Requirement of NF-κB activation to suppress p53-independent apoptosis induced by oncogenic ras

Science

Volumn 278, Issue 5344, 1997, Pages 1812-1815

  Mayo, Marty W ^a   Wang, Cun Yu ^a,b,c   Cogswell, Patricia C ^a   Rogers Graham, Kelley S ^a   Lowe, Scott W ^d   Der, Channing J ^a,b   Baldwin Jr , Albert S ^a,b,e  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b Curriculum Genet and Molec Biol ^*  (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P53; TRANSCRIPTION FACTOR; E1A PROTEIN;

ANIMAL CELL; APOPTOSIS; CARCINOGENESIS; CONTROLLED STUDY; GENETIC TRANSCRIPTION; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; RAT; REVIEW; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; ANIMAL; ARTICLE; CELL LINE; CELL STRAIN 3T3; CELL SURVIVAL; CELL TRANSFORMATION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOUSE; PHYSIOLOGY;

ANIMALIA;

3T3 CELLS; ADENOVIRUS E1A PROTEINS; ANIMALS; APOPTOSIS; CELL LINE, TRANSFORMED; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; GENES, RAS; MICE; NF-KAPPA B; RATS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030612937     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.278.5344.1812     Document Type: Review

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60. We thank Y. Kaziro for permission to use the Rat-1: iRas cells and M. McMahon for providing the cell line; D. Ballard for the super-repressor lκBα construct; M. Ostrowski for the Ets-transformed cell line; S. Drouin for immunoblotting; L. Arnold and J. Watson for FACS analysis; E. Reap for helpful discussions; and S. Earp and D. Guttridge for reading the manuscript and for helpful suggestions. Supported by NIH grant CA72771 and by the Department of the Army grant DAMD17-94-J-4053 to A.S.B. C.J.D and S.W.L. are supported by NIH grants CA52072 and CA13106, respectwely. M.W.M. is supported by NIH postdoctoral fellowship 1F32-CA69790. C.-Y.W. is supported by a Dentist Scientist Award from NIH.