Constitutive activation of NF-κB is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein

EMBO Journal

Volumn 15, Issue 4, 1996, Pages 873-887

  Yamaoka, Shoji ^a   Inoue, Hiroshi ^a   Sakurai, Mamoru ^a   Sugiyama, Takeki ^a   Hazama, Masaaki ^a   Yamada, Toshiko ^a   Hatanaka, Masakazu ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

HTLV I; NF B; Tax; Transformation

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TAX PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FIBROBLAST; GENE MUTATION; HUMAN T CELL LEUKEMIA VIRUS 1; LONG TERMINAL REPEAT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; RAT; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; VIRUS CELL TRANSFORMATION;

EID: 0029670843     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00422.x     Document Type: Article

References (102)

1. Adya, N. and Giam, C.-Z (1995) Distinct region in human T-cell lymphotropic virus type I Tax mediate interactions with activation protein CREB and basal transcription factors. J. Virol., 69, 1834-1841.
2. Alexandre, C., Chamay, P. and Verrier, B. (1991) Trans-activation of Krox-20 and Krox-24 promoters by the HTLV-1 Tax protein through common regulatory elements. Oncogene, 6, 1851-1857.
3. Arima, N., Molitor, J.A., Smith, M.R., Kim, J.H., Daitoku, Y. and Greene, W.R. (1991) Human T-cell leukemia virus type I tax induces expression of the rel-related family of κB enhancer-binding proteins: evidence for a pretranslational component of regulation. J. Virol., 65, 6892-6899.
4. Baeuerle, P.A. (1991) The inducible transcription factor NF-κB: regulation by distinct protein subunits. Biochim. Biophys. Acta, 1088, 171-182.
5. Baker, S.J., Markowitz, S., Fearon, E.R., Willson, J.K.V. and Vogelstein, B (1990) Suppression of human colorectal carcinoma cell growth by wildtype p53. Science, 249, 912-915.
6. Baldwin, A.S., Jr, Azizkhan, J.C., Jensen, D.E., Beg, A.A. and Coodly, L.R. (1991) Induction of NF-κB DNA-binding activity during the G0-to-G1 transition in mouse fibroblasts. Mol. Cell. Biol., 11, 4943-4951.
7. Ballard, D.W., Bohnlein, E., Lowenthal, J.W., Wano, Y., Franza, B.R. and Greene, W.C. (1988) HTLV-I Tax induces cellular proteins that activate the KB element in the IL-2 receptor a gene. Science, 241, 1652-1655.
8. Béraud, C., Sun, S.-C., Ganchi, P., Ballard, D.W. and Greene, WC (1994) Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-κB p100 gene product: implications for viral latency. Mol. Cell Biol., 14, 1374-1382.
9. Böhnlein, E. et al. (1989) Stimulation of human immunodeficiency virus type I enhancer by the human T-cell leukemia virus type I tax gene product involves the actions of inducible cellular proteins. J Virol., 63, 1578-1586.
10. Bosselut, R., Duvall, J.F., Gégonne, A., Bailly, M., Hemar, A., Brady, J. and Ghysdael, J. (1990) The product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia virus HTLV-I. EMBO J., 9, 3137-3144.
11. Brown, K., Park, S., Kanno, T., Franzoso, O. and Siebenlist, U. (1993 Mutual regulation of the transcriptional activator NF-κB and its inhibitor. IκB-α. Proc. Natl Acad. Sci. USA, 90, 2532-2536.
12. Chellappan, S.P., Hiebert, S., Mudryj, M., Horowitz, J.M. and Nevins, J.R. (1991) The E2F transcription factor is a cellular target for the RB protein. Cell, 65, 1053-1061.
13. Cornelius, P., Marlowe, M., Lee, M. and Pekala, P. (1990) Growth factor-like effects of tumornecrosis factor α. J. Biol. Chem., 265, 20506-20516.
14. DeCaprio, J.A., Ludlow, J.W., Figge, J., Shew, J.-Y., Huang, C.-M., Lee, W.-H., Marsilio, E., Paucha, E. and Livingston, D.M. (1988) SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell, 54, 275-283
15. de-Larco, J.E. and Todaro, G.J. (1987) Epithelioid and fibroblastic rat kidney cell clones: epidermal growth factor (EGF) receptors and the effect of mouse sarcoma virus transformation. J. Cell. Physiol., 94, 335-342.
16. Dyson, N., Howley, P.M., Munger, K. and Harlow, E. (1989) The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science, 243, 934-937.
17. 1 protein of human T-cell leukemia virus type I Proc. Natl. Acad. Sci. USA, 85, 8526-8530.
18. SRF causes the aberrant induction of cellular immediate early genes through CArG boxes. Genes Dev., 6, 2066-2076.
19. x of HTLV-I EMBO J., 5, 713-718.
20. Gessain, A., Barin, F., Vernant, J.C., Gout, O., Maurs, L., Calender, A. and deThe, G. (1985) Antibodies to human T-lymphotropic virus type-1 in patients with tropical spastic paraparesis. Lancet, ii, 407-410.
21. Goh, W.C., Sodroski, J.G., Rosen, C.A., Essex, M. and Haseltine, W.A. (1985) Subcellular localization of the product of the long open reading frame of human T-cell leukemia virus type I. Science, 227, 1227-1228.
22. Gorman, C.M., Moffatt, L.F. and Howard, B.H. (1982) Recombinant genomes which express chloramphenicol acetyl-transferase in mammalian cells. Mol. Cell. Biol., 2, 1044-1051.
23. Graham, F. and van der Eb, A. (1973) Transformation of rat cells by DNA of human adenovirus 5. Virology, 54, 536-539.
24. Grassmann, R., Dengler, C., Muller-Fleckenstein, B., Fleckenstein, K., McGuire, K., Dokhelar, M.-C., Sodroski, J. and Haseltine, W. (1989) Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemic virus type I X-region genes transduced by a Herpesvirus saimiri vector. Proc. Natl. Acad. Sci. USA, 86, 3351-3355.
25. Grimm, S. and Baeuerle, P.A. (1994) Failure of the splicing variant p65Δ of the NF-kB subunit p65 to transform fibroblasts. Oncogene, 9, 2391-2398.
26. Higgins, K.A., Perez, J.R., Coleman, T.A., Dorshkind, K., McComas, W.A., Sarmiento, U.M., Rosen, C.A. and Narayanan, R. (1993) Antisense inhibition of the p65 subunit of NF-κB blocks tumorigenicity and causes tumor regression. Proc. Natl Acad. Sci. USA, 90, 9901-9905.
27. Hirai, H., Fujisawa, J., Suzuki, T., Ueda, K., Muramatsu, M., Tsuboi, A., Arai, N. and Yoshida, M. (1992) Transcriptional activator tax of HTLV-1 binds to the NF-κB precursor p105. Oncogene, 7, 1737-1742.
28. Hirai, H., Suzuki, T., Fujisawa, J.-I., Inoue, J.-I. and Yoshida, M. (1994) Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor κB and induces nuclear translocation of transcription factor NF-κB proteins for transcriptional activation. Proc. Natl Acad. Sci. USA, 91, 3584-3588.
29. Ho, S.N., Hunt, H.D., Horton, R.M., Pullen, J.K. and Pease, L.R. (1989) Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene, 7, 51-59.
30. Huen, D.S., Henderson, S.A., Croom-Carter, D. and Rowe, M. (1995) The Epstem-Barr virus latent membrane protein-1 (LMP-1) mediates activation of NF-κB and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain. Oncogene, 10, 549-560.
31. Izumi, M., Miyazawa, H., Kamakura, T., Yamaguchi, I., Endo, T. and Hanoka, F. (1991) Blasticidin S-resistance gene (bir): A novel selectable marker for mammalian cells. Exp. Cell Res., 197, 229-233.
32. Kanno, T., Brown, K., Franzoso, G. and Siebenlist, U. (1994a) Kinetic analysis of humn T-cell leukemia virus type I Tax-mediated activation of NF-κB. Mol. Cell. Biol., 14, 6443-6451.
33. Kanno, T., Brown, K., Franzoso, G. and Siebenlist, U. (1994b) Human T-cell leukemia virus type I Tax-protein-mediated activation of NF-κB from p100 (NF-κB2)-inhibited cytoplasmic reservoirs. Proc. Natl Acad. Sci. USA, 81, 12634-12638.
34. Kitajima, I., Shinohara, T., Bilakovics, J., Brown, D.A., Xu, X. and Nerenberg, M. (1992) Ablation of transplanted HTLV-I tax-transformed tumors in mice by antisense inhibition of NF-κB. Science, 258, 1792-1795.
35. Kiyokawa, T., Seiki, M., Iwashita, S., Iwanaga, K., Shimizu, K. and Yoshida, M. (1985) Association of the pX gene product of human T-cell leukemia virus type-1 with nucleus. Virology, 147, 462-465.
36. Lacoste, J., Cohen, L. and Hiscott, J. (1991) NF-kB activity in T cells stably expressing the Tax protein of human T cell lymphotropic virus type I. Virology, 184, 553-562.
37. Lacoste, J., Petropoulos, L., Pepin, N. and Hiscott, J. (1995) Constitutive phosphorylation and turnover of I kappa B in human T-cell leukemia virus type I-infected and Tax-expressing cells. J. Virol., 69, 564-569.
38. Lane, D.P. and Crawford L.V. (1979) T antigen is bound to a host protein in SV40-transformed cells. Nature, 278, 261-263.
39. Lanoix, J., Lacoste, J., Pepin, N., Rice, N. and Hiscott, J. (1994) Overproduction of NFKB2 (lyt-10) and c-Rel: a mechanism for HTLV-I Tax-mediated trans-activation via the NF-κB signalling pathway. Oncogene, 9, 841-852.
40. Leung, K. and Nabel, G.J. (1988) HTLV-I transactivator induces interleukin-2 receptor expression through an NF-κB-like factor. Narure, 333, 776-778.
41. Li, C.-C.H., Ruscetti, F.W., Rice, N.R., Chen, E., Yang, N.-S., Mikovits, J. and Longo, D.L. (1993) Differential expression of Rel family members in human T-cell leukemia virus type I-infected cells: transcriptional activation of c-rel by Tax protein. J. Virol., 67, 4205-4213.
42. Lowenthal, J.W., Bohnlein, E., Ballard, D.W. and Greene, W.C. (1988) Regulation of interleukin 2 receptor α subunit (Tac or CD 25 antigen) gene expression: binding of inducible nuclear proteins to discrete promoter sequences correlates with transcriptional activation. Proc. Natl. Acad. Sci. USA, 85, 4468-4472
43. Luckow, B. and Schtitz, G. (1987) CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res., 15, 5490.
44. MacGregor, G.R. and Caskey, C.T. (1989) Construction of plasmids that express E. coli β-galactosidase in mammalian cells. Nucleic Acids Res., 17, 2365.
45. x and T3/Ti complex triggering. Cell, 48, 343-350.
46. McKnight, S.L. and Kingsbury, R. (1982) Transcriptional control signals of a eukaryotic protein-coding gene. Science, 217, 316-324.
47. Mercurio, F., DiDonato, J.A., Rosette, C. and Karin, M. (1993) p105 and p98 precursor proteins play an active role in NF-κB-mediated signal transduction Genes Dev.. 7, 705-718
48. Mishina, M. et al. (1984) Expression of functional acetylcholine receptor from cloned cDNAs. Nature, 307, 604-608
49. x protein and bovine papilloma virus encoded E2 protein. Nucleic Acids Res., 16, 6547-6566.
50. x protein activate the mouse granulocyte-macrophage colony-stimulating factor gene through a common DNA element. Mol. Cell. Biol., 8, 5581-5587.
51. Mori, K., Sabe, H., Siomi, H., Imo, T., Tanaka, A., Takeuchi, K., Hirayoshi, K. and Hatanaka, M. (1987) Expression of a provirus of human T cell leukemia virus type I by DNA transfection. J. Gen. Virol., 68, 499-506.
52. Mosialos, G., Birkenbach, M., Yalamanchili, R., VanArsdale, T., Ware, C. and Kieff, E. (1995) The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell, 80, 389-399.
53. Munger, K., Werness, B.A., Dyson, N., Phelps, W.C., Harlow, E. and Howley, P.M. (1989) Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product EMBO J., 8, 4099-4105.
54. Muñoz, E., Courtois, G., Veschambre, P., Jalinot, P. and Israël, A. (1994) Tax induces nuclear translocation of NF-κB through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of IkBα/MAD3. J. Virol., 68, 8035-8044.
55. Murakami, T., Hirai, H., Suzuki, T., Fujisawa, J. and Yoshida, M. (1995) HTLV-1 Tax enhances NF-κB2 expression and binds to the products p52 and p100, but does not suppress the inhibitory function of p100. Virology, 206, 1066-1074.
56. Naumann, M., Wulczyn, F.G. and Scheidereit, C. (1993a) The NF-κB precursor p105 and the proto-oncogene product Bcl-3 are IκB molecules and control nuclear translocation of NF-κB. EMBO J., 12, 213-222.
57. Naumann, M., Nieters, A., Hatada, E.N. and Scheidereit, C. (1993b) NF-κB precursor p100 inhibits nuclear translocation and DNA binding of NF-κB/rel-factors. Oncogene, 8, 2275-2281
58. Nerenberg, M., Hinrichs, S.H., Reynolds, R.K., Khoury, G. and Jay, G. (1987) The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science, 237, 1324-1329.
59. Neri, A., Chang, C.-C., Lombardi, L., Salina, M., Corradini, P., Maiolo, A.T., Chaganti, R.S.K. and Dalla-Favera, R. (1991) B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50. Cell, 67, 1075-1087.
60. Nevins, J.R. (1992) E2F: A link between the Rb tumor suppressor protein and viral oncoproteins. Science, 258, 424-429.
61. Norman, C., Runswick, M., Pollock, R. and Treisman, R. (1988) Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. Cell, 55, 989-1003.
62. Ormo, H., Takimoto, G. and McKeithan, T.W. (1990) The candidate protooncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. Cell, 60, 991-997.
63. Okamoto, T., Ohno, Y., Tsugane, S., Watanabe, S., Shimoyama, M., Tajima, K., Miwa, M. and Shimotohno, K. (1989) Multi-step carcinogenesis model for adult T-cell leukemia. Jpn. J. Cancer Res., 80, 191-195.
64. Osame, M., Usuku, K., Ijichi, N., Amitani, H., Igata, A., Matsumoto, M. and Tera, H. (1986) HTLV-I associated myelopathy, a new clinical entity Lancet, i, 1031-1032.
65. Pepin, N., Roulston, A., Lacoste, J., Lin, R. and Hiscott, J. (1994) Subcellular redistribution of HTLV-I Tax protein by NF-κB/Rel transcription factors. Virology, 204, 706-716.
66. Poiesz, B.J., Ruscetti, F.W., Gazder, A.F., Bunn, P.A., Minna, J.D. and Gallo, R.C. (1980) Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc. Natl Acad. Sci. USA, 77, 7415-7419.
67. Pozzatti, R., Vogel, J. and Jay, G. (1990) The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic trasformation of cells. Mol. Cell. Biol., 10, 413-417.
68. Rice, N.R., MacKichan, M.L. and Israël, A. (1992) The precursor of NF-κB p50 has IκB-like functions. Cell, 71, 243-253.
69. Ruben, S.M. and Rosen, C.A. (1990) Suppression of signals required for activation of transcription factor NF-κB in cells constitutively expressing the HTLV-I Tax protein. New Biol., 2, 894-902.
70. Sadowski, I., Ma, J., Triezenberg, S. and Ptashne, M. (1988) GAL4-VP16 is an unusually potent transcriptional activator. Nature, 335, 563-564.
71. Sakurai, M., Yamaoka, S., Nosaka, T., Akayama, M., Tanaka, A., Maki, M. and Hatanaka, M. (1992) Transforming activity and the level of tax protein: effect of one point mutation in HTLV-I tax gene. Int. J. Cancer, 52, 323-328.
72. Sarnow, P., Ho, Y.S., Williams, J. and Levine, A.J. (1982) Adenovirus Elb 58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kDa cellular protein in transformed cells. Cell, 28, 387-394.
73. Schmid, R.M., Perkins, N.D., Duckett, C.S., Andrews, P.C. and Nabel, G.J. (1991) Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65. Nature, 352, 733-736.
74. Schreiber, E., Matthias, P., Müller, M.M. and Schaffner, W. (1989) Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res., 17, 6419.
75. Scott, M.L., Fujita, T., Liou, H.-C., Nolan, G.P. and Baltimore, D. (1993) The p65 subunit of NF-κB regulates IκB by two distinct mechanisms. Genes Dev., 7, 1266-1276.
76. Seiki, M., Hattori, S., Hirayama, Y. and Yoshida, M. (1983) Human adult T cell leukemia virus: Complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc. Natl Acad. Sci. USA, 80, 3618-3622.
77. Seiki, M., Eddy, R., Shows, T.B. and Yoshida, M. (1984) Nonspecific integration of the HTLV provirus genome into adult T-cell leukemia cells. Nature, 309, 640-642.
78. x of human T-cell leukemia virus type I is a trans-acting transcriptiondl activator. EMBO J., 5, 561-565.
79. Semmes, O.J. and Jeang, K.-T. (1992) Mutational analysis of human T-cell leukemia virus type I tax: Regions necessary for function determined with 47 mutant proteins. J. Virol., 66, 7183-7192.
80. Semmes, O.J. and Jeang, K.-T. (1995) Definition of a minimal activation domain in human T-cell leukemia virus type I Tax. J. Virol., 69, 1827-1833.
81. Siekevitz, M., Feinberg, M.B., Holbrook, N., Wong-Staal, F. and Greene, W.C. (1987a) Activation of the interleukin-2 and interleukin-2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I. Proc Natl Acad. Sci. USA, 84, 5389-5393.
82. Siekevitz, M., Josephs, S.J., Dukovitch, M., Peffer, N., Wong-Staal, F. and Greene, W.C (1987b) Activation of the HIV-I LTR by T cell mitogens and trans-activator protein of HTLV-I. Science, 238, 1575-1578
83. Smith, M.R. and Greene, W.C. (1990) Identification of HTLV-I tax transactivator mutants exhibiting novel transcriptional phenotypes. Genes Dev., 4, 1875-1885.
84. Smith, M.R. and Greene, W.C. (1991) Type I human T cell leukemia virus Tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway. J Clin. Invest., 88, 1038-1042.
85. Sodroski, J., Rosen, C.A., Goh, W.C. and Haseltine, W.A. (1985) A transcriptional activator protein encoded by the x-LOR region of the human T-cell leukemia virus. Science, 228, 1430-1433.
86. Sun, S.-C., Ganchi, P.A., Ballard, D.W and Greene, W.C. (1993) NF-κB controls expression of inhibitor IκBα: Evidence for an inducible autoregulatory pathway. Science, 259, 1912-1915.
87. Sun, S.C., Elwood, J., Béaud, C. and Greene, W.C. (1994) Human T-cell leukemia virus type I Tax activation of NF-kapppa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene. Mol Cell. Biol., 14, 7377-7384.
88. Suzuki, T., Hirai, H., Murakami, T. and Yoshida, M (1995) Tax protein of HTLV-1 destabilizes the complexes of NF-κB and IκB-α and induces nuclear translocation of NF-κB for transcriptional activation. Oncogene, 10, 1199-1207.
89. Tanaka, A., Takahashi, C., Yamaoka, S., Nosaka, T., Maki, M. and Hatanaka, M. (1990) Oncogenic transformation by the tax gene of human T-cell leukemia virus type 1 in vitro. Proc. Natl Acad. Sci. USA, 87, 1071-1075.
90. Thompson, J.E., Phillips, R.J., Erdjument-Bromage, H., Tempst, P. and Ghosh, S. (1995) IκB-β regulates the persistent response in a biphasic activation of NF-κB. Cell, 80, 573-582.
91. Topp, W.C. (1981) Normal rat cell lines deficient in nuclear thymidine kinase. Virology, 113, 408-411.
92. Tsuchiya, H., Fujii, M., Tanaka, Y., Tozawa, H. and Seiki, M. (1994) Two distinct regions form a functional activation domain of the HTLV-1 trans-activator Tax1. Oncogene, 9, 337-340.
93. Watanabe, M., Muramatsu, M., Hirai, H., Sizuki, T., Fujisawa, J., Yoshida, M., Arai, K. and Arai, N. (1993) HTLV-I Tax in association with NF-κB precursor p105 enhances nuclear localization of NF-κB p50 and p65 in transfected cells. Oncogene, 8, 2949-2958.
94. Watanabe, M., Muramatsu, M., Tsuboi, A. and Arai, K. (1994) Differential response of NF-κB1 p105 and NF-κB2 p100 to HTLV-I encoded Tax. FEBS Lett., 342, 115-118.
95. Werness, B.A., Levine, A.J. and Howley, P.M. (1990) Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science, 248, 76-79.
96. Whyte, P., Buchkovich, K.J. Horowitz, J.M., Friend, S.H., Raybuch, M., Weinberg, R.A. and Harlow, E. (1988) Association between an oncogene and anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product Nature, 334, 124-129.
97. Wilhelmsen, K.C., Eggleton, K. and Temin, H.M. (1984) Nucleic acid sequence of the oncogene v-rel in reticuloendotheliosis virus strain T and its cellular homolog, the proto-oncogenec-rel. J. Virol., 52, 172-182.
98. Willems, L., Grimonpont, C., Heremans, H., Rebeyrotte, N., Chen, G., Portetelle, D., Burny, A. and Kettmann, R. (1992) Mutations in the bovine leukemia virus Tax protein can abrogate the long terminal repeat-directed transactivating activity without concomitant loss of transforming potential. Proc. Natl Acad Sci. USA, 89, 3957-3961.
99. Yamaoka, S., Tobe, T. and Hatanaka, M. (1992) Tax protein of human T-cell leukemia virus type I is required for maintenance of the transformed phenotype. Oncogene, 7, 433-437
100. Yin, M.-J., Paulssen, E.J., Seeler, J.-S. and Gaynor, R.B. (1995) Protein domain involved in both in vivo and vitro interactions between human T-cell leukemia virus type I Tax and CREB. J. Virol., 69, 3420-3432
101. Yoshida, M. and Seiki, M. (1989) Molecular biology of HTLV-I: Biological significance of viral genes in its replication and leukemogeneus. In Gallo, R.C. and Wong-Staal, F. Seds), Retrovirus Biology and Human Disease. Marcel Dekker, New York, pp. 161-186.
102. Yoshida, M., Miyoshi, I. and Hinuma, Y. (1982) Isolation and characterization of retrovirus from cell lines of human adult T cell leukemia and its implication in the diseases. Proc. Natl Acad. Sci. USA, 79, 2031-2035.