Transient activation of NF-κB through a TAK1/IKK kinase pathway by TGF-β1 inhibits AP-1/SMAD signaling and apoptosis: Implications in liver tumor formation

Oncogene

Volumn 22, Issue 3, 2003, Pages 412-425

  Arsura, Marcello ^a   Panta, Ganesh R ^a   Bilyeu, Jennifer D ^a   Cavin, Lakita G ^a   Sovak, Mika A ^b   Oliver, Aundrea A ^b   Factor, Valentina ^c   Heuchel, Rainer ^d   Mercurio, Frank ^e   Thorgeirsson, Snorri S ^c   Sonenshein, Gail E ^b  

^a UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^e CELGENE CORPORATION   (United States)

Author keywords

AP 1; Apoptosis; JNK; NF B IKK; TGF 1

Indexed keywords

I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PHOSPHOTRANSFERASE; PROTEIN C JUN; SMAD PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CANCER GROWTH; CARCINOGENESIS; CELL DEATH; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELLS, CULTURED; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HEPATOCYTES; I-KAPPA B KINASE; I-KAPPA B PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS; MAP KINASE KINASE KINASES; MICE; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-MYC; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR AP-1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMALIA; MURINAE; MUS MUSCULUS;

EID: 0037461958     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206132     Document Type: Article

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