NF-κB function in growth control: Regulation of cyclin D1 expression and G0/G1-to-S-phase transition

Molecular and Cellular Biology

Volumn 19, Issue 4, 1999, Pages 2690-2698

  Hinz, Michael ^a   Krappmann, Daniel ^b   Eichten, Alexandra ^a   Heder, Andreas ^a   Scheidereit, Claus ^b   Strauss, Michael ^a,c  

^a HUMBOLDT UNIVERSITY   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; CDK4 PROTEIN, HUMAN; CDK4 PROTEIN, MOUSE; CDK6 PROTEIN, HUMAN; CDK6 PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; DNA BINDING PROTEIN; I KAPPA B; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION; ANIMAL; BIOSYNTHESIS; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL STRAIN 3T3; CELL STRAIN COS1; DRUG ANTAGONISM; GENETICS; HELA CELL; INTERPHASE; METABOLISM; MUTATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSACTIVATION;

ANIMALIA;

3T3 CELLS; ANIMALS; COS CELLS; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASES; DNA-BINDING PROTEINS; G0 PHASE; G1 PHASE; HELA CELLS; HUMANS; I-KAPPA B PROTEINS; INTERPHASE; MICE; MUTATION; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; S PHASE; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS);

EID: 0032588170     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.4.2690     Document Type: Article

References (56)

1. Aktas, H., H. Cai, and G. M. Cooper. 1997. Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1. Mol. Cell. Biol. 17:3850-3857.
2. Albanese, C., J. Johnson, G. Watanabe, N. Eklund, D. Vu, A. Arnold, and R. G. Pestell. 1995. Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J. Biol. Chem. 270: 23589-23597.
3. Baeuerle, P. A., and D. Baltimore. 1996. NF-κB: ten years after. Cell 87:13-20.
4. Baichwal, V. R., and P. A. Baeuerle. 1997. Activate NF-κB or die? Curr. Biol. 7:R94-R96.
5. Baldwin, A. S., Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649-683.
6. 1 transition in mouse fibroblasts. Mol. Cell. Biol. 11:4943-4951.
7. Bargou, R. C., F. Emmerich, D. Krappmann, K. Bommert, M. Y. Mapara, W. Arnold, H. D. Royer, E. Grienstein, A. Greiner, C. Scheidereit, and B. Dörken. 1997. Constitutive nuclear factor-κB-RclA activation is required for proliferation and survival of Hodgkin's disease tumor cells. J. Clin. Invest. 100:2961-2969.
8. Bartek, J., J. Bartkova, and J. Lukas. 1996. The retinoblastoma protein pathway and the restriction point. Curr. Opin. Cell Biol. 8:805-814.
9. 1/S-phase transition. Mol. Cell Biol. 17:6526-6536.
10. Beg, A. A., W. C. Sha, R. T. Bronson, S. Ghosh, and D. Baltimore. 1995. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 376:167-170.
11. Beijersbergen, R. L., and R. Bernards. 1996. Cell cycle regulation by the retinoblastoma family of growth inhihitory proteins. Biochim. Biophys. Acta 1287:103-120.
12. Chen, Z. J., L. Parent, and T. Maniatis. 1996. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 84:853-862.
13. Cressman, D. E., L. E. Greenbaum, B. A. Haber, and R. Taub. 1994. Rapid activation of post-hepatectomy factor nuclear factor κB in hepatocytes, a primary response in the regenerating liver J. Biol. Chem. 269:30429-30435.
14. Cressman, D. E., and R. Taub. 1994. Physiologic turnover of nuclear factor κB by nuclear proteolysis. J. Biol. Chem. 269:26594-26597.
15. Duckett, C. S., N. D. Perkins, K. Leung, A. B. Agranoff, and G. J. Nabel. 1995. Cytokine induction of nuclear factor κB in cycling and growth-arrested cells. Evidence for cell cycle-independent activation. J. Biol. Chem. 270: 18836-18840.
16. Finco, T. S., and A. S. Baldwin, Jr. 1993. κB site-dependent induction of gene expression by diverse inducers of nuclear factor κB requires Raf-1. J. Biol. Chem. 268:17676-17679.
17. Finco, T. S., J. K. Westwick, J. L. Norris, A. A. Beg, C. J. Der, and A. S. Baldwin, Jr. 1997. Oncogenic Ha-Ras-induced signaling activates NF-κB transcriptional activity, which is required for cellular transformation. J. Biol. Chem. 272:24113-24116.
18. FitzGerald, M. J., E. M. Webber, J. R. Donovan, and N. Fausto. 1995. Rapid DNA binding by nuclear factor κB in hepatocytes at the start of liver regeneration. Cell Growth Differ. 6:417-427.
19. Ghoda, L., X. Lin, and W. C. Greene. 1997. The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IκBα and stimulates its degradation in vitro. J. Biol. Chem. 272:21281-21288.
20. Heldin, C. H. 1995. Dimerization of cell surface receptors in signal transduction. Cell 80:213-223.
21. Helin, K., and E. Harlow. 1993. The retinoblastoma protein as a transcriptional repressor. Trends Cell Biol. 3:43-46.
22. Herber, B., M. Truss, M. Beato, and R. Muller. 1994. Inducible regulatory elements in the human cyclin D1 promoter. Oncogene 9:2105-2107.
23. Hill, C. S., and R. Treisman. 1995. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 80:199-211.
24. Kanno, T., and U. Siebenlist. 1996. Activation of nuclear factor-κB via T cell receptor requires a Raf kinase and Ca2+ influx. Functional synergy between Raf and calcineurin. J. Immunol. 157:5277-5283.
25. Krappmann, D., F. G. Wulczyn, and C. Scheidereit. 1996. Different mechanisms control signal-induced degradation and basal turnover of the NF-κB inhibitor IκB alpha in vivo. EMBO J. 15:6716-6726.
26. Kundu, M., M. Guermah, R. G. Roeder, S. Amini, and K. Khalili. 1997. Interaction between cell cycle regulator. E2F-1, and NF-κB mediates repression of HIV-1 gene transcription. J. Biol. Chem. 272:29468-29474.
27. LaThangue, N. B. 1994. DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sci. 19:108-114.
28. Lavoie, J. N., G. L'Allemain, A. Brunet, R. Muller, and J. Pouyssegur. 1996. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J. Biol. Chem. 271:20608-20616.
29. Lee, F. S., J. Hagler, Z. J. Chen, and T. Maniatis. 1997. Activation of the IκBα a kinase complex by MEKKI, a kinase of the JNK pathway. Cell 88: 213-222.
30. Li, S., and J. M. Sedivj. 1993. Raf-1 protein kinase activates the NF-κB transcription factor by dissociating the cytoplasmic NF-κB-IκB complex. Proc. Natl. Acad. Sci. USA 90:9247-9251.
31. 1 checkpoint. Mol. Cell. Biol. 16:6917-6925.
32. 1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Mol. Cell. Biol. 15:2600-2611.
33. Marshall, C. J. 1996. Ras effectors. Curr. Opin. Cell Biol. 8:197-204.
34. May, M. J., and S. Ghosh. 1997. Rel/NF-κB and IκB proteins: an overview. Semin. Cancer Biol. 8:63-73.
35. Mayo, M. W., C. Y. Wang, P. C. Cogswell, K. S. Rogers Graham, S. W. Lowe, C. J. Der, and A. S. Baldwin, Jr. 1997. Requirement of NF-κB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science 278: 1812-1815.
36. Muller, H., J. Lukas, A. Schneider, P. Warthoe, J. Bartek, M. Eilers, and M. Strauss. 1994. Cyclin D1 expression is regulated by the retinoblastoma protein. Proc. Natl. Acad. Sci. USA 91:2945-2949.
37. Musgrove, E. A., C. S. L. Lee, M. F. Buckley, and R. L. Sutherland. 1994. Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle. Proc. Natl. Acad. Sci. USA 91:8022-8026.
38. Naumann, M., F. G. Wulczyn, and C. Scheidereit. 1993. The NF-κB precursor p105 and the proto-oncogene product Bcl-3 are IκB molecules and control nuclear translocation of NF-κB. EMBO J. 12:213-222.
39. Nevins, J. R. 1992. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429.
40. Peeper, D. S., T. M. Upton, M. H. Ladha, E. Neuman, J. Zalvide, R. Bernards, J. A. DeCaprio, and M. E. Ewen. 1997. Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein. Nature 386:177-181.
41. Perkins, N. D., L. K. Felzien, J. C. Belts, K. Leung, D. H. Beach, and G. J. Nabel. 1997. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science 275:523-527.
42. Russell, M., C. A. Lange Carter, and G. L. Johnson. 1995. Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1). J. Biol. Chem. 270:11757-11760.
43. Schouten, G. J., A. C. Vertegaal, S. T. Whiteside, A. Israel, M. Toebes, J. C. Dorsman, A. J. van der Eb, and A. Zantema. 1997. IκBα is a target for the mitogen-activated 90 kDa ribosomal S6 kinase. EMBO J. 16:3133-3144.
44. Sherr, C. J. 1993. Mammalian G1 cyclins. Cell 73:1059-1065.
45. Sherr, C. J. 1996. Cancer cell cycles. Science 274:1672-1677.
46. Sherr, C. J., and J. M. Roberts. 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9:1149-1163.
47. Siebenlist, U., G. Franzoso, and K. Brown. 1994. Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10:405-455.
48. Sovak, M. A., R. E. Bellas, D. W. Kim, G. J. Zanieski, A. E. Rogers, A. M. Traish, and G. E. Sonenshein. 1997. Aberrant nuclear factor-κB/Rel expression and the pathogenesis of breast cancer. J. Clin. Invest. 100:2952-2960.
49. Verma, I. M., J. K. Stevenson, E. M. Schwarz, D. Van Antwerp, and S. Miyamoto. 1995. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9:2723-2735.
50. Watanabe, G., C. Albanese, J. Lee, A. Reutens, G. Vario, B. Henglein, and R. G. Pestell. 1998. Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1. Mol. Cell. Biol. 18:3212-3222.
51. Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323-330.
52. Wu, M., H. Lee, R. E. Bellas, S. L. Schauer, M. Arsura, D. Katz, M. J. FitzGerald, T. L. Rothstein, D. H. Sherr, and G. E. Sonenshein. 1996 Inhibition of NF-κB/Rel induces apoptosis of murine B cells. EMBO J. 15:4682-4690.
53. Wulczyn, F. G., D. Krappmann, and C. Scheidereit. 1996. The NF-κB/Rel and IκB gene families: mediators of immune response and inflammation. J. Mol. Med. 74:749-769.
54. Yamada, Y., I. Kirillova, J. J. Peschon, and N. Fausto. 1997. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc. Natl. Acad. Sci. USA 94:1441-1446.
55. Zhong, H., H. SuYang, H. Erdjument Bromage, P. Tempst, and S. Ghosh. 1997. The transcriptional activity of NF-κB is regulated by the IκB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell 89:413-424.
56. Zhong, H., R. E. Voll, and S. Ghosh. 1998. Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell 1:661-672.