-1594.
    • (2003) Blood , vol.102 , pp. 1588-1594
    • Soverini, S.1    Cavo, M.2    Cellini, C.3
  • 47
    • 0142151221 scopus 로고    scopus 로고
    • t(11;14) and t(4;14) translocations correlated with mature lymphoplasmacytoid and immature morphology, respectively, in multiple myeloma
    • Garand R, Avet-Loiseau H, Accard F, Moreau P, Harousseau JL, Bataílle R. t(11;14) and t(4;14) translocations correlated with mature lymphoplasmacytoid and immature morphology, respectively, in multiple myeloma. Leukemia. 2003;17:2032-2035.
    • (2003) Leukemia , vol.17 , pp. 2032-2035
    • Garand, R.1    Avet-Loiseau, H.2    Accard, F.3    Moreau, P.4    Harousseau, J.L.5    Bataílle, R.6
  • 48
    • 0037441892 scopus 로고    scopus 로고
    • Translocation t(11;14)(q13;q32) is the hallmark of IgM, IgE, and nonsecretory multiple myeloma variants
    • Avet-Loiseau H, Garand R, Lode L, Harousseau JL, Bataille R. Translocation t(11;14)(q13;q32) is the hallmark of IgM, IgE, and nonsecretory multiple myeloma variants. Blood. 2003;101:1570-1571.
    • (2003) Blood , vol.101 , pp. 1570-1571
    • Avet-Loiseau, H.1    Garand, R.2    Lode, L.3    Harousseau, J.L.4    Bataille, R.5
  • 49
    • 0037092981 scopus 로고    scopus 로고
    • Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients
    • Fonseca R, Blood EA, Oken MM, et al. Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients. Blood. 2002;99:3735-3741.
    • (2002) Blood , vol.99 , pp. 3735-3741
    • Fonseca, R.1    Blood, E.A.2    Oken, M.M.3
  • 50
    • 0035754080 scopus 로고    scopus 로고
    • To cycle or not to cycle: A critical decision in cancer
    • Malumbres M, Barbacid M. To cycle or not to cycle: a critical decision in cancer. Nat Rev Cancer. 2001;1:222-231.
    • (2001) Nat Rev Cancer , vol.1 , pp. 222-231
    • Malumbres, M.1    Barbacid, M.2
  • 51
    • 0037276902 scopus 로고    scopus 로고
    • The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells
    • Zhu WG, Otterson GA. The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells. Curr Med Chem Anti-Canc Agents. 2003;3:187-199.
    • (2003) Curr Med Chem Anti-Canc Agents , vol.3 , pp. 187-199
    • Zhu, W.G.1    Otterson, G.A.2
  • 52
    • 0034467556 scopus 로고    scopus 로고
    • Post-translational modifications of eukaryotic initiation factor-5A (elF-5A) as a new target for anti-cancer therapy
    • Caraglia M, Tagliaferri P, Budillon A, Abbruzzese A. Post-translational modifications of eukaryotic initiation factor-5A (elF-5A) as a new target for anti-cancer therapy. Adv Exp Med Biol. 1999;472:187-198.
    • (1999) Adv Exp Med Biol , vol.472 , pp. 187-198
    • Caraglia, M.1    Tagliaferri, P.2    Budillon, A.3    Abbruzzese, A.4
  • 53
    • 0343851156 scopus 로고    scopus 로고
    • Inhibition of translation initiation mediates the anticancer effect of the n-3 polyunsaturated fatty acid eicosapentaenoic acid
    • Palakurthi SS, Fluckiger R, Aktas H, et al. Inhibition of translation initiation mediates the anticancer effect of the n-3 polyunsaturated fatty acid eicosapentaenoic acid. Cancer Res. 2000;60:2919-2925.
    • (2000) Cancer Res , vol.60 , pp. 2919-2925
    • Palakurthi, S.S.1    Fluckiger, R.2    Aktas, H.3
  • 55
    • 0042858146 scopus 로고    scopus 로고
    • Regulation of cell proliferation by autocrine motility factor/phosphoglucose isomerase signaling
    • Tsutsumi S, Yanagawa T, Shimura T, et al. Regulation of cell proliferation by autocrine motility factor/phosphoglucose isomerase signaling. J Biol Chem. 2003;278:32165-32172.
    • (2003) J Biol Chem , vol.278 , pp. 32165-32172
    • Tsutsumi, S.1    Yanagawa, T.2    Shimura, T.3
  • 56
    • 0001510491 scopus 로고    scopus 로고
    • The RB p53 pathways in cancer
    • Sherr CJ, McCormick F. The RB and p53 pathways in cancer. Cancer Cell. 2002;2:103-112.
    • (2002) Cancer Cell , vol.2 , pp. 103-112
    • Sherr, C.J.1    McCormick, F.2
  • 57
    • 1942456800 scopus 로고    scopus 로고
    • Inhibition of fibroblast growth factor 3 induces differentiation and apoptosis in t(4;14) myeloma
    • Prepublished on January 8, as DOI 10.1182/blood-2003-10-3650
    • Trudel S, Ely SA, Farooqi Y, et al. Inhibition of fibroblast growth factor 3 induces differentiation and apoptosis in t(4;14) myeloma. Blood. Prepublished on January 8, 2004, as DOI 10.1182/blood-2003-10-3650. (Now available as Blood. 2004;103:3521-3528.)
    • (2004) Blood
    • Trudel, S.1    Ely, S.A.2    Farooqi, Y.3
  • 58
    • 1942456800 scopus 로고    scopus 로고
    • Now available as
    • Trudel S, Ely SA, Farooqi Y, et al. Inhibition of fibroblast growth factor 3 induces differentiation and apoptosis in t(4;14) myeloma. Blood. Prepublished on January 8, 2004, as DOI 10.1182/blood-2003-10-3650. (Now available as Blood. 2004;103:3521-3528.)
    • (2004) Blood , vol.103 , pp. 3521-3528
  • 59
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteotytic lesions in multiple myeloma
    • Tian E, Zhan F, Walker R, et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteotytic lesions in multiple myeloma. N Engl J Med. 2003;349:2483-2494.
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3
  • 60
    • 0035869257 scopus 로고    scopus 로고
    • Chromosome 13 abnormalities identified by FISH analysis and serum beta2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy
    • Facon T, Avet-Loiseau H, Guillerm G, et al. Chromosome 13 abnormalities identified by FISH analysis and serum beta2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy. Blood. 2001;97:1566-1571.
    • (2001) Blood , vol.97 , pp. 1566-1571
    • Facon, T.1    Avet-Loiseau, H.2    Guillerm, G.3
  • 61
    • 0035921689 scopus 로고    scopus 로고
    • Biologic sequelae of interteukin-6 induced P13-K/Akt signaling in multiple myeloma
    • Hideshima T, Nakamura N, Chauhan D, Anderson KC. Biologic sequelae of interteukin-6 induced P13-K/Akt signaling in multiple myeloma. Oncogene. 2001;20:5991-6000.
    • (2001) Oncogene , vol.20 , pp. 5991-6000
    • Hideshima, T.1    Nakamura, N.2    Chauhan, D.3    Anderson, K.C.4
  • 62
    • 0032533225 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
    • Diehl JA, Cheng M, Roussel MF, Sherr, CJ. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 1998;12:3499-3511.
    • (1998) Genes Dev , vol.12 , pp. 3499-3511
    • Diehl, J.A.1    Cheng, M.2    Roussel, M.F.3    Sherr, C.J.4
  • 63
    • 0032588170 scopus 로고    scopus 로고
    • NF-kappaB function in growth control: Regulation of cyclin D1 expression and GO/G1-to-S-phase transition
    • Hinz M, Krappmann D, Eichten A, Heder A, Scheidereit C, Strauss M. NF-kappaB function in growth control: regulation of cyclin D1 expression and GO/G1-to-S-phase transition. Mol Cell Biol. 1999;19:2690-2698.
    • (1999) Mol Cell Biol , vol.19 , pp. 2690-2698
    • Hinz, M.1    Krappmann, D.2    Eichten, A.3    Heder, A.4    Scheidereit, C.5    Strauss, M.6
  • 64
    • 0032588186 scopus 로고    scopus 로고
    • NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1
    • Guttridge DC, Albanese C, Reuther JY, Pestell RG, Baldwin AS Jr. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol. 1999;19:5785-5799.
    • (1999) Mol Cell Biol , vol.19 , pp. 5785-5799
    • Guttridge, D.C.1    Albanese, C.2    Reuther, J.Y.3    Pestell, R.G.4    Baldwin Jr., A.S.5
  • 65
    • 0030889389 scopus 로고    scopus 로고
    • Interaction of tumor and host cells with adhesion and extracellular matrix molecules in the development of multiple myeloma
    • Teoh G, Anderson KC. Interaction of tumor and host cells with adhesion and extracellular matrix molecules in the development of multiple myeloma. Hematol Oncol Clin North Am. 1997;11:27-42.
    • (1997) Hematol Oncol Clin North Am , vol.11 , pp. 27-42
    • Teoh, G.1    Anderson, K.C.2
  • 66
    • 0033105537 scopus 로고    scopus 로고
    • Cell adhesion mediated drug resistance (CAM-DR): Role of integrins and resistance to apoptosis in human myeloma cell lines
    • Damiano JS, Cress AE, Hazlehurst LA, Shtil AA, Dalton WS. Cell adhesion mediated drug resistance (CAM-DR): Role of integrins and resistance to apoptosis in human myeloma cell lines. Blood. 1999;93:1658-1667.
    • (1999) Blood , vol.93 , pp. 1658-1667
    • Damiano, J.S.1    Cress, A.E.2    Hazlehurst, L.A.3    Shtil, A.A.4    Dalton, W.S.5
  • 67
    • 0034618384 scopus 로고    scopus 로고
    • Adhesion to fibronectin via betal integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAMDR)
    • Hazlehurst LA, Damiano JS, Buyuksal I, Pledger WJ, Dalton WS. Adhesion to fibronectin via betal integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAMDR). Oncogene. 2000;19:4319-4327.
    • (2000) Oncogene , vol.19 , pp. 4319-4327
    • Hazlehurst, L.A.1    Damiano, J.S.2    Buyuksal, I.3    Pledger, W.J.4    Dalton, W.S.5
  • 68
    • 10744227500 scopus 로고    scopus 로고
    • Genotypic and phenotypic comparisons of de novo and acquired melphalan resistance in an isogenic multiple myeloma cell line model
    • Hazlehurst LA, Enkemann SA, Beam CA, et al. Genotypic and phenotypic comparisons of de novo and acquired melphalan resistance in an isogenic multiple myeloma cell line model. Cancer Res. 2003;63:7900-7906.
    • (2003) Cancer Res , vol.63 , pp. 7900-7906
    • Hazlehurst, L.A.1    Enkemann, S.A.2    Beam, C.A.3
  • 70
    • 0030864876 scopus 로고    scopus 로고
    • Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism
    • Chauhan D, Pandey P, Ogata A, et al. Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism. Oncogene. 1997;15:837-843.
    • (1997) Oncogene , vol.15 , pp. 837-843
    • Chauhan, D.1    Pandey, P.2    Ogata, A.3
  • 71
    • 0031029911 scopus 로고    scopus 로고
    • Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells
    • Chauhan D, Kharbanda S, Ogata A, et al. Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells. Blood. 1997;89:227-234.
    • (1997) Blood , vol.89 , pp. 227-234
    • Chauhan, D.1    Kharbanda, S.2    Ogata, A.3
  • 72
    • 0034548453 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase/AKT kinase pathway in multiple myeloma plasma cells: Roles in cytokine-dependent survival and proliferative responses
    • Tu Y, Gardner A, Lichtenstein A. The phosphatidylinositol 3-kinase/AKT kinase pathway in multiple myeloma plasma cells: roles in cytokine-dependent survival and proliferative responses. Cancer Res. 2000;60:6763-6770.
    • (2000) Cancer Res , vol.60 , pp. 6763-6770
    • Tu, Y.1    Gardner, A.2    Lichtenstein, A.3
  • 73
    • 0037484893 scopus 로고    scopus 로고
    • The IGF/IGF-1R system is a major therapeutic target for multiple myeloma, other hematologic malignancies and solid tumors
    • Mitsiades CS, Mitsiades N, Kung AL, et al, The IGF/IGF-1R system is a major therapeutic target for multiple myeloma, other hematologic malignancies and solid tumors [abstract]. Blood. 2002;100;170a.
    • (2002) Blood , vol.100
    • Mitsiades, C.S.1    Mitsiades, N.2    Kung, A.L.3
  • 74
    • 0036884062 scopus 로고    scopus 로고
    • Molecular mechanisms of novel therapeutic approaches for multiple myeloma
    • Hideshima T, Anderson KC. Molecular mechanisms of novel therapeutic approaches for multiple myeloma. Nat Rev Cancer. 2002;2:927-937.
    • (2002) Nat Rev Cancer , vol.2 , pp. 927-937
    • Hideshima, T.1    Anderson, K.C.2
  • 75
    • 0032523191 scopus 로고    scopus 로고
    • Syndecan-1 is a multifunctional regulator of myeloma pathobiology: Control of tumor cell survival, growth, and bone cell differentiation
    • Dhodapkar MV, Abe E, Theus A, et al. Syndecan-1 is a multifunctional regulator of myeloma pathobiology: control of tumor cell survival, growth, and bone cell differentiation. Blood. 1998;91:2679-2688.
    • (1998) Blood , vol.91 , pp. 2679-2688
    • Dhodapkar, M.V.1    Abe, E.2    Theus, A.3
  • 77
    • 0030041147 scopus 로고    scopus 로고
    • Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kB
    • Chauhan D, Uchiyama H, Akbarali Y, et al. Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kB. Blood. 1996;87:1104-1112.
    • (1996) Blood , vol.87 , pp. 1104-1112
    • Chauhan, D.1    Uchiyama, H.2    Akbarali, Y.3
  • 78
    • 0035300479 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
    • Hideshima T, Richardson P, Chauhan D, et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells, Cancer Res. 2001;61:3071-3076.
    • (2001) Cancer Res , vol.61 , pp. 3071-3076
    • Hideshima, T.1    Richardson, P.2    Chauhan, D.3
  • 79
    • 18544367201 scopus 로고    scopus 로고
    • NF-kB as a therapeutic target in multiple myeloma
    • Hideshima T, Chauhan D, Richardson P, et al. NF-kB as a therapeutic target in multiple myeloma. J Biol Chem. 2002;277:16639-16647.
    • (2002) J Biol Chem , vol.277 , pp. 16639-16647
    • Hideshima, T.1    Chauhan, D.2    Richardson, P.3
  • 80
    • 0035958517 scopus 로고    scopus 로고
    • Role of TNF-a in the pathophysiology of human multiple myeloma: Therapeutic applications
    • Hideshima T, Chauhan D, Schlossman RL, Richardson PR, Anderson KC. Role of TNF-a in the pathophysiology of human multiple myeloma: therapeutic applications. Oncogene. 2001;20:4519-4527.
    • (2001) Oncogene , vol.20 , pp. 4519-4527
    • Hideshima, T.1    Chauhan, D.2    Schlossman, R.L.3    Richardson, P.R.4    Anderson, K.C.5
  • 81
    • 0030026437 scopus 로고    scopus 로고
    • Transforming growth factor bl: Differential effects on multiple myeloma versus normal B cells
    • Urashima M, Ogata A, Chauhan D, et al. Transforming growth factor bl: Differential effects on multiple myeloma versus normal B cells. Blood. 1996;87:1928-1938.
    • (1996) Blood , vol.87 , pp. 1928-1938
    • Urashima, M.1    Ogata, A.2    Chauhan, D.3
  • 82
    • 0034655957 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma
    • Dankar B, Padro T, Leo R, et al. Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma. Blood. 2000;95:2630-2636.
    • (2000) Blood , vol.95 , pp. 2630-2636
    • Dankar, B.1    Padro, T.2    Leo, R.3
  • 83
    • 0030746359 scopus 로고    scopus 로고
    • The development of a model for the homing of multiple myeloma cells to human bone marrow
    • Urashima M, Chen BP, Chen S, et al. The development of a model for the homing of multiple myeloma cells to human bone marrow. Blood. 1997;90:754-765.
    • (1997) Blood , vol.90 , pp. 754-765
    • Urashima, M.1    Chen, B.P.2    Chen, S.3
  • 84
    • 0032532608 scopus 로고    scopus 로고
    • Primary myeloma cells growting in SCID-hu mice: A model for studying the biology and treatment of myeloma and its manifestations
    • Yaccoby S, Barlogie B, Epstein J. Primary myeloma cells growting in SCID-hu mice: a model for studying the biology and treatment of myeloma and its manifestations. Blood. 1998;92:2908-2913.
    • (1998) Blood , vol.92 , pp. 2908-2913
    • Yaccoby, S.1    Barlogie, B.2    Epstein, J.3
  • 86
    • 24444477113 scopus 로고    scopus 로고
    • In vitro and in vivo molecular profiling of multiple myeloma (MM) cell interaction with bone marrow (BM) microenvironment: Insight into the role of novel anti-MM agents in counteracting BM-mediated drug-resistance in MM [abstract]
    • Mitsiades CS, Mitsiades N, McMullan CJ, et al. In vitro and in vivo molecular profiling of multiple myeloma (MM) cell interaction with bone marrow (BM) microenvironment: insight into the role of novel anti-MM agents in counteracting BM-mediated drug-resistance in MM [abstract]. Blood. 2003;102:441a.
    • (2003) Blood , vol.102
    • Mitsiades, C.S.1    Mitsiades, N.2    McMullan, C.J.3
  • 87
    • 0142188727 scopus 로고    scopus 로고
    • Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: Biologic and clinical implications
    • Mitsiades CS, Mitsiades NS, Bronson RT, et al. Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: biologic and clinical implications. Cancer Res. 2003;63:6689-6696.
    • (2003) Cancer Res , vol.63 , pp. 6689-6696
    • Mitsiades, C.S.1    Mitsiades, N.S.2    Bronson, R.T.3
  • 89
    • 0030004658 scopus 로고    scopus 로고
    • Constituents of autocrine IL-6 loops in myeloma cell lines and their targeting for suppression of neoplastic growth by antibody strategies
    • Villunger A, Egle A, Kos M, Hittmair A, Maly K, Greil R. Constituents of autocrine IL-6 loops in myeloma cell lines and their targeting for suppression of neoplastic growth by antibody strategies. Int J Cancer. 1996;65:498-505.
    • (1996) Int J Cancer , vol.65 , pp. 498-505
    • Villunger, A.1    Egle, A.2    Kos, M.3    Hittmair, A.4    Maly, K.5    Greil, R.6
  • 90
    • 0024503249 scopus 로고
    • Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6
    • Klein B, Zhang XG, Jourdan M, et al. Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. Blood. 1989;73:517-526.
    • (1989) Blood , vol.73 , pp. 517-526
    • Klein, B.1    Zhang, X.G.2    Jourdan, M.3
  • 91
    • 0028267592 scopus 로고
    • High levels of interleukin-6 are associated with low tumor burden and low growth fraction in multiple myelorna
    • Ballester OF, Moscinski LC, Lyman GH, et al. High levels of interleukin-6 are associated with low tumor burden and low growth fraction in multiple myelorna. Blood. 1994;83:1903-1908.
    • (1994) Blood , vol.83 , pp. 1903-1908
    • Ballester, O.F.1    Moscinski, L.C.2    Lyman, G.H.3
  • 93
    • 0035195019 scopus 로고    scopus 로고
    • Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: Therapeutic applications
    • Gupta D, Treon SP, Shima Y, et al. Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications. Leukemia. 2001;15:1950-1961.
    • (2001) Leukemia , vol.15 , pp. 1950-1961
    • Gupta, D.1    Treon, S.P.2    Shima, Y.3
  • 94
    • 0037085809 scopus 로고    scopus 로고
    • Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6
    • Ishikawa H, Tsuyama N, Abroun S, et al. Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6. Blood. 2002;15:2172-2178.
    • (2002) Blood , vol.15 , pp. 2172-2178
    • Ishikawa, H.1    Tsuyama, N.2    Abroun, S.3
  • 95
    • 0038336720 scopus 로고    scopus 로고
    • A cellular model for myeloma cell growth and maturation based on an intraclonal CD45 hierarchy
    • Bataille R, Robillard N, Pellat-Deceunynck C, Amiot M. A cellular model for myeloma cell growth and maturation based on an intraclonal CD45 hierarchy. Immunol Rev. 2003;194:105-111.
    • (2003) Immunol Rev , vol.194 , pp. 105-111
    • Bataille, R.1    Robillard, N.2    Pellat-Deceunynck, C.3    Amiot, M.4
  • 96
    • 0024393839 scopus 로고
    • Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
    • Taga T, Hibi M, Hirata Y, et al. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell. 1989;58:573-581.
    • (1989) Cell , vol.58 , pp. 573-581
    • Taga, T.1    Hibi, M.2    Hirata, Y.3
  • 97
    • 0028344845 scopus 로고
    • Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130
    • Nishimoto N, Ogata A, Shima Y, et al. Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130, J Exp Med. 1994;179:1343-1347.
    • (1994) J Exp Med , vol.179 , pp. 1343-1347
    • Nishimoto, N.1    Ogata, A.2    Shima, Y.3
  • 98
    • 0029052318 scopus 로고
    • Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytekine signal transducer, and their association
    • Matsuda T, Fukada T, Takahashi-Tezuka M, et al. Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytekine signal transducer, and their association. J Biol Chem. 1995;270:11037-11039.
    • (1995) J Biol Chem , vol.270 , pp. 11037-11039
    • Matsuda, T.1    Fukada, T.2    Takahashi-Tezuka, M.3
  • 99
    • 0033083941 scopus 로고    scopus 로고
    • Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes
    • Kurth I, Horsten U, Pflanz S, et al. Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes. J Immunol. 1999;162:1480-1487.
    • (1999) J Immunol , vol.162 , pp. 1480-1487
    • Kurth, I.1    Horsten, U.2    Pflanz, S.3
  • 100
    • 0030049565 scopus 로고    scopus 로고
    • Interleukin-6 induces tyrosine phosphorylation of the Ras activating protein Shc, and its complex formation with Grb2 in the human multiple myeloma cell line LP-1
    • Neumann C, Zehentmaier G, Danhauser-Riedl S, Emmerich B, Hallek M. Interleukin-6 induces tyrosine phosphorylation of the Ras activating protein Shc, and its complex formation with Grb2 in the human multiple myeloma cell line LP-1. Eur J Immunol. 1996;26:379-384.
    • (1996) Eur J Immunol , vol.26 , pp. 379-384
    • Neumann, C.1    Zehentmaier, G.2    Danhauser-Riedl, S.3    Emmerich, B.4    Hallek, M.5
  • 101
    • 0031225483 scopus 로고    scopus 로고
    • Interleukin-6 triggers cell growth via the ras-dependent mitogen-activated protein kinase cascade
    • Ogata A, Chauhan D, Teoh G, et al. Interleukin-6 triggers cell growth via the ras-dependent mitogen-activated protein kinase cascade. J Immunol. 1997;159:2212-2221.
    • (1997) J Immunol , vol.159 , pp. 2212-2221
    • Ogata, A.1    Chauhan, D.2    Teoh, G.3
  • 102
    • 0032984589 scopus 로고    scopus 로고
    • Constitutive activation of STAT-3 signaling confers resistance to apoptosis in human U266 myeloma cells
    • Catlett-Falcone R, Landowski TH, Oshiro MM, et al. Constitutive activation of STAT-3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity. 1999;10:105-115.
    • (1999) Immunity , vol.10 , pp. 105-115
    • Catlett-Falcone, R.1    Landowski, T.H.2    Oshiro, M.M.3
  • 103
    • 0142078327 scopus 로고    scopus 로고
    • Effect of farnesyl transferase inhibitor R115777 on the growth of fresh and cloned myeloma cells in vitro
    • Ochiai N, Uchida R, Fuchida S, et al. Effect of farnesyl transferase inhibitor R115777 on the growth of fresh and cloned myeloma cells in vitro. Blood. 2003;102:3349-3353.
    • (2003) Blood , vol.102 , pp. 3349-3353
    • Ochiai, N.1    Uchida, R.2    Fuchida, S.3
  • 104
    • 0037372488 scopus 로고    scopus 로고
    • Efficacy of the farnesyl transferase inhibitor R 115777 in chronic myeloid leukemia and other hematologic malignancies
    • Cortes J, Albitar M, Thomas D, et al. Efficacy of the farnesyl transferase inhibitor R 115777 in chronic myeloid leukemia and other hematologic malignancies. Blood. 2003;101:1692-1697.
    • (2003) Blood , vol.101 , pp. 1692-1697
    • Cortes, J.1    Albitar, M.2    Thomas, D.3
  • 105
    • 0038281345 scopus 로고    scopus 로고
    • Downstream effectors of oncogenic ras in multiple myeloma cells
    • Hu L, Shi Y, Hsu JH, Gera J, Van Ness B, Lichtenstein A. Downstream effectors of oncogenic ras in multiple myeloma cells. Blood. 2003;101:3126-3135.
    • (2003) Blood , vol.101 , pp. 3126-3135
    • Hu, L.1    Shi, Y.2    Hsu, J.H.3    Gera, J.4    Van Ness, B.5    Lichtenstein, A.6
  • 106
    • 0032711250 scopus 로고    scopus 로고
    • IL-6 up-regulates mcl-1 in human myeloma cells through JAK/STAT rather than ras/MAP kinase pathway
    • Puthier D, Bataille R, Amiot M. IL-6 up-regulates mcl-1 in human myeloma cells through JAK/STAT rather than ras/MAP kinase pathway. Eur J Immunol. 1999;29:3945-3950.
    • (1999) Eur J Immunol , vol.29 , pp. 3945-3950
    • Puthier, D.1    Bataille, R.2    Amiot, M.3
  • 107
    • 0037085778 scopus 로고    scopus 로고
    • Myeloid cell factor-1 is a critical survival factor for multiple myeloma
    • Zhang B, Gojo I, Fenton RG. Myeloid cell factor-1 is a critical survival factor for multiple myeloma, Blood. 2002;99:1885-1893.
    • (2002) Blood , vol.99 , pp. 1885-1893
    • Zhang, B.1    Gojo, I.2    Fenton, R.G.3
  • 108
    • 0038021146 scopus 로고    scopus 로고
    • A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells
    • Jourdan M, Veyrune JL, Vos JD, Redal N, Couderc G, Klein B. A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells. Oncogene. 2003;22:2950-2959.
    • (2003) Oncogene , vol.22 , pp. 2950-2959
    • Jourdan, M.1    Veyrune, J.L.2    Vos, J.D.3    Redal, N.4    Couderc, G.5    Klein, B.6
  • 109
    • 0035678875 scopus 로고    scopus 로고
    • Inhibition of JAK kinase activity enhances Fasmediated apoptosis but reduces cytotoxic activity of topoisomerase II inhibitors in U266 myeloma cells
    • Oshiro MM, Landowski TH, Catlett-Falcone R, et al. Inhibition of JAK kinase activity enhances Fasmediated apoptosis but reduces cytotoxic activity of topoisomerase II inhibitors in U266 myeloma cells. Clin Cancer Res. 2001;7:4262-4271.
    • (2001) Clin Cancer Res , vol.7 , pp. 4262-4271
    • Oshiro, M.M.1    Landowski, T.H.2    Catlett-Falcone, R.3
  • 110
    • 0037468570 scopus 로고    scopus 로고
    • IL-6-independent expression of Mcl-1 in human multiple myeloma
    • Zhang B, Potyagayfo V, Fenton RG. IL-6-independent expression of Mcl-1 in human multiple myeloma. Oncogene. 2003;22:1848-1859.
    • (2003) Oncogene , vol.22 , pp. 1848-1859
    • Zhang, B.1    Potyagayfo, V.2    Fenton, R.G.3
  • 111
    • 0036659905 scopus 로고    scopus 로고
    • Antisense strategy shows that Mcl-1 rather than BcI-2 or BcI-x(L) is an essenfial survival protein of human myeloma cells
    • Derenne S, Monia B, Dean NM, et al. Antisense strategy shows that Mcl-1 rather than BcI-2 or BcI-x(L) is an essenfial survival protein of human myeloma cells. Blood. 2002;100:194-199.
    • (2002) Blood , vol.100 , pp. 194-199
    • Derenne, S.1    Monia, B.2    Dean, N.M.3
  • 112
    • 0036850211 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of McI-1
    • Gojo I, Zhang B, Fenton RG. The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of McI-1. Clin Cancer Res. 2002;8:3527-3538.
    • (2002) Clin Cancer Res , vol.8 , pp. 3527-3538
    • Gojo, I.1    Zhang, B.2    Fenton, R.G.3
  • 113
    • 0027960892 scopus 로고
    • Interleukin-6 prevents dexamethasone-induced myeloma cell death
    • Hardin J, Macleod S, Grigorieva I, et al. Interleukin-6 prevents dexamethasone-induced myeloma cell death. Blood. 1994;84:3063-3070.
    • (1994) Blood , vol.84 , pp. 3063-3070
    • Hardin, J.1    Macleod, S.2    Grigorieva, I.3
  • 114
    • 15144349717 scopus 로고    scopus 로고
    • Cytochrome-c dependent and independent induction of apoptosis in multiple myeloma cells
    • Chauhan D, Pandey P, Ogata A, et al. Cytochrome-c dependent and independent induction of apoptosis in multiple myeloma cells. J Biol Chem. 1997;272:29995-29997.
    • (1997) J Biol Chem , vol.272 , pp. 29995-29997
    • Chauhan, D.1    Pandey, P.2    Ogata, A.3
  • 115
    • 0035816553 scopus 로고    scopus 로고
    • Apaf-1/cytochrome c independent and Smac dependent induction of apoptosis in multiple myeloma cells
    • Chauhan D, Hideshima T, Rosen S, Reed JC, Kharbanda S, Anderson KC. Apaf-1/cytochrome c independent and Smac dependent induction of apoptosis in multiple myeloma cells. J Biol Chem. 2001;276:24453-24456.
    • (2001) J Biol Chem , vol.276 , pp. 24453-24456
    • Chauhan, D.1    Hideshima, T.2    Rosen, S.3    Reed, J.C.4    Kharbanda, S.5    Anderson, K.C.6
  • 116
    • 0032515027 scopus 로고    scopus 로고
    • Regulation of cell death protease caspase-9 by phosphorylation
    • Cardone MH, Roy N, Stennicke HR, et al. Regulation of cell death protease caspase-9 by phosphorylation. Science. 1998;282:1318-1321.
    • (1998) Science , vol.282 , pp. 1318-1321
    • Cardone, M.H.1    Roy, N.2    Stennicke, H.R.3
  • 117
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A, Bonni A, Zigmond MJ, et al, Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 1999;96:857-868.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3
  • 118
    • 18144438312 scopus 로고    scopus 로고
    • Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cells
    • Wen XY, Stewart AK, Sooknanan RR, et al. Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cells. Int J Oncol. 1999;15:173-178.
    • (1999) Int J Oncol , vol.15 , pp. 173-178
    • Wen, X.Y.1    Stewart, A.K.2    Sooknanan, R.R.3
  • 119
    • 0038542892 scopus 로고    scopus 로고
    • Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays
    • Chauhan D, Li G, Auclair D, et al. Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays. Blood, 2003;101:3606-3614.
    • (2003) Blood , vol.101 , pp. 3606-3614
    • Chauhan, D.1    Li, G.2    Auclair, D.3
  • 120
    • 0035913294 scopus 로고    scopus 로고
    • Plasma cell differentiation requires the transcription factor XBP-1
    • Reimold AM, Iwakoshi NN, Manis J, et al. Plasma cell differentiation requires the transcription factor XBP-1. Nature. 2001;412:300-307.
    • (2001) Nature , vol.412 , pp. 300-307
    • Reimold, A.M.1    Iwakoshi, N.N.2    Manis, J.3
  • 122
    • 0037458621 scopus 로고    scopus 로고
    • Essential role of caveolae in interleukin-6- and insulin-like growth factor 1-triggered Akt-1-mediated survival of multiple myeloma cells
    • Podar K, Tai YT, Cole CE, et al. Essential role of caveolae in interleukin-6- and insulin-like growth factor 1-triggered Akt-1-mediated survival of multiple myeloma cells. J Biol Chem. 2003;278:5794-5801.
    • (2003) J Biol Chem , vol.278 , pp. 5794-5801
    • Podar, K.1    Tai, Y.T.2    Cole, C.E.3
  • 124
    • 0029914360 scopus 로고    scopus 로고
    • Soluble interleukin-6 receptor (sIL-6R), a new prognostic factor in multiple myeloma
    • Kyrtsonis MC, Dedoussis G, Zervas C, et al. Soluble interleukin-6 receptor (sIL-6R), a new prognostic factor in multiple myeloma. Br J Haematol. 1996;93:398-400.
    • (1996) Br J Haematol , vol.93 , pp. 398-400
    • Kyrtsonis, M.C.1    Dedoussis, G.2    Zervas, C.3
  • 125
    • 0032525085 scopus 로고    scopus 로고
    • The prognostic value of soluble interleukin-6 receptor in patients with multiple myeloma
    • Stasi R, Brunetti M, Parma A, Di Giulio C, Terzoli E, Pagano A. The prognostic value of soluble interleukin-6 receptor in patients with multiple myeloma. Cancer. 1998;82:1860-1866.
    • (1998) Cancer , vol.82 , pp. 1860-1866
    • Stasi, R.1    Brunetti, M.2    Parma, A.3    Di Giulio, C.4    Terzoli, E.5    Pagano, A.6
  • 126
    • 0027893260 scopus 로고
    • A monoclonal anti-human IL-6 receptor antibody inhibits the proliferation of human myeloma cells
    • Huang YW, Vitetta ES. A monoclonal anti-human IL-6 receptor antibody inhibits the proliferation of human myeloma cells. Hybridoma. 1993;12:621-630.
    • (1993) Hybridoma , vol.12
    • Huang, Y.W.1    Vitetta, E.S.2
  • 127
    • 0028590077 scopus 로고
    • Rational design of a receptor super-antagonist of human interleukin-6
    • Savino R, Ciapponi L, Lahm A, et al. Rational design of a receptor super-antagonist of human interleukin-6. Embo J. 1994;13:5863-5870.
    • (1994) Embo J , vol.13 , pp. 5863-5870
    • Savino, R.1    Ciapponi, L.2    Lahm, A.3
  • 128
    • 0028900662 scopus 로고
    • Pharmacokinetic study of anti-interleukin-6 (IL-6) therapy with monoclonal antibodies: Enhancement of IL-6 clearance by cocktails of anti-IL-6 antibodies
    • Montero-Julian FA, Klein B, Gautherot E, Brailly H. Pharmacokinetic study of anti-interleukin-6 (IL-6) therapy with monoclonal antibodies: enhancement of IL-6 clearance by cocktails of anti-IL-6 antibodies. Blood. 1995;85:917-924.
    • (1995) Blood , vol.85 , pp. 917-924
    • Montero-Julian, F.A.1    Klein, B.2    Gautherot, E.3    Brailly, H.4
  • 129
    • 0028920301 scopus 로고
    • Effect of IL-6 receptor anti-sense oligodeoxynucleotide on in vitro proliferation of myeloma cells
    • Keller ET, Ershler WB. Effect of IL-6 receptor anti-sense oligodeoxynucleotide on in vitro proliferation of myeloma cells. J Immunol. 1995;154:4091-4098.
    • (1995) J Immunol , vol.154 , pp. 4091-4098
    • Keller, E.T.1    Ershler, W.B.2
  • 130
    • 0029812490 scopus 로고    scopus 로고
    • Interleukin-6 receptor superantagonists are potent inducers of human multiple myeloma cell death
    • Demartis A, Bernassola F, Savino R, Melins G, Ciliberto G. Interleukin-6 receptor superantagonists are potent inducers of human multiple myeloma cell death. Cancer Res. 1996;56:4213-4218.
    • (1996) Cancer Res , vol.56 , pp. 4213-4218
    • Demartis, A.1    Bernassola, F.2    Savino, R.3    Melins, G.4    Ciliberto, G.5
  • 131
    • 0034667606 scopus 로고    scopus 로고
    • Insulin-like growth factor I is a dual effector of multiple myeloma cell growth
    • Ge NL, Rudikoff S. Insulin-like growth factor I is a dual effector of multiple myeloma cell growth. Blood. 2000;96:2856-2861.
    • (2000) Blood , vol.96 , pp. 2856-2861
    • Ge, N.L.1    Rudikoff, S.2
  • 132
    • 0036625066 scopus 로고    scopus 로고
    • Insulinlike growth factor-I signaling in multiple myeloma: Downstream elements, functional correlates, and pathway cross-talk
    • Qiang YW, Kopantzev E, Rudikoff S. Insulinlike growth factor-I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk. Blood. 2002;99:4138-4146.
    • (2002) Blood , vol.99 , pp. 4138-4146
    • Qiang, Y.W.1    Kopantzev, E.2    Rudikoff, S.3
  • 133
    • 0037158513 scopus 로고    scopus 로고
    • Activation of NF-kB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: Therapeutic implications
    • Mitsiades CS, Mitsiades N, Poulaki V, et al. Activation of NF-kB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications, Oncogene. 2002;21:5673-5683.
    • (2002) Oncogene , vol.21 , pp. 5673-5683
    • Mitsiades, C.S.1    Mitsiades, N.2    Poulaki, V.3
  • 134
    • 0036645153 scopus 로고    scopus 로고
    • Cytokines modulate telomerase activity in a human multiple myeloma cell line
    • Akiyama M, Hideshima T, Hayashi T, et al. Cytokines modulate telomerase activity in a human multiple myeloma cell line. Cancer Res. 2002;62:3876-3882.
    • (2002) Cancer Res , vol.62 , pp. 3876-3882
    • Akiyama, M.1    Hideshima, T.2    Hayashi, T.3
  • 135
    • 0037207872 scopus 로고    scopus 로고
    • Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein
    • Akiyama M, Hideshima T, Hayashi T, et al. Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein. Cancer Res. 2003;63:18-21.
    • (2003) Cancer Res , vol.63 , pp. 18-21
    • Akiyama, M.1    Hideshima, T.2    Hayashi, T.3
  • 136
    • 0035210921 scopus 로고    scopus 로고
    • Angiogenesis in multiple myeloma
    • Rajkumar SV, Kyle RA. Angiogenesis in multiple myeloma. Semin Oncol. 2001;28:560-564.
    • (2001) Semin Oncol , vol.28 , pp. 560-564
    • Rajkumar, S.V.1    Kyle, R.A.2
  • 137
    • 0036066144 scopus 로고    scopus 로고
    • Proliferation, apoptosis, and intratumoral vascularity in multiple myeloma: Correlation with the clinical stage and cytological grade
    • Xu JL, Lai R, Kinoshita T, Nakashima N, Nagasaka T. Proliferation, apoptosis, and intratumoral vascularity in multiple myeloma: correlation with the clinical stage and cytological grade. J Clin Pathol. 2002;55:530-534.
    • (2002) J Clin Pathol , vol.55 , pp. 530-534
    • Xu, J.L.1    Lai, R.2    Kinoshita, T.3    Nakashima, N.4    Nagasaka, T.5
  • 138
    • 0037082449 scopus 로고    scopus 로고
    • CD40 activation induces p53-dependent vascular endotheliel growth factor secretion in human multiple myeloma cells
    • Tai YT, Podar K, Gupta D, et al. CD40 activation induces p53-dependent vascular endotheliel growth factor secretion in human multiple myeloma cells. Blood. 2002;99:1419-1427.
    • (2002) Blood , vol.99 , pp. 1419-1427
    • Tai, Y.T.1    Podar, K.2    Gupta, D.3
  • 139
    • 0035880256 scopus 로고    scopus 로고
    • Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration
    • Podar K, Tai YT, Davies FE, et al. Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration. Blood. 2001;98:428-435.
    • (2001) Blood , vol.98 , pp. 428-435
    • Podar, K.1    Tai, Y.T.2    Davies, F.E.3
  • 140
    • 18544377343 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin-and phosphatidylinositol 3-kinase-dependent PKC alpha activation
    • Podar K, Tai YT, Lin BK, et al. Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin-and phosphatidylinositol 3-kinase-dependent PKC alpha activation. J Biol Chem. 2002;277:7875-7881.
    • (2002) J Biol Chem , vol.277 , pp. 7875-7881
    • Podar, K.1    Tai, Y.T.2    Lin, B.K.3
  • 141
    • 0036731996 scopus 로고    scopus 로고
    • The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment
    • Lin B, Podar K, Gupta D, et al. The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment. Cancer Res. 2002;62:5019-5026.
    • (2002) Cancer Res , vol.62 , pp. 5019-5026
    • Lin, B.1    Podar, K.2    Gupta, D.3
  • 143
    • 11144354204 scopus 로고    scopus 로고
    • Now available as
    • Podar K, Catley LP, Tai YT, et al. GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment. Prepublished on November 26, 2003, as DOI 10.1182/ blood-2003-10-3527. (Now available as Blood. 2004;103:3474-3479.)
    • (2004) Blood , vol.103 , pp. 3474-3479
  • 144
    • 0023227925 scopus 로고
    • Production of lymphotoxin, a bone-resorbing cytokine, by cultured human myeloma cells
    • Garrett IR, Durie BG, Nedwin GE, et al. Production of lymphotoxin, a bone-resorbing cytokine, by cultured human myeloma cells. N Engl J Med. 1987;317:526-532.
    • (1987) N Engl J Med , vol.317 , pp. 526-532
    • Garrett, I.R.1    Durie, B.G.2    Nedwin, G.E.3
  • 145
    • 0024419152 scopus 로고
    • Production of cytokines by bone marrow cells obtained from patients with multiple myeloma
    • Lichtenstein A, Berenson D, Norman MP, Chang MP, Carlile A. Production of cytokines by bone marrow cells obtained from patients with multiple myeloma. Blood. 1989;74:1266-1273.
    • (1989) Blood , vol.74 , pp. 1266-1273
    • Lichtenstein, A.1    Berenson, D.2    Norman, M.P.3    Chang, M.P.4    Carlile, A.5
  • 146
    • 0030039882 scopus 로고    scopus 로고
    • Cytokines (IL-6, TNF-alpha, IL-1 alpha) and soluble interleukin-2 receptor as serum tumor markers in multiple myeloma
    • Filella X, Blade J, Guillermo AL, Molina R, Rozman C, Ballesta AM. Cytokines (IL-6, TNF-alpha, IL-1 alpha) and soluble interleukin-2 receptor as serum tumor markers in multiple myeloma. Cancer Detect Prev. 1996;20:52-56.
    • (1996) Cancer Detect Prev , vol.20 , pp. 52-56
    • Filella, X.1    Blade, J.2    Guillermo, A.L.3    Molina, R.4    Rozman, C.5    Ballesta, A.M.6
  • 147
    • 0033868516 scopus 로고    scopus 로고
    • High-producer haplotypes of tumor necrosis factor alpha and lymphotoxin alpha are associated with an increased risk of myeloma and have an improved progression-free survival after treatment
    • Davies FE, Rollinson SJ, Rawstron AC, et al. High-producer haplotypes of tumor necrosis factor alpha and lymphotoxin alpha are associated with an increased risk of myeloma and have an improved progression-free survival after treatment. J Clin Oncol. 2000;18:2843-2851.
    • (2000) J Clin Oncol , vol.18 , pp. 2843-2851
    • Davies, F.E.1    Rollinson, S.J.2    Rawstron, A.C.3
  • 148
    • 0034680899 scopus 로고    scopus 로고
    • Fas- and tumor necrosis factor-mediated apoptosis uses the same binding surface of FADD to trigger signal transduction. A typical model for convergent signal transduction
    • Bang S, Jeong EJ, Kim IK, Jung YK, Kim KS. Fas- and tumor necrosis factor-mediated apoptosis uses the same binding surface of FADD to trigger signal transduction. A typical model for convergent signal transduction. J Biol Chem. 2000;2000:36217-36222.
    • (2000) J Biol Chem , vol.2000 , pp. 36217-36222
    • Bang, S.1    Jeong, E.J.2    Kim, I.K.3    Jung, Y.K.4    Kim, K.S.5
  • 149
    • 0035896592 scopus 로고    scopus 로고
    • Pro-caspase-8 is predominantly localized in mitochondria and released into cytoplasm upon apoptotic stimulation
    • Qin ZH, Wang Y, Kikly KK, et al. Pro-caspase-8 is predominantly localized in mitochondria and released into cytoplasm upon apoptotic stimulation. J Biol Chem. 2001;276:8079-8086.
    • (2001) J Biol Chem , vol.276 , pp. 8079-8086
    • Qin, Z.H.1    Wang, Y.2    Kikly, K.K.3
  • 150
    • 0033557372 scopus 로고    scopus 로고
    • BcI-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-kappaB
    • Badrichani AZ, Stroka DM, Bilbao G, Curiel DT, Bach FH, Ferran C. BcI-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-kappaB. J Clin Invest. 1999;103:543-553.
    • (1999) J Clin Invest , vol.103 , pp. 543-553
    • Badrichani, A.Z.1    Stroka, D.M.2    Bilbao, G.3    Curiel, D.T.4    Bach, F.H.5    Ferran, C.6
  • 151
    • 0032827012 scopus 로고    scopus 로고
    • Induction of Bcl-x(L) expression by human T-cell leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax
    • Tsukahara T, Kannagi M, Ohashi T, et al. Induction of Bcl-x(L) expression by human T-cell leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax. J Virol. 1999;73:7981-7987.
    • (1999) J Virol , vol.73 , pp. 7981-7987
    • Tsukahara, T.1    Kannagi, M.2    Ohashi, T.3
  • 152
    • 0032490670 scopus 로고    scopus 로고
    • Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis
    • Stehlik C, de Martin R, Kumabashiri I, Schmid JA, Binder BR, Lipp J. Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis. J Exp Med. 1998;188:211-216.
    • (1998) J Exp Med , vol.188 , pp. 211-216
    • Stehlik, C.1    De Martin, R.2    Kumabashiri, I.3    Schmid, J.A.4    Binder, B.R.5    Lipp, J.6
  • 153
    • 0032508414 scopus 로고    scopus 로고
    • NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
    • Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS Jr. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science. 1998;281:1680-1683.
    • (1998) Science , vol.281 , pp. 1680-1683
    • Wang, C.Y.1    Mayo, M.W.2    Korneluk, R.G.3    Goeddel, D.V.4    Baldwin Jr., A.S.5
  • 154
    • 0033168605 scopus 로고    scopus 로고
    • Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-a
    • Corral LG, Haslett PAJ, Muller GW, et al. Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-a. J Immunol. 1999;163:380-386.
    • (1999) J Immunol , vol.163 , pp. 380-386
    • Corral, L.G.1    Haslett, P.A.J.2    Muller, G.W.3
  • 155
    • 0027950375 scopus 로고
    • CD40 expression in malignant plasma cells: Role in stimulation of autocrine IL-6 secretion by a human myeloma cell line
    • Westendorf J, Ahmann G, Armitage R, et al. CD40 expression in malignant plasma cells: Role in stimulation of autocrine IL-6 secretion by a human myeloma cell line. J Immunol. 1994;152:117-128.
    • (1994) J Immunol , vol.152 , pp. 117-128
    • Westendorf, J.1    Ahmann, G.2    Armitage, R.3
  • 156
    • 12944283267 scopus 로고    scopus 로고
    • CD40 activation mediates p53-dependent cell cycle regulation in human multiple myeloma cell lines
    • Teoh G, Tai YT, Urashima M, et al, CD40 activation mediates p53-dependent cell cycle regulation in human multiple myeloma cell lines. Blood. 2000;95:1039-1046.
    • (2000) Blood , vol.95 , pp. 1039-1046
    • Teoh, G.1    Tai, Y.T.2    Urashima, M.3
  • 157
    • 0038784379 scopus 로고    scopus 로고
    • CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling
    • Tai YT, Podar K, Mitsiades N, et al. CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling. Blood. 2003;101:2762-2769.
    • (2003) Blood , vol.101 , pp. 2762-2769
    • Tai, Y.T.1    Podar, K.2    Mitsiades, N.3
  • 158
    • 0036561859 scopus 로고    scopus 로고
    • The biological sequelae of stromal cell-derived factor-1 alpha in multiple myeloma
    • Hideshima T, Chauhan D, Hayashi T, et al. The biological sequelae of stromal cell-derived factor-1 alpha in multiple myeloma. Mol Cancer Ther. 2002;1:539-544.
    • (2002) Mol Cancer Ther , vol.1 , pp. 539-544
    • Hideshima, T.1    Chauhan, D.2    Hayashi, T.3
  • 159
    • 0035863789 scopus 로고    scopus 로고
    • Chemokine stromal cell-derived factor-1 alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1
    • Sanz-Rodriguez F, Hidalgo A, Teixido J. Chemokine stromal cell-derived factor-1 alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1. Blood. 2001;97:346-351.
    • (2001) Blood , vol.97 , pp. 346-351
    • Sanz-Rodriguez, F.1    Hidalgo, A.2    Teixido, J.3
  • 160
    • 24444476567 scopus 로고    scopus 로고
    • TGF-b receptor I kinase inhibitor downregulates cytokine secretion and multiple myeloma cell proliferation in the bone marrow microenvironment
    • Hayashi T, Hideshima T, Podar K, et al. TGF-b receptor I kinase inhibitor downregulates cytokine secretion and multiple myeloma cell proliferation in the bone marrow microenvironment [abstract]. Blood. 2003;102:388b.
    • (2003) Blood , vol.102
    • Hayashi, T.1    Hideshima, T.2    Podar, K.3
  • 162
    • 10744227618 scopus 로고    scopus 로고
    • Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival
    • Burger R, Bakker F, Guenther A, et al. Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival. Br J Haematol. 2003;123:869-878.
    • (2003) Br J Haematol , vol.123 , pp. 869-878
    • Burger, R.1    Bakker, F.2    Guenther, A.3
  • 163
    • 0027136189 scopus 로고
    • Soluble interteukin-6 receptor triggers osteoclast formation by interleukin 6
    • Tamura T, Udagawa N, Takahashi N, et al. Soluble interteukin-6 receptor triggers osteoclast formation by interleukin 6. Proc Natl Acad Sci U S A. 1993;90:11924-11928.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 11924-11928
    • Tamura, T.1    Udagawa, N.2    Takahashi, N.3
  • 164
    • 0035425227 scopus 로고    scopus 로고
    • Biology of osteoclast activation in cancer
    • Roodman GD. Biology of osteoclast activation in cancer. J Clin Oncol. 2001;19:3562-3571.
    • (2001) J Clin Oncol , vol.19 , pp. 3562-3571
    • Roodman, G.D.1
  • 165
    • 0037443533 scopus 로고    scopus 로고
    • RANK ligand and osteoprotegerin in myeloma bone disease
    • Sezer O, Heider U, Zavrski I, Kuhne CA, Hofbauer LC. RANK ligand and osteoprotegerin in myeloma bone disease. Blood. 2003;101:2094-2099.
    • (2003) Blood , vol.101 , pp. 2094-2099
    • Sezer, O.1    Heider, U.2    Zavrski, I.3    Kuhne, C.A.4    Hofbauer, L.C.5
  • 166
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature. 2003;423:337-342.
    • (2003) Nature , vol.423 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 167
    • 0141594593 scopus 로고    scopus 로고
    • Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury
    • Jaeschke H, Lemasters JJ. Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury. Gastroenterology. 2003;125:1246-1257.
    • (2003) Gastroenterology , vol.125 , pp. 1246-1257
    • Jaeschke, H.1    Lemasters, J.J.2
  • 168
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • Thornberry NA, Lazebnik Y. Caspases: enemies within. Science. 1998;281:1312-1318.
    • (1998) Science , vol.281 , pp. 1312-1318
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 169
    • 0041507093 scopus 로고    scopus 로고
    • Apoptotic signaling in multiple myeloma: Therapeutic implications
    • Chauhan D, Hideshima T, Anderson KC. Apoptotic signaling in multiple myeloma: therapeutic implications. Int J Hematol. 2003;78:114-120.
    • (2003) Int J Hematol , vol.78 , pp. 114-120
    • Chauhan, D.1    Hideshima, T.2    Anderson, K.C.3
  • 170
    • 0037097595 scopus 로고    scopus 로고
    • Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications
    • Mitsiades N, Mitsiades CS, Poulaki V, et al. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood. 2002;99:4525-4530.
    • (2002) Blood , vol.99 , pp. 4525-4530
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3
  • 171
    • 0035496921 scopus 로고    scopus 로고
    • Apo2L/TRAIL and BcI-2-related proteins regulate type I interferon-induced apoptosis in multiple myeloma
    • Chen Q, Gong B, Mahmoud-Ahmed AS, et al. Apo2L/TRAIL and BcI-2-related proteins regulate type I interferon-induced apoptosis in multiple myeloma. Blood. 2001;98:2183-2192.
    • (2001) Blood , vol.98 , pp. 2183-2192
    • Chen, Q.1    Gong, B.2    Mahmoud-Ahmed, A.S.3
  • 172
    • 0346996812 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondriai dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL
    • Dai Y, Dent P, Grant S. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondriai dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL. Mol Pharmacol. 2003;64:1402-1409.
    • (2003) Mol Pharmacol , vol.64 , pp. 1402-1409
    • Dai, Y.1    Dent, P.2    Grant, S.3
  • 173
    • 0037441760 scopus 로고    scopus 로고
    • Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341
    • Hideshima T, Mitsiades C, Akiyama M, et al. Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. Blood. 2003;101:1530-1534.
    • (2003) Blood , vol.101 , pp. 1530-1534
    • Hideshima, T.1    Mitsiades, C.2    Akiyama, M.3
  • 174
    • 0038719671 scopus 로고    scopus 로고
    • JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells
    • Chauhan D, Li G, Hideshima T, et al. JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells. J Biol Chem. 2003;278:17593-17596.
    • (2003) J Biol Chem , vol.278 , pp. 17593-17596
    • Chauhan, D.1    Li, G.2    Hideshima, T.3
  • 175
    • 10744221197 scopus 로고    scopus 로고
    • Antitumor activity of lysophosphatidic acid acyltransferase (LPAAT)-b inhibitors, a novel class of agents, in multiple myeloma
    • Hicleshima T, Chauhan D, Hayashi T, et al. Antitumor activity of lysophosphatidic acid acyltransferase (LPAAT)-b inhibitors, a novel class of agents, in multiple myeloma. Cancer Res. 2003;63:8428-8436.
    • (2003) Cancer Res , vol.63 , pp. 8428-8436
    • Hicleshima, T.1    Chauhan, D.2    Hayashi, T.3
  • 176
    • 0034525417 scopus 로고    scopus 로고
    • Regulation of BcI-2-family proteins in myeloma cells by three myeloma survival factors: Interleukin-6, interferon-alpha and insulin-like growth factor 1
    • Jourdan M, De Vos J, Mechti N, Klein B. Regulation of BcI-2-family proteins in myeloma cells by three myeloma survival factors: interleukin-6, interferon-alpha and insulin-like growth factor 1. Cell Death Differ. 2000;7:1244-1252.
    • (2000) Cell Death Differ , vol.7 , pp. 1244-1252
    • Jourdan, M.1    De Vos, J.2    Mechti, N.3    Klein, B.4
  • 177
    • 0036843032 scopus 로고    scopus 로고
    • Combination therapy with thalidomide plus dexamethasone for newly diagnosed myeloma
    • Rajkumar SV, Hayman S, Gertz MA, et al. Combination therapy with thalidomide plus dexamethasone for newly diagnosed myeloma. J Clin Oncol. 2002;20:4319-4323.
    • (2002) J Clin Oncol , vol.20 , pp. 4319-4323
    • Rajkumar, S.V.1    Hayman, S.2    Gertz, M.A.3
  • 178
    • 0037208595 scopus 로고    scopus 로고
    • Thalidomide alone or with dexamethasone for previously untreated multiple myeloma
    • Weber D, Rankin K, Gavino M, Delasalle K, Alexanian R. Thalidomide alone or with dexamethasone for previously untreated multiple myeloma. J Clin Oncol. 2003;21:16-19.
    • (2003) J Clin Oncol , vol.21 , pp. 16-19
    • Weber, D.1    Rankin, K.2    Gavino, M.3    Delasalle, K.4    Alexanian, R.5
  • 179
    • 0037443551 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: Therapeutic applications
    • Mitsiades N, Mitsiades CS, Richardson PG, et al. The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood. 2003;101:2377-2380.
    • (2003) Blood , vol.101 , pp. 2377-2380
    • Mitsiades, N.1    Mitsiades, C.S.2    Richardson, P.G.3
  • 180
    • 0000481441 scopus 로고    scopus 로고
    • Phase I study of the proteasome inhibitor bortezomib (PS-341, Velcade) in combination with pegylated liposomal doxorubicin (Doxil) in patients with refractory helatologic malignancies
    • Orlowski RZ, Hall M, Voorhees P, et al. Phase I study of the proteasome inhibitor bortezomib (PS-341, Velcade) in combination with pegylated liposomal doxorubicin (Doxil) in patients with refractory helatologic malignancies [abstract]. Blood. 2002;100:105a.
    • (2002) Blood , vol.100
    • Orlowski, R.Z.1    Hall, M.2    Voorhees, P.3
  • 181
    • 6344259003 scopus 로고    scopus 로고
    • ™ and melphalan combination therapy (Ve+M) for patients with relapsed or refractory multiple myeloma (MM)
    • ™ and melphalan combination therapy (Ve+M) for patients with relapsed or refractory multiple myeloma (MM) [abstract]. Blood. 2003;102:235a.
    • (2003) Blood , vol.102
    • Yang, H.H.1    Swift, R.2    Sadler, K.3
  • 182
    • 0034331194 scopus 로고    scopus 로고
    • Thalidomide and its analogues overcome drug resistance of human multiple myeloma cells to conventional therapy
    • Hideshima T, Chauhan D, Shima Y, et al. Thalidomide and its analogues overcome drug resistance of human multiple myeloma cells to conventional therapy. Blood. 2000;96:2943-2950.
    • (2000) Blood , vol.96 , pp. 2943-2950
    • Hideshima, T.1    Chauhan, D.2    Shima, Y.3
  • 183
    • 0035412366 scopus 로고    scopus 로고
    • Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
    • Davies FE, Raje N, Hideshima T, et al. Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood. 2001;98:210-216.
    • (2001) Blood , vol.98 , pp. 210-216
    • Davies, F.E.1    Raje, N.2    Hideshima, T.3
  • 184
    • 0037262242 scopus 로고    scopus 로고
    • Immunodulatory analogs of thalidomide inhibit growth of HS Sultan cells and angiogenesis in vivo
    • Lentzsch S, LeBlanc R, Podar K, et al. Immunodulatory analogs of thalidomide inhibit growth of HS Sultan cells and angiogenesis in vivo. Leukemia. 2003;17:41-44.
    • (2003) Leukemia , vol.17 , pp. 41-44
    • Lentzsch, S.1    LeBlanc, R.2    Podar, K.3
  • 185
    • 0042738871 scopus 로고    scopus 로고
    • Ex vivo induction of multiple myeloma-specific cytotoxic T lymphocytes
    • Hayashi T, Hideshima T, Akiyama M, et al. Ex vivo induction of multiple myeloma-specific cytotoxic T lymphocytes. Blood. 2003;102:1435-1442.
    • (2003) Blood , vol.102 , pp. 1435-1442
    • Hayashi, T.1    Hideshima, T.2    Akiyama, M.3
  • 186
    • 0242496212 scopus 로고    scopus 로고
    • Molecular sequelae of proteasome inhibition in human multiple myeloma cells
    • Mitsiades N, Mitsiades CS, Poulaki V, et al. Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc Natl Acad Sci U S A. 2002;99:14374-14379.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 14374-14379
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3
  • 187
    • 0036735298 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model
    • LeBlanc R, Catley LP, Hideshima T, et al. Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. Cancer Res. 2002;62:4996-5000.
    • (2002) Cancer Res , vol.62 , pp. 4996-5000
    • LeBlanc, R.1    Catley, L.P.2    Hideshima, T.3
  • 188
    • 0346122900 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma
    • Hideshima T, Chauhan D, Hayashi T, et al. Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma. Oncogene. 2003;22:8386-8393.
    • (2003) Oncogene , vol.22 , pp. 8386-8393
    • Hideshima, T.1    Chauhan, D.2    Hayashi, T.3
  • 189
    • 0037589018 scopus 로고    scopus 로고
    • Molecular sequelae of histone deacetylase inhibition in human malignant B cells
    • Mitsiades N, Mitsiades CS, Richardson PG, et al. Molecular sequelae of histone deacetylase inhibition in human malignant B cells. Blood. 2003;101:4055-4062.
    • (2003) Blood , vol.101 , pp. 4055-4062
    • Mitsiades, N.1    Mitsiades, C.S.2    Richardson, P.G.3
  • 190
    • 0141593496 scopus 로고    scopus 로고
    • NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma
    • Catley L, Weisberg E, Tai YT, et al. NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Blood. 2003;102:2615-2622.
    • (2003) Blood , vol.102 , pp. 2615-2622
    • Catley, L.1    Weisberg, E.2    Tai, Y.T.3
  • 191
    • 0037105379 scopus 로고    scopus 로고
    • 2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells
    • Chauhan D, Catley L, Hideshima T, et al. 2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells. Blood. 2002;100:2187-2194.
    • (2002) Blood , vol.100 , pp. 2187-2194
    • Chauhan, D.1    Catley, L.2    Hideshima, T.3
  • 192
    • 0036690367 scopus 로고    scopus 로고
    • Arsenic trioxide inhibits growth of human multiple myeloma cells in the bone marrow microenvironment
    • Hayashi T, Hideshima T, Akiyama M, et al. Arsenic trioxide inhibits growth of human multiple myeloma cells in the bone marrow microenvironment. Mol Cancer Ther. 2002;1:851-860.
    • (2002) Mol Cancer Ther , vol.1 , pp. 851-860
    • Hayashi, T.1    Hideshima, T.2    Akiyama, M.3
  • 193
    • 24444446128 scopus 로고    scopus 로고
    • Telomerase inhibition and apoptotic cell death following Telomestatin treatment of multiple myeloma
    • Shammas MA, Shmookler Reis RJ, Koley H, et al. Telomerase inhibition and apoptotic cell death following Telomestatin treatment of multiple myeloma [abstract]. Blood. 2002;100:810a.
    • (2002) Blood , vol.100
    • Shammas, M.A.1    Shmookler Reis, R.J.2    Koley, H.3
  • 194
    • 0035437171 scopus 로고    scopus 로고
    • TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: Therapeutic applications
    • Mitsiades CS, Treon SP, Mitsiades N, et al, TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications. Blood. 2001;98:795-804.
    • (2001) Blood , vol.98 , pp. 795-804
    • Mitsiades, C.S.1    Treon, S.P.2    Mitsiades, N.3
  • 195
    • 4244167024 scopus 로고    scopus 로고
    • HMG-CoA inhibitors (statins) induce growth arrest, apoptosis of multiple myeloma (MM) and Walden-strom's Macroglobulinemia (WM) cells and enhance their sensitivity to conventional or novel therapies. Molecular profiling of HMG-CoA inhibition in MM/WM and framework for translation to therapeutic application
    • Mitsiades CS, Mitsiades N, Poulaki V, et al. HMG-CoA inhibitors (statins) induce growth arrest, apoptosis of multiple myeloma (MM) and Walden-strom's Macroglobulinemia (WM) cells and enhance their sensitivity to conventional or novel therapies. Molecular profiling of HMG-CoA inhibition in MM/WM and framework for translation to therapeutic application [abstract]. Blood. 2002;100:597a.
    • (2002) Blood , vol.100
    • Mitsiades, C.S.1    Mitsiades, N.2    Poulaki, V.3
  • 196
    • 0037438374 scopus 로고    scopus 로고
    • Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu
    • Hideshima T, Akiyama M, Hayashi T, et al. Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu. Blood. 2003;101:703-705.
    • (2003) Blood , vol.101 , pp. 703-705
    • Hideshima, T.1    Akiyama, M.2    Hayashi, T.3
  • 197
    • 0037973279 scopus 로고    scopus 로고
    • A phase 2 study of bortezomib in relapsed, refractory myeloma
    • Richardson PG, Barlogie B, Berenson J, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med. 2003;348:2609-2617.
    • (2003) N Engl J Med , vol.348 , pp. 2609-2617
    • Richardson, P.G.1    Barlogie, B.2    Berenson, J.3
  • 198
    • 0036839013 scopus 로고    scopus 로고
    • Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma
    • Richardson PG, Schlossman RL, Weller E, et al. Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood. 2002;100:3063-3067.
    • (2002) Blood , vol.100 , pp. 3063-3067
    • Richardson, P.G.1    Schlossman, R.L.2    Weller, E.3
  • 199
    • 10744231548 scopus 로고    scopus 로고
    • Identification of genes modulated in multiple myeloma using genetically identical twin samples
    • Munshi NC, Hideshima T, Carrasco D, et al. Identification of genes modulated in multiple myeloma using genetically identical twin samples. Blood. 2004;103:1799-1806.
    • (2004) Blood , vol.103 , pp. 1799-1806
    • Munshi, N.C.1    Hideshima, T.2    Carrasco, D.3


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