Molecular profiling of transformed and metastatic murine squamous carcinoma cells by differential display and cDNA microarray reveals altered expression of multiple genes related to growth, apoptosis, angiogenesis, and the NF-κB signal pathway

Cancer Research

Volumn 61, Issue 12, 2001, Pages 4797-4808

  Dong, Gang ^a   Loukinova, Elena ^a   Chen, Zhong ^a   Gangi, Lisa ^b   Chanturita, Tatyana I ^a   Liu, Edison T ^b   Van Waes, Carter ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYCLIN D1; FAS ANTIGEN; GLUTATHIONE TRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P21; PROTEIN P27;

ANGIOGENESIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CLUSTER ANALYSIS; CONTROLLED STUDY; DNA MICROARRAY; EARLY RESPONSE GENE; EXPRESSED SEQUENCE TAG; GENE EXPRESSION; MALIGNANT TRANSFORMATION; METASTASIS; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; TUMOR GROWTH; VALIDATION PROCESS;

ANIMALS; APOPTOSIS; BLOTTING, NORTHERN; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, NEOPLASTIC; CLUSTER ANALYSIS; DISEASE PROGRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; KERATINOCYTES; MALE; MICE; MICE, INBRED BALB C; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; UP-REGULATION;

EID: 0035874877     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (87)

1. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
2. Levels of TGF-α and EGFR protein in head and neck squamous cell carcinoma and patient survival
3. The A9 antigen associated with aggressive human squamous carcinoma is structurally and functionally similar to the newly defined integrin α6 β4
4. Increase in suprabasilar integrin adhesion molecule expression in human epidermal neoplasms accompanies increased proliferation occurring with immortalization and tumor progression
5. The plasminogen activation system in tumor growth, invasion, and metastasis
6. Effects of IL- 1α, IL-IRA and neutralizing antibody on proinflammatory cytokine expression by human squamous cell carcinoma lines
7. Expression of proinflammatory and proangiogenic cytokines in human head and neck patients
8. Constitutive expression of proinflammatory cytokines and survival in head and neck squamous cell carcinoma cell lines
9. Expression of a dominant negative inhibitor factor-κBα in a human head and neck squamous cell carcinoma inhibits NF-κB, proinflammatory cytokine expression and tumor growth in vivo
10. Stat-3 STAT signaling in head and neck cancer
11. Control of apoptosis by Rel/NF-κB transcription factors
12. The transcription factor NF-κB: Control of oncogenesis and cancer therapy resistance
13. Aberrant rel/nfkb genes and activity in human cancer
14. Inhibition of both nuclear factor-κB and activator protein-1 activation block the neoplastic transformation response
15. Expression of dominant negative Jun inhibits elevated AP-1 and NF-κB transactivation and suppresses anchorage independent growth of HPV immortalized human keratinocytes
16. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
17. A survey of transformation markers in differentiating epidermal cell lines
18. Metastatic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line acquire a differential growth advantage requiring tumor-host interaction
19. Genes differentially expressed with malignant transformation and metastatic tumor progression of murine squamous cell carcinoma
20. The host environment promotes the development of primary and metastatic squamous cell carcinoma that constitutively express proinflammatory cytokines, IL-1α, IL-6, GM-CSF and KC
21. The host environment promotes the constitutive activation of NF-κB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma
22. Ratio-based decisions and the quantitative analysis of cDNA microarray images
23. Cluster analysis and display of genome-wide expression patterns
24. The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet α-granule proteins
25. Constitutive activation of a C-X-C chemokine KC promotes metastatic potential in murine squamous cell carcinoma
26. Proto-oncogene PML controls genes devoted to MHC class I antigen presentation
27. The GPI-linked Ly-6 antigen E48 regulates expression levels of the FX enzyme and of E-selectin ligands on head and neck squamous carcinoma cells
28. Hepatocyte growth factor/scatter factor-Met signaling in tumorigenicity and invasion/metastasis
29. HMGI(Y) sp1 in addition to NF-κB regulate transcription of the MGSA/GRO α gene
30. All in the family? New insights and questions regarding interconnectivity of Ras, Raps1 and Ra1
31. Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain
32. Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5′-terminal oligopyrimidine gene family reveals common features of snoRNA host genes
33. Nedd8 modification of cul-1 activates SCF[β(TrCP)]-dependent ubiquitination of IκBα
34. METH-1 a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with anglo-inhibitory activity
35. Immunohistochemical staining for glutathione S-transferase predicts response to platinum-based chemotherapy in head and neck cancer
36. Mapping of the mouse actin capping protein α subunit genes and pseudogenes
37. The Pezcoller lecture: Cancer cell cycles revisited
38. Deregulation of the cell cycle in cancer
39. The functions of the cdk-cyclin kinase inhibitor p21WAFI
40. P27kip1: A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers
41. Phospahatases and tumorigenesis
42. Cell cycle: On target with Myc
43. MAZ, a zinc finger protein binds to c-Myc and C2 gene sequences regulating transcriptional initiation and termination
44. The JAK-STAT pathway: Signal transduction involved in proliferation, differentiation and transformation
45. Upregulation of E2F transcription factors in chemically induced mouse skin tumors
46. The syk tyrosine kinase suppresses malignant growth of human breast cancer cells
47. Growth factor mRNA expression in human head and neck malignant tumors
48. Fas ligand is expressed on human squamous cell carcinomas of the head and neck, and it promotes apoptosis of T lymphocytes
49. Complement component C3 production in IL-1β-stimulated human intestinal epithelial cells is blocked by NF-κB inhibitors and by transfection with ser 32/36 mutant IκBα
50. Induction of interleukin-12/p40 by superantigens in macrophages is mediated by activation of nuclear factor-κB
51. Clinical significance of combined use of macrophage colony-stimulating factor and squamous cell carcinoma antigen as a selective diagnostic marker for squamous cell carcinoma arising in mature cystic teratoma of the ovary
52. Effect of all-trans-retinoic acid on c-fms proto-oncogene [colony-stimulating factor 1 (CSF-1) receptor] expression and CSF-1-induced invasion and anchorage-independent growth of human breast carcinoma cells
53. Distinct roles of osteopontin in host defense activity and tumor survival during squamous cell carcinoma progression in vivo
54. Osteopontin induces increased invasiveness and plasminogen activator expression of human mammary epithelial cells
55. Osteopontin augments CD3-mediated interferon-γ and CD40 ligand expression by T cells, which results in IL- 12 production from peripheral blood mononuclear cells
56. Overexpression of scatter factor and its receptor (c-met) in oral squamous cell carcinoma
57. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
58. Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase α
59. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
60. Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
61. Regulation of FasL by NF-κB and AP-1 in Fas-dependent thymineless death of human colon carcinoma cells
62. PED/PEA-15: An anti-apoptotic molecule that regulates FAS/TNFR-1 induced apoptosis
63. NF-κB mediated ανβ3 integrin-induced endothelial cell survival
64. Vascular endothelial growth factor and osteopontin in stage I lung adenocarcinoma
65. Differential expression and translocation of protein tyrosine phophatase IB-related proteins in ME-180 tumor cells expressing apoptotic sensitivity and resistance to tumor necrosis factor: Potential interaction with epidermal growth factor receptor
66. Site-specific phosphorylation of IκBα by a novel ubiqutination-dependent protein kinase activity
67. Modes of regulation of ubiquitin-mediated protein degradation
68. Novel proteasome inhibitor PS-341 inhibits activation of NF-κB, cell survival, tumor growth and angiogenesis in squamous cell carcinoma
69. Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library
70. Cloning oncogenic ras-regulated genes by differential display
71. Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays
72. Gene expression profiles in squamous cell carcinomas of the oral cavity: Use of laser capture microdissection for the construction and analysis of stage specific cDNA libraries
73. Genomic analysis of metastasis reveals an essential role for RhoC
74. Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes
75. Association of protein-tyrosine phosphatase PTP-BAS with the transcription-factor-inhibitory protein IκBα through interaction between the PDZI domain and ankyrin repeats
76. Nuclear factor of activated T cells contributes to the function of the CD28 response region of the granulocyte macrophage-colony stimulating factor promoter
77. Staging of head and neck squamous cell carcinoma using the MET oncogene product as marker of tumor cells in lymph node metastases
78. Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas
79. Epidermal growth factor receptor blockade with C225 modelates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck
80. The biological role of oncogenes - Insights from platelet-derived growth factor
81. Platelet-derived growth factor: Mechanism of action and relation to oncogenes
82. Ret-mediated mitogenesis requires Src kinase activity
83. Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene
84. The exon/intron organization and chromosomal mapping of the mouse ADAMTS-1 gene encoding an ADAM family protein with TSP motifs
85. ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix
86. Inhibition of transcription factor nuclear factor-κB by a mutant inhibitor-κBα attenuates resistance of human head and neck squamous cell carcinoma to TNF-α caspase-mediated cell death
87. Cisplatin and radiation sensitivity are independently modulated by glutathione and transcription factor nuclear factor-κB in head and neck squamous carcinomas