-
1
-
-
10344258041
-
Targeting the mitogen-activated protein kinase cascade to treat cancer
-
Sebolt-Leopold, J. S. & Herrera, R. Targeting the mitogen-activated protein kinase cascade to treat cancer. Nature Rev. Cancer 4, 937-947 (2004).
-
(2004)
Nature Rev. Cancer
, vol.4
, pp. 937-947
-
-
Sebolt-Leopold, J.S.1
Herrera, R.2
-
2
-
-
0034213138
-
p38 MAP kinases: Beyond the stress response
-
Nebreda, A. R. & Porras, A. p38 MAP kinases: beyond the stress response. Trends Biochem. Sci. 25, 257-260 (2000).
-
(2000)
Trends Biochem. Sci
, vol.25
, pp. 257-260
-
-
Nebreda, A.R.1
Porras, A.2
-
3
-
-
0035066383
-
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
-
Kyriakis, J. M. & Avruch, J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81, 807-869 (2001).
-
(2001)
Physiol. Rev
, vol.81
, pp. 807-869
-
-
Kyriakis, J.M.1
Avruch, J.2
-
4
-
-
21344474327
-
From JNK to pay dirt: Jun kinases, their biochemistry, physiology and clinical importance
-
Karin, M. & Gallagher, E. From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance. IUBMB Life 57, 283-295 (2005).
-
(2005)
IUBMB Life
, vol.57
, pp. 283-295
-
-
Karin, M.1
Gallagher, E.2
-
5
-
-
33847754623
-
The JNK signal transduction pathway
-
Weston, C. R. & Davis, R. J. The JNK signal transduction pathway. Curr. Opin. Cell Biol. 19, 142-149 (2007).
-
(2007)
Curr. Opin. Cell Biol
, vol.19
, pp. 142-149
-
-
Weston, C.R.1
Davis, R.J.2
-
6
-
-
61849123548
-
Regulation of the immune response by stress-activated protein kinases
-
Rincon, M. & Davis, R. J. Regulation of the immune response by stress-activated protein kinases. Immunol. Rev. 228, 212-224 (2009).
-
(2009)
Immunol. Rev
, vol.228
, pp. 212-224
-
-
Rincon, M.1
Davis, R.J.2
-
7
-
-
0035282334
-
Mammalian MAP kinase signalling cascades
-
Chang, L. & Karin, M. Mammalian MAP kinase signalling cascades. Nature 410, 37-40 (2001).
-
(2001)
Nature
, vol.410
, pp. 37-40
-
-
Chang, L.1
Karin, M.2
-
8
-
-
0344393408
-
Regulation of MAP kinase signaling modules by scaffold proteins in mammals
-
Morrison, D. K. & Davis, R. J. Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu. Rev. Cell Dev. Biol. 19, 91-118 (2003).
-
(2003)
Annu. Rev. Cell Dev. Biol
, vol.19
, pp. 91-118
-
-
Morrison, D.K.1
Davis, R.J.2
-
9
-
-
34547179997
-
MAP kinase pathways: The first twenty years
-
Avruch, J. MAP kinase pathways: the first twenty years. Biochim. Biophys. Acta. 1773, 1150-1160 (2007).
-
(2007)
Biochim. Biophys. Acta
, vol.1773
, pp. 1150-1160
-
-
Avruch, J.1
-
10
-
-
0029885419
-
Selective interaction of JNK protein kinase isoforms with transcription factors
-
Gupta, S. et al. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 15, 2760-2770 (1996).
-
(1996)
EMBO J
, vol.15
, pp. 2760-2770
-
-
Gupta, S.1
-
11
-
-
34248563299
-
Role of mitogen-activated protein kinase kinase kinases in signal integration
-
Cuevas, B. D., Abell, A. N. & Johnson, G. L. Role of mitogen-activated protein kinase kinase kinases in signal integration. Oncogene 26, 3159-3171 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 3159-3171
-
-
Cuevas, B.D.1
Abell, A.N.2
Johnson, G.L.3
-
12
-
-
34547857049
-
The functional contrariety of JNK
-
Bode, A. M. & Dong, Z. The functional contrariety of JNK. Mol. Carcinog. 46, 591-598 (2007).
-
(2007)
Mol. Carcinog
, vol.46
, pp. 591-598
-
-
Bode, A.M.1
Dong, Z.2
-
13
-
-
0242691046
-
AP-1: A double-edged sword in tumorigenesis
-
Eferl, R. & Wagner, E. F. AP-1: a double-edged sword in tumorigenesis. Nature Rev. Cancer 3, 859-868 (2003).
-
(2003)
Nature Rev. Cancer
, vol.3
, pp. 859-868
-
-
Eferl, R.1
Wagner, E.F.2
-
14
-
-
0035749803
-
The promise of retinoids to fight against cancer
-
Altucci, L. & Gronemeyer, H. The promise of retinoids to fight against cancer. Nature Rev. Cancer 1, 181-193 (2001).
-
(2001)
Nature Rev. Cancer
, vol.1
, pp. 181-193
-
-
Altucci, L.1
Gronemeyer, H.2
-
15
-
-
0028605318
-
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
-
Lee, J. C. et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372, 739-746 (1994).
-
(1994)
Nature
, vol.372
, pp. 739-746
-
-
Lee, J.C.1
-
16
-
-
0034595828
-
Distinct carboxytermini confer divergent characteristics to the mitogen-activated protein kinase p38α and its splice isoform Mxi2
-
Sanz, V., Arozarena, I. & Crespo, P. Distinct carboxytermini confer divergent characteristics to the mitogen-activated protein kinase p38α and its splice isoform Mxi2. FEBS Lett. 474, 169-174 (2000).
-
(2000)
FEBS Lett
, vol.474
, pp. 169-174
-
-
Sanz, V.1
Arozarena, I.2
Crespo, P.3
-
17
-
-
0033965158
-
The p38 signal transduction pathway: Activation and function
-
Ono, K. & Han, J. The p38 signal transduction pathway: activation and function. Cell Signal 12, 1-13 (2000).
-
(2000)
Cell Signal
, vol.12
, pp. 1-13
-
-
Ono, K.1
Han, J.2
-
18
-
-
34547154349
-
p38 MAP-kinases pathway regulation, function and role in human diseases
-
Cuenda, A. & Rousseau, S. p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim. Biophys. Acta 1773, 1358-1375 (2007).
-
(2007)
Biochim. Biophys. Acta
, vol.1773
, pp. 1358-1375
-
-
Cuenda, A.1
Rousseau, S.2
-
19
-
-
25444503315
-
Activating p38 MAPK: New tricks for an old kinase
-
Mittelstadt, P. R., Salvador, J. M., Fornace, A. J. Jr & Ashwell, J. D. Activating p38 MAPK: new tricks for an old kinase. Cell Cycle 4, 1189-1192 (2005).
-
(2005)
Cell Cycle
, vol.4
, pp. 1189-1192
-
-
Mittelstadt, P.R.1
Salvador, J.M.2
Fornace Jr, A.J.3
Ashwell, J.D.4
-
20
-
-
7644223136
-
p38 MAP kinase's emerging role as a tumor suppressor
-
Bulavin, D. V. & Fornace, A. J. Jr. p38 MAP kinase's emerging role as a tumor suppressor. Adv. Cancer Res. 92, 95-118 (2004).
-
(2004)
Adv. Cancer Res
, vol.92
, pp. 95-118
-
-
Bulavin, D.V.1
Fornace Jr., A.J.2
-
22
-
-
35848938280
-
p38α: A suppressor of cell proliferation and tumorigenesis
-
Hui, L., Bakiri, L., Stepniak, E. & Wagner, E. F. p38α: a suppressor of cell proliferation and tumorigenesis. Cell Cycle 6, 2429-2433 (2007).
-
(2007)
Cell Cycle
, vol.6
, pp. 2429-2433
-
-
Hui, L.1
Bakiri, L.2
Stepniak, E.3
Wagner, E.F.4
-
23
-
-
4444341881
-
Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation
-
Sabapathy, K. et al. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol. Cell 15, 713-725 (2004).
-
(2004)
Mol. Cell
, vol.15
, pp. 713-725
-
-
Sabapathy, K.1
-
24
-
-
17144371848
-
JNK2: A negative regulator of cellular proliferation
-
Sabapathy, K. & Wagner, E. F. JNK2: a negative regulator of cellular proliferation. Cell Cycle 3, 1520-1523 (2004).
-
(2004)
Cell Cycle
, vol.3
, pp. 1520-1523
-
-
Sabapathy, K.1
Wagner, E.F.2
-
25
-
-
0029829562
-
Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase
-
Fuchs, S. Y., Dolan, L., Davis, R. J. & Ronai, Z. Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase. Oncogene 13, 1531-1535 (1996).
-
(1996)
Oncogene
, vol.13
, pp. 1531-1535
-
-
Fuchs, S.Y.1
Dolan, L.2
Davis, R.J.3
Ronai, Z.4
-
26
-
-
33748436341
-
JNK2 is a positive regulator of the cJun transcription factor
-
Jaeschke, A. et al. JNK2 is a positive regulator of the cJun transcription factor. Mol. Cell 23, 899-911 (2006).
-
(2006)
Mol. Cell
, vol.23
, pp. 899-911
-
-
Jaeschke, A.1
-
27
-
-
35648935982
-
Suppression of p53-dependent senescence by the JNK signal transduction pathway
-
This paper links the JNK pathway to p53-dependent senescence using a conditional JNK1 allele and supports an oncogenic role of this pathway in tumours
-
Das, M. et al. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc. Natl Acad. Sci. USA 104, 15759-15764 (2007). This paper links the JNK pathway to p53-dependent senescence using a conditional JNK1 allele and supports an oncogenic role of this pathway in tumours.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 15759-15764
-
-
Das, M.1
-
28
-
-
0034607702
-
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
-
Tournier, C. et al. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288, 870-874 (2000).
-
(2000)
Science
, vol.288
, pp. 870-874
-
-
Tournier, C.1
-
29
-
-
85047700485
-
Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis
-
Hochedlinger, K., Wagner, E. F. & Sabapathy, K. Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis. Oncogene 21, 2441-2445 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 2441-2445
-
-
Hochedlinger, K.1
Wagner, E.F.2
Sabapathy, K.3
-
30
-
-
33344477350
-
Chemical genetic analysis of the time course of signal transduction by JNK
-
Ventura, J. J. et al. Chemical genetic analysis of the time course of signal transduction by JNK. Mol. Cell 21, 701-710 (2006).
-
(2006)
Mol. Cell
, vol.21
, pp. 701-710
-
-
Ventura, J.J.1
-
31
-
-
32044447161
-
L turnover
-
L turnover. Cell 124, 601-613 (2006).
-
(2006)
Cell
, vol.124
, pp. 601-613
-
-
Chang, L.1
-
32
-
-
0141953270
-
A JNK-dependent pathway is required for TNFα-induced apoptosis
-
Deng, Y., Ren, X., Yang, L., Lin, Y. & Wu, X. A JNK-dependent pathway is required for TNFα-induced apoptosis. Cell 115, 61-70 (2003).
-
(2003)
Cell
, vol.115
, pp. 61-70
-
-
Deng, Y.1
Ren, X.2
Yang, L.3
Lin, Y.4
Wu, X.5
-
33
-
-
43049152912
-
TNF-α induces two distinct caspase-8 activation pathways
-
Wang, L., Du, F. & Wang, X. TNF-α induces two distinct caspase-8 activation pathways. Cell 133, 693-703 (2008).
-
(2008)
Cell
, vol.133
, pp. 693-703
-
-
Wang, L.1
Du, F.2
Wang, X.3
-
34
-
-
0038495741
-
JNK phosphorylates paxillin and regulates cell migration
-
Huang, C., Rajfur, Z., Borchers, C., Schaller, M. D. & Jacobson, K. JNK phosphorylates paxillin and regulates cell migration. Nature 424, 219-223 (2003).
-
(2003)
Nature
, vol.424
, pp. 219-223
-
-
Huang, C.1
Rajfur, Z.2
Borchers, C.3
Schaller, M.D.4
Jacobson, K.5
-
35
-
-
0037113034
-
JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation- dependent and -independent mechanisms
-
David, J. P., Sabapathy, K., Hoffmann, O., Idarraga, M. H. & Wagner, E. F. JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation- dependent and -independent mechanisms. J. Cell Sci. 115, 4317-4325 (2002).
-
(2002)
J. Cell Sci
, vol.115
, pp. 4317-4325
-
-
David, J.P.1
Sabapathy, K.2
Hoffmann, O.3
Idarraga, M.H.4
Wagner, E.F.5
-
36
-
-
0032538817
-
+thymocytes
-
+thymocytes. J. Exp. Med. 188, 1817-1830 (1998).
-
(1998)
J. Exp. Med
, vol.188
, pp. 1817-1830
-
-
Rincon, M.1
-
37
-
-
0034757779
-
Cell cycle regulation by p38 MAP kinases
-
Ambrosino, C. & Nebreda, A. R. Cell cycle regulation by p38 MAP kinases. Biol. Cell 93, 47-51 (2001).
-
(2001)
Biol. Cell
, vol.93
, pp. 47-51
-
-
Ambrosino, C.1
Nebreda, A.R.2
-
38
-
-
60149093582
-
Non-classical p38 MAP kinase functions: Cell cycle checkpoints and survival
-
Thornton, T. M. & Rincon, M. Non-classical p38 MAP kinase functions: cell cycle checkpoints and survival. Int. J. Biol. Sci. 5, 44-51 (2009).
-
(2009)
Int. J. Biol. Sci
, vol.5
, pp. 44-51
-
-
Thornton, T.M.1
Rincon, M.2
-
39
-
-
0033625759
-
Involvement of the MKK6-p38δ cascade in γ-radiation-induced cell cycle arrest
-
Wang, X. et al. Involvement of the MKK6-p38δ cascade in γ-radiation-induced cell cycle arrest. Mol. Cell Biol. 20, 4543-4552 (2000).
-
(2000)
Mol. Cell Biol
, vol.20
, pp. 4543-4552
-
-
Wang, X.1
-
40
-
-
34547212349
-
The pathways to tumor suppression via route p38
-
Han, J. & Sun, P. The pathways to tumor suppression via route p38. Trends Biochem. Sci. 32, 364-371 (2007).
-
(2007)
Trends Biochem. Sci
, vol.32
, pp. 364-371
-
-
Han, J.1
Sun, P.2
-
41
-
-
18844383961
-
p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes
-
Engel, F. B. et al. p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev. 19, 1175-1187 (2005).
-
(2005)
Genes Dev
, vol.19
, pp. 1175-1187
-
-
Engel, F.B.1
-
42
-
-
34249334506
-
p38α suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway
-
Genetically engineered mouse models show that p38α negatively regulates the proliferation of hepatocytes, fibroblasts and haematopoietic cells, as well as liver tumorigenesis. Downregulation of the JNK/JUN pathway has an important role in these effects of p38α
-
Hui, L. et al. p38α suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Nature Genet. 39, 741-749 (2007). Genetically engineered mouse models show that p38α negatively regulates the proliferation of hepatocytes, fibroblasts and haematopoietic cells, as well as liver tumorigenesis. Downregulation of the JNK/JUN pathway has an important role in these effects of p38α.
-
(2007)
Nature Genet
, vol.39
, pp. 741-749
-
-
Hui, L.1
-
43
-
-
34249807348
-
-
Ventura, J. J. et al. p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nature Genet. 39, 750-758 (2007). This paper provides genetic evidence for the role of p38α in coordinating proliferation and differentiation of lung epithelial cells. As a consequence, p38α-deficient mice are highly sensitized to Kras-induced lung tumorigenesis.
-
Ventura, J. J. et al. p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nature Genet. 39, 750-758 (2007). This paper provides genetic evidence for the role of p38α in coordinating proliferation and differentiation of lung epithelial cells. As a consequence, p38α-deficient mice are highly sensitized to Kras-induced lung tumorigenesis.
-
-
-
-
44
-
-
66349138173
-
p38α Mitogen-activated protein kinase is essential for skin tumor development in mice
-
Schindler, E. M. et al. p38α Mitogen-activated protein kinase is essential for skin tumor development in mice. Cancer Res. 69, 4648-4655 (2009).
-
(2009)
Cancer Res
, vol.69
, pp. 4648-4655
-
-
Schindler, E.M.1
-
45
-
-
0038792224
-
MAP kinase signaling pathways and hematologic malignancies
-
Platanias, L. C. MAP kinase signaling pathways and hematologic malignancies. Blood 101, 4667-4679 (2003).
-
(2003)
Blood
, vol.101
, pp. 4667-4679
-
-
Platanias, L.C.1
-
46
-
-
0033548548
-
pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells
-
Lee, R. J. et al. pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells. J. Biol. Chem. 274, 7341-7350 (1999).
-
(1999)
J. Biol. Chem
, vol.274
, pp. 7341-7350
-
-
Lee, R.J.1
-
47
-
-
2442644183
-
p38 MAP kinase signaling is necessary for rat chondrosarcoma cell proliferation
-
Halawani, D., Mondeh, R., Stanton, L. A. & Beier, F. p38 MAP kinase signaling is necessary for rat chondrosarcoma cell proliferation. Oncogene 23, 3726-3731 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 3726-3731
-
-
Halawani, D.1
Mondeh, R.2
Stanton, L.A.3
Beier, F.4
-
48
-
-
32244446906
-
The p38 transduction pathway in prostatic neoplasia
-
Ricote, M. et al. The p38 transduction pathway in prostatic neoplasia. J. Pathol. 208, 401-407 (2006).
-
(2006)
J. Pathol
, vol.208
, pp. 401-407
-
-
Ricote, M.1
-
49
-
-
0037034199
-
Hepatocyte growth factor/scatter factor activates proliferation in melanoma cells through p38 MAPK, ATF-2 and cyclin D1
-
Recio, J. A. & Merlino, G. Hepatocyte growth factor/scatter factor activates proliferation in melanoma cells through p38 MAPK, ATF-2 and cyclin D1. Oncogene 21, 1000-1008 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 1000-1008
-
-
Recio, J.A.1
Merlino, G.2
-
50
-
-
39049190957
-
A novel role of p38α MAPK in mitotic progression independent of its kinase activity
-
Fan, L. et al. A novel role of p38α MAPK in mitotic progression independent of its kinase activity. Cell Cycle 4, 1616-1624 (2005).
-
(2005)
Cell Cycle
, vol.4
, pp. 1616-1624
-
-
Fan, L.1
-
51
-
-
0037019186
-
Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells
-
Neve, R. M., Holbro, T. & Hynes, N. E. Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells. Oncogene 21, 4567-4576 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 4567-4576
-
-
Neve, R.M.1
Holbro, T.2
Hynes, N.E.3
-
52
-
-
33846811520
-
p38α MAP kinase as a sensor of reactive oxygen species in tumorigenesis
-
This paper shows that p38α negatively regulates the initiation of tumorigenesis by sensing the oncogene-induced accumulation of reactive oxygen species and triggering apoptosis
-
Dolado, I. et al. p38α MAP kinase as a sensor of reactive oxygen species in tumorigenesis. Cancer Cell 11, 191-205 (2007). This paper shows that p38α negatively regulates the initiation of tumorigenesis by sensing the oncogene-induced accumulation of reactive oxygen species and triggering apoptosis.
-
(2007)
Cancer Cell
, vol.11
, pp. 191-205
-
-
Dolado, I.1
-
53
-
-
2442534165
-
Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo
-
Kaiser, R. A. et al. Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo. J. Biol. Chem. 279, 15524-15530 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 15524-15530
-
-
Kaiser, R.A.1
-
54
-
-
0032569019
-
Induction of apoptosis by SB202190 through inhibition of p38β mitogen-activated protein kinase
-
Nemoto, S., Xiang, J., Huang, S. & Lin, A. Induction of apoptosis by SB202190 through inhibition of p38β mitogen-activated protein kinase. J. Biol. Chem. 273, 16415-16420 (1998).
-
(1998)
J. Biol. Chem
, vol.273
, pp. 16415-16420
-
-
Nemoto, S.1
Xiang, J.2
Huang, S.3
Lin, A.4
-
55
-
-
33746215182
-
The antiapoptotic effect of heme oxygenase-1 in endothelial cells involves the degradation of p38α MAPK isoform
-
Silva, G., Cunha, A., Gregoire, I. P., Seldon, M. P. & Soares, M. P. The antiapoptotic effect of heme oxygenase-1 in endothelial cells involves the degradation of p38α MAPK isoform. J. Immunol. 177, 1894-1903 (2006).
-
(2006)
J. Immunol
, vol.177
, pp. 1894-1903
-
-
Silva, G.1
Cunha, A.2
Gregoire, I.P.3
Seldon, M.P.4
Soares, M.P.5
-
56
-
-
35548936833
-
Models, mechanisms and clinical evidence for cancer dormancy
-
Aguirre-Ghiso, J. A. Models, mechanisms and clinical evidence for cancer dormancy. Nature Rev. Cancer 7, 834-846 (2007).
-
(2007)
Nature Rev. Cancer
, vol.7
, pp. 834-846
-
-
Aguirre-Ghiso, J.A.1
-
57
-
-
33947418965
-
A novel cell type-specific role of p38α in the control of autophagy and cell death in colorectal cancer cells
-
Comes, F. et al. A novel cell type-specific role of p38α in the control of autophagy and cell death in colorectal cancer cells. Cell Death Differ. 14, 693-702 (2007).
-
(2007)
Cell Death Differ
, vol.14
, pp. 693-702
-
-
Comes, F.1
-
58
-
-
43249106330
-
Phosphorylation by p38 MAPK as an alternative pathway for GSK3β inactivation
-
Thornton, T. M. et al. Phosphorylation by p38 MAPK as an alternative pathway for GSK3β inactivation. Science 320, 667-670 (2008).
-
(2008)
Science
, vol.320
, pp. 667-670
-
-
Thornton, T.M.1
-
59
-
-
33746325064
-
p38 mitogen-activated protein kinase activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis
-
Aouadi, M. et al. p38 mitogen-activated protein kinase activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis. Stem Cells 24, 1399-1406 (2006).
-
(2006)
Stem Cells
, vol.24
, pp. 1399-1406
-
-
Aouadi, M.1
-
60
-
-
33845647995
-
Embryonic stem cells utilize reactive oxygen species as transducers of mechanical strain-induced cardiovascular differentiation
-
Schmelter, M., Ateghang, B., Helmig, S., Wartenberg, M. & Sauer, H. Embryonic stem cells utilize reactive oxygen species as transducers of mechanical strain-induced cardiovascular differentiation. FASEB J. 20, 1182-1184 (2006).
-
(2006)
FASEB J
, vol.20
, pp. 1182-1184
-
-
Schmelter, M.1
Ateghang, B.2
Helmig, S.3
Wartenberg, M.4
Sauer, H.5
-
61
-
-
30444440735
-
Regulation of skeletal muscle gene expression by p38 MAP kinases
-
Lluis, F., Perdiguero, E., Nebreda, A. R. & Muñoz-Canoves, P. Regulation of skeletal muscle gene expression by p38 MAP kinases. Trends Cell Biol. 16, 36-44 (2006).
-
(2006)
Trends Cell Biol
, vol.16
, pp. 36-44
-
-
Lluis, F.1
Perdiguero, E.2
Nebreda, A.R.3
Muñoz-Canoves, P.4
-
63
-
-
33645506693
-
Hepatocyte growth factor effects on mesenchymal stem cells: Proliferation, migration, and differentiation
-
Forte, G. et al. Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation. Stem Cells 24, 23-33 (2006).
-
(2006)
Stem Cells
, vol.24
, pp. 23-33
-
-
Forte, G.1
-
64
-
-
33947100032
-
Genetic analysis of p38 MAP kinases in myogenesis: Fundamental role of p38α in abrogating myoblast proliferation
-
Perdiguero, E. et al. Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38α in abrogating myoblast proliferation. EMBO J. 26, 1245-1256 (2007).
-
(2007)
EMBO J
, vol.26
, pp. 1245-1256
-
-
Perdiguero, E.1
-
65
-
-
0034162714
-
Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells
-
Puri, P. L. et al. Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. Genes Dev. 14, 574-584 (2000).
-
(2000)
Genes Dev
, vol.14
, pp. 574-584
-
-
Puri, P.L.1
-
66
-
-
1842785873
-
Daphnetin induced differentiation of human renal carcinoma cells and its mediation by p38 mitogen-activated protein kinase
-
Finn, G. J., Creaven, B. S. & Egan, D. A. Daphnetin induced differentiation of human renal carcinoma cells and its mediation by p38 mitogen-activated protein kinase. Biochem. Pharmacol. 67, 1779-1788 (2004).
-
(2004)
Biochem. Pharmacol
, vol.67
, pp. 1779-1788
-
-
Finn, G.J.1
Creaven, B.S.2
Egan, D.A.3
-
67
-
-
58149186769
-
RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells
-
Ordonez-Moran, P. et al. RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells. J. Cell Biol. 183, 697-710 (2008).
-
(2008)
J. Cell Biol
, vol.183
, pp. 697-710
-
-
Ordonez-Moran, P.1
-
68
-
-
0030220456
-
p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient
-
Hazzalin, C. A. et al. p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient. Curr. Biol. 6, 1028-1031 (1996).
-
(1996)
Curr. Biol
, vol.6
, pp. 1028-1031
-
-
Hazzalin, C.A.1
-
69
-
-
0031844392
-
Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy
-
Nemoto, S., Sheng, Z. & Lin, A. Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy. Mol. Cell Biol. 18, 3518-3526 (1998).
-
(1998)
Mol. Cell Biol
, vol.18
, pp. 3518-3526
-
-
Nemoto, S.1
Sheng, Z.2
Lin, A.3
-
70
-
-
13444283604
-
p38α, but not p38β, inhibits the phosphorylation and presence of c-FLIPS in DISC to potentiate Fas-mediated caspase-8 activation and type I apoptotic signaling
-
Tourian, L. Jr, Zhao, H. & Srikant, C. B. p38α, but not p38β, inhibits the phosphorylation and presence of c-FLIPS in DISC to potentiate Fas-mediated caspase-8 activation and type I apoptotic signaling. J. Cell Sci. 117, 6459-6471 (2004).
-
(2004)
J. Cell Sci
, vol.117
, pp. 6459-6471
-
-
Tourian Jr, L.1
Zhao, H.2
Srikant, C.B.3
-
71
-
-
37349081594
-
Antagonistic control of cell fates by JNK and p38-MAPK signaling
-
Wada, T. et al. Antagonistic control of cell fates by JNK and p38-MAPK signaling. Cell Death Differ. 15, 89-93 (2008).
-
(2008)
Cell Death Differ
, vol.15
, pp. 89-93
-
-
Wada, T.1
-
72
-
-
0242473165
-
Feedback control of the protein kinase TAK1 by SAPK2a/p38α
-
Cheung, P. C., Campbell, D. G., Nebreda, A. R. & Cohen, P. Feedback control of the protein kinase TAK1 by SAPK2a/p38α. EMBO J. 22, 5793-5805 (2003).
-
(2003)
EMBO J
, vol.22
, pp. 5793-5805
-
-
Cheung, P.C.1
Campbell, D.G.2
Nebreda, A.R.3
Cohen, P.4
-
73
-
-
39149122494
-
Activation of c-Jun N.-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: A MLK3-MKK7-dependent mechanism
-
Muniyappa, H. & Das, K. C. Activation of c-Jun N.-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK3-MKK7-dependent mechanism. Cell Signal 20, 675-683 (2008).
-
(2008)
Cell Signal
, vol.20
, pp. 675-683
-
-
Muniyappa, H.1
Das, K.C.2
-
74
-
-
33747377165
-
c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity
-
Stepniak, E. et al. c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity. Genes Dev. 20, 2306-2314 (2006).
-
(2006)
Genes Dev
, vol.20
, pp. 2306-2314
-
-
Stepniak, E.1
-
75
-
-
53249111250
-
-
Heinrichsdorff, J., Luedde, T., Perdiguero, E., Nebreda, A. R. & Pasparakis, M. p38α MAPK inhibits JNK activation and collaborates with IκB kinase 2 to prevent endotoxin-induced liver failure. EMBO Rep. 9, 1048-1054 (2008).
-
Heinrichsdorff, J., Luedde, T., Perdiguero, E., Nebreda, A. R. & Pasparakis, M. p38α MAPK inhibits JNK activation and collaborates with IκB kinase 2 to prevent endotoxin-induced liver failure. EMBO Rep. 9, 1048-1054 (2008).
-
-
-
-
76
-
-
14844327760
-
-
Kamata, H. et al. Reactive oxygen species promote TNFα-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120, 649-661 (2005). The paper shows that hepatocytes lacking IKKβ show reduced JNK phosphatase activity, leading to sustained JNK1 activation and increased liver carcinogenesis.
-
Kamata, H. et al. Reactive oxygen species promote TNFα-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120, 649-661 (2005). The paper shows that hepatocytes lacking IKKβ show reduced JNK phosphatase activity, leading to sustained JNK1 activation and increased liver carcinogenesis.
-
-
-
-
77
-
-
1642602694
-
Gadd45β mediates the NF-κB suppression of JNK signalling by targeting MKK7/JNKK2
-
Papa, S. et al. Gadd45β mediates the NF-κB suppression of JNK signalling by targeting MKK7/JNKK2. Nature Cell Biol. 6, 146-153 (2004).
-
(2004)
Nature Cell Biol
, vol.6
, pp. 146-153
-
-
Papa, S.1
-
78
-
-
43049132158
-
Gadd45β promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling
-
Papa, S. et al. Gadd45β promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling. J. Clin. Invest. 118, 1911-1923 (2008).
-
(2008)
J. Clin. Invest
, vol.118
, pp. 1911-1923
-
-
Papa, S.1
-
79
-
-
33745298519
-
Nuclear factor-κB in cancer development and progression
-
Karin, M. Nuclear factor-κB in cancer development and progression. Nature 441, 431-436 (2006).
-
(2006)
Nature
, vol.441
, pp. 431-436
-
-
Karin, M.1
-
80
-
-
47949096781
-
Cancer-related inflammation
-
Mantovani, A., Allavena, P., Sica, A. & Balkwill, F. Cancer-related inflammation. Nature 454, 436-444 (2008).
-
(2008)
Nature
, vol.454
, pp. 436-444
-
-
Mantovani, A.1
Allavena, P.2
Sica, A.3
Balkwill, F.4
-
81
-
-
0344496062
-
IKKβ is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFα
-
Maeda, S. et al. IKKβ is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFα. Immunity 19, 725-737 (2003).
-
(2003)
Immunity
, vol.19
, pp. 725-737
-
-
Maeda, S.1
-
82
-
-
36749084608
-
Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase
-
Hasselblatt, P., Rath, M., Komnenovic, V., Zatloukal, K. & Wagner, E. F. Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase. Proc. Natl Acad. Sci. USA 104, 17105-17110 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 17105-17110
-
-
Hasselblatt, P.1
Rath, M.2
Komnenovic, V.3
Zatloukal, K.4
Wagner, E.F.5
-
83
-
-
21244472975
-
IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
-
References 81-83 clearly show that the JNK pathway induces cell death in Con A-induced hepatitis and cytokine-driven hepatocarcinogenesis, whereas JUN/AP1 is hepatoprotective in the Con A model of hepatitis and antagonizes JNK function
-
Maeda, S., Kamata, H., Luo, J. L., Leffert, H. & Karin, M. IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121, 977-990 (2005). References 81-83 clearly show that the JNK pathway induces cell death in Con A-induced hepatitis and cytokine-driven hepatocarcinogenesis, whereas JUN/AP1 is hepatoprotective in the Con A model of hepatitis and antagonizes JNK function.
-
(2005)
Cell
, vol.121
, pp. 977-990
-
-
Maeda, S.1
Kamata, H.2
Luo, J.L.3
Leffert, H.4
Karin, M.5
-
84
-
-
58249093873
-
Induction of hepatitis by JNK-mediated expression of TNF-α
-
Das, M. et al. Induction of hepatitis by JNK-mediated expression of TNF-α. Cell 136, 249-260 (2009).
-
(2009)
Cell
, vol.136
, pp. 249-260
-
-
Das, M.1
-
85
-
-
50249086073
-
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
-
Kaser, A. et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134, 743-756 (2008).
-
(2008)
Cell
, vol.134
, pp. 743-756
-
-
Kaser, A.1
-
86
-
-
34347392053
-
Regulation of the JNK pathway by TGF-β activated kinase 1 in rheumatoid arthritis synoviocytes
-
Hammaker, D. R., Boyle, D. L., Inoue, T. & Firestein, G. S. Regulation of the JNK pathway by TGF-β activated kinase 1 in rheumatoid arthritis synoviocytes. Arthritis Res. Ther. 9, R57 (2007).
-
(2007)
Arthritis Res. Ther
, vol.9
-
-
Hammaker, D.R.1
Boyle, D.L.2
Inoue, T.3
Firestein, G.S.4
-
87
-
-
9444277846
-
Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis
-
Ricci, R. et al. Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science 306, 1558-1561 (2004).
-
(2004)
Science
, vol.306
, pp. 1558-1561
-
-
Ricci, R.1
-
88
-
-
1242295291
-
UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression
-
Bachelor, M. A. & Bowden, G. T. UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression. Semin. Cancer Biol. 14, 131-138 (2004).
-
(2004)
Semin. Cancer Biol
, vol.14
, pp. 131-138
-
-
Bachelor, M.A.1
Bowden, G.T.2
-
89
-
-
33646163924
-
COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer
-
Timoshenko, A. V., Chakraborty, C., Wagner, G. F. & Lala, P. K. COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer. Br. J. Cancer 94, 1154-1163 (2006).
-
(2006)
Br. J. Cancer
, vol.94
, pp. 1154-1163
-
-
Timoshenko, A.V.1
Chakraborty, C.2
Wagner, G.F.3
Lala, P.K.4
-
90
-
-
34447121976
-
EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas
-
Xu, K. & Shu, H. K. EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas. Cancer Res. 67, 6121-6129 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 6121-6129
-
-
Xu, K.1
Shu, H.K.2
-
91
-
-
0142026209
-
p38 MAP kinases: Key signalling molecules as therapeutic targets for inflammatory diseases
-
Kumar, S., Boehm, J. & Lee, J. C. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nature Rev. Drug Discov. 2, 717-726 (2003).
-
(2003)
Nature Rev. Drug Discov
, vol.2
, pp. 717-726
-
-
Kumar, S.1
Boehm, J.2
Lee, J.C.3
-
92
-
-
0038538477
-
Posttranscriptional regulation of gene expression by mitogen-activated protein kinase p38
-
Clark, A. R., Dean, J. L. & Saklatvala, J. Posttranscriptional regulation of gene expression by mitogen-activated protein kinase p38. FEBS Lett. 546, 37-44 (2003).
-
(2003)
FEBS Lett
, vol.546
, pp. 37-44
-
-
Clark, A.R.1
Dean, J.L.2
Saklatvala, J.3
-
93
-
-
50049122380
-
The kinase p38α serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
-
Kim, C. et al. The kinase p38α serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression. Nature Immunol. 9, 1019-1027 (2008).
-
(2008)
Nature Immunol
, vol.9
, pp. 1019-1027
-
-
Kim, C.1
-
94
-
-
44449100233
-
Macrophage deletion of p38α partially impairs lipopolysaccharide-induced cellular activation
-
References 93 and 94 provide genetic evidence for the regulation of cytokine production and inflammatory responses by p38α in myeloid and epithelial cells
-
Kang, Y. J. et al. Macrophage deletion of p38α partially impairs lipopolysaccharide-induced cellular activation. J. Immunol. 180, 5075-5082 (2008). References 93 and 94 provide genetic evidence for the regulation of cytokine production and inflammatory responses by p38α in myeloid and epithelial cells.
-
(2008)
J. Immunol
, vol.180
, pp. 5075-5082
-
-
Kang, Y.J.1
-
95
-
-
27944461325
-
Generation and characterization of p38β (MAPK11) gene-targeted mice
-
Beardmore, V. A. et al. Generation and characterization of p38β (MAPK11) gene-targeted mice. Mol. Cell. Biol. 25, 10454-10464 (2005).
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 10454-10464
-
-
Beardmore, V.A.1
-
96
-
-
36849034334
-
Chemical genetics define the roles of p38α and p38β in acute and chronic inflammation
-
O'Keefe, S. J. et al. Chemical genetics define the roles of p38α and p38β in acute and chronic inflammation. J. Biol. Chem. 282, 34663-34671 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, pp. 34663-34671
-
-
O'Keefe, S.J.1
-
97
-
-
20344386238
-
Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling
-
Emerling, B. M. et al. Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Mol. Cell Biol. 25, 4853-4862 (2005).
-
(2005)
Mol. Cell Biol
, vol.25
, pp. 4853-4862
-
-
Emerling, B.M.1
-
98
-
-
34249314755
-
p38 mitogen-activated protein kinase pathway is involved in protein kinase Cα-regulated invasion in human hepatocellular carcinoma cells
-
Hsieh, Y. H. et al. p38 mitogen-activated protein kinase pathway is involved in protein kinase Cα-regulated invasion in human hepatocellular carcinoma cells. Cancer Res. 67, 4320-4327 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 4320-4327
-
-
Hsieh, Y.H.1
-
99
-
-
34547809513
-
p38α and p38δ mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells
-
Junttila, M. R. et al. p38α and p38δ mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells. Oncogene 26, 5267-5279 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 5267-5279
-
-
Junttila, M.R.1
-
100
-
-
34248152719
-
MAP-ing glioma invasion: Mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival
-
Demuth, T. et al. MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival. Mol. Cancer Ther. 6, 1212-1222 (2007).
-
(2007)
Mol. Cancer Ther
, vol.6
, pp. 1212-1222
-
-
Demuth, T.1
-
101
-
-
33845982933
-
Involvement of p38α mitogen-activated protein kinase in lung metastasis of tumor cells
-
Matsuo, Y. et al. Involvement of p38α mitogen-activated protein kinase in lung metastasis of tumor cells. J. Biol. Chem. 281, 36767-36775 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 36767-36775
-
-
Matsuo, Y.1
-
102
-
-
42949102509
-
The p38 MAPK stress pathway as a tumor suppressor or more?
-
Loesch, M. & Chen, G. The p38 MAPK stress pathway as a tumor suppressor or more? Front. Biosci. 13, 3581-3593 (2008).
-
(2008)
Front. Biosci
, vol.13
, pp. 3581-3593
-
-
Loesch, M.1
Chen, G.2
-
103
-
-
33644502513
-
The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma
-
Hickson, J. A. et al. The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma. Cancer Res. 66, 2264-2270 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 2264-2270
-
-
Hickson, J.A.1
-
104
-
-
28244493042
-
Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7
-
Vander Griend, D. J. et al. Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7. Cancer Res. 65, 10984-10991 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 10984-10991
-
-
Vander Griend, D.J.1
-
105
-
-
0141482096
-
p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells
-
Kim, M. S., Lee, E. J., Kim, H. R. & Moon, A. p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells. Cancer Res. 63, 5454-5461 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 5454-5461
-
-
Kim, M.S.1
Lee, E.J.2
Kim, H.R.3
Moon, A.4
-
106
-
-
33646361573
-
Oncogenic K-Ras downregulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38
-
Dreissigacker, U. et al. Oncogenic K-Ras downregulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38. Cell Signal. 18, 1156-1168 (2006).
-
(2006)
Cell Signal
, vol.18
, pp. 1156-1168
-
-
Dreissigacker, U.1
-
107
-
-
20444385832
-
Activation of p38 has opposing effects on the proliferation and migration of endothelial cells
-
McMullen, M. E., Bryant, P. W., Glembotski, C. C., Vincent, P. A. & Pumiglia, K. M. Activation of p38 has opposing effects on the proliferation and migration of endothelial cells. J. Biol. Chem. 280, 20995-21003 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 20995-21003
-
-
McMullen, M.E.1
Bryant, P.W.2
Glembotski, C.C.3
Vincent, P.A.4
Pumiglia, K.M.5
-
108
-
-
33749257848
-
CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway
-
Rousseau, S. et al. CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway. Cell Signal 18, 1897-1905 (2006).
-
(2006)
Cell Signal
, vol.18
, pp. 1897-1905
-
-
Rousseau, S.1
-
109
-
-
33751504690
-
Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
-
Hiratsuka, S., Watanabe, A., Aburatani, H. & Maru, Y. Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nature Cell Biol. 8, 1369-1375 (2006).
-
(2006)
Nature Cell Biol
, vol.8
, pp. 1369-1375
-
-
Hiratsuka, S.1
Watanabe, A.2
Aburatani, H.3
Maru, Y.4
-
110
-
-
33644508365
-
MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration
-
Kobayashi, M., Nishita, M., Mishima, T., Ohashi, K. & Mizuno, K. MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration. EMBO J. 25, 713-726 (2006).
-
(2006)
EMBO J
, vol.25
, pp. 713-726
-
-
Kobayashi, M.1
Nishita, M.2
Mishima, T.3
Ohashi, K.4
Mizuno, K.5
-
111
-
-
0037462454
-
Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53
-
Eferl, R. et al. Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53. Cell 112, 181-192 (2003).
-
(2003)
Cell
, vol.112
, pp. 181-192
-
-
Eferl, R.1
-
112
-
-
33746032571
-
Loss of hepatic NF-κB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation
-
Sakurai, T., Maeda, S., Chang, L. & Karin, M. Loss of hepatic NF-κB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc. Natl Acad. Sci. USA 103, 10544-10551 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 10544-10551
-
-
Sakurai, T.1
Maeda, S.2
Chang, L.3
Karin, M.4
-
113
-
-
57449109370
-
Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation
-
References 112 and 113 describe the molecular functions of JNK1 and JNK2 in mouse and human liver cancer cells using mouse liver carcinogenesis models and human liver cancer cell lines
-
Hui, L., Zatloukal, K., Scheuch, H., Stepniak, E. & Wagner, E. F. Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation. J. Clin. Invest. 118, 3943-3953 (2008). References 112 and 113 describe the molecular functions of JNK1 and JNK2 in mouse and human liver cancer cells using mouse liver carcinogenesis models and human liver cancer cell lines.
-
(2008)
J. Clin. Invest
, vol.118
, pp. 3943-3953
-
-
Hui, L.1
Zatloukal, K.2
Scheuch, H.3
Stepniak, E.4
Wagner, E.F.5
-
114
-
-
65949125078
-
Beyond apoptosis of JNK1 in liver cancer
-
Chen, F. & Castranova, V. Beyond apoptosis of JNK1 in liver cancer. Cell Cycle 8, 1145-1147 (2009).
-
(2009)
Cell Cycle
, vol.8
, pp. 1145-1147
-
-
Chen, F.1
Castranova, V.2
-
115
-
-
0036494195
-
Deficiency of c-Jun-NH2-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate
-
She, Q. B., Chen, N., Bode, A. M., Flavell, R. A. & Dong, Z. Deficiency of c-Jun-NH2-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 62, 1343-1348 (2002).
-
(2002)
Cancer Res
, vol.62
, pp. 1343-1348
-
-
She, Q.B.1
Chen, N.2
Bode, A.M.3
Flavell, R.A.4
Dong, Z.5
-
116
-
-
0035872409
-
2-terminal kinase-2-deficient mice
-
2-terminal kinase-2-deficient mice. Cancer Res. 61, 3908-3912 (2001).
-
(2001)
Cancer Res
, vol.61
, pp. 3908-3912
-
-
Chen, N.1
-
117
-
-
24644478136
-
Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
-
Nateri, A. S., Spencer-Dene, B. & Behrens, A. Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 437, 281-285 (2005).
-
(2005)
Nature
, vol.437
, pp. 281-285
-
-
Nateri, A.S.1
Spencer-Dene, B.2
Behrens, A.3
-
118
-
-
67650507032
-
JNK signalling modulates intestinal homeostasis and tumourigenesis in mice
-
Sancho, R. et al. JNK signalling modulates intestinal homeostasis and tumourigenesis in mice. EMBO J. (2009).
-
(2009)
EMBO J
-
-
Sancho, R.1
-
119
-
-
54049122614
-
-
Hasselblatt, P., Gresh, L., Kudo, H., Guinea-Viniegra, J. & Wagner, E. F. The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice. Oncogene 27, 6102-6109 (2008).
-
Hasselblatt, P., Gresh, L., Kudo, H., Guinea-Viniegra, J. & Wagner, E. F. The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice. Oncogene 27, 6102-6109 (2008).
-
-
-
-
120
-
-
34547653108
-
c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression
-
Tong, C. et al. c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. Am. J. Pathol. 171, 297-303 (2007).
-
(2007)
Am. J. Pathol
, vol.171
, pp. 297-303
-
-
Tong, C.1
-
121
-
-
48549093239
-
c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice
-
Shibata, W. et al. c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice. Cancer Res. 68, 5031-5039 (2008).
-
(2008)
Cancer Res
, vol.68
, pp. 5031-5039
-
-
Shibata, W.1
-
123
-
-
0036613212
-
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
-
Bulavin, D. V. et al. Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity. Nature Genet. 31, 210-215 (2002).
-
(2002)
Nature Genet
, vol.31
, pp. 210-215
-
-
Bulavin, D.V.1
-
124
-
-
0041660960
-
Mechanism of p38 MAP kinase activation in vivo
-
Brancho, D. et al. Mechanism of p38 MAP kinase activation in vivo. Genes Dev. 17, 1969-1978 (2003).
-
(2003)
Genes Dev
, vol.17
, pp. 1969-1978
-
-
Brancho, D.1
-
126
-
-
34247099845
-
The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis
-
References 125 and 126 provide in vivo evidence for the role of PPM1D, a negative regulator of p38α, in mammary gland tumorigenesis
-
Demidov, O. N. et al. The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis. Oncogene 26, 2502-2506 (2007). References 125 and 126 provide in vivo evidence for the role of PPM1D, a negative regulator of p38α, in mammary gland tumorigenesis.
-
(2007)
Oncogene
, vol.26
, pp. 2502-2506
-
-
Demidov, O.N.1
-
127
-
-
33749023927
-
Gadd45a suppresses Ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence
-
Tront, J. S., Hoffman, B. & Liebermann, D. A. Gadd45a suppresses Ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence. Cancer Res. 66, 8448-8454 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 8448-8454
-
-
Tront, J.S.1
Hoffman, B.2
Liebermann, D.A.3
-
128
-
-
33744801153
-
Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2
-
Yang, Y. A., Zhang, G. M., Feigenbaum, L. & Zhang, Y. E. Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2. Cancer Cell 9, 445-457 (2006).
-
(2006)
Cancer Cell
, vol.9
, pp. 445-457
-
-
Yang, Y.A.1
Zhang, G.M.2
Feigenbaum, L.3
Zhang, Y.E.4
-
129
-
-
34547946030
-
Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells
-
Breitwieser, W. et al. Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev. 21, 2069-2082 (2007).
-
(2007)
Genes Dev
, vol.21
, pp. 2069-2082
-
-
Breitwieser, W.1
-
130
-
-
48649109203
-
Hepatocyte necrosis induced by oxidative stress and IL-1α release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis
-
This paper shows that p38α may indirectly control liver carcinogenesis by suppressing hepatocyte necrosis and the release of IL-1α
-
Sakurai, T. et al. Hepatocyte necrosis induced by oxidative stress and IL-1α release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell 14, 156-165 (2008). This paper shows that p38α may indirectly control liver carcinogenesis by suppressing hepatocyte necrosis and the release of IL-1α.
-
(2008)
Cancer Cell
, vol.14
, pp. 156-165
-
-
Sakurai, T.1
-
131
-
-
33846282393
-
PRAK is essential for ras-induced senescence and tumor suppression
-
Sun, P. et al. PRAK is essential for ras-induced senescence and tumor suppression. Cell 128, 295-308 (2007).
-
(2007)
Cell
, vol.128
, pp. 295-308
-
-
Sun, P.1
-
132
-
-
10744224857
-
Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination
-
Shi, Y. et al. Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination. Mol. Cell. Biol. 23, 7732-7741 (2003).
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 7732-7741
-
-
Shi, Y.1
-
133
-
-
34248597048
-
Role of mitogen-activated protein kinase kinase 4 in cancer
-
Whitmarsh, A. J. & Davis, R. J. Role of mitogen-activated protein kinase kinase 4 in cancer. Oncogene 26, 3172-3184 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 3172-3184
-
-
Whitmarsh, A.J.1
Davis, R.J.2
-
134
-
-
34547164540
-
The c-jun kinase/stress-activated pathway: Regulation, function and role in human disease
-
Johnson, G. L. & Nakamura, K. The c-jun kinase/stress-activated pathway: Regulation, function and role in human disease. Biochim. et Biophys. Acta 1773, 1341-1348 (2007).
-
(2007)
Biochim. et Biophys. Acta
, vol.1773
, pp. 1341-1348
-
-
Johnson, G.L.1
Nakamura, K.2
-
135
-
-
33947101019
-
Patterns of somatic mutation in human cancer genomes
-
Greenman, C. et al. Patterns of somatic mutation in human cancer genomes. Nature 446, 153-158 (2007).
-
(2007)
Nature
, vol.446
, pp. 153-158
-
-
Greenman, C.1
-
136
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones, S. et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321, 1801-1806 (2008).
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
-
137
-
-
58149460979
-
Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer
-
Chang, Q. et al. Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer. J. Hepatol. 50, 323-333 (2009).
-
(2009)
J. Hepatol
, vol.50
, pp. 323-333
-
-
Chang, Q.1
-
138
-
-
0034744305
-
The c-Jun NH2-terminal kinase 3 (JNK3) gene: Genomic structure, chromosomal assignment, and loss of expression in brain tumors
-
Yoshida, S. et al. The c-Jun NH2-terminal kinase 3 (JNK3) gene: genomic structure, chromosomal assignment, and loss of expression in brain tumors. J. Hum. Genet. 46, 182-187 (2001).
-
(2001)
J. Hum. Genet
, vol.46
, pp. 182-187
-
-
Yoshida, S.1
-
139
-
-
34249815200
-
-
Vivanco, I. et al. Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell 11, 555-569 (2007). This paper shows that PTEN loss leads to AKT activation and to increased JNK activity in human cancer cell lines and clinical prostate samples.
-
Vivanco, I. et al. Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell 11, 555-569 (2007). This paper shows that PTEN loss leads to AKT activation and to increased JNK activity in human cancer cell lines and clinical prostate samples.
-
-
-
-
140
-
-
42049109923
-
Activator protein-1 transcription factors are associated with progression and recurrence of prostate cancer
-
Ouyang, X. et al. Activator protein-1 transcription factors are associated with progression and recurrence of prostate cancer. Cancer Res. 68, 2132-2144 (2008).
-
(2008)
Cancer Res
, vol.68
, pp. 2132-2144
-
-
Ouyang, X.1
-
141
-
-
51649089443
-
Function of JunB in transient amplifying cell senescence and progression of human prostate cancer
-
Konishi, N. et al. Function of JunB in transient amplifying cell senescence and progression of human prostate cancer. Clin. Cancer Res. 14, 4408-4416 (2008).
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 4408-4416
-
-
Konishi, N.1
-
142
-
-
60349085402
-
Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer
-
Liu, J. et al. Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. Science 323, 1218-1222 (2009).
-
(2009)
Science
, vol.323
, pp. 1218-1222
-
-
Liu, J.1
-
143
-
-
18544385947
-
Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23
-
Li, J. et al. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nature Genet. 31, 133-134 (2002).
-
(2002)
Nature Genet
, vol.31
, pp. 133-134
-
-
Li, J.1
-
144
-
-
33847219580
-
A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity
-
Yu, W. et al. A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity. Oncogene 26, 1178-1187 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 1178-1187
-
-
Yu, W.1
-
145
-
-
0038390661
-
Involvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma
-
Iyoda, K. et al. Involvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma. Cancer 97, 3017-3026 (2003).
-
(2003)
Cancer
, vol.97
, pp. 3017-3026
-
-
Iyoda, K.1
-
146
-
-
0038471347
-
Involvement of multiple signaling pathways in follicular lymphoma transformation: P38-mitogen-activated protein kinase as a target for therapy
-
Elenitoba-Johnson, K. S. et al. Involvement of multiple signaling pathways in follicular lymphoma transformation: p38-mitogen-activated protein kinase as a target for therapy. Proc. Natl Acad. Sci. USA 100, 7259-7264 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 7259-7264
-
-
Elenitoba-Johnson, K.S.1
-
147
-
-
0036010518
-
Selective p38 activation in human non-small cell lung cancer
-
Greenberg, A. K. et al. Selective p38 activation in human non-small cell lung cancer. Am. J. Respir. Cell. Mol. Biol. 26, 558-564 (2002).
-
(2002)
Am. J. Respir. Cell. Mol. Biol
, vol.26
, pp. 558-564
-
-
Greenberg, A.K.1
-
148
-
-
9144267697
-
Prognostic significance of phosphorylated p38 mitogen-activated protein kinase and HER-2 expression in lymph node-positive breast carcinoma
-
Esteva, F. J. et al. Prognostic significance of phosphorylated p38 mitogen-activated protein kinase and HER-2 expression in lymph node-positive breast carcinoma. Cancer 100, 499-506 (2004).
-
(2004)
Cancer
, vol.100
, pp. 499-506
-
-
Esteva, F.J.1
-
149
-
-
33745726743
-
High-level expression, activation, and subcellular localization of p38-MAP kinase in thyroid neoplasms
-
Pomerance, M., Quillard, J., Chantoux, F., Young, J. & Blondeau, J. P. High-level expression, activation, and subcellular localization of p38-MAP kinase in thyroid neoplasms. J. Pathol. 209, 298-306 (2006).
-
(2006)
J. Pathol
, vol.209
, pp. 298-306
-
-
Pomerance, M.1
Quillard, J.2
Chantoux, F.3
Young, J.4
Blondeau, J.P.5
-
150
-
-
33646473843
-
p38 MAP kinase inhibitors: A future therapy for inflammatory diseases
-
Mayer, R. J. & Callahan, J. F. p38 MAP kinase inhibitors: a future therapy for inflammatory diseases. Drug Discovery Today 3, 49-54 (2006).
-
(2006)
Drug Discovery Today
, vol.3
, pp. 49-54
-
-
Mayer, R.J.1
Callahan, J.F.2
-
151
-
-
33846821915
-
p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
-
This paper shows that the p38-activated kinase MK2 is important for the survival of cancer cells treated with chemotherapeutic drugs that induce DNA damage
-
Reinhardt, H. C., Aslanian, A. S., Lees, J. A. & Yaffe, M. B. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell 11, 175-189 (2007). This paper shows that the p38-activated kinase MK2 is important for the survival of cancer cells treated with chemotherapeutic drugs that induce DNA damage.
-
(2007)
Cancer Cell
, vol.11
, pp. 175-189
-
-
Reinhardt, H.C.1
Aslanian, A.S.2
Lees, J.A.3
Yaffe, M.B.4
-
152
-
-
49749140733
-
Suppression of p38-stress kinase sensitizes quiescent leukemic cells to anti-mitotic drugs by inducing proliferative responses in them
-
Vaidya, A. A., Sharma, M. B. & Kale, V. P. Suppression of p38-stress kinase sensitizes quiescent leukemic cells to anti-mitotic drugs by inducing proliferative responses in them. Cancer Biol. Ther. 7, 1232-1240 (2008).
-
(2008)
Cancer Biol. Ther
, vol.7
, pp. 1232-1240
-
-
Vaidya, A.A.1
Sharma, M.B.2
Kale, V.P.3
-
153
-
-
1442274808
-
p38 MAP kinase: A convergence point in cancer therapy
-
Olson, J. M. & Hallahan, A. R. p38 MAP kinase: a convergence point in cancer therapy. Trends Mol. Med. 10, 125-129 (2004).
-
(2004)
Trends Mol. Med
, vol.10
, pp. 125-129
-
-
Olson, J.M.1
Hallahan, A.R.2
-
154
-
-
38149078120
-
Inhibitors of c-Jun N-terminal kinases: JuNK no more?
-
Bogoyevitch, M. A. & Arthur, P. G. Inhibitors of c-Jun N-terminal kinases: JuNK no more? Biochim. Biophys. Acta 1784, 76-93 (2008).
-
(2008)
Biochim. Biophys. Acta
, vol.1784
, pp. 76-93
-
-
Bogoyevitch, M.A.1
Arthur, P.G.2
-
155
-
-
35348935662
-
c-Jun N-terminal kinases as potential therapeutic targets
-
Salh, B. c-Jun N-terminal kinases as potential therapeutic targets. Expert Opin. Ther. Targets. 11, 1339-1353 (2007).
-
(2007)
Expert Opin. Ther. Targets
, vol.11
, pp. 1339-1353
-
-
Salh, B.1
-
156
-
-
67649311246
-
A selective small-molecule inhibitor of c-Jun N-terminal kinase 1
-
Yao, K. et al. A selective small-molecule inhibitor of c-Jun N-terminal kinase 1. FEBS Lett. 583, 2208-2212 (2009).
-
(2009)
FEBS Lett
, vol.583
, pp. 2208-2212
-
-
Yao, K.1
-
157
-
-
0141724805
-
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia
-
Borsello, T. et al. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nature Med. 9, 1180-1186 (2003).
-
(2003)
Nature Med
, vol.9
, pp. 1180-1186
-
-
Borsello, T.1
-
158
-
-
55949100580
-
Identification of a new JNK inhibitor targeting the JNK-JIP interaction site
-
Stebbins, J. L. et al. Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc. Natl Acad. Sci. USA 105, 16809-16813 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 16809-16813
-
-
Stebbins, J.L.1
-
159
-
-
57349101675
-
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
-
Sabio, G. et al. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322, 1539-1543 (2008).
-
(2008)
Science
, vol.322
, pp. 1539-1543
-
-
Sabio, G.1
-
160
-
-
0033622470
-
Essential role of p38α MAP kinase in placental but not embryonic cardiovascular development
-
Adams, R. H. et al. Essential role of p38α MAP kinase in placental but not embryonic cardiovascular development. Mol. Cell 6, 109-116 (2000).
-
(2000)
Mol. Cell
, vol.6
, pp. 109-116
-
-
Adams, R.H.1
-
161
-
-
0034641614
-
Essential role for p38α mitogen-activated protein kinase in placental angiogenesis
-
Mudgett, J. S. et al. Essential role for p38α mitogen-activated protein kinase in placental angiogenesis. Proc. Natl Acad. Sci. USA 97, 10454-10459 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 10454-10459
-
-
Mudgett, J.S.1
-
162
-
-
0034697904
-
Requirement for p38α in erythropoietin expression: A role for stress kinases in erythropoiesis
-
Tamura, K. et al. Requirement for p38α in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102, 221-231 (2000).
-
(2000)
Cell
, vol.102
, pp. 221-231
-
-
Tamura, K.1
-
163
-
-
20244365497
-
p38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP
-
Sabio, G. et al. p38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. EMBO J. 24, 1134-1145 (2005).
-
(2005)
EMBO J
, vol.24
, pp. 1134-1145
-
-
Sabio, G.1
-
164
-
-
58249087541
-
Regulation of PKD by the MAPK p38δ in insulin secretion and glucose homeostasis
-
Sumara, G. et al. Regulation of PKD by the MAPK p38δ in insulin secretion and glucose homeostasis. Cell 136, 235-248 (2009).
-
(2009)
Cell
, vol.136
, pp. 235-248
-
-
Sumara, G.1
|