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Volumn 38, Issue 10, 2006, Pages 1647-1653

NFκB pathway: A good signaling paradigm and therapeutic target

Author keywords

I B; IKK; NEMO; NF B; p65; TRAF

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

EID: 33745342580     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2006.03.023     Document Type: Short Survey
Times cited : (202)

References (36)
  • 1
    • 4544342570 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: The enemy within
    • Aggarwal B.B. Nuclear factor-kappaB: The enemy within. Cancer Cell 6 (2004) 203-208
    • (2004) Cancer Cell , vol.6 , pp. 203-208
    • Aggarwal, B.B.1
  • 2
    • 0036144763 scopus 로고    scopus 로고
    • Regulatory functions of ubiquitination in the immune system
    • Ben Neriah Y. Regulatory functions of ubiquitination in the immune system. Nat. Immunol. 3 (2002) 20-26
    • (2002) Nat. Immunol. , vol.3 , pp. 20-26
    • Ben Neriah, Y.1
  • 3
    • 0042467554 scopus 로고    scopus 로고
    • Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB
    • Brummelkamp T.R., Nijman S.M., Dirac A.M., and Bernards R. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature 424 (2003) 797-801
    • (2003) Nature , vol.424 , pp. 797-801
    • Brummelkamp, T.R.1    Nijman, S.M.2    Dirac, A.M.3    Bernards, R.4
  • 5
    • 23144449789 scopus 로고    scopus 로고
    • Ubiquitin signalling in the NF-kappaB pathway
    • Chen Z.J. Ubiquitin signalling in the NF-kappaB pathway. Nat. Cell. Biol. 7 (2005) 758-765
    • (2005) Nat. Cell. Biol. , vol.7 , pp. 758-765
    • Chen, Z.J.1
  • 6
    • 0037025395 scopus 로고    scopus 로고
    • The kappa B DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription
    • Chen-Park F.E., Huang D.B., Noro B., Thanos D., and Ghosh G. The kappa B DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription. J. Biol. Chem. 277 (2002) 24701-24708
    • (2002) J. Biol. Chem. , vol.277 , pp. 24701-24708
    • Chen-Park, F.E.1    Huang, D.B.2    Noro, B.3    Thanos, D.4    Ghosh, G.5
  • 8
    • 23844485308 scopus 로고    scopus 로고
    • The NF-kappaB signaling pathway in human genetic diseases
    • Courtois G. The NF-kappaB signaling pathway in human genetic diseases. Cell Mol. Life Sci. 62 (2005) 1682-1691
    • (2005) Cell Mol. Life Sci. , vol.62 , pp. 1682-1691
    • Courtois, G.1
  • 9
    • 0033537719 scopus 로고    scopus 로고
    • Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation
    • Delhase M., Hayakawa M., Chen Y., and Karin M. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 284 (1999) 309-313
    • (1999) Science , vol.284 , pp. 309-313
    • Delhase, M.1    Hayakawa, M.2    Chen, Y.3    Karin, M.4
  • 10
    • 0033105577 scopus 로고    scopus 로고
    • Nuclear import of the drosophila rel protein dorsal is regulated by phosphorylation
    • Drier E.A., Huang L.H., and Steward R. Nuclear import of the drosophila rel protein dorsal is regulated by phosphorylation. Genes Dev. 13 (1999) 556-568
    • (1999) Genes Dev. , vol.13 , pp. 556-568
    • Drier, E.A.1    Huang, L.H.2    Steward, R.3
  • 11
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-kappaB puzzle
    • Ghosh S., and Karin M. Missing pieces in the NF-kappaB puzzle. Cell 109 Suppl (2002) S81-S96
    • (2002) Cell , vol.109 , Issue.SUPPL
    • Ghosh, S.1    Karin, M.2
  • 12
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-kappaB
    • Hayden M.S., and Ghosh S. Signaling to NF-kappaB. Genes Dev. 18 (2004) 2195-2224
    • (2004) Genes Dev. , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 13
    • 6344241039 scopus 로고    scopus 로고
    • SMRT derepression by the IkappaB kinase alpha: A prerequisite to NF-kappaB transcription and survival
    • Hoberg J.E., Yeung F., and Mayo M.W. SMRT derepression by the IkappaB kinase alpha: A prerequisite to NF-kappaB transcription and survival. Mol. Cell 16 (2004) 245-255
    • (2004) Mol. Cell , vol.16 , pp. 245-255
    • Hoberg, J.E.1    Yeung, F.2    Mayo, M.W.3
  • 14
    • 0344305376 scopus 로고    scopus 로고
    • Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress
    • Huang T.T., Wuerzberger-Davis S.M., Wu Z.H., and Miyamoto S. Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell 115 (2003) 565-576
    • (2003) Cell , vol.115 , pp. 565-576
    • Huang, T.T.1    Wuerzberger-Davis, S.M.2    Wu, Z.H.3    Miyamoto, S.4
  • 15
    • 0027511507 scopus 로고
    • Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen
    • Jiang J., and Levine M. Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen. Cell 72 (1993) 741-752
    • (1993) Cell , vol.72 , pp. 741-752
    • Jiang, J.1    Levine, M.2
  • 16
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity
    • Karin M., and Ben Neriah Y. Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity. Annu. Rev. Immunol. 18 (2000) 621-663
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 621-663
    • Karin, M.1    Ben Neriah, Y.2
  • 17
    • 17844386319 scopus 로고    scopus 로고
    • IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation
    • Lawrence T., Bebien M., Liu G.Y., Nizet V., and Karin M. IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature 434 (2005) 1138-1143
    • (2005) Nature , vol.434 , pp. 1138-1143
    • Lawrence, T.1    Bebien, M.2    Liu, G.Y.3    Nizet, V.4    Karin, M.5
  • 18
    • 0036781052 scopus 로고    scopus 로고
    • NF-kappaB regulation in the immune system
    • Li Q., and Verma I.M. NF-kappaB regulation in the immune system. Nat. Rev. Immunol. 2 (2002) 725-734
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 19
    • 0346025729 scopus 로고    scopus 로고
    • NF-kappaB signaling in lymphocytes: A new cast of characters
    • Lucas P.C., McAllister-Lucas L.M., and Nunez G. NF-kappaB signaling in lymphocytes: A new cast of characters. J. Cell Sci. 117 (2004) 31-39
    • (2004) J. Cell Sci. , vol.117 , pp. 31-39
    • Lucas, P.C.1    McAllister-Lucas, L.M.2    Nunez, G.3
  • 20
    • 16844366650 scopus 로고    scopus 로고
    • Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs
    • Nakanishi C., and Toi M. Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs. Nat. Rev. Cancer 5 (2005) 297-309
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 297-309
    • Nakanishi, C.1    Toi, M.2
  • 21
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • Pahl H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Ontogeny 18 (1999) 6853-6866
    • (1999) Ontogeny , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 22
    • 10644239087 scopus 로고    scopus 로고
    • Regulation of NF-kappaB by atypical activators and tumour suppressors
    • Perkins N.D. Regulation of NF-kappaB by atypical activators and tumour suppressors. Brioche. Soc. Trans. 32 (2004) 936-939
    • (2004) Brioche. Soc. Trans. , vol.32 , pp. 936-939
    • Perkins, N.D.1
  • 23
    • 0037496130 scopus 로고    scopus 로고
    • Transducing signals from antigen receptors to nuclear factor kappaB
    • Ruland J., and Mak T.W. Transducing signals from antigen receptors to nuclear factor kappaB. Immunol. Rev. 193 (2003) 93-100
    • (2003) Immunol. Rev. , vol.193 , pp. 93-100
    • Ruland, J.1    Mak, T.W.2
  • 24
    • 3142771914 scopus 로고    scopus 로고
    • Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response
    • Saccani S., Marazzi I., Beg A.A., and Natoli G. Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response. J. Exp. Med. 200 (2004) 107-113
    • (2004) J. Exp. Med. , vol.200 , pp. 107-113
    • Saccani, S.1    Marazzi, I.2    Beg, A.A.3    Natoli, G.4
  • 25
    • 0038771214 scopus 로고    scopus 로고
    • Modulation of NF-kappaB activity by exchange of dimers
    • Saccani S., Pantano S., and Natoli G. Modulation of NF-kappaB activity by exchange of dimers. Mol. Cell 11 (2003) 1563-1574
    • (2003) Mol. Cell , vol.11 , pp. 1563-1574
    • Saccani, S.1    Pantano, S.2    Natoli, G.3
  • 26
    • 27744577296 scopus 로고    scopus 로고
    • TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
    • Shim J.H., Xiao C., Paschal A.E., Bailey S.T., Rao P., Hayden M.S., et al. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 19 (2005) 2668-2681
    • (2005) Genes Dev. , vol.19 , pp. 2668-2681
    • Shim, J.H.1    Xiao, C.2    Paschal, A.E.3    Bailey, S.T.4    Rao, P.5    Hayden, M.S.6
  • 27
    • 0035883151 scopus 로고    scopus 로고
    • NF-kappaB signaling pathways in mammalian and insect innate immunity
    • Silverman N., and Maniatis T. NF-kappaB signaling pathways in mammalian and insect innate immunity. Genes Dev. 15 (2001) 2321-2342
    • (2001) Genes Dev. , vol.15 , pp. 2321-2342
    • Silverman, N.1    Maniatis, T.2
  • 28
    • 0141780826 scopus 로고    scopus 로고
    • NF-kappaB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism
    • Sitcheran R., Cogswell P.C., and Baldwin Jr. A.S. NF-kappaB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism. Genes Dev. 17 (2003) 2368-2373
    • (2003) Genes Dev. , vol.17 , pp. 2368-2373
    • Sitcheran, R.1    Cogswell, P.C.2    Baldwin Jr., A.S.3
  • 29
    • 0036771830 scopus 로고    scopus 로고
    • The NF-kappaB signalling pathway in human diseases: From incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes
    • Smahi A., Courtois G., Rabia S.H., Doffinger R., Bodemer C., Munnich A., et al. The NF-kappaB signalling pathway in human diseases: From incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes. Hum. Mol. Genet. 11 (2002) 2371-2375
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 2371-2375
    • Smahi, A.1    Courtois, G.2    Rabia, S.H.3    Doffinger, R.4    Bodemer, C.5    Munnich, A.6
  • 30
    • 0036244951 scopus 로고    scopus 로고
    • The art and design of genetic screens: Drosophila melanogaster
    • St Johnston D. The art and design of genetic screens: Drosophila melanogaster. Nat. Rev. Genet. 3 (2002) 176-188
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 176-188
    • St Johnston, D.1
  • 31
    • 0242664121 scopus 로고    scopus 로고
    • IkappaB kinase-independent IkappaBalpha degradation pathway: Functional NF-kappaB activity and implications for cancer therapy
    • Tergaonkar V., Bottero V., Ikawa M., Li Q., and Verma I.M. IkappaB kinase-independent IkappaBalpha degradation pathway: Functional NF-kappaB activity and implications for cancer therapy. Mol. Cell Biol. 23 (2003) 8070-8083
    • (2003) Mol. Cell Biol. , vol.23 , pp. 8070-8083
    • Tergaonkar, V.1    Bottero, V.2    Ikawa, M.3    Li, Q.4    Verma, I.M.5
  • 32
    • 26944443968 scopus 로고    scopus 로고
    • Distinct roles of IkappaB proteins in regulating constitutive NF-kappaB activity
    • Tergaonkar V., Correa R.G., Ikawa M., and Verma I.M. Distinct roles of IkappaB proteins in regulating constitutive NF-kappaB activity. Nat. Cell Biol. 7 (2005) 921-923
    • (2005) Nat. Cell Biol. , vol.7 , pp. 921-923
    • Tergaonkar, V.1    Correa, R.G.2    Ikawa, M.3    Verma, I.M.4
  • 33
    • 2442612540 scopus 로고    scopus 로고
    • CARMA1, BCL-10 and MALT1 in lymphocyte development and activation
    • Thome M. CARMA1, BCL-10 and MALT1 in lymphocyte development and activation. Nat. Rev. Immunol. 4 (2004) 348-359
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 348-359
    • Thome, M.1
  • 34
    • 0028971289 scopus 로고
    • Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation
    • Verma I.M., Stevenson J.K., Schwarz E.M., Van Antwerp D., and Miyamoto S. Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation. Genes Dev. 9 (1995) 2723-2735
    • (1995) Genes Dev. , vol.9 , pp. 2723-2735
    • Verma, I.M.1    Stevenson, J.K.2    Schwarz, E.M.3    Van Antwerp, D.4    Miyamoto, S.5
  • 35
    • 11844269840 scopus 로고    scopus 로고
    • Phosphorylation of NF-kappaB and IkappaB proteins: Implications in cancer and inflammation
    • Viatour P., Merville M.P., Bours V., and Chariot A. Phosphorylation of NF-kappaB and IkappaB proteins: Implications in cancer and inflammation. Trends Brioche. Sci. 30 (2005) 43-52
    • (2005) Trends Brioche. Sci. , vol.30 , pp. 43-52
    • Viatour, P.1    Merville, M.P.2    Bours, V.3    Chariot, A.4
  • 36
    • 3943054838 scopus 로고    scopus 로고
    • De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
    • Wertz I.E., O'Rourke K.M., Zhou H., Eby M., Aravind L., Seshagiri S., et al. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 430 (2004) 694-699
    • (2004) Nature , vol.430 , pp. 694-699
    • Wertz, I.E.1    O'Rourke, K.M.2    Zhou, H.3    Eby, M.4    Aravind, L.5    Seshagiri, S.6


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