The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNFα-induced apoptosis

Genes and Development

Volumn 13, Issue 4, 1999, Pages 382-387

  Zong, Wei Xing ^a,b   Edelstein, Leonard C ^a,b   Chen, Cailin ^a   Bash, Judy ^a,c,e   Gélinas, Céline ^a,d  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^e RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

A1; Apoptosis; Bfl 1; NF B; Rel; TNF

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

EID: 0033558215     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.4.382     Document Type: Article

References (37)

1. Adams, J.M. and S. Cory. 1998. The Bcl-2 protein family: Arbiters of cell survival. Science 281:1322-1326.
2. Bash, J., W.-X. Zong, and C. Gélinas. 1997. c-Rel arrests the proliferation of HeLa cells and affects critical regulators of the G1/S-phase transition. Mol. Cell. Biol. 17:6526-6536.
3. Beg, A.A. and D. Baltimore. 1996. An essential role for NF-κB in preventing TNFα-induced cell death. Science 274: 782-784.
4. Beg, A.A., W.C. Sha, R.T. Bronson, and D. Baltimore. 1995. Constitutive NF-κB activation, enhanced granulopoiesis, and neonatal lethality in IκBα-deficient mice. Genes & Dev. 9: 2736-2746.
5. Cai, Z., M. Korner, N. Tarantino, and S. Chouaib. 1997. IκBα overexpression in human breast carcinoma MCF7 cells inhibits nuclear factor-κB activation but not tumor necrosis factor α-induced apoptosis. J. Biol. Chem. 272: 96-101.
6. Carrasco, D., F. Weih, and R. Bravo. 1994. Developmental expression of the mouse c-rel proto-oncogene in hematopoietic organs. Development 120: 2991-3004.
7. Choi, S.S., I.-C. Park, J.W. Yun, Y.C. Sung, S.I. Hong, and H.-S. Shin. 1995. A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow. Oncogene 11: 1693-1698.
8. Chu, Z.-L., T.A. McKinsey, L. Liu, J.J. Gentry, M.H. Malim, and D.W. Ballard. 1997. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control. Proc. Natl. Acad. Sci. 94: 10057-10062.
9. D'Sa-Eipper, C., T. Subramanian, and G. Chinnadurai. 1996. Bfl-1, a Bcl-2 homologue, suppresses p53-induced apoptosis and exhibits potent cooperative transforming activity. Cancer Res. 56: 3879-3882.
10. Feinberg, A.P. and B. Vogelstein. 1983. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132: 6-13.
11. Gossen, M. and H. Bujard. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. 89: 5547-5551.
12. Jung-ha, H., D. Kim, S.-B. Lee, S.-I. Hone, S.-Y. Park, J. Huh, C.-W. Kim, S.-S. Kim, Y. Lee, S.S. Choi, and H.-S. Shin. 1998. Expression of Bfl-1 in normal and tumor tissues: Bfl-1 overexpression in cancer is attributable to its preferential expression in infiltrating inflammatory cells. Hum. Pathol. 29: 723-728.
13. Karsan, A., E. Yee, and J.M. Harlan. 1996a. Endothelial cell death induced by tumor necrosis factor a is inhibited by the Bcl-2 family member, A1. J. Biol. Chem. 271: 27201-27204.
14. Karsan, A., E. Yee, K. Kaushansky, and J.M. Harlan. 1996b. Cloning of a human Bcl-2 homologue: Inflammatory cytokines induce human A1 in cultured endothelial cells. Blood 87: 3089-3096.
15. Krajewski, S., S. Tanaka, S. Takayama, M.J. Schibler, W. Fenton, and J.C. Reed. 1993. Investigation of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res. 53: 4701-4714.
16. Krikos, A., C.D. Laherty, and V.M. Dixit. 1992. Transcriptional activation of the tumor necrosis factor α-inducible zinc finger protein, A20, is mediated by κB elements. J. Biol. Chem. 267: 17971-17976.
17. Lin, E.Y., A. Orlofsky, M.S. Berger, and M.B. Prystowsky. 1993. Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2. J. Immunol. 151: 1979-1988.
18. Lin, E.Y., A. Orlofsky, H.G. Wang, J.C. Reed, and M.B. Prystowsky. 1996. A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation. Blood 87: 983-992.
19. Liou, H.C., W.C. Sha, M.L. Scott, and D. Baltimore. 1994. Sequential induction of NF-κB/Rel family proteins during B-cell terminal differentiation. Mol. Cell. Biol. 14: 5349-5359.
20. Liu, Z., H. Hsu, D.V. Goeddel, and M. Karin. 1996. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87: 565-576.
21. Miyamoto, S., M.J. Schmitt, and I.M. Verma. 1994. Qualitative changes in the subunit composition of κB-binding complexes during murine B-cell differentiation. Proc. Natl. Acad. Sci. 91: 5056-5060.
22. Moreb, J.S. and M. Schweder. 1997. Human A1, a Bcl-2-related gene, is induced in leukemic cells by cytokines as well as differentiating factors. Leukemia 11: 998-1004.
23. Nagata, S. 1997. Apoptosis by death factor. Cell 88: 355-365.
24. Reed, J.C. 1996. Mechanisms of Bcl-2 family protein function and dysfunction in health and disease. Behring Inst. Mitt. 97: 72-100.
25. Sonenshein, G.E. 1997. Rel/NF-κB transcription factors and the control of apoptosis. Sem. Cancer Biol. 8: 113-119.
26. Van Antwerp, D.J., S.J. Martin, T. Kafri, D.R. Green, and I.M. Verma. 1996. Suppression of TNFα-induced apoptosis by NF-κB. Science 274: 787-789.
27. Van Antwerp, D.J., S.J. Martin, I.M. Verma, and D.R. Green. 1998. Inhibition of TNFα-induced apoptosis by NF-κB. Trends Cell Biol. 8 107-111.
28. Wang, C.-Y., M.W. Mayo, R.G. Korneluk, D.V. Goeddel, and A.S. Baldwin, Jr. 1998. NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281: 1680-1683.
29. Wang, C.-Y., M.W. Mayo, and A.S. Baldwin, Jr. 1996. TNFα and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274: 784-787.
30. White, D.W., A. Roy, and T.D. Gilmore. 1995. The v-Rel oncoprotein blocks apoptosis and proteolysis of IκBα in transformed chicken spleen cells. Oncogene 10: 857-868.
31. White, E., P. Sabbatini, M. Debbas, W.S.M. Wold, D.I. Kusher, and L.R. Gooding. 1992. The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor α. Mol. Cell. Biol. 12: 2570-2580.
32. Wu, M., H. Lee, R.E. Bellas, S.L. Schauer, M. Arsura, D. Katz, M.J. FitzGerald, T.L. Rothstein, D.H. Sherr, and G.E. Sonenshein. 1996. Inhibition of NF-κB/Rel induces apoptosis of murine B cells. EMBO J. 15: 4682-4690.
33. Wu, M.X., Z. Ao, K.V.S. Prasad, R. Wu, and S.F. Schlossman. 1998. IEX-1L, an apoptosis inhibitor involved in NF-κB-mediated cell survival. Science 281: 998-1001.
34. Xu, X., C. Prorock, H. Ishikawa, E. Maldonado, Y. Ito, and C. Gélinas. 1993. Functional interaction of the v-Rel and c-Rel oncoproteins with the TATA-binding protein and association with transcription factor IIB. Mol. Cell. Biol. 13: 6733-6741.
35. You, M., P.-T. Ku, R. Hrdlickova, and H.R. Bose. 1997. ch-IAP1, a member of the inhibitor-of-apoptosis protein family, is a mediator of the antiapoptotic activity of the v-Rel oncoprotem. Mol. Cell. Biol. 17: 7328-7341.
36. Zong, W.-X., M. Farrell, J. Bash, and C. Gélinas. 1997. v-Rel prevents apoptosis in transformed lymphoid cells and blocks TNFα-induced cell death. Oncogene 15: 971-980.
37. Zong, W.-X., J. Bash, and C. Gélinas. 1998. Rel blocks both anti-Fas- and TNFα-induced apoptosis and an intact Rel transactivation domain is essential for this effect. Cell Death Differ. 5: 963-972.