Mechanisms of constitutive NF-κB activation in human prostate cancer cells

Prostate

Volumn 52, Issue 3, 2002, Pages 183-200

  Suh, Junghan ^a,b   Payvandi, Faribourz ^a   Edelstein, Leonard C ^a,b   Amenta, Peter S ^b,c   Zong, Wei Xing ^a,b   Gélinas, Céline ^a,b,c   Rabson, Arnold B ^a,b,c,d  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^d CABM   (United States)

Author keywords

Androgen receptor; I B Kinase; NF B; NF B inducing kinase; Prostate cancer; Transcription

Indexed keywords

ANDROGEN RECEPTOR; DNA; I KAPPA B; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE;

ARTICLE; CANCER CELL CULTURE; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DNA BINDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION INITIATION;

DNA-BINDING PROTEINS; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; MALE; NF-KAPPA B; PROSTATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; TUMOR CELLS, CULTURED;

EID: 0036680137     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/pros.10082     Document Type: Article

References (88)

1. Prostate disease: Epidemiology, natural history and demographic shifts
2. Molecular genetics of prostate cancer
3. Genetic alterations in human prostate cancer: A review of current literature
4. Molecular biology of progression of prostate cancer
5. Pathology of prostatic intraepithelial neoplasia and adenocarcinoma of the prostate: Prognostic influences of stage, tumor volume, grade, and margins of resection
6. Prostate cancer progression: Implications of histopathology
7. Defining the biologic role of genes that regulate prostate cancer metastasis
8. Metastasis-related genes in prostate cancer
9. NF-kappaB and Rel proteins: Evolutionarily conserved mediators of immune responses
10. Rel/NF-kappa B and I kappa B proteins: An overview
11. The Rel/NF-kappaB signal transduction pathway: Introduction
12. Phosphorylation meets ubiquitination: The control of NF-κB activity
13. Activators and target genes of Rel/NF-kappaB transcription factors
14. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1
15. NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176
16. Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
17. MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta
18. Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase
19. The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-beta
20. Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta
21. The proto-oncogene Cot kinase participates in CD3/ CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases
22. NAK is an IkappaB kinase-activating kinase
23. NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase
24. Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription
25. Aberrant rel/nfkb genes and activity in human cancer
26. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB
27. Oncogenic Ha-Ras-induced signaling activates NF-κB transcriptional activity, which is required for cellular transformation
28. A requirement for NF-κB activation in Bcr-Abl-mediated transformation
29. Elevated constitutive IKB kinase activity and IκB-α phosphorylation in HS294T melanoma cells lead to increased basal MGSA/Gro-α transcription
30. Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA
31. Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB
32. Molecular profiling of transformed and metastatic murine squamous carcinoma cells by differential display and cDNA microarray reveals altered expression of multiple genes related to growth, apoptosis, angiogenesis, and the NF-kappaB signal pathway
33. Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen
34. Mutual transcriptional interference between RelA and androgen receptor
35. Bcl-2 suppresses apoptosis resulting from disruption of the NF-kappa B survival pathway
36. Tumor necrosis factor-alpha-induced apoptosis in prostate cancer cells through inhibition of nuclear factor-kappaB by an IkappaBalpha "super-repressor."
37. Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
38. A new human prostate carcinoma cell line, 22Rv1
39. Transcription of the murine interleukin 5 gene is regulated by multiple promoter elements
40. Variable role of the long terminal repeat Sp1-binding sites in human immunodeficiency virus replication in T lymphocytes
41. A lymphoid cell-specific nuclear factor containing c-Rel-like proteins preferentially interacts with interleukin-6 B-related motifs whose activities are repressed in lymphoid cells
42. Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation
43. Phosphorylation of human IKB-α on serines 32 and 36 controls IKB-α proteolysis and NF-κB activation in response to diverse stimuli
44. Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity
45. Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases
46. Cloning of rat MEK kinase I cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain
47. Nuclear factor-kappa B activation by the CXC chemokine melanoma growth-stimulatory activity/growth-regulated protein involves the MEKK1/p38 mitogen activated protein kinase pathway
48. CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1
49. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
50. The expression of drug resistance gene products during the progression of human prostate cancer
51. Establishment and characterization of a human prostatic carcinoma cell line (PC-3)
52. Isolation of a human prostate carcinoma cell line (DU 145)
53. LNCaP model of human prostatic carcinoma
54. Immortalized and tumorigenic adult human prostatic epithelial cell lines: Characteristics and application part 2. Tumorigenic cell lines
55. Establishment and characterization of a new human prostatic carcinoma cell line (DuPro-1)
56. Establishment of a new prostatic carcinoma cell line (TSU-Prl)
57. Tsu-Prl and JCA-1 cells are derivatives of T24 bladder carcinoma cells and are not of prostatic origin
58. Constitutive phosphorylation of I kappa B alpha by casein kinase II
59. Constitutive phosphorylation of IkappaBalpha by casein kinase II occurs preferentially at serine 293: Requirement for degradation of free IkappaBalpha
60. Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-kappaB in breast cancer
61. Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions
62. IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity
63. The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome
64. Sequential DNA damage-independent and -dependent activation of NF-kappaB by UV
65. Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms
66. Tyrosine phosphorylation of IκB-α activates NF-κB without proteolytic degradation of IκB-α
67. Androgen receptor expression in androgen-independent prostate cancer cell lines
68. Rearrangement and altered expression of the NFKB-2 gene in human cutaneous T-lymphoma cells
69. Mutations in the IKBα gene in Hodgkin's disease suggest a tumour suppressor role for IKB
70. Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells
71. The nuclear factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
72. Constitutive activation of nuclear factor kappaB in hepatocellular carcinoma
73. Nuclear factor-kappaB is constitutively active in C-cell carcinoma and required for RET-induced transformation
74. Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer
75. Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth
76. Selective activation of NF-kappa B subunits in human breast cancer: Potential roles for NF-kappa B2/p52 and for Bcl-3
77. Constitutive IkappaB kinase activity correlates with nuclear factor-kappaB activation in human melanoma cells
78. HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation
79. A novel NIK-MAPK signaling pathway upregulates NF-KB activity in melanoma cells
80. Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association
81. Genistein inhibits NF-kappa B activation in prostate cancer cells
82. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation
83. Tyrosine kinase inhibition: An approach to drug development
84. An essential role for nuclear factor kappa B in preventing TNF-alpha-induced cell death in prostate cancer cells
85. Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer
86. Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression
87. Inhibition of NF-κB activity through maintenance of IKBα levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter
88. Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro