Akt-dependent phosphorylation specifically regulates Cot induction of NF-κB-dependent transcription

Molecular and Cellular Biology

Volumn 22, Issue 16, 2002, Pages 5962-5974

  Kane, Lawrence P ^a   Mollenauer, Marianne N ^a   Xu, Zheng ^a   Turck, Christoph W ^a   Weiss, Arthur ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE B;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL TRANSFORMATION; COMPLEX FORMATION; ENZYME SPECIFICITY; GENE DELETION; GENE LOCUS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; CELL LINE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B KINASE; MAP KINASE KINASE KINASES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NF-KAPPA B; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0036316344     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.16.5962-5974.2002     Document Type: Article

References (50)

1. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase
2. The Akt kinase: Molecular determinants of oncogenicity
3. Cot kinase regulation of IL-2 production in Jurkat T cells
4. Cot kinase activates tumor necrosis factor-alpha gene expression in a cyclosporin A-resistant manner
5. TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105
6. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
7. Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation
8. Cellular survival: A play in three Akts
9. TNF-α induction by LPS is regulated posttranscriptionally via a Tpl-2/ERK dependent pathway
10. Involvement of the Tpl-2/col oncogene in MMTV tumorigenesis
11. Col protooncoprotein activates the dual specificity kinases MEK-1 and SEK-1 and induces differentiation of PC12 cells
12. Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IκB kinase complex
13. Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo
14. Akt provides the CD28 co-stimulatory signal for upregulation of IL-2 and IFN-γ but not Th2 cytokines
15. Signal transduction by the TCR for antigen
16. Induction of NF-κB by the Akt/PKB kinase
17. PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization
18. Primary human CD4+ T cells contain heterogeneous I kappa B kinase complexes: Role in activation of the IL-2 promoter
19. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase I
20. Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression
21. T cell receptor signalling
22. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-κB acting through the NF-κB inducing kinase and IκB kinases
23. Molecular determinants of NF-κB-inducing kinase action
24. Akt stimulates the transactivation potential of the Rc1A/p65 subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38
25. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-κB
26. Genomic organization and expression of Tpl-2 in normal cells and Moloney murine leukemia virus-induced rat T-cell lymphomas: Activation by provirus insertion
27. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-I
28. Structure and transforming potential of the human cot oncogene encoding a putative protein kinase
29. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB
30. The murine cot proto-oncogene: Genome structure and tissue-specific expression
31. Collaboration of signal transducer and activator of transcription I (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes
32. NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase
33. Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation
34. Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase
35. NF-κB is a target of AKT in anti-apoptotic PDGF signalling
36. Activation of MEK-I and SEK-I by Tpl-2 prolo-oncoprotein, a novel MAP kinase kinase kinase
37. Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis
38. The Tao of MEKK
39. Deficiency of PTEN in Jurkat T cells causes constitutive localization of itk to the plasma membrane and hyperresponsiveness to CD3 stimulation
40. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-I sites
41. Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase
42. The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines
43. Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB
44. Mitogen-activated kinase kinase kinase I regulates T cell receptor-and CD28-mediated signaling events which lead to NF-κB activation
45. Differential regulation of c-Rel translocation in activated B and T cells
46. Mutations in the Drosophila dTAKI gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses
47. Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-kappa B-inducing kinase
48. The essential role of MEKK3 in TNF-induced NF-kappaB activation
49. Ser727-dependent recruitment of MCM5 by Slatlalpha in IFN-gamma-induced transcriptional activation
50. Mitogen-activated protein ginase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta