Bcl-2 suppresses apoptosis resulting from disruption of the NF-κB survival pathway

Experimental Cell Research

Volumn 237, Issue 1, 1997, Pages 101-109

  Herrmann, John L ^a   Beham, Alexander W ^a   Sarkiss, Mona ^a   Chiao, Paul J ^a   Rands, M Todd ^a   Bruckheimer, Elizabeth M ^a   Brisbay, Shawn ^a   McDonnell, Timothy J ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Apoptosis; Bcl 2; NF B; Prostate cancer; TNF

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN INDUCTION;

EID: 0031586606     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1997.3737     Document Type: Article

References (21)

1. 1. McDonnell, T. J., Troncoso, P., Brisbay, S. M., Logothetis, C., Chung, W. K., Hsieh, J-T., Tu, S-M., and Cambell, M. L. (1992) Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer. Cancer Res. 52, 6940-6944.
2. 2. McDonnell, T. J., and Korsmeyer, S. J. (1991) Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18). Nature 349, 254-256.
3. 3. Herrmann, J. L., Bruckheimer, E., and McDonnell, T. J. (1996) Cell death signal transduction and bcl-2 function. Biochem. Soc. Trans. 24, 1059-1065.
4. 4. Beg, A. A., and Baltimore, D. (1996) As essential role for NF-κB in preventing TNF-α-induced cell death. Science 274, 782-784.
5. 5. Liu, Z., Hsu, H., Goeddel, D. V., and Karin, M. (1996) Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87, 565-576.
6. 6. Van Antwerp, D. J., Martin, S. J., Kafri, T., Green, D. R., and Verma, I. M. (1996) Suppression of TNF-α-induced apoptosis by NF-κB. Science 274, 787-789.
7. 7. Wang, C.-Y., Mayo, M. W., and Baldwin, A. S., Jr. (1996) TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB. Science 274, 784-787.
8. 8. Baeurle, P. A., and Baltimore, D. (1996) NF-κB: Ten years later. Cell 87, 13-20.
9. 9. Schreck, R., Meier, B., Mannel, D. N., Droge, W., and Baeuerle, P. A. (1992) Dithiocarbamates as potent inhibitors of nuclear factor κB activation in intact cells. J. Exp. Med. 175, 1181-1194.
10. 10. Brown, K., Gertsberger, S., Carlson, L., Frazoso, G., and Siebenlist, U. (1995) Control of IκB-α proteolysis by site-specific signal-induced phosphorylation. Science 267, 1485-1488.
11. 11. Tu, S.-M., McConnell, K., Marin, M. C., Cambell, M. L., Fernandez, A., von Eschenbach, A. C., and McDonnell, T. J. (1995) Combination adriamycin and suramin induces apoptosis in bcl-2 expressing prostate carcinoma cells. Cancer Lett. 93, 147-155.
12. 2+. Oncogene 12, 2259-2266.
13. 13. Lin, K.-I., Lee, S-H., Naayanan, R., Baraban, J. M., Hardwick, J. M., and Ratan, R. R. (1995) Thiol agents and bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-κB. J. Cell Biol. 131, 1149-1161.
14. 14. Grimm, S., Bauer, M. K. A., Baeuerle, P.A., and Schulze-Osthoff, K. (1996) Bcl-2 down-regulates the activity of transcription factor NF-κB induced upon apoptosis. J. Cell Biol. 134, 13-23.
15. 15. Meyer, M., Schreck, R., and Baeuerle, P. A. (1994) Redox control of gene expression by eukaryotic transcription factors NF-κB, AP-1 and SRF/TCF. in Oxidative Stress, Cell Activation and Viral Infection. (Packer, C., Ed.), Birkhauser Verlag, Basel, Switzerland.
16. 16. Hockenbery, D. M., Oltvai, Z. N., Yin, X. M., Milliman, C. L., and Korsmeyer, S. J. (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75, 241-251.
17. 17. Nakajima, Y., DelliPizza, A., Mallouh, C., and Ferreri, N. R. (1995) Effects of tumor necrosis factor-alpha and interferon-gamma on the growth of human prostate cancer cell lines. Urol. Res. 23, 205-210.
18. 18. Jaattela, M., Benedict, M., Tewari, M., Shayman, J. A., and Dixit, V. M. (1995) Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. Oncogene 10, 2297-2305.
19. 19. Jung, M., Zhang, Y., Lee, S., and Dritshillo, A. (1995) Correction of radiation sensitivity in ataxia telangiectasia cells by a truncated IκB-α. Science 268, 1619-1621.
20. 20. Mandal, M., Maggirwar, S. B., Sharma, N., Kaufmann, S. H., Sun, S-C., and Kumar, R. (1996) Bcl-2 prevents CD95 (Fas/Apo-1)-induced degradation of lamin B and poly(ADP-ribose) polymerase and restores the NF-κB signaling pathway. J. Biol. Chem. 48, 30354-30359.
21. 21. Chiao, P. J., Miyamoto, S., and Verma, I. M. (1994) Autoregulation of I kappa B alpha activity. Proc. Natl. Acad. Sci. USA 91, 28-32.