Nuclear factor (NF)-κB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor α-induced apoptosis

Journal of Experimental Medicine

Volumn 188, Issue 1, 1998, Pages 211-216

  Stehlik, Christian ^a   De Martin, Rainer ^a   Kumabashiri, Ichiro ^a,b   Schmid, Johannes A ^a   Binder, Bernd R ^a   Lipp, Joachim ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b Keiju Medical Center   (Japan)

Author keywords

Activation; Adenovirus; Endothelial cells; Inhibitor of apoptosis gene family; Nuclear factor B

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MULTIGENE FAMILY; PRIORITY JOURNAL; X CHROMOSOME;

ADENOVIRIDAE; APOPTOSIS; CELLS, CULTURED; DNA; DNA FRAGMENTATION; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; LINKAGE (GENETICS); NEOPLASM PROTEINS; NF-KAPPA B; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; VIRAL PROTEINS; X CHROMOSOME;

EID: 0032490670     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.1.211     Document Type: Article

References (33)

1. Hale, A.J., C.A. Smith, L.C. Sutherland, V.E.A. Stoneman, V.L. Longthorne, A.C. Culhane, and G.T. Williams. 1996. Apoptosis: molecular regulation of cell death. Eur. J. Biochem. 236:1-26.
2. Barinaga, M. 1996. Forging a path to cell death. Science. 273: 735-737.
3. Wang, C.Y., M.W. Mayo, and A.S. Baldwin, Jr. 1996. TNF-and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science. 274:784-787.
4. Van Antwerpen, D.J., S.J. Martin, T. Kafri, D.R. Green, and I.M. Verma. 1996. Suppression of TNF-α-induced apoptosis by NF-κB. Science. 274:787-789.
5. Beg, A.A., and D. Baltimore. 1996. An essential role for NF-κB in preventing TNF-α-induced cell death. Science. 274:782-784.
6. Crook, N.E., R.J. Clem, and L.K. Miller. 1993. An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif. J. Virol. 67:2168-2174.
7. Birnbaum, M.J., R.J. Clem, and L.K. Miller. 1994. An apoptosis inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs. J. Virol. 68: 2521-2528.
8. Hay, B.A., D.A. Wassarman, and G.M. Rubin. 1995. Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Cell. 83:1253-1262.
9. Rothe, M., M.G. Pan, W.J. Henzel, T.M. Ayres, and D.V. Goeddel. 1995. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell. 83:1243-1252.
10. Roy, N., M.S. Mahadevan, M. McLean, G. Shutler, Z. Yaraghi, R. Farahani, S. Baird, A. Besner-Johnston, C. Lefebvre, X. Kang, et al. 1995. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell. 80:167-178.
11. Duckett, C.S., V.E. Nava, R.W. Gedrich, R.J. Clem, J.L. Van Dongen, M.C. Gilfillan, H. Shiels, J.M. Hardwick, and C.B. Thompson. 1996. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. EMBO (Eur. Mol. Biol. Organ.) J. 15:2685-2694.
12. Liston, P., N. Roy, K. Tamai, C. Lefebvre, S. Baird, G. Cherton-Horvat, R. Farahani, M. McLean, J.E. Ikeda, A. MacKenzie, and R.G. Korneluk. 1996. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature. 379:349-353.
13. Uren, A.G., M. Pakusch, C.J. Hawkins, K.L. Puls, and D.L. Vaux. 1996. Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. Proc. Natl. Acad. Sci. USA. 93:4974-4978.
14. Clem, R.J., and C.S. Duckett. 1997. The iap genes: unique arbitrators of cell death. Trends Cell Biol. 7:337-339.
15. Shu, H.B., M. Takeuchi, and D.V. Goeddel. 1996. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-JAP1 are components of the tumor necrosis factor receptor 1 signaling complex. Proc. Natl. Acad. Sci. USA. 93:13973-13978.
16. Roy, N., Q.L. Deveraux, R. Takahashi, G.S. Salvesen, and J.C. Reed. 1997. The c-IAP and c-IAP proteins are direct inhibitors of specific caspases. EMBO (Eur. Mol. Biol. Organ.) J. 16:6914-6925.
17. Deveraux, Q.L., R. Takahashi, G.S. Salvesen, and J.C. Reed. 1997. X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 388:300-304.
18. Baeuerle, P.A., and D. Baltimore. 1996. NF-κB: ten years after. Cell. 87:13-20.
19. Baldwin, A.S., Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649-681.
20. Gomex-Foix, A.M., W.S. Coats, S. Baques, T. Alam, R.D. Gerard, and C.B. Newgard. 1992. Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism. J. Biol. Chem. 267:25129-25134.
21. McGrory, W.J., D.S. Bautista, and F.L. Graham. 1988. A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology. 163:614-617.
22. Evan, G.I., K.G. Lewis, G. Ramsay, and M. Bishop. 1985. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell Biol. 5:3610-3616.
23. Graham, F.L., and A.J. Van der Eb. 1973. A neu technique for the assay of infectivity of human adenovirus 5 DNA. Virology. 52:456-467.
24. Stehlik, C., M. de Martin, B.R. Binder, and J. Lipp. 1998. Cytokine induced expression of porcine inhibitor of apoptosis protein (iap) family member is regulated by NF-κB. Biochem. Biophys. Res. Commun. 243:827-832.
25. Collins, T. 1993. Biology of disease: endothelial nuclear factor-κB and the initiation of the atherosclerotic lesion. Lab. Invest. 68:499-508.
26. Collins, T., M.A. Read, A.S. Neish, M.Z. Whitley, D. Thanos, and T. Maniatis. 1995. Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers. FASEB (Fed. Am. Soc. Exp. Biol.) J. 9:899-909.
27. Wrighton, C.J., R. Hofer-Warbinek, T. Moll, R. Eytner, F.H. Bach, and R. de Martin. 1996. Inhibition of endothelial cell activation by adenovirus-mediated expression of I κBα, an inhibitor of the transcription factor NF-κB. J. Exp. Med. 183:1013-1022.
28. de Martin, R., M. Raidl, E. Hofer, and B.R. Binder. 1997. Adenovirus-mediated expression of green fluorescent protein. Gene Ther. 4:493-495.
29. Opipari, A.W., Jr, H.M. Hu, R. Yabkowitz, and V.M. Dixit. 1992. The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. J. Biol. Chem. 267:12424-12427.
30. Wong, G.H.W., J.H. Elwell, L.W. Oberley, and D.V. Goeddel. 1989. Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor. Cell. 58:923-931.
31. Kumar, S., and C. Baglioni. 1991. Protection from tumor necrosis factor-mediated cytolysis by overexpression of plasminogen activator inhibitor type-2. J. Biol. Chem. 266:20960-20964.
32. Karsan, A., E. Yee, K. Kaushansky, and J.M. Harlan. 1996. Cloning of a human bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells. Blood. 87:3089-3096.
33. Chu, Z.L., T.A. McKinsey, L. Liu, J.J. Gentry, M.H. Malim, and D.W. Ballard. 1997. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-iap2 is under NF-κB control. Proc. Natl. Acad. Sci. USA. 94:10057-10062.